TWAS
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Traits
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Traits
:
Heel bone mineral density (BMD) T-score, automated (left)
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chr6:132,368,241-134,546,685
Best TWAS P=1.58e-11 · Best GWAS P=2.08e-36 conditioned to 2.27e-18
132.5M
133M
133.5M
134M
134.5M
0
10
20
30
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
EYA4
0.03
0.03
enet
8
0.02
5.5e-05
-5.3
6.7
1.6e-11
0.22
0.97
0.00
TRUE
5
The Cancer Genome Atlas
Head and Neck Squamous Cell Carcinoma
C6orf192
0.05
0.02
enet
11
0.02
2.5e-03
3.4
-5.4
8.3e-08
-0.04
0.00
0.02
TRUE
2
METSIM
Adipose
VNN2
0.08
0.06
lasso
5
0.05
3.5e-08
4.1
-5.1
2.9e-07
-0.09
1.00
0.00
TRUE
6
The Cancer Genome Atlas
Brain Lower Grade Glioma
EYA4
0.03
0.03
lasso
2
0.02
1.1e-03
-4.9
-5.1
3.1e-07
-0.32
0.27
0.02
TRUE
1
CommonMind
Brain Pre-frontal Cortex
EYA4
0.15
0.07
blup
567
0.12
2.0e-14
-4.9
-6.3
2.5e-10
-0.49
1.00
0.00
FALSE
4
The Cancer Genome Atlas
Breast Invasive Carcinoma
VNN2
0.07
0.06
blup
85
0.07
7.9e-14
4.1
-5.2
2.6e-07
-0.10
0.00
0.87
FALSE