[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr11:67,339,278-69,623,641

Best TWAS P=3.73e-17 · Best GWAS P=4.51e-23 conditioned to 4.96e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MTL5	0.05	0.02	bslmm	426	0.05	2.6e-06	-3.8	5.5	3.7e-08	-0.38	0.92	0.01	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TPCN2	0.17	0.10	lasso	6	0.10	9.3e-12	-5.0	-5.4	6.6e-08	0.13	1.00	0.00	FALSE
3	GTEx	Artery Aorta	TPCN2	0.21	0.17	lasso	2	0.16	5.5e-09	6.5	6.2	6.7e-10	-0.06	0.99	0.00	FALSE
4	GTEx	Artery Tibial	TPCN2	0.37	0.12	enet	25	0.22	2.3e-17	4.6	6.3	2.4e-10	-0.08	1.00	0.00	FALSE
5	GTEx	Esophagus Mucosa	TPCN2	0.20	0.07	lasso	8	0.06	5.6e-05	4.9	6.2	4.2e-10	-0.07	0.67	0.03	FALSE
6	GTEx	Esophagus Muscularis	IGHMBP2	0.12	0.06	enet	17	0.06	9.4e-05	3.5	5.5	4.8e-08	-0.32	0.68	0.21	FALSE
7	GTEx	Esophagus Muscularis	TPCN2	0.23	0.01	lasso	5	0.01	6.0e-02	-4.3	5.3	1.1e-07	-0.63	0.08	0.37	FALSE
8	GTEx	Esophagus Muscularis	MRGPRF	0.09	0.01	lasso	3	0.01	1.3e-01	-5.6	6.3	3.0e-10	-0.54	0.12	0.14	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	TPCN2	0.19	0.10	lasso	4	0.10	3.0e-06	6.5	6.5	7.7e-11	-0.10	0.91	0.00	TRUE
10	GTEx	Skin Sun Exposed Lower leg	TPCN2	0.09	0.00	lasso	5	0.03	8.0e-04	6.5	5.1	2.8e-07	-0.10	0.12	0.21	FALSE
11	GTEx	Testis	TPCN2	0.26	0.05	lasso	3	0.07	5.9e-04	6.5	5.5	2.8e-08	-0.10	0.13	0.05	FALSE
12	GTEx	Testis	RP11-554A11.9	0.25	0.13	enet	11	0.18	2.8e-08	4.3	-5.2	2.7e-07	0.03	0.02	0.98	FALSE
13	GTEx	Vagina	C11orf24	0.24	0.04	lasso	9	0.08	5.8e-03	2.0	5.3	1.3e-07	-0.65	0.04	0.52	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	GAL	0.21	0.17	bslmm	393	0.17	1.5e-21	-5.7	-6.6	3.0e-11	0.48	1.00	0.00	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	PPP6R3	0.04	0.01	blup	421	0.02	3.2e-04	-9.8	7.7	1.4e-14	-0.86	0.03	0.96	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SAPS3	0.04	0.02	blup	84	0.04	2.5e-05	-8.8	8.4	3.7e-17	-0.86	0.13	0.86	TRUE