Best TWAS P=5.83e-74 · Best GWAS P=1.49e-89 conditioned to 2.68e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ROSMAP | Brain Pre-frontal Cortex | ECHDC1 | 0.22 | 0.11 | enet | 54 | 0.12 | 1.5e-14 | -2.877 | -5.4 | 6.2e-08 | -0.10 | 1.00 | 0.00 | TRUE |
| 2 | YFS | Blood | RNF146 | 0.01 | 0.00 | bslmm | 323 | 0.00 | 4.8e-02 | 0.014 | -7.9 | 2.7e-15 | -0.40 | 0.05 | 0.11 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RSPO3 | 0.02 | 0.02 | blup | 60 | 0.02 | 2.8e-04 | 15.735 | 16.9 | 2.5e-64 | 0.86 | 0.10 | 0.70 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RSPO3 | 0.02 | 0.03 | blup | 60 | 0.02 | 1.3e-03 | 19.298 | 18.2 | 5.8e-74 | 0.92 | 0.02 | 0.96 | TRUE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RSPO3 | 0.06 | 0.02 | blup | 60 | 0.04 | 9.3e-05 | 19.298 | 15.8 | 1.6e-56 | 0.82 | 0.01 | 0.97 | FALSE |