TWAS hub - RSPO3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0157	0.0098	0.00110	0.016	0.016	0.015	NA	0.013	0.0002	2.8e-04	0.00042	NA	0.0007
2	TCGA	Lung Squamous Cell Carcinoma	0.0248	0.0151	0.00097	0.028	0.022	0.013	NA	0.013	0.0003	1.3e-03	0.01100	NA	0.0110
3	TCGA	Prostate Adenocarcinoma	0.0562	0.0285	0.00014	0.024	0.037	0.033	NA	0.024	0.0013	9.3e-05	0.00020	NA	0.0013

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Heel T-Score	170.8	1358.2	1600.0	37.4	40.0	32.8
Heel bone mineral density (BMD) T-score, automated (left)	127.3	288.8	331.2	16.9	18.2	15.8
Heel bone mineral density (BMD) T-score, automated (right)	124.2	284.7	331.2	16.9	18.2	15.4
Waist Hip Ratio (WHR)	86.5	388.9	533.6	23.1	21.6	12.9
Fractured/broken bones in last 5 years	35.1	45.4	51.7	-7.1	-7.2	-5.8
Blood Red Count	12.3	118.4	127.7	11.2	11.3	10.1
Crohns Disease (2017)	11.2	24.6	26.5	4.6	5.1	5.1
Crohns Disease (2012)	10.1	16.2	18.9	3.6	4.1	4.4
Triglycerides	9.4	15.4	19.3	4.4	4.4	2.8
HDL Cholesterol	8.8	14.7	19.6	-4.4	-4.3	-2.4
Hip circumference	8.7	37.5	56.2	-7.5	-7.2	-2.2
Osteoporosis (self-reported)	8.1	10.0	11.0	-3.2	-3.3	-3.0
Birth weight	7.9	17.0	22.8	3.4	4.1	4.8
Ever had hysterectomy (womb removed)	7.0	7.9	10.0	2.6	2.7	3.2
Supplements: Calcium	6.7	7.4	10.1	-2.3	-2.6	-3.2
Bilateral oophorectomy (both ovaries removed)	6.4	7.4	8.3	2.9	2.9	2.4
High blood pressure (mother)	5.2	7.3	9.7	-3.1	-3.1	-1.6
Waist circumference	5.2	18.9	21.6	4.3	4.1	4.6
Diabetes (self-reported)	4.8	7.4	13.4	-1.9	-2.3	-3.7
Myopia	4.7	6.8	8.1	-2.8	-2.8	-2.1
Breast Cancer	4.6	11.0	12.4	3.5	3.5	2.9
Hair/balding pattern: Pattern 4	4.6	11.1	13.5	3.5	3.7	2.8
Happiness	4.4	5.4	7.0	-2.6	-2.5	-1.6
Bipolar Disorder (2011)	4.2	4.1	5.8	-2.3	-2.4	-1.0
Medication: Bendroflumethiazide	4.2	6.4	8.6	-2.9	-2.9	-1.5
Wheeze or whistling in the chest in last year	4.1	7.3	8.9	-2.9	-3.0	-2.2
Irritable Bowel Disease (IBD)	3.8	9.1	13.0	2.5	2.8	3.6
Diabetes diagnosed by doctor	3.7	6.1	13.2	-1.3	-1.9	-3.6
Type 2 Diabetes (T2D) (2018)	3.6	6.8	15.8	-1.1	-1.8	-4.0
Medication for hormone replacement therapy	3.6	4.0	5.6	2.4	2.3	1.2
Pulse wave peak to peak time	3.6	4.3	7.2	-1.9	-1.5	-2.7
Hand grip strength (left)	3.5	9.2	12.4	3.5	3.5	1.8
Pulse rate, automated reading	3.5	11.4	17.1	4.1	3.6	2.1
Pulse wave Arterial Stiffness index	3.3	3.8	5.7	1.9	1.5	2.4
Migraine (self-reported)	3.3	4.1	6.9	2.3	2.6	-0.1
Loud music exposure frequency	3.2	3.5	5.8	1.4	1.6	2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.2	3.7	5.3	2.3	2.3	0.9
Supplements: Zinc	2.9	3.2	4.9	-2.2	-1.8	-1.2
Birth weight of first child	2.9	5.3	6.4	2.5	2.5	1.9
Number of incorrect matches in round	2.8	4.7	6.0	-2.4	-2.3	-1.7
Medication: Gliclazide	2.8	3.1	4.1	-1.5	-1.7	-2.0
Heart disease (siblings)	2.8	3.5	5.7	1.5	1.5	2.4
Forced expiratory volume in 1-second (FEV1)	2.7	9.2	13.5	3.7	3.5	1.3
Vitamin and mineral supplements	2.6	3.5	3.8	1.9	1.8	1.9
Alcohol intake frequency.	2.6	6.0	7.4	2.7	2.5	2.1
Smoking status: Current	2.6	4.2	4.9	-1.9	-2.0	-2.2
Medication: Metformin	2.5	3.5	5.5	-1.4	-1.8	-2.3
Had other major operations	2.5	3.1	4.2	2.0	2.0	0.9
Pulse rate	2.5	4.3	7.3	2.7	2.1	1.1
Chronotype (morning person)	2.4	5.6	7.9	2.6	2.8	1.5
Medication: Co-codamol	2.4	2.7	3.2	1.7	1.4	1.8
Hand grip strength (right)	2.4	6.5	8.4	2.9	2.8	1.7
Current tobacco smoking	2.4	4.0	4.5	-1.9	-2.0	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.9	4.5	-2.0	-2.1	-0.3
Ovarian Cancer	2.3	3.0	3.8	-1.5	-2.0	-1.7
Forced vital capacity (FVC)	2.3	8.8	13.5	3.7	3.4	1.1
Hypertension (Self-reported)	2.3	6.4	9.9	-2.9	-3.1	-1.1
Hayfever/allergic rhinitis (self-reported)	2.2	3.0	3.8	-1.6	-1.9	-1.6
Mouth/teeth dental problems: Dentures	2.2	3.7	4.8	-2.0	-2.2	-1.5
Headache pain in last month	2.2	3.8	4.4	1.7	2.1	2.0
Medication: Blood pressure	2.2	4.2	6.6	-2.2	-2.6	-1.0
High blood pressure	2.1	6.0	9.4	-2.8	-3.1	-0.8
Alcohol drinker status: Never	2.1	2.5	2.8	1.5	1.6	1.7
Risk taking	2.1	3.0	4.4	-1.6	-2.1	-1.5
Diabetes (father)	2.0	2.5	6.0	-0.6	-1.1	-2.4
Impedance of leg (left)	1.9	9.2	14.2	3.8	3.4	1.3
Supplements: Vitamin C	1.9	2.2	2.6	-1.6	-1.3	-1.6
Osteoarthritis (self-reported)	1.9	2.4	3.7	1.9	1.7	0.9
Pain experienced in last month	1.9	3.2	6.4	-1.2	-1.3	-2.5
Sitting height	1.8	12.7	24.1	4.9	3.7	-0.4
Medication: Ramipril	1.8	2.3	2.7	-1.5	-1.6	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.9	6.2	2.2	2.5	0.8
Schizophrenia (2014)	1.7	3.7	5.3	-2.3	-2.1	-1.1
Blood Platelet Count	1.7	19.6	20.6	-4.3	-4.5	-4.5
Cardiovascular Disease	1.7	5.7	8.8	-2.6	-3.0	-1.2
Severe depression (siblings)	1.7	1.9	2.1	-1.3	-1.4	-1.4
Chronic bronchitis/emphysema (father)	1.7	2.0	3.0	-1.7	-1.6	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	3.2	-1.8	-1.8	-0.5
Number of children fathered	1.7	1.9	2.3	1.5	1.4	1.1
Guilty feelings	1.7	2.6	3.6	-1.9	-1.8	-1.0
Intelligence (Savage-Jansen 2018)	1.6	4.8	11.9	-0.8	-1.3	-3.4
Primary Biliary Cirrhosis	1.6	2.4	4.0	1.2	1.2	2.0
Hearing difficulty/problems: Yes	1.6	2.4	6.4	0.5	0.8	2.5
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	4.8	0.6	0.2	-2.2
Angina	1.6	2.1	3.3	1.2	1.2	1.8
Impedance of leg (right)	1.6	7.8	11.8	3.4	3.2	1.3
Chronic bronchitis/emphysema (mother)	1.6	1.9	2.9	-1.7	-1.6	-0.1
Family relationship satisfaction	1.6	2.0	3.3	-1.1	-1.2	-1.8
Illnesses of father: None of the above (group 1)	1.6	2.0	3.2	1.8	1.7	0.3
Bipolar Disorder or Schizophrenia	1.5	3.5	5.2	-2.3	-2.0	-1.1
Verbal and Numeric Reasoning (VNR)	1.5	3.5	7.4	-1.0	-1.5	-2.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.8	7.8	2.8	2.6	0.3
Neck or shoulder pain in last month	1.5	2.1	3.2	1.3	1.2	1.8
Medication: Seretide 50 evohaler	1.5	1.8	4.3	0.7	0.8	2.1
Illnesses of father: High blood pressure	1.5	1.9	2.2	-1.2	-1.4	-1.5
Heart attack	1.4	1.8	5.0	0.2	0.5	2.2
Illnesses of mother	1.4	1.8	2.8	1.6	1.7	-0.0
Peak expiratory flow (PEF)	1.4	3.4	4.4	2.1	2.0	1.2
Angina (self-reported)	1.4	1.9	2.9	1.1	1.2	1.7
Number of full sisters	1.4	1.7	2.3	-1.5	-1.5	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	2.8	1.1	1.1	1.7
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.9	0.2	0.5	2.2
Systolic Blood Pressure	1.3	6.4	8.8	-2.7	-3.0	-1.7
Lung FVC	1.3	6.7	8.5	2.6	2.9	2.2
Medication for pain relief, constipation, heartburn	1.3	2.2	2.4	-1.6	-1.4	-1.5
Medication: Blood pressure	1.3	2.4	3.5	-1.8	-1.9	0.5
Breast cancer (self-reported)	1.3	1.5	1.7	-1.3	-1.1	-1.3
Medication: Aspirin	1.3	1.8	2.5	1.6	1.4	0.9
Taking other prescription medications	1.2	1.9	3.3	1.1	1.0	1.8
Medication: Lansoprazole	1.2	1.4	4.2	-0.1	0.1	2.0
Tense / ‘highly strung’	1.2	2.1	3.1	-1.8	-1.7	-0.6
Number of full brothers	1.2	1.5	2.0	-1.1	-1.1	-1.4
Commuting to job workplace: Car/motor vehicle	1.2	1.4	1.8	1.3	0.9	1.3
Medication: Aspirin	1.2	1.6	1.9	1.4	1.3	1.1
Bipolar Disorder (2018)	1.1	1.8	2.2	-1.5	-1.4	-1.0
Sensitivity / hurt feelings	1.1	1.9	2.9	-1.7	-1.6	0.7
Townsend deprivation index at recruitment	1.1	1.5	1.8	-1.2	-1.3	-1.1
Medication: Atenolol	1.1	1.3	2.5	0.9	0.8	1.6
Hearing difficulty/problems with background noise	1.1	1.8	4.5	0.5	0.9	2.1
Health satisfaction	1.1	1.4	2.2	-1.1	-1.0	1.5
Shortness of breath walking on level ground	1.1	1.3	3.9	0.1	0.1	2.0
Commuting to job workplace: Walk	1.1	1.2	3.5	0.1	0.3	1.9
Vascular/heart problems diagnosed by doctor	1.1	3.1	5.0	2.0	2.2	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	1.6	1.3	1.2	1.0
Lung FEV1/FVC ratio	1.0	5.3	7.6	2.6	2.8	1.3
Multivitamins +/- minerals	1.0	1.2	1.6	-1.1	-1.0	-1.2
Qualifications: A levels/AS levels or equivalent	1.0	2.1	3.6	-0.9	-1.4	-1.9
Leg fat percentage (right)	1.0	3.8	10.0	-0.9	-0.6	3.2
Overall health rating	1.0	2.1	3.1	-1.8	-1.8	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.1	1.0	1.5	0.6
Schizophrenia (2018)	0.9	1.8	3.0	-1.7	-1.4	-0.7
Lupus	0.9	1.4	2.0	-1.0	-1.4	-1.1
Body mass index (BMI)	0.9	3.8	4.7	-2.2	-1.8	1.9
Pain all over the body in last month	0.9	1.0	1.4	-0.8	-1.2	-0.9
Forced vital capacity (FVC), Best measure	0.9	3.5	5.8	2.4	2.1	-0.5
Qualifications: College or University degree	0.9	2.8	4.5	-1.1	-1.6	-2.1
Medication: Omeprazole	0.9	1.1	1.9	1.4	1.1	0.3
Average weekly champagne plus white wine intake	0.9	1.2	2.2	-0.8	-0.8	-1.5
High cholesterol (Self-reported)	0.9	1.7	2.2	1.5	1.3	1.0
Leg fat percentage (left)	0.9	3.2	8.8	-0.7	-0.5	3.0
Diastolic blood pressure, automated reading	0.9	2.7	4.3	-1.7	-2.1	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	1.7	-1.1	-1.3	-0.8
Arm fat percentage (right)	0.8	3.1	5.8	-1.6	-1.1	2.4
Pulse wave reflection index	0.8	1.0	2.9	-0.3	-0.3	1.7
Chest pain or discomfort	0.8	1.1	3.0	0.4	0.4	1.7
Arm fat percentage (left)	0.8	3.2	4.0	-1.9	-1.5	2.0
Wears glasses or contact lenses	0.8	0.9	1.6	-0.8	-0.6	1.2
Mother’s age at death	0.8	1.0	2.1	-0.6	-0.8	-1.5
Eye problems/disorders: Glaucoma	0.8	0.9	1.5	1.2	1.1	0.2
Number of operations (self-reported)	0.8	1.1	1.9	0.9	0.9	1.4
Impedance of whole body	0.8	3.9	6.5	2.5	2.3	-0.1
Body Mass Index (BMI) (2010)	0.7	1.0	1.2	1.1	1.1	0.8
Coronary Artery Disease (CAD)	0.7	0.9	1.2	0.9	1.1	0.8
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.4	-0.2	-0.3	-1.5
Allergy or Eczema	0.7	1.8	2.7	-1.3	-1.6	-1.0
Relative age of first facial hair	0.7	1.5	1.8	-1.4	-1.2	-1.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.4	1.2	1.0	0.6
Systolic blood pressure, automated reading	0.7	2.1	3.2	-1.7	-1.8	-0.5
Fed-up feelings	0.7	1.3	2.4	-1.5	-1.1	-0.5
Qualifications: None of the above	0.7	1.5	2.0	1.0	1.1	1.4
Neuroticism score	0.7	1.5	2.1	-1.5	-1.4	0.7
Standing height	0.7	7.0	11.6	3.4	2.2	-2.1
Worry too long after embarrassment	0.7	1.2	2.9	-0.8	-0.5	1.7
Eye problems/disorders: None of the above	0.7	0.9	1.2	-1.1	-1.1	-0.5
Emphysema/chronic bronchitis	0.7	0.8	1.1	-1.1	-0.8	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.0	1.0	0.8	0.8
Mineral and other dietary supplements	0.7	0.9	1.0	1.0	0.9	1.0
Financial situation satisfaction	0.7	0.9	1.4	-1.2	-1.1	-0.2
Cholesterol lowering medication	0.7	1.1	1.4	1.0	0.8	1.2
Smoking Status	0.6	1.3	2.2	-1.5	-1.2	-0.5
Age when periods started (menarche)	0.6	1.5	2.5	-1.6	-1.4	-0.2
Qualifications: CSEs or equivalent	0.6	0.8	1.5	-1.0	-1.2	-0.1
Asthma	0.6	1.2	1.5	-1.2	-1.2	-0.9
Length of working week for main job	0.6	0.7	1.0	-0.9	-1.0	-0.6
Blood clot in the leg (DVT)	0.6	0.8	1.8	0.4	0.6	1.3
Gout (self-reported)	0.6	0.9	1.4	-0.7	-0.9	-1.2
Body fat percentage	0.6	2.5	6.7	-0.8	-0.6	2.6
Medication: Ibuprofen	0.6	0.7	1.6	0.5	0.4	1.3
Leg fat mass (right)	0.6	2.4	5.8	-0.9	-0.8	2.4
Back pain experienced in last month	0.6	0.9	2.3	0.5	0.5	1.5
Asthma (self-reported)	0.6	1.3	1.5	-1.2	-1.2	-0.9
Leg fat mass (left)	0.6	2.2	5.5	-0.8	-0.7	2.3
Neuroticism (Nagel 2018)	0.5	1.3	2.1	-1.1	-0.6	1.4
Alzheimer’s Disease (including proxy)	0.5	0.7	0.8	0.9	0.6	0.9
Blood White Count	0.5	4.1	4.8	1.9	2.2	2.0
BMI	0.5	3.0	4.3	-1.6	-1.4	2.1
Average weekly spirits intake	0.5	0.6	0.8	-0.9	-0.8	-0.7
Pack years adult smoking proportion	0.5	0.7	0.9	-1.0	-0.9	-0.5
Trunk fat percentage	0.5	1.9	5.7	-0.2	-0.1	2.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.1	0.6	0.4	1.0
Stomach or abdominal pain in last month	0.5	0.6	1.4	-0.5	-0.2	1.2
Had menopause	0.5	0.6	1.0	-0.7	-1.0	-0.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	0.7	0.8	0.7	0.8
Financial difficulties in last 2 years	0.5	0.6	1.0	0.7	1.0	0.7
Mouth/teeth dental problems	0.5	0.7	0.9	0.8	0.9	0.8
Arm fat mass (right)	0.5	1.9	3.7	-1.1	-0.9	1.9
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.4	1.1	1.2	-0.4
High blood pressure (siblings)	0.5	0.7	1.1	-0.7	-1.1	-0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.0	-0.6	-0.6	-1.0
Eye problems/disorders: Cataract	0.5	0.6	1.1	0.4	0.7	1.1
Arm fat mass (left)	0.5	2.1	3.4	-1.3	-1.1	1.9
Hearing aid user	0.5	0.6	0.7	-0.8	-0.7	0.8
Medication: Paracetamol	0.5	0.8	1.1	0.8	0.9	1.1
Age started oral contraceptive pill	0.5	0.6	0.8	-0.7	-0.7	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.4	0.5	0.6	1.2
Depressed Affect (Nagel 2018)	0.4	0.8	1.6	-1.2	-0.6	0.7
Alzheimer’s Disease (in father)	0.4	0.5	0.9	0.9	0.7	-0.3
Major Depression (MDD)	0.4	0.5	1.3	0.4	0.3	-1.1
LDL Cholesterol	0.4	0.6	0.8	0.8	0.9	0.4
Ulcerative Colitis	0.4	0.5	0.6	-0.6	-0.8	0.8
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.3	-0.9	-1.2	-0.9
Supplements: Glucosamine	0.4	0.6	1.0	0.5	0.6	-1.0
Nervous feelings	0.4	0.8	1.4	-1.2	-1.0	0.2
Allergy	0.4	0.9	1.5	1.1	1.2	0.3
Medication: Simvastatin	0.4	0.6	1.0	0.8	0.6	1.0
Fluid intelligence score	0.4	0.7	1.7	0.6	0.2	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.7	0.5	0.6	0.8
Lung cancer (father)	0.4	0.4	1.0	0.2	0.4	1.0
Medication: Amlodipine	0.4	0.5	1.2	-0.6	-1.1	-0.2
Heart disease (mother)	0.4	0.5	1.0	0.4	0.6	1.0
Whole body fat mass	0.4	1.6	3.8	-0.7	-0.6	2.0
Mood swings	0.4	0.7	1.2	-1.1	-0.8	0.5
Ever had bowel cancer screening	0.4	0.4	0.7	-0.9	-0.6	0.4
Irritability	0.4	0.7	1.5	-0.7	-0.4	1.2
Pack years of smoking	0.4	0.5	0.8	-0.9	-0.8	-0.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.0	-0.5	-0.2	-1.0
Mean Putamen Volume	0.3	0.3	0.5	0.4	0.5	-0.7
Fasting Glucose	0.3	0.4	0.9	-0.3	-0.4	-1.0
HbA1C	0.3	0.3	0.7	0.5	0.3	-0.9
Blood Eosinophil Count	0.3	2.1	3.3	1.8	1.7	0.1
Height	0.3	6.0	12.7	3.6	2.3	-0.2
Neuroticism	0.3	0.7	1.1	-1.1	-0.9	0.4
Average weekly fortified wine intake	0.3	0.4	0.4	-0.7	-0.6	0.6
Relative age voice broke	0.3	0.5	1.4	-0.1	-0.3	-1.2
Serious illness, injury or assault to yourself	0.3	0.4	0.7	-0.6	-0.8	-0.3
Trunk fat mass	0.3	1.2	3.5	-0.2	-0.3	1.9
Past tobacco smoking	0.3	0.5	0.7	-0.5	-0.9	-0.7
Hair/balding pattern: Pattern 3	0.3	0.5	0.7	-0.8	-0.8	-0.4
Impedance of arm (left)	0.3	1.2	1.8	1.0	0.8	-1.3
Exposure to tobacco smoke at home	0.3	0.3	0.5	0.6	0.7	-0.0
Comparative body size at age 10	0.3	0.9	1.5	0.7	0.8	1.2
Comparative height size at age 10	0.3	1.7	2.7	1.6	0.8	-1.4
Suffer from ‘nerves’	0.3	0.5	0.8	-0.7	-0.9	0.5
Had major operations	0.3	0.4	1.1	-0.2	0.0	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.2	1.1	0.6	-0.5
Loneliness, isolation	0.3	0.5	1.3	0.2	0.3	1.1
Long-standing illness, disability or infirmity	0.3	0.4	0.6	-0.5	-0.6	0.7
Number of self-reported non-cancer illnesses	0.3	0.5	0.7	-0.8	-0.8	0.3
Miserableness	0.3	0.5	1.1	-0.6	-0.4	1.0
Commuting to job workplace: Public transport	0.3	0.4	0.4	0.7	0.5	-0.6
Average weekly beer plus cider intake	0.3	0.5	0.6	-0.8	-0.7	-0.6
Ever depressed for a whole week	0.3	0.3	0.6	0.6	0.4	-0.8
Alcohol drinker status: Previous	0.3	0.4	0.7	0.8	0.5	0.5
Worry (Nagel 2018)	0.2	0.4	1.0	-0.4	-0.2	1.0
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.5	0.2	0.7
Rheumatoid Arthritis	0.2	0.3	0.6	0.4	0.3	-0.8
Leg fat-free mass (left)	0.2	1.1	1.7	-1.0	-1.3	-0.6
Maternal smoking around birth	0.2	0.3	0.5	-0.7	-0.7	0.1
Leg predicted mass (left)	0.2	0.9	1.5	-0.9	-1.2	-0.6
Alcohol usually taken with meals	0.2	0.3	0.4	0.4	0.6	0.6
Impedance of arm (right)	0.2	1.2	1.4	1.2	1.1	-0.9
Worrier / anxious feelings	0.2	0.4	0.5	0.7	0.6	0.5
Falls in the last year	0.2	0.3	0.7	0.8	0.5	-0.1
Noisy workplace	0.2	0.3	0.3	-0.5	-0.6	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	0.0	-0.2	0.8
Prospective memory result	0.2	0.2	0.5	-0.3	-0.7	0.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.4	0.7	0.6	-0.2
Age at first live birth	0.2	0.3	0.9	-0.1	-0.1	0.9
Medication: Allopurinol	0.2	0.3	0.4	-0.6	-0.6	0.1
Age at last live birth	0.2	0.4	0.6	-0.5	-0.5	0.8
Illnesses of father: Heart disease	0.2	0.3	0.9	0.2	0.3	0.9
Leg fat-free mass (right)	0.2	1.0	1.5	-0.9	-1.2	-0.9
Medication for cholesterol	0.2	0.3	0.5	-0.7	-0.4	-0.5
Leg predicted mass (right)	0.2	0.9	1.3	-0.8	-1.1	-0.9
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	-0.2	-0.2	0.7
Basal cell carcinoma (self-reported)	0.2	0.3	0.7	0.3	0.1	-0.8
Ulcerative Colitis (UC)	0.1	0.3	0.3	-0.5	-0.5	0.6
Reaction Time	0.1	0.2	0.3	-0.3	-0.4	-0.5
Age at First Birth	0.1	0.2	0.2	-0.3	-0.4	-0.5
Neuroticism (2016)	0.1	0.2	0.2	-0.5	-0.4	-0.4
Respiratory disease	0.1	0.3	0.4	-0.6	-0.6	-0.1
Number of treatments/medications taken	0.1	0.2	0.5	-0.0	-0.1	0.7
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.2	-0.5	-0.4	0.4
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	0.1	-0.4	0.6
Diabetes (mother)	0.1	0.1	0.2	-0.0	-0.5	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.4	0.3	0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.3	0.5	0.0	-0.4
Medication: Levothyroxine sodium	0.1	0.1	0.3	-0.2	-0.3	-0.5
Hair/balding pattern: Pattern 2	0.1	0.2	0.4	-0.4	-0.6	0.1
Weight	0.1	0.7	1.0	-0.6	-0.8	1.0
Time employed in main current job	0.1	0.1	0.3	0.5	0.4	-0.1
Alcohol intake versus 10 years previously	0.1	0.2	0.4	0.5	0.3	0.6
Father’s age at death	0.1	0.1	0.2	-0.2	-0.4	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.3	-0.2	0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.5	0.4	-0.5
Glaucoma (self-reported)	0.1	0.1	0.2	0.5	0.4	0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	-0.2	-0.2	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.1	0.0	-0.4
Mean time to correctly identify matches	0.1	0.2	0.4	-0.2	-0.2	-0.6
Leg pain on walking	0.1	0.1	0.3	0.5	0.2	0.3
Illnesses of siblings: Diabetes	0.1	0.1	0.1	0.1	-0.3	-0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.2	-0.4	0.1
Qualifications: nursing, teaching	0.1	0.1	0.1	-0.3	-0.4	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	0.3	0.2	0.5
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.4	-0.2	0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	0.3	0.2	-0.3
Medication: Lisinopril	0.1	0.1	0.1	-0.3	-0.3	-0.1
Medication: Atorvastatin	0.1	0.1	0.1	0.4	0.2	-0.0
Ever smoked	0.1	0.2	0.5	0.4	0.7	0.1
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.0	-0.3	0.4
Commuting to job workplace: Cycle	0.1	0.2	0.5	0.1	0.1	-0.7
Arm predicted mass (left)	0.1	0.6	0.7	0.8	0.5	0.9
Depression (Nagel 2018)	0.0	0.0	0.1	0.1	-0.0	0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Hypothyroidism (self reported)	0.0	0.1	0.2	-0.1	-0.5	-0.1
Hair Pigment	0.0	0.5	0.9	0.5	0.5	1.0
Tanning	0.0	0.0	0.1	0.0	0.1	0.2
Illnesses of siblings	0.0	0.0	0.1	0.1	0.3	0.1
Trunk fat-free mass	0.0	0.3	0.5	0.6	0.1	-0.7
Number of live births	0.0	0.1	0.1	-0.2	-0.0	-0.4
Medication: Cholesterol lowering	0.0	0.0	0.0	-0.1	-0.2	-0.1
Depression (self-reported)	0.0	0.1	0.1	-0.2	0.1	0.3
Trunk predicted mass	0.0	0.2	0.4	0.5	0.1	-0.6
Breastfed as a baby	0.0	0.0	0.0	-0.0	-0.1	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.0	-0.1	-0.1	0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.3	-0.1	-0.0
Medication: Paracetamol	0.0	0.0	0.0	-0.1	-0.1	0.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.1	0.3	0.2	0.2
Arm fat-free mass (right)	0.0	0.0	0.1	0.2	-0.2	-0.0
Exposure to tobacco smoke outside home	0.0	0.1	0.1	-0.3	-0.3	-0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.1	0.1	0.2	0.1	0.4
Arm predicted mass (right)	0.0	0.1	0.2	0.4	-0.1	-0.0
Knee pain experienced in last month	0.0	0.0	0.1	0.3	0.1	-0.1
Smoking status: Previous	0.0	0.0	0.1	-0.0	0.3	0.1
Whole body fat-free mass	0.0	0.2	0.4	-0.0	-0.4	-0.7
Average weekly red wine intake	0.0	0.1	0.1	-0.3	-0.3	-0.1
Friendships satisfaction	0.0	0.1	0.1	0.2	0.2	-0.3
Whole body water mass	0.0	0.2	0.3	0.0	-0.4	-0.6
Ever taken oral contraceptive pill	0.0	0.0	0.1	-0.0	0.1	0.2
Basal metabolic rate	0.0	0.1	0.3	-0.2	-0.5	-0.1
Arm fat-free mass (left)	0.0	0.2	0.3	0.6	0.2	0.5
Unable to work because of sickness or disability	0.0	0.0	0.0	0.0	0.1	0.1

Hub : Genes

RSPO3

Models

Trait associations