Best TWAS P=6.46e-31 · Best GWAS P=3.8e-45 conditioned to 1.79e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | GTEx | Nerve Tibial | RP11-356J5.12 | 0.24 | 0.12 | lasso | 12 | 0.13 | 1.6e-09 | -10.43 | -11.6 | 6.5e-31 | -0.78 | 0.96 | 0.04 | TRUE |
| 1 | GTEx | Colon Transverse | BCO2 | 0.15 | 0.02 | lasso | 6 | 0.03 | 1.1e-02 | -4.24 | -5.4 | 6.0e-08 | -0.09 | 0.12 | 0.06 | TRUE |
| 6 | GTEx | Vagina | BCO2 | 0.43 | 0.12 | lasso | 7 | 0.11 | 1.8e-03 | 8.25 | -7.8 | 4.0e-15 | -0.52 | 0.09 | 0.18 | FALSE |
| 2 | GTEx | Esophagus Mucosa | BCO2 | 0.10 | 0.04 | enet | 34 | 0.08 | 5.1e-06 | 0.49 | -6.1 | 8.9e-10 | -0.25 | 0.30 | 0.14 | FALSE |
| 3 | GTEx | Esophagus Muscularis | BCO2 | 0.14 | 0.12 | lasso | 5 | 0.11 | 3.5e-07 | -4.96 | -5.2 | 2.1e-07 | -0.08 | 0.92 | 0.02 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | BCO2 | 0.18 | 0.11 | enet | 4 | 0.12 | 2.7e-07 | -5.40 | -5.2 | 2.6e-07 | -0.07 | 0.98 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | BCO2 | 0.05 | 0.03 | enet | 12 | 0.04 | 2.6e-09 | 0.49 | -5.2 | 2.6e-07 | -0.16 | 0.90 | 0.09 | FALSE |