Best TWAS P=3.43e-16 · Best GWAS P=2.93e-18 conditioned to 0.0251
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 8 | GTEx | Nerve Tibial | DOCK9 | 0.17 | 0.17 | lasso | 1 | 0.16 | 4.1e-11 | 8.2 | -8.2 | 3.4e-16 | -0.90 | 0.16 | 0.84 | TRUE |
| 2 | GTEx | Artery Tibial | DOCK9 | 0.09 | 0.02 | lasso | 3 | 0.03 | 1.2e-03 | 6.2 | -7.6 | 2.9e-14 | -0.68 | 0.05 | 0.87 | TRUE |
| 6 | GTEx | Esophagus Mucosa | DOCK9 | 0.18 | 0.09 | lasso | 5 | 0.13 | 6.9e-09 | -5.8 | -7.2 | 7.5e-13 | -0.67 | 0.96 | 0.02 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | DOCK9-AS2 | 0.14 | 0.07 | lasso | 9 | 0.04 | 2.0e-02 | 6.3 | -6.9 | 4.0e-12 | -0.69 | 0.08 | 0.70 | FALSE |
| 5 | GTEx | Esophagus Gastroesophageal Junction | DOCK9-AS2 | 0.11 | 0.02 | lasso | 6 | 0.05 | 4.9e-03 | -5.8 | -6.6 | 3.6e-11 | -0.50 | 0.25 | 0.31 | FALSE |
| 1 | GTEx | Artery Aorta | DOCK9-AS2 | 0.16 | 0.11 | lasso | 6 | 0.17 | 2.1e-09 | -6.3 | -6.5 | 5.9e-11 | -0.49 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Pancreas | DOCK9-AS2 | 0.09 | 0.08 | lasso | 6 | 0.08 | 3.0e-04 | -5.8 | -6.4 | 1.5e-10 | -0.56 | 0.27 | 0.23 | FALSE |
| 11 | GTEx | Spleen | DOCK9 | 0.34 | 0.11 | enet | 35 | 0.12 | 5.3e-04 | 5.8 | 6.0 | 2.5e-09 | 0.55 | 0.21 | 0.40 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | DOCK9-AS2 | 0.14 | 0.08 | lasso | 9 | 0.08 | 7.7e-05 | 4.5 | -5.8 | 6.3e-09 | -0.58 | 0.77 | 0.20 | FALSE |
| 7 | GTEx | Muscle Skeletal | DOCK9-AS2 | 0.22 | 0.24 | lasso | 8 | 0.21 | 7.8e-20 | -5.8 | -5.7 | 9.0e-09 | -0.43 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | DOCK9-AS2 | 0.20 | 0.25 | enet | 17 | 0.22 | 3.1e-12 | -5.0 | -5.3 | 1.3e-07 | -0.40 | 1.00 | 0.00 | FALSE |