Best TWAS P=9.73e-09 · Best GWAS P=2.58e-07 conditioned to 0.109
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | RP11-296I10.6 | 0.13 | 0.09 | enet | 18 | 0.04 | 1.4e-02 | -4.3 | -5.2 | 2.4e-07 | -0.73 | 0.05 | 0.72 | FALSE |
2 | GTEx | Artery Aorta | SF3B3 | 0.05 | 0.01 | enet | 9 | 0.01 | 6.4e-02 | 5.2 | 5.1 | 2.9e-07 | 0.95 | 0.02 | 0.84 | FALSE |
3 | GTEx | Brain Cerebellum | PDPR | 0.23 | 0.06 | enet | 20 | 0.11 | 3.7e-04 | -4.3 | -5.3 | 1.2e-07 | -0.58 | 0.03 | 0.51 | FALSE |
4 | GTEx | Breast Mammary Tissue | PDXDC2P | 0.55 | 0.24 | enet | 35 | 0.36 | 1.4e-19 | -4.4 | -5.3 | 1.4e-07 | -0.76 | 0.06 | 0.92 | FALSE |
5 | GTEx | Breast Mammary Tissue (Female) | PDXDC2P | 0.44 | 0.14 | enet | 16 | 0.16 | 1.9e-05 | -4.6 | -5.3 | 1.4e-07 | -0.78 | 0.05 | 0.82 | FALSE |
6 | GTEx | Colon Transverse | PDXDC2P | 0.52 | 0.28 | enet | 24 | 0.33 | 2.7e-16 | 4.6 | -5.3 | 1.0e-07 | -0.75 | 0.04 | 0.94 | FALSE |
7 | GTEx | Esophagus Gastroesophageal Junction | RP11-296I10.6 | 0.26 | 0.22 | enet | 15 | 0.20 | 7.9e-08 | -4.3 | -5.3 | 1.2e-07 | -0.87 | 0.04 | 0.93 | FALSE |
8 | GTEx | Skin Not Sun Exposed Suprapubic | PDXDC2P | 0.36 | 0.22 | enet | 24 | 0.24 | 4.1e-13 | 4.6 | -5.2 | 2.0e-07 | -0.75 | 0.04 | 0.94 | FALSE |
9 | GTEx | Stomach | RP11-296I10.6 | 0.24 | 0.15 | enet | 14 | 0.16 | 4.5e-08 | -4.3 | -5.7 | 9.7e-09 | -0.70 | 0.10 | 0.84 | TRUE |
10 | GTEx | Thyroid | PDXDC2P | 0.41 | 0.27 | lasso | 10 | 0.30 | 5.0e-23 | 4.7 | -5.5 | 3.0e-08 | -0.87 | 0.04 | 0.94 | FALSE |
11 | GTEx | Whole Blood | PDXDC2P | 0.16 | 0.05 | lasso | 3 | 0.07 | 9.0e-07 | -3.7 | -5.2 | 2.0e-07 | -0.73 | 0.09 | 0.86 | FALSE |
12 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | COG4 | 0.25 | -0.01 | enet | 6 | 0.05 | 4.4e-03 | -2.8 | 5.5 | 4.2e-08 | 0.66 | 0.01 | 0.38 | FALSE |
13 | The Cancer Genome Atlas | Rectum Adenocarcinoma | COG4 | 0.33 | 0.09 | enet | 12 | 0.15 | 2.5e-04 | 4.9 | 5.3 | 9.3e-08 | 0.75 | 0.01 | 0.88 | FALSE |