Hub : Genes

DOCK9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.0943 0.0356 4.1e-03 0.019 NA 0.031 NA 0.033 1.1e-02 NA 1.8e-03 NA 1.2e-03
2 GTEx Cells Transformed fibroblasts 0.3880 0.0620 8.3e-11 0.181 NA 0.271 NA 0.260 1.6e-13 NA 1.9e-20 NA 1.4e-19
3 GTEx Esophagus Mucosa 0.1810 0.0490 1.1e-05 0.090 NA 0.090 NA 0.128 1.3e-06 NA 1.4e-06 NA 6.9e-09
4 GTEx Nerve Tibial 0.1708 0.0501 3.1e-05 0.169 NA 0.144 NA 0.155 5.2e-12 NA 2.3e-10 NA 4.1e-11
5 GTEx Spleen 0.3370 0.1090 2.6e-03 0.113 NA 0.121 NA 0.096 7.8e-04 NA 5.3e-04 NA 1.9e-03
6 TCGA Breast Invasive Carcinoma 0.0229 0.0107 2.8e-03 0.003 0.011 0.004 NA 0.005 6.9e-02 0.0017 4.2e-02 NA 2.6e-02
7 TCGA Thyroid Carcinoma 0.0600 0.0270 1.7e-03 0.023 0.024 0.017 NA 0.017 2.4e-03 0.0019 7.9e-03 NA 7.6e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.2 0.3 0.8 -0.1 -0.9 0.1 0.4 -0.6 0.8 0.4
Bipolar Disorder or Schizophrenia 0.0 0.1 0.2 0.5 0.3 0.0 0.0 -0.3 -0.2 -0.4
Depressed Affect (Nagel 2018) 1.1 2.4 3.8 2.0 -0.3 1.5 2.0 -1.3 1.9 1.2
Depression (Nagel 2018) 0.5 0.8 2.6 0.7 -0.5 1.6 0.5 0.5 -1.2 0.5
Intelligence (Savage-Jansen 2018) 0.8 2.5 7.9 0.5 -1.5 2.2 1.1 -0.7 -0.3 2.8
Neuroticism (Nagel 2018) 1.5 3.4 6.5 2.0 -0.7 2.1 2.5 -1.9 1.8 1.4
Schizophrenia (2018) 0.2 0.5 1.2 0.7 1.1 -0.0 -0.3 0.1 -0.9 -0.8
Schizophrenia vs Biploar Disorder 0.7 1.0 2.4 1.0 -0.3 1.1 0.8 -1.1 0.2 1.6
Worry (Nagel 2018) 2.3 4.8 7.6 2.7 -1.0 1.8 2.8 -2.6 2.6 1.2
Alzheimer’s Disease (in mother) 1.0 1.1 5.6 -0.7 0.7 0.9 -0.6 0.4 -2.4 0.0
Alzheimer’s Disease (in father) 0.7 0.8 1.6 1.0 0.4 1.3 1.2 0.5 0.3 0.9
Alzheimer’s Disease (including proxy) 0.7 1.1 2.9 -0.3 1.6 0.6 0.4 1.2 -1.7 -0.3
Crohns Disease (2017) 0.3 0.7 2.4 0.2 -0.1 1.6 1.0 -0.2 -1.0 0.4
Irritable Bowel Disease (IBD) 0.8 1.9 3.3 1.8 -0.1 1.8 1.8 -1.2 0.7 1.1
Ulcerative Colitis (UC) 1.3 2.4 5.3 2.3 0.3 1.2 1.9 -1.3 1.7 1.2
Major Depression (MDD) 0.3 0.4 1.3 0.5 -0.0 0.9 0.3 0.7 -1.1 0.2
Reaction Time 1.2 2.2 3.9 2.0 0.6 1.6 1.9 -0.8 0.7 1.9
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.4 -0.6 -0.3 -0.0 0.6 0.0 0.5 0.6
Breast Cancer 1.6 3.9 12.0 -2.0 -0.5 -2.4 -3.5 1.1 -1.7 -0.8
Ovarian Cancer 3.6 4.8 12.7 -2.7 0.5 -0.4 -3.1 1.8 -3.6 -0.7
Prostate Cancer 1.0 1.4 4.1 0.1 -0.3 2.0 0.7 -0.4 -1.0 2.0
Age at First Birth 0.3 0.4 1.0 0.2 0.4 0.5 0.3 1.0 -0.9 -0.6
Bipolar Disorder (2011) 0.1 0.1 0.4 0.2 -0.6 0.6 -0.0 -0.1 -0.0 0.3
Body Mass Index (BMI) (2010) 0.3 0.4 1.5 0.8 1.2 0.3 -0.3 -0.6 0.5 0.1
Coronary Artery Disease (CAD) 0.2 0.2 0.8 -0.5 0.3 -0.1 0.4 -0.9 -0.3 -0.4
Crohns Disease (2012) 0.2 0.3 0.8 -0.0 0.5 -0.6 0.2 0.5 0.5 -0.9
Mean Putamen Volume 2.7 3.1 7.4 0.6 -1.2 2.7 1.0 -1.4 -1.4 2.7
Fasting Glucose 0.6 0.7 2.2 -0.1 -0.2 -1.0 -1.5 0.2 0.1 -1.2
HbA1C 3.4 3.8 8.2 -2.9 0.2 -1.9 -2.4 2.1 -2.1 -0.4
HDL Cholesterol 1.2 2.1 4.6 -0.5 2.1 -1.5 -0.9 1.5 -1.1 -1.7
LDL Cholesterol 1.1 1.7 4.9 1.2 0.4 2.2 0.9 -0.8 -0.5 2.0
Lupus 0.1 0.1 0.4 0.7 0.2 -0.0 -0.0 0.2 -0.1 0.5
Neuroticism (2016) 1.2 1.7 4.2 1.3 0.1 1.9 2.1 -1.4 0.4 0.5
Primary Biliary Cirrhosis 2.3 3.2 7.0 2.6 -0.1 1.0 2.0 -2.6 1.8 1.0
Rheumatoid Arthritis 0.9 1.2 4.8 -0.8 0.8 -1.4 -2.2 0.3 -0.3 -0.5
Schizophrenia (2014) 0.0 0.0 0.1 0.3 -0.3 0.2 0.1 0.1 0.2 0.1
Triglycerides 0.5 0.9 1.8 -0.0 -1.0 0.7 0.3 -1.3 1.1 1.3
Type 2 Diabetes (T2D) (2012) 1.8 2.1 6.4 -1.3 -0.3 -2.1 -1.3 0.5 0.2 -2.5
Ulcerative Colitis 2.4 3.5 8.0 2.7 -0.3 0.7 1.8 -1.8 2.8 1.4
Blood Eosinophil Count 0.6 5.0 13.6 -3.7 -2.2 -1.4 -1.9 1.4 -3.0 -0.4
Blood Platelet Count 1.0 11.4 24.6 -5.0 -0.0 -3.1 -2.6 4.9 -2.5 -2.9
Blood Red Count 1.6 15.6 20.1 4.5 -3.9 3.9 3.8 -4.0 3.4 4.1
Blood White Count 0.7 4.9 10.2 -2.0 -3.1 -3.2 -1.7 0.4 2.0 -1.9
Heel T-Score 18.6 147.6 313.3 -13.7 0.5 -14.0 -17.7 12.4 -8.6 -10.4
BMI 0.3 1.7 5.0 -0.8 1.2 -2.2 -1.2 0.4 0.1 -1.8
Height 2.3 44.8 82.1 -8.4 -1.3 -5.6 -9.1 8.1 -6.1 -5.0
Waist Hip Ratio (WHR) 0.8 3.7 10.9 -2.3 -1.7 -1.1 0.5 3.3 0.0 -2.3
Systolic Blood Pressure 0.3 1.4 3.5 1.4 0.9 0.3 1.3 -1.3 1.9 0.4
Smoking Status 0.8 1.9 4.8 1.3 0.4 2.2 2.1 0.3 -0.9 1.0
Allergy or Eczema 1.4 3.8 12.3 -2.7 -0.1 -0.4 -2.0 1.5 -3.5 0.2
Cardiovascular Disease 0.4 1.3 4.6 0.6 -0.7 1.1 1.5 -2.2 0.6 0.4
Hypothyroidism (self reported) 0.6 1.3 4.7 0.9 0.2 1.2 2.2 -0.8 0.8 0.8
Respiratory disease 1.2 2.6 4.5 -1.8 -2.1 -2.0 -0.6 0.9 1.0 -2.1
Type 2 Diabetes (T2D) (2018) 0.4 0.8 2.4 -0.9 0.5 -1.6 -0.5 0.1 0.3 -1.3
Lung FEV1/FVC ratio 1.4 7.0 14.4 1.6 3.8 3.0 2.6 -2.1 -2.3 2.6
Lung FVC 0.9 4.5 8.1 2.6 0.9 2.2 2.2 -2.8 1.0 2.1
Neuroticism 0.8 1.9 4.8 1.2 -0.3 2.2 1.8 -1.6 -0.0 0.9
Chronotype (morning person) 3.6 8.2 16.9 -2.9 2.1 -4.1 -3.4 2.6 -0.9 -2.9
Hair Pigment 0.1 1.8 4.8 -0.3 1.6 -2.2 -0.3 -0.0 0.4 -2.1
Tanning 0.1 0.7 1.6 -0.7 -1.2 0.3 -1.3 0.4 -0.8 0.9
Hand grip strength (left) 0.9 2.3 5.6 -2.4 -1.7 0.8 -1.2 0.8 -2.2 0.3
Number of treatments/medications taken 1.0 1.7 4.7 0.6 -1.3 1.9 2.2 -0.6 0.7 1.0
Average weekly spirits intake 0.6 0.7 2.0 1.4 -0.9 0.6 0.9 -0.4 0.9 0.4
Sensitivity / hurt feelings 0.3 0.6 1.3 0.5 -0.0 0.2 1.1 -1.1 1.1 0.2
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.6 0.7 0.4 1.3 0.4 0.2 -1.2 0.1
Hearing difficulty/problems: Yes 1.1 1.8 8.1 0.3 1.0 1.0 2.9 -0.7 1.2 -0.5
Relative age of first facial hair 2.5 5.2 10.2 2.7 2.7 2.7 3.2 -1.4 0.3 1.5
Other serious medical condition/disability diagnosed by doctor 2.0 2.6 6.7 1.8 -0.3 2.6 2.4 -0.7 0.8 1.0
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.9 -0.7 0.9 -1.0 0.7 -0.2 0.3 -0.4
Ever had hysterectomy (womb removed) 0.0 0.0 0.2 -0.0 0.1 -0.2 0.4 0.1 0.1 -0.0
Systolic blood pressure, automated reading 0.3 0.9 3.3 0.7 1.8 -0.5 0.8 0.2 1.0 -0.9
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 1.5 0.8 0.1 -1.2 -1.0 -0.1 1.0 -1.2
Angina 0.6 0.8 2.0 0.9 0.6 1.4 1.1 -0.7 -0.8 0.7
Medication for hormone replacement therapy 0.8 0.9 3.9 -0.9 -0.6 0.2 2.0 0.2 0.8 0.6
Vitamin and mineral supplements 0.8 1.1 3.0 -0.5 -0.1 -1.6 -0.7 0.4 1.7 -1.2
Supplements: Zinc 0.2 0.2 0.5 -0.7 -0.2 -0.5 -0.2 0.1 -0.0 0.7
Medication: Co-codamol 0.5 0.6 1.5 1.2 0.4 0.4 0.9 -0.2 0.8 0.9
Medication: Metformin 1.3 1.9 5.2 -2.0 0.5 -2.3 -1.0 0.3 0.1 -1.6
Diabetes (father) 0.3 0.4 2.1 0.1 -0.1 0.2 0.2 -1.5 0.1 0.6
Diabetes (mother) 0.7 0.8 1.8 -1.1 -0.8 -0.4 -1.4 1.3 -0.4 -0.6
Severe depression (siblings) 1.4 1.6 7.3 -1.3 0.1 0.3 -0.4 1.2 -2.7 -0.3
Pack years adult smoking proportion 0.3 0.5 2.0 0.5 -0.0 -1.0 0.2 0.3 1.4 -0.3
Impedance of leg (right) 0.6 3.1 9.2 1.3 -1.1 2.5 3.0 -0.6 0.2 1.8
Leg fat-free mass (left) 2.0 10.6 24.1 -3.7 0.7 -3.8 -4.9 3.3 -2.0 -2.7
Trunk fat percentage 0.5 2.2 4.2 -1.4 2.0 -1.8 -0.2 2.0 -0.9 -1.1
Hand grip strength (right) 0.5 1.3 2.8 -1.2 -1.4 1.2 -0.5 1.1 -1.7 0.7
Townsend deprivation index at recruitment 0.6 0.8 1.9 -0.1 1.3 -1.4 -0.9 0.1 -0.3 -1.0
Current tobacco smoking 0.6 1.0 2.8 1.7 0.4 0.8 1.2 0.2 1.0 0.7
Average weekly fortified wine intake 0.3 0.4 1.0 0.4 1.0 0.4 0.7 -1.0 -0.2 0.2
Maternal smoking around birth 1.0 1.5 3.4 -0.1 1.8 -1.2 -1.3 0.2 -0.8 -1.8
Fed-up feelings 1.6 2.9 5.5 2.4 0.1 0.9 1.9 -2.3 2.0 0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.7 0.8 -1.3 0.9 0.2 -0.0 0.1 0.0
Relative age voice broke 1.3 1.9 3.7 1.2 1.9 1.6 1.4 0.2 -0.8 1.7
Taking other prescription medications 1.2 1.8 5.3 0.5 -1.3 1.9 2.3 -0.7 0.6 1.0
Age when periods started (menarche) 0.6 1.4 3.1 -1.0 -1.8 0.9 -0.2 -0.3 -1.8 1.4
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 4.3 -0.6 1.1 -2.1 -0.3 0.7 1.5 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 15.4 35.0 66.5 -7.6 -0.4 -7.2 -8.2 6.0 -3.1 -4.8
Tinnitus: Yes, but not now, but have in the past 1.0 1.1 3.5 -0.6 -1.9 -1.2 -0.5 -0.7 1.2 -0.5
Qualifications: CSEs or equivalent 1.1 1.4 3.1 1.2 -1.6 -0.1 0.4 -1.6 1.8 0.1
Serious illness, injury or assault to yourself 1.6 2.0 3.9 2.0 -1.0 1.4 1.4 -1.9 0.8 0.9
High blood pressure 0.2 0.5 1.9 0.5 0.3 -0.1 0.4 -1.4 0.7 -0.7
Hayfever, allergic rhinitis or eczema 1.3 2.9 9.0 -2.4 -0.5 -0.6 -1.7 1.4 -3.0 -0.1
Multivitamins +/- minerals 0.6 0.7 1.7 -0.1 0.3 1.1 0.9 0.3 -1.3 1.1
Stomach or abdominal pain in last month 4.3 5.3 9.4 2.1 -3.0 3.1 1.4 -2.4 0.5 2.6
Supplements: Glucosamine 0.2 0.2 0.7 -0.3 0.8 0.3 0.8 0.2 -0.2 -0.2
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.1 0.6 0.5 0.9 1.1 -0.3 0.7 0.2
Medication: Atenolol 0.6 0.8 3.1 -0.5 0.8 -1.1 -1.8 -0.1 -0.4 -0.2
Medication: Levothyroxine sodium 0.5 0.8 2.9 -1.0 0.3 0.7 -0.3 0.7 -1.7 0.5
Sitting height 1.3 9.2 22.1 -3.4 -1.2 -1.9 -4.7 3.3 -3.6 -1.3
Chronic bronchitis/emphysema (father) 0.7 0.8 3.1 -0.6 -1.8 0.2 1.0 -0.9 0.6 -0.3
High blood pressure (mother) 1.2 1.6 3.6 -1.9 -0.5 -1.5 -1.6 1.6 -0.3 -0.3
Body mass index (BMI) 0.6 2.5 6.2 -1.3 1.7 -2.5 -1.5 1.1 -0.0 -1.8
Impedance of leg (left) 0.6 2.9 7.2 0.8 -1.6 2.6 2.7 -0.3 -0.4 1.7
Leg predicted mass (left) 2.0 10.6 24.5 -3.7 0.7 -3.8 -4.9 3.2 -2.0 -2.7
Trunk fat mass 1.2 5.1 9.6 -2.5 1.7 -2.7 -1.8 3.1 -1.5 -1.9
Waist circumference 1.5 5.3 9.5 -2.4 1.4 -2.8 -1.7 2.8 -1.0 -3.1
Number of incorrect matches in round 1.2 2.0 5.4 0.2 1.0 -2.3 -0.8 0.6 2.0 -1.6
Past tobacco smoking 0.6 1.2 2.2 0.9 -1.3 -0.6 -0.6 -1.4 1.5 1.0
Alcohol usually taken with meals 0.3 0.4 0.8 0.7 -0.7 0.7 0.9 -0.2 0.7 0.5
Nervous feelings 2.4 4.5 11.9 2.2 -1.2 1.5 1.5 -3.4 2.4 1.7
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.1 4.4 1.8 1.0 2.1 2.0 -0.7 -0.2 0.9
Hearing difficulty/problems with background noise 1.7 2.7 8.0 1.4 0.0 1.6 2.8 -2.1 1.3 0.7
Hair/balding pattern: Pattern 2 0.3 0.4 0.8 0.2 0.7 -0.1 -0.9 0.6 -0.9 -0.6
Had menopause 1.2 1.5 3.7 1.7 0.6 -0.8 0.6 -1.9 1.6 -0.4
Had other major operations 1.1 1.4 4.0 2.0 -0.6 1.0 0.7 -1.4 0.8 1.1
Forced vital capacity (FVC) 0.4 1.5 4.5 -1.2 -0.3 -0.3 -2.1 0.7 -1.8 0.4
Heel bone mineral density (BMD) T-score, automated (right) 18.5 42.4 72.8 -8.0 1.0 -8.0 -8.5 7.3 -3.2 -5.7
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 2.5 0.7 -0.4 1.6 0.7 -0.7 -0.4 1.0
Qualifications: None of the above 1.9 4.1 9.5 0.3 1.9 -3.1 -1.8 0.5 1.9 -2.9
Financial difficulties in last 2 years 1.0 1.3 3.6 1.0 0.7 -0.3 1.4 -1.2 1.9 1.0
Mouth/teeth dental problems 0.3 0.4 1.3 -1.1 -0.5 -0.3 -0.3 0.1 -0.4 -1.2
Heart attack 0.3 0.3 1.1 -1.1 0.2 0.0 -0.2 0.0 -1.0 -0.5
Allergy 1.6 3.7 7.9 2.8 1.0 1.8 2.0 -2.1 2.0 1.4
Pain all over the body in last month 0.4 0.4 1.1 0.6 1.1 -0.1 0.7 -0.9 0.2 -0.0
Diabetes (self-reported) 0.5 0.8 2.1 0.1 1.0 -1.5 -0.5 -0.1 0.9 -1.1
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.9 0.3 -0.9 0.6 0.8 -0.6 -0.2 0.2
Medication: Ramipril 0.7 0.8 2.1 0.6 -0.2 0.5 1.4 -1.4 1.1 0.1
Medication: Simvastatin 0.3 0.4 0.9 0.0 0.5 0.8 0.7 -0.9 -0.3 0.4
Fluid intelligence score 0.3 0.5 1.4 -1.2 0.7 -0.5 0.2 1.0 0.8 -0.0
Illnesses of siblings 0.7 1.0 2.1 0.3 -1.4 1.2 -0.7 0.9 -1.1 1.0
Neuroticism score 1.8 3.8 7.6 1.9 -0.5 2.5 2.4 -2.8 1.1 1.4
Weight 1.9 9.6 16.5 -3.5 1.0 -3.6 -4.1 3.4 -2.1 -2.9
Impedance of arm (right) 0.6 2.7 5.6 1.7 0.5 1.9 2.4 -1.5 -0.2 2.0
Arm fat percentage (right) 0.4 1.4 4.0 -0.6 2.0 -1.9 -0.3 1.0 0.1 -1.1
Trunk fat-free mass 2.9 16.9 41.2 -4.7 -0.5 -4.1 -6.4 4.5 -2.5 -3.5
Hip circumference 1.1 4.8 8.1 -2.0 1.7 -2.2 -2.8 2.4 -2.0 -1.9
Time employed in main current job 0.6 0.7 3.4 -0.3 -1.8 -0.1 0.0 -0.8 0.8 0.4
Alcohol intake versus 10 years previously 4.9 7.3 14.9 3.9 -1.6 2.1 2.4 -3.4 3.0 1.7
Father’s age at death 0.8 1.1 1.5 1.0 -0.7 0.9 1.2 -1.1 1.2 1.0
Worrier / anxious feelings 0.9 1.6 4.4 0.8 -0.9 1.6 1.1 -2.1 0.5 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.9 1.1 -0.4 0.4 1.1 -0.9 1.4 0.5
Falls in the last year 1.4 1.9 4.0 2.0 1.7 0.5 1.6 -1.7 1.0 0.2
Hair/balding pattern: Pattern 3 0.3 0.5 1.6 -1.3 -0.2 -0.1 -0.8 0.6 -0.7 0.7
Number of live births 1.6 2.2 4.7 1.4 -1.3 1.6 1.8 -2.2 1.0 0.6
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 5.1 -0.8 0.4 0.4 -1.2 0.0 -2.3 1.1
Pulse rate 0.4 0.6 2.4 -0.8 -0.7 -0.7 -0.6 1.6 0.1 0.4
Happiness 0.9 1.1 3.3 0.8 0.6 1.8 1.1 0.3 -1.1 1.1
Noisy workplace 1.7 2.0 4.9 1.7 -1.3 0.5 0.7 -1.7 2.2 1.1
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.4 -0.6 0.6 0.5 0.7 -0.3 -0.4 -0.5
Serious illness, injury or assault of a close relative in last 2 years 2.0 2.3 6.5 0.3 -1.7 2.0 1.1 -1.0 -0.6 2.6
Mouth/teeth dental problems: Dentures 0.4 0.6 1.9 1.3 1.4 0.0 -0.1 -0.1 0.6 0.5
Asthma 0.8 1.7 3.8 -1.6 -1.6 -1.3 -0.2 0.9 0.2 -1.9
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.8 1.1 -1.3 0.7 0.5 0.1 0.7 0.2
Medication: Cholesterol lowering 0.6 0.9 2.3 0.3 1.5 1.5 1.1 -0.3 -0.7 0.4
Depression (self-reported) 0.5 0.6 1.7 0.8 -0.6 0.4 0.9 -0.0 1.3 0.5
Medication: Lansoprazole 2.6 3.0 6.2 2.5 0.7 2.4 2.1 -1.0 0.6 1.6
Prospective memory result 1.0 1.2 4.3 0.1 -2.1 0.6 0.9 -1.4 0.7 0.9
Lung cancer (father) 0.7 0.8 2.1 -1.1 -0.2 -1.2 -0.2 0.8 0.1 -1.5
Illnesses of mother 1.1 1.3 2.8 1.6 1.6 0.5 1.7 -0.7 0.7 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 4.3 -0.2 1.3 1.1 0.0 -0.2 -2.1 1.3
Pulse wave Arterial Stiffness index 1.2 1.4 3.6 1.3 -0.3 1.1 1.9 -1.3 0.6 1.1
Impedance of arm (left) 0.5 2.3 6.6 1.0 0.6 1.9 2.6 -0.9 -0.8 1.7
Arm fat mass (right) 1.1 4.5 8.8 -2.1 1.8 -3.0 -2.2 2.2 -0.9 -2.2
Trunk predicted mass 2.9 16.7 41.0 -4.6 -0.5 -4.1 -6.4 4.5 -2.5 -3.5
Standing height 2.1 20.7 39.7 -5.7 -1.5 -3.1 -6.3 5.5 -4.9 -2.8
Length of working week for main job 0.5 0.5 2.9 0.5 -0.7 -0.1 0.0 -0.5 1.7 0.0
Exposure to tobacco smoke at home 1.0 1.1 2.8 1.1 0.8 -0.0 1.1 -1.1 1.7 -0.7
Breastfed as a baby 0.4 0.5 1.7 0.3 -0.6 0.8 0.7 -1.3 -0.2 0.3
Tense / ‘highly strung’ 2.4 4.0 7.0 2.3 -1.1 1.4 2.2 -2.7 2.6 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 3.3 1.2 -0.0 1.4 1.2 -1.8 0.4 1.6
Hair/balding pattern: Pattern 4 0.7 1.8 6.0 -2.0 -0.7 0.7 -0.7 0.7 -2.5 0.7
Birth weight of first child 0.5 0.8 3.5 -0.1 -1.9 0.9 -0.3 -0.3 -1.1 0.1
Peak expiratory flow (PEF) 0.6 1.3 4.2 -2.0 0.5 -0.8 -0.9 0.8 -1.6 -0.2
Pulse wave reflection index 3.1 3.8 8.1 2.4 -0.1 2.1 2.2 -2.9 0.0 1.8
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.9 -1.4 -0.9 -0.9 -0.2 0.5 0.2 -1.3
Loud music exposure frequency 0.7 0.8 2.9 -0.5 -0.9 0.8 -0.7 -0.1 -1.7 -0.4
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.4 -0.4 -0.9 0.8 0.9 -1.2 0.3 1.0
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.5 0.4 1.2 -0.5 -0.1 0.2 0.2 -0.2
Blood clot in the leg (DVT) 0.5 0.6 2.5 0.3 0.4 -0.6 -0.5 0.9 0.2 -1.6
Medication: Paracetamol 0.8 1.4 4.8 0.1 -0.7 -1.1 0.3 0.7 2.2 -1.6
Headache pain in last month 2.4 4.1 18.3 -0.2 -4.3 1.7 -0.0 -1.1 -0.5 2.4
Medication for cholesterol, blood pressure or diabetes 0.3 0.6 1.8 -0.1 -0.1 -1.0 -1.3 0.3 -0.3 -1.0
Glaucoma (self-reported) 1.5 1.8 4.7 -1.6 0.7 -0.8 -0.3 2.2 -1.7 -1.0
Gout (self-reported) 0.4 0.6 1.9 0.9 -0.6 1.4 0.2 0.0 -0.4 0.9
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 1.3 -0.3 -0.3 1.2 0.5 0.7 -0.5 0.9
Medication: Amlodipine 1.4 2.0 5.3 -2.3 1.3 -1.0 -1.1 1.4 -1.6 -0.3
Medication: Ventolin 100micrograms inhaler 0.7 0.9 2.5 -0.2 -1.6 -0.7 -0.4 0.2 0.8 -1.5
Birth weight 0.4 1.0 2.5 -0.7 -0.5 0.8 0.1 1.6 -1.1 1.2
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.1 -0.7 0.3 -1.4 -0.8 0.5 -0.3 -1.4
High blood pressure (siblings) 0.3 0.4 0.9 -0.9 0.5 -0.3 0.5 -0.9 -0.5 0.1
Forced vital capacity (FVC), Best measure 0.2 0.7 2.8 -0.8 0.2 0.3 -0.9 0.4 -1.7 0.6
Body fat percentage 0.5 1.8 4.2 -1.1 2.0 -1.7 0.0 1.7 -0.5 -1.1
Leg fat percentage (right) 0.2 0.9 2.4 -0.3 1.5 -1.3 0.5 0.9 0.7 -0.6
Arm fat-free mass (right) 2.9 15.0 28.3 -4.6 -0.0 -4.1 -5.3 4.5 -2.3 -3.6
Exposure to tobacco smoke outside home 0.3 0.4 1.7 0.6 1.3 0.6 0.2 -0.7 -0.4 0.2
Comparative body size at age 10 0.3 0.8 2.2 -0.2 1.5 -1.3 -0.8 -0.1 0.8 -0.7
Number of full brothers 0.8 1.0 2.3 -1.5 0.4 -1.5 -0.4 1.0 -0.2 -1.0
Worry too long after embarrassment 1.8 3.0 9.5 1.0 -1.6 3.1 1.4 -1.4 -0.1 2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 2.6 3.4 6.1 2.5 -0.9 1.3 1.7 -2.4 2.0 1.7
Wheeze or whistling in the chest in last year 1.1 1.9 4.8 -0.9 -1.8 -1.7 -0.9 0.6 0.8 -2.2
Number of children fathered 0.4 0.5 0.9 -0.5 0.8 -0.9 0.1 0.9 0.7 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 0.9 -0.3 -0.7 0.9 0.7 -0.7 0.1 0.7
Age at first live birth 0.3 0.6 2.1 -0.5 0.8 0.9 -0.5 0.4 -1.5 0.0
Pulse wave peak to peak time 2.0 2.4 5.8 -1.7 0.2 -1.4 -2.4 1.6 -1.1 -1.4
Health satisfaction 0.6 0.8 3.0 -0.4 -0.4 0.7 0.8 1.7 -0.8 0.6
Shortness of breath walking on level ground 1.9 2.3 5.4 -2.3 -1.5 -1.7 -1.7 1.3 -0.1 -1.1
Qualifications: College or University degree 0.6 2.0 4.5 -0.3 -1.8 1.8 0.2 1.1 -2.1 1.1
Eye problems/disorders: None of the above 2.6 3.0 4.7 2.2 -0.7 1.7 1.8 -1.8 1.6 1.9
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.1 0.2 0.6 -1.3 0.4 -0.0 1.4 -0.7
Emphysema/chronic bronchitis 0.7 0.8 2.1 0.4 -1.5 0.8 1.0 -0.5 0.9 0.6
Medication for pain relief, constipation, heartburn 1.4 2.5 4.6 -1.4 1.8 -1.9 -2.1 1.3 -1.3 -0.3
Neck or shoulder pain in last month 0.1 0.2 0.6 0.2 0.3 0.8 0.1 -0.0 -0.5 -0.4
Medication: Blood pressure 0.1 0.2 0.5 0.1 -0.3 0.4 0.7 -0.2 0.5 0.7
Angina (self-reported) 0.4 0.5 1.2 0.6 0.5 1.1 0.7 -0.4 -0.9 0.5
Migraine (self-reported) 1.2 1.5 2.6 0.5 -1.5 1.4 1.0 -1.6 -0.1 1.5
Medication: Ibuprofen 0.3 0.4 1.0 1.0 -0.7 1.0 0.2 0.1 -0.1 0.6
Medication: Allopurinol 0.9 1.2 2.9 0.4 -0.4 1.7 -0.2 -0.5 -1.4 1.6
Medication: Omeprazole 1.1 1.3 4.2 0.7 -0.3 2.1 1.8 0.7 0.5 0.7
Medication: Seretide 50 evohaler 5.6 6.5 15.5 -3.3 -1.4 -1.8 -2.1 3.9 -2.1 -2.1
Mean time to correctly identify matches 1.5 2.9 6.5 2.5 1.3 1.4 2.0 -1.6 0.8 1.6
Heart disease (mother) 0.2 0.3 0.8 0.4 -0.0 0.9 0.9 -0.2 -0.1 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.3 6.5 -1.5 -0.0 -1.7 -1.7 1.0 -0.7 -2.5
Whole body fat mass 1.1 4.8 7.8 -2.2 1.9 -2.8 -1.9 2.8 -1.1 -2.1
Leg fat mass (right) 1.0 3.7 7.4 -1.9 1.3 -2.7 -1.7 2.5 -0.4 -2.0
Arm predicted mass (right) 2.9 15.1 31.5 -4.5 -0.1 -4.0 -5.6 4.5 -2.5 -3.5
Pulse rate, automated reading 0.2 0.7 1.9 -1.2 -1.4 -0.2 -0.3 1.1 0.0 -0.7
Alcohol intake frequency. 1.2 2.7 5.0 2.2 -1.1 1.3 1.6 -2.1 1.6 1.4
Comparative height size at age 10 1.2 6.4 12.2 -2.4 0.7 -2.9 -3.2 3.5 -1.2 -2.5
Number of full sisters 1.5 1.8 5.1 1.0 -0.9 -0.1 1.4 -1.8 2.3 0.6
Suffer from ‘nerves’ 0.7 1.1 2.2 1.1 0.2 1.5 1.4 -1.1 0.4 1.2
Overall health rating 1.0 2.2 7.9 1.8 -0.4 0.4 1.5 -0.7 2.8 1.0
Chest pain or discomfort 0.5 0.7 2.5 -0.9 -0.0 -1.1 0.0 -0.2 0.6 -1.6
Had major operations 0.6 0.7 3.0 0.8 -0.4 1.7 1.0 -0.1 -0.3 0.3
Age at last live birth 0.7 1.0 3.9 1.0 -0.2 2.0 1.1 -0.8 -0.6 0.2
Family relationship satisfaction 0.8 1.0 2.3 1.1 1.3 1.5 1.0 0.0 -0.8 0.6
Leg pain on walking 0.9 1.1 2.5 1.0 -0.8 0.2 1.1 -1.6 1.6 -0.3
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 1.7 0.4 0.5 1.1 -0.1 0.6 -1.3 1.3
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.9 -0.5 0.9 -0.6 -0.0 0.3 0.6 -0.9
Illness, injury, bereavement, stress in last 2 years 1.8 2.2 4.5 -1.4 1.5 -0.4 -1.1 2.1 -1.2 -1.9
Medication: Aspirin 1.1 1.4 3.6 0.8 -1.0 1.6 1.2 -1.9 0.6 0.6
Supplements: Vitamin C 0.5 0.6 3.5 0.1 -1.9 0.5 -0.2 -0.1 -0.6 0.6
Knee pain experienced in last month 1.2 1.8 5.9 1.3 2.4 0.3 1.8 -0.4 1.3 -0.1
Hypertension (Self-reported) 0.2 0.5 2.3 0.3 0.2 0.3 0.7 -1.5 0.4 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.0 3.5 11.0 1.4 0.8 3.3 2.6 -0.4 -0.7 1.8
Illnesses of father: Heart disease 1.7 2.3 6.5 1.6 -0.1 2.5 1.2 -1.4 -0.5 1.9
Illnesses of siblings: Diabetes 1.8 2.2 7.5 -0.4 1.0 -2.7 -1.2 -0.1 1.5 -1.9
Smoking status: Previous 0.7 1.0 2.3 -1.1 0.7 0.3 0.5 1.2 -1.5 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 1.5 3.0 7.3 -2.7 -1.4 -1.2 -2.2 1.8 -1.5 -0.7
Whole body fat-free mass 2.6 15.1 36.1 -4.4 0.0 -4.1 -6.0 4.2 -2.4 -3.3
Leg fat-free mass (right) 2.0 10.7 25.1 -3.8 0.5 -3.5 -5.0 3.3 -2.2 -2.6
Arm fat percentage (left) 0.5 2.0 4.9 -0.9 2.2 -2.0 -0.2 1.5 -0.2 -1.3
Average weekly red wine intake 1.2 1.8 3.1 -1.8 0.4 -1.5 -1.1 1.7 -0.8 -1.6
Handedness (chirality/laterality): Left-handed 0.4 0.4 1.4 0.7 -0.7 1.2 0.7 -0.2 -0.1 0.4
Mood swings 1.8 3.2 5.8 1.9 -0.2 2.4 2.4 -2.1 0.9 1.4
Loneliness, isolation 0.4 0.6 2.8 0.6 0.3 -0.5 -0.2 -0.1 0.8 -1.7
Long-standing illness, disability or infirmity 0.7 1.0 3.3 0.8 0.0 1.2 1.8 -1.0 0.6 0.3
Ever had bowel cancer screening 0.7 0.8 4.5 0.1 2.1 -0.3 0.6 0.1 -0.4 -0.7
Diabetes diagnosed by doctor 0.3 0.5 1.4 -0.5 0.3 -1.2 -0.3 0.2 0.5 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 2.6 2.8 9.3 1.9 0.2 1.5 3.0 -1.2 1.6 0.6
Friendships satisfaction 0.6 0.7 2.2 -0.1 -0.2 1.5 0.4 0.6 -1.3 0.6
Qualifications: nursing, teaching 0.7 1.1 4.2 0.3 0.9 0.7 2.0 -1.3 0.6 0.6
Commuting to job workplace: Walk 2.1 2.3 9.6 -1.3 0.4 -0.3 -1.5 1.4 -3.1 -0.5
Eye problems/disorders: Cataract 1.6 1.8 3.4 -1.5 0.4 -1.1 -1.5 1.6 -0.9 -1.8
Mouth/teeth dental problems: Mouth ulcers 1.4 2.3 4.2 0.8 -2.1 2.1 1.5 -1.3 -0.1 1.7
Medication for cholesterol 0.3 0.5 1.3 0.2 1.1 0.0 -0.6 1.1 -0.8 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 1.2 1.1 -0.2 0.0 -0.3 -0.2 0.1 -0.3
Back pain experienced in last month 0.3 0.4 0.9 0.5 -0.6 0.8 0.9 -0.0 -0.2 0.9
Mineral and other dietary supplements 0.4 0.5 2.1 0.6 -0.1 0.0 0.8 -0.5 1.4 0.2
Breast cancer (self-reported) 1.5 1.8 5.1 2.3 -0.4 0.1 1.4 -0.7 2.2 -0.0
Asthma (self-reported) 0.8 1.6 3.7 -1.5 -1.6 -1.4 -0.2 0.9 0.5 -1.9
Osteoporosis (self-reported) 0.3 0.4 1.6 0.2 0.9 0.6 0.0 0.2 -1.3 0.3
Osteoarthritis (self-reported) 1.1 1.4 5.0 -0.4 2.2 -1.3 0.3 0.7 1.2 -0.9
Medication: Aspirin 1.5 2.0 6.2 1.0 -0.8 1.9 1.1 -2.5 0.4 1.1
Medication: Gliclazide 2.0 2.2 4.9 -0.5 2.0 -2.2 -0.3 0.1 1.7 -1.9
Illnesses of father: None of the above (group 1) 2.8 3.5 7.2 -2.4 0.6 -1.7 -1.5 2.7 -1.3 -2.0
Smoking status: Current 0.5 0.8 1.7 1.3 0.1 1.0 1.3 0.4 0.6 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.8 3.9 6.4 2.0 2.2 1.8 2.4 -2.5 -0.1 1.6
Whole body water mass 2.6 14.7 34.3 -4.3 0.0 -4.0 -5.9 4.2 -2.3 -3.3
Leg predicted mass (right) 1.9 10.3 24.3 -3.7 0.5 -3.5 -4.9 3.2 -2.1 -2.6
Arm fat mass (left) 1.2 5.1 8.9 -2.2 1.9 -3.0 -2.2 2.6 -1.1 -2.3
Number of self-reported non-cancer illnesses 1.1 2.0 7.1 1.2 -0.2 1.9 2.7 -0.9 0.6 0.3
Average weekly champagne plus white wine intake 0.9 1.2 3.1 -0.1 0.7 1.8 0.6 1.0 -1.7 0.9
Miserableness 1.4 2.4 4.6 1.8 0.2 2.1 2.1 -1.4 0.8 1.5
Guilty feelings 1.5 2.3 6.3 0.7 -0.6 1.8 0.8 -2.5 -0.5 2.2
Wears glasses or contact lenses 1.5 1.7 5.1 -1.3 1.0 -0.1 -1.1 0.7 -2.2 -1.5
Ever taken oral contraceptive pill 0.3 0.4 1.0 -0.3 -0.6 0.8 1.0 -0.2 -0.3 0.6
Hearing aid user 1.1 1.2 3.8 1.3 1.1 0.3 1.1 -0.5 1.9 -0.4
Mother’s age at death 0.7 0.8 2.3 -1.5 -1.3 -1.0 0.0 0.8 0.6 0.1
Financial situation satisfaction 0.2 0.3 1.0 -0.4 -0.7 0.0 0.6 1.0 -0.1 0.1
Tinnitus: Yes, now most or all of the time 1.3 1.6 3.9 1.3 -1.0 0.4 0.2 -1.7 2.0 1.1
Commuting to job workplace: Public transport 1.7 2.0 7.6 -1.2 -0.8 -0.0 -1.5 1.4 -2.8 0.5
Eye problems/disorders: Glaucoma 1.8 2.1 4.3 -1.6 1.1 -1.2 -0.6 2.0 -2.1 -0.8
Medication: Blood pressure 0.0 0.1 0.2 -0.2 0.2 -0.2 -0.3 -0.3 -0.3 -0.4
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.9 0.2 -0.6 0.5 0.3 -1.0 0.3 0.3
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.8 -0.2 0.1 -0.7 -0.9 0.8 -0.7 -0.7
High cholesterol (Self-reported) 1.7 3.0 7.6 1.4 -0.2 1.8 2.2 -2.8 1.1 1.5
Medication: Bendroflumethiazide 1.1 1.7 3.1 -1.7 0.2 -0.7 -1.2 1.2 -1.8 -1.6
Medication: Paracetamol 0.4 0.6 2.4 0.2 -0.7 -0.6 -0.1 0.1 1.6 -0.9
Medication: Lisinopril 1.3 1.7 5.3 -1.7 -0.4 -1.1 -2.3 0.5 -1.1 -0.9
Medication: Atorvastatin 0.7 0.8 2.4 1.4 0.5 0.9 0.6 -1.6 0.4 0.0
Illnesses of father: High blood pressure 0.9 1.1 2.2 0.3 -1.4 1.5 0.5 -1.3 -0.5 1.2
Alcohol drinker status: Never 0.7 0.8 3.2 1.0 0.6 0.9 1.8 -0.1 0.5 -0.2
Ever smoked 0.5 0.8 2.5 -0.1 1.6 0.8 1.0 0.9 -0.5 -0.7
Basal metabolic rate 2.5 14.0 31.4 -4.3 0.3 -4.0 -5.6 4.0 -2.4 -3.2
Leg fat percentage (left) 0.3 1.0 2.2 -0.8 1.3 -1.5 0.1 1.3 0.3 -0.8
Arm fat-free mass (left) 2.9 14.8 32.1 -4.4 0.0 -4.1 -5.7 4.2 -2.4 -3.5
Number of operations (self-reported) 1.4 2.0 3.5 1.5 -1.8 1.7 1.9 -0.8 1.0 0.8
Average weekly beer plus cider intake 1.0 1.5 6.4 0.8 2.5 0.9 0.3 -0.5 -1.2 0.9
Irritability 0.6 1.0 2.8 0.3 0.1 1.4 1.7 -1.2 -0.4 0.2
Risk taking 0.7 1.1 3.6 0.1 0.8 0.8 1.1 -0.8 -0.9 1.9
Ever had prostate specific antigen (PSA) test 2.2 2.5 7.0 0.9 -0.7 2.2 2.6 -0.2 0.2 2.1
Fractured/broken bones in last 5 years 0.6 0.7 1.6 1.1 1.3 0.9 -0.1 0.5 -0.8 0.6
Age started oral contraceptive pill 1.4 1.8 3.4 0.9 -0.4 1.6 -0.4 -1.7 -1.8 1.5
Diastolic blood pressure, automated reading 0.2 0.6 2.1 0.5 0.8 1.1 1.4 0.5 -0.3 0.1
Ever depressed for a whole week 0.1 0.1 0.5 -0.2 0.0 0.3 -0.1 -0.6 -0.7 0.1
Unable to work because of sickness or disability 0.4 0.6 1.5 0.5 -0.1 -0.8 -0.7 1.2 0.5 -0.9
Commuting to job workplace: Cycle 0.7 0.9 2.0 1.4 0.9 -0.2 0.1 -1.3 1.2 -0.6
Myopia 2.9 4.2 8.2 -2.9 -2.5 -1.9 -2.9 0.2 -1.3 -1.1
Vascular/heart problems diagnosed by doctor 0.2 0.6 2.9 -0.6 -0.1 -0.3 -0.6 1.7 -0.3 0.3
Cholesterol lowering medication 1.3 2.0 9.5 1.0 -1.2 0.7 0.6 -3.1 0.9 0.5
Medication: Omeprazole (e.g. Zanprol) 1.9 2.3 5.9 1.1 -0.6 2.4 2.4 -0.2 1.2 1.3
Pain experienced in last month 1.0 1.7 5.7 -0.8 0.1 -2.4 -1.0 1.0 1.1 -1.5
Supplements: Calcium 1.1 1.2 4.0 1.4 0.6 1.3 2.0 -0.6 -0.1 0.3
Basal cell carcinoma (self-reported) 3.0 3.5 7.4 1.8 -2.2 2.2 0.7 -2.0 0.0 2.7
Heart attack/myocardial infarction (self-reported) 0.4 0.5 2.0 -1.0 -0.0 0.4 -0.3 0.1 -1.4 -0.3
Deep venous thrombosis (DVT) (self-reported) 0.5 0.7 2.5 0.4 0.6 -0.6 -0.5 1.0 0.1 -1.6
Heart disease (siblings) 1.1 1.4 4.0 0.8 -0.8 0.6 1.4 -1.2 2.0 0.9
Alcohol drinker status: Previous 1.1 1.2 2.1 0.6 0.6 1.5 1.1 -1.4 -0.6 1.4
Pack years of smoking 0.3 0.4 1.2 0.3 0.1 -1.0 -0.0 0.3 1.1 -0.5
Impedance of whole body 0.7 3.4 10.0 1.0 -0.6 2.7 3.2 -0.8 -0.6 2.1
Leg fat mass (left) 1.0 3.9 7.4 -2.2 1.0 -2.7 -1.9 2.5 -0.6 -2.0
Arm predicted mass (left) 2.6 13.0 30.3 -4.0 -0.2 -3.8 -5.5 3.9 -2.2 -3.2