Best TWAS P=2.52e-08 · Best GWAS P=2.18e-09 conditioned to 0.0675
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | GLYR1 | 0.14 | 0.03 | bslmm | 416 | 0.07 | 3.8e-09 | -1.5 | 5.6 | 2.6e-08 | 0.06 | 0.34 | 0.23 | TRUE |
| 2 | GTEx | Brain Cortex | AC006111.1 | 0.32 | 0.02 | enet | 16 | 0.00 | 3.2e-01 | -2.9 | 5.5 | 3.7e-08 | -0.01 | 0.04 | 0.06 | TRUE |
| 3 | GTEx | Heart Atrial Appendage | NUDT16L1 | 0.12 | 0.17 | lasso | 1 | 0.17 | 4.8e-08 | -5.1 | 5.1 | 3.0e-07 | -0.01 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Heart Left Ventricle | MGRN1 | 0.32 | 0.10 | enet | 18 | 0.33 | 3.6e-18 | 2.7 | 5.4 | 7.5e-08 | -0.02 | 0.18 | 0.63 | FALSE |
| 5 | GTEx | Muscle Skeletal | MGRN1 | 0.16 | 0.06 | lasso | 7 | 0.15 | 1.1e-14 | 3.5 | 5.4 | 5.5e-08 | -0.01 | 0.25 | 0.50 | TRUE |
| 6 | METSIM | Adipose | NUDT16L1 | 0.06 | 0.03 | bslmm | 392 | 0.04 | 2.2e-06 | -3.7 | -5.4 | 8.8e-08 | -0.02 | 0.02 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NAT15 | 0.05 | 0.04 | blup | 56 | 0.03 | 1.7e-07 | 4.8 | -5.6 | 2.5e-08 | -0.89 | 0.04 | 0.96 | TRUE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | NAT15 | 0.06 | 0.04 | blup | 56 | 0.04 | 4.1e-05 | 6.0 | -5.5 | 4.0e-08 | -0.88 | 0.00 | 1.00 | FALSE |