Best TWAS P=2.29e-12 · Best GWAS P=4.05e-13 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CFDP1 | 0.08 | 0.04 | lasso | 4 | 0.04 | 1.6e-05 | -7.1 | -6.9 | 4.1e-12 | 0.93 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | TMEM170A | 0.11 | 0.00 | lasso | 5 | 0.01 | 6.7e-02 | -5.3 | -5.5 | 4.5e-08 | 0.79 | 0.04 | 0.87 | FALSE |
| 3 | GTEx | Adrenal Gland | TMEM170A | 0.11 | 0.06 | enet | 4 | 0.04 | 1.7e-02 | -6.5 | 6.6 | 3.5e-11 | -0.95 | 0.03 | 0.90 | FALSE |
| 4 | GTEx | Artery Aorta | BCAR1 | 0.18 | 0.13 | lasso | 3 | 0.11 | 9.8e-07 | -6.5 | 6.7 | 2.5e-11 | -0.95 | 0.02 | 0.98 | FALSE |
| 5 | GTEx | Artery Tibial | BCAR1 | 0.07 | 0.06 | lasso | 1 | 0.04 | 2.4e-04 | -6.6 | 6.6 | 3.1e-11 | -0.96 | 0.02 | 0.96 | FALSE |
| 6 | GTEx | Brain Cerebellum | BCAR1 | 0.18 | 0.08 | enet | 12 | 0.09 | 1.1e-03 | -7.0 | -6.8 | 9.0e-12 | 0.81 | 0.02 | 0.92 | FALSE |
| 7 | GTEx | Brain Cerebellum | CFDP1 | 0.25 | -0.01 | lasso | 2 | 0.05 | 1.7e-02 | -6.5 | -5.2 | 1.6e-07 | 0.77 | 0.04 | 0.78 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | CFDP1 | 0.17 | 0.20 | enet | 10 | 0.24 | 9.9e-18 | -7.0 | -7.0 | 2.3e-12 | 0.97 | 0.01 | 0.99 | TRUE |
| 9 | GTEx | Esophagus Mucosa | BCAR1 | 0.16 | 0.13 | lasso | 8 | 0.14 | 1.8e-09 | -6.8 | -6.7 | 2.8e-11 | 0.93 | 0.05 | 0.95 | FALSE |
| 10 | GTEx | Nerve Tibial | CFDP1 | 0.16 | 0.14 | lasso | 3 | 0.12 | 1.6e-08 | -4.6 | -5.4 | 5.2e-08 | 0.76 | 0.36 | 0.64 | FALSE |
| 11 | GTEx | Nerve Tibial | TMEM170A | 0.12 | 0.09 | enet | 7 | 0.11 | 4.1e-08 | -4.0 | -6.3 | 2.3e-10 | 0.87 | 0.02 | 0.98 | FALSE |
| 12 | METSIM | Adipose | TMEM170A | 0.03 | 0.01 | lasso | 3 | 0.02 | 1.5e-03 | -7.1 | -6.0 | 2.6e-09 | 0.88 | 0.01 | 0.99 | FALSE |
| 13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CFDP1 | 0.02 | 0.02 | lasso | 4 | 0.02 | 1.9e-03 | -6.7 | -6.7 | 2.7e-11 | 0.93 | 0.02 | 0.87 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | TMEM170A | 0.08 | 0.10 | blup | 36 | 0.13 | 9.1e-08 | -5.6 | -6.2 | 6.1e-10 | 0.89 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CFDP1 | 0.04 | 0.02 | lasso | 6 | 0.03 | 4.0e-04 | -3.8 | -5.8 | 6.6e-09 | 0.86 | 0.03 | 0.96 | FALSE |
| 16 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CFDP1 | 0.23 | 0.00 | blup | 70 | 0.02 | 4.2e-02 | -4.8 | -5.5 | 3.4e-08 | 0.66 | 0.02 | 0.31 | FALSE |
| 17 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CFDP1 | 0.10 | 0.00 | blup | 70 | 0.04 | 1.4e-02 | -6.7 | -6.1 | 1.4e-09 | 0.87 | 0.02 | 0.44 | FALSE |
| 18 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CHST6 | 0.20 | 0.08 | enet | 10 | 0.10 | 2.2e-04 | -6.0 | 5.9 | 3.8e-09 | -0.85 | 0.01 | 0.90 | FALSE |