Hub : Genes

DOCK9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0943	0.0356	4.1e-03	0.019	NA	0.031	NA	0.033	1.1e-02	NA	1.8e-03	NA	1.2e-03
2	GTEx	Cells Transformed fibroblasts	0.3880	0.0620	8.3e-11	0.181	NA	0.271	NA	0.260	1.6e-13	NA	1.9e-20	NA	1.4e-19
3	GTEx	Esophagus Mucosa	0.1810	0.0490	1.1e-05	0.090	NA	0.090	NA	0.128	1.3e-06	NA	1.4e-06	NA	6.9e-09
4	GTEx	Nerve Tibial	0.1708	0.0501	3.1e-05	0.169	NA	0.144	NA	0.155	5.2e-12	NA	2.3e-10	NA	4.1e-11
5	GTEx	Spleen	0.3370	0.1090	2.6e-03	0.113	NA	0.121	NA	0.096	7.8e-04	NA	5.3e-04	NA	1.9e-03
6	TCGA	Breast Invasive Carcinoma	0.0229	0.0107	2.8e-03	0.003	0.011	0.004	NA	0.005	6.9e-02	0.0017	4.2e-02	NA	2.6e-02
7	TCGA	Thyroid Carcinoma	0.0600	0.0270	1.7e-03	0.023	0.024	0.017	NA	0.017	2.4e-03	0.0019	7.9e-03	NA	7.6e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.2	0.3	0.8	-0.1	-0.9	0.1	0.4	-0.6	0.8	0.4
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	0.5	0.3	0.0	0.0	-0.3	-0.2	-0.4
Depressed Affect (Nagel 2018)	1.1	2.4	3.8	2.0	-0.3	1.5	2.0	-1.3	1.9	1.2
Depression (Nagel 2018)	0.5	0.8	2.6	0.7	-0.5	1.6	0.5	0.5	-1.2	0.5
Intelligence (Savage-Jansen 2018)	0.8	2.5	7.9	0.5	-1.5	2.2	1.1	-0.7	-0.3	2.8
Neuroticism (Nagel 2018)	1.5	3.4	6.5	2.0	-0.7	2.1	2.5	-1.9	1.8	1.4
Schizophrenia (2018)	0.2	0.5	1.2	0.7	1.1	-0.0	-0.3	0.1	-0.9	-0.8
Schizophrenia vs Biploar Disorder	0.7	1.0	2.4	1.0	-0.3	1.1	0.8	-1.1	0.2	1.6
Worry (Nagel 2018)	2.3	4.8	7.6	2.7	-1.0	1.8	2.8	-2.6	2.6	1.2
Alzheimer’s Disease (in mother)	1.0	1.1	5.6	-0.7	0.7	0.9	-0.6	0.4	-2.4	0.0
Alzheimer’s Disease (in father)	0.7	0.8	1.6	1.0	0.4	1.3	1.2	0.5	0.3	0.9
Alzheimer’s Disease (including proxy)	0.7	1.1	2.9	-0.3	1.6	0.6	0.4	1.2	-1.7	-0.3
Crohns Disease (2017)	0.3	0.7	2.4	0.2	-0.1	1.6	1.0	-0.2	-1.0	0.4
Irritable Bowel Disease (IBD)	0.8	1.9	3.3	1.8	-0.1	1.8	1.8	-1.2	0.7	1.1
Ulcerative Colitis (UC)	1.3	2.4	5.3	2.3	0.3	1.2	1.9	-1.3	1.7	1.2
Major Depression (MDD)	0.3	0.4	1.3	0.5	-0.0	0.9	0.3	0.7	-1.1	0.2
Reaction Time	1.2	2.2	3.9	2.0	0.6	1.6	1.9	-0.8	0.7	1.9
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	-0.6	-0.3	-0.0	0.6	0.0	0.5	0.6
Breast Cancer	1.6	3.9	12.0	-2.0	-0.5	-2.4	-3.5	1.1	-1.7	-0.8
Ovarian Cancer	3.6	4.8	12.7	-2.7	0.5	-0.4	-3.1	1.8	-3.6	-0.7
Prostate Cancer	1.0	1.4	4.1	0.1	-0.3	2.0	0.7	-0.4	-1.0	2.0
Age at First Birth	0.3	0.4	1.0	0.2	0.4	0.5	0.3	1.0	-0.9	-0.6
Bipolar Disorder (2011)	0.1	0.1	0.4	0.2	-0.6	0.6	-0.0	-0.1	-0.0	0.3
Body Mass Index (BMI) (2010)	0.3	0.4	1.5	0.8	1.2	0.3	-0.3	-0.6	0.5	0.1
Coronary Artery Disease (CAD)	0.2	0.2	0.8	-0.5	0.3	-0.1	0.4	-0.9	-0.3	-0.4
Crohns Disease (2012)	0.2	0.3	0.8	-0.0	0.5	-0.6	0.2	0.5	0.5	-0.9
Mean Putamen Volume	2.7	3.1	7.4	0.6	-1.2	2.7	1.0	-1.4	-1.4	2.7
Fasting Glucose	0.6	0.7	2.2	-0.1	-0.2	-1.0	-1.5	0.2	0.1	-1.2
HbA1C	3.4	3.8	8.2	-2.9	0.2	-1.9	-2.4	2.1	-2.1	-0.4
HDL Cholesterol	1.2	2.1	4.6	-0.5	2.1	-1.5	-0.9	1.5	-1.1	-1.7
LDL Cholesterol	1.1	1.7	4.9	1.2	0.4	2.2	0.9	-0.8	-0.5	2.0
Lupus	0.1	0.1	0.4	0.7	0.2	-0.0	-0.0	0.2	-0.1	0.5
Neuroticism (2016)	1.2	1.7	4.2	1.3	0.1	1.9	2.1	-1.4	0.4	0.5
Primary Biliary Cirrhosis	2.3	3.2	7.0	2.6	-0.1	1.0	2.0	-2.6	1.8	1.0
Rheumatoid Arthritis	0.9	1.2	4.8	-0.8	0.8	-1.4	-2.2	0.3	-0.3	-0.5
Schizophrenia (2014)	0.0	0.0	0.1	0.3	-0.3	0.2	0.1	0.1	0.2	0.1
Triglycerides	0.5	0.9	1.8	-0.0	-1.0	0.7	0.3	-1.3	1.1	1.3
Type 2 Diabetes (T2D) (2012)	1.8	2.1	6.4	-1.3	-0.3	-2.1	-1.3	0.5	0.2	-2.5
Ulcerative Colitis	2.4	3.5	8.0	2.7	-0.3	0.7	1.8	-1.8	2.8	1.4
Blood Eosinophil Count	0.6	5.0	13.6	-3.7	-2.2	-1.4	-1.9	1.4	-3.0	-0.4
Blood Platelet Count	1.0	11.4	24.6	-5.0	-0.0	-3.1	-2.6	4.9	-2.5	-2.9
Blood Red Count	1.6	15.6	20.1	4.5	-3.9	3.9	3.8	-4.0	3.4	4.1
Blood White Count	0.7	4.9	10.2	-2.0	-3.1	-3.2	-1.7	0.4	2.0	-1.9
Heel T-Score	18.6	147.6	313.3	-13.7	0.5	-14.0	-17.7	12.4	-8.6	-10.4
BMI	0.3	1.7	5.0	-0.8	1.2	-2.2	-1.2	0.4	0.1	-1.8
Height	2.3	44.8	82.1	-8.4	-1.3	-5.6	-9.1	8.1	-6.1	-5.0
Waist Hip Ratio (WHR)	0.8	3.7	10.9	-2.3	-1.7	-1.1	0.5	3.3	0.0	-2.3
Systolic Blood Pressure	0.3	1.4	3.5	1.4	0.9	0.3	1.3	-1.3	1.9	0.4
Smoking Status	0.8	1.9	4.8	1.3	0.4	2.2	2.1	0.3	-0.9	1.0
Allergy or Eczema	1.4	3.8	12.3	-2.7	-0.1	-0.4	-2.0	1.5	-3.5	0.2
Cardiovascular Disease	0.4	1.3	4.6	0.6	-0.7	1.1	1.5	-2.2	0.6	0.4
Hypothyroidism (self reported)	0.6	1.3	4.7	0.9	0.2	1.2	2.2	-0.8	0.8	0.8
Respiratory disease	1.2	2.6	4.5	-1.8	-2.1	-2.0	-0.6	0.9	1.0	-2.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	2.4	-0.9	0.5	-1.6	-0.5	0.1	0.3	-1.3
Lung FEV1/FVC ratio	1.4	7.0	14.4	1.6	3.8	3.0	2.6	-2.1	-2.3	2.6
Lung FVC	0.9	4.5	8.1	2.6	0.9	2.2	2.2	-2.8	1.0	2.1
Neuroticism	0.8	1.9	4.8	1.2	-0.3	2.2	1.8	-1.6	-0.0	0.9
Chronotype (morning person)	3.6	8.2	16.9	-2.9	2.1	-4.1	-3.4	2.6	-0.9	-2.9
Hair Pigment	0.1	1.8	4.8	-0.3	1.6	-2.2	-0.3	-0.0	0.4	-2.1
Tanning	0.1	0.7	1.6	-0.7	-1.2	0.3	-1.3	0.4	-0.8	0.9
Hand grip strength (left)	0.9	2.3	5.6	-2.4	-1.7	0.8	-1.2	0.8	-2.2	0.3
Number of treatments/medications taken	1.0	1.7	4.7	0.6	-1.3	1.9	2.2	-0.6	0.7	1.0
Average weekly spirits intake	0.6	0.7	2.0	1.4	-0.9	0.6	0.9	-0.4	0.9	0.4
Sensitivity / hurt feelings	0.3	0.6	1.3	0.5	-0.0	0.2	1.1	-1.1	1.1	0.2
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.6	0.7	0.4	1.3	0.4	0.2	-1.2	0.1
Hearing difficulty/problems: Yes	1.1	1.8	8.1	0.3	1.0	1.0	2.9	-0.7	1.2	-0.5
Relative age of first facial hair	2.5	5.2	10.2	2.7	2.7	2.7	3.2	-1.4	0.3	1.5
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	6.7	1.8	-0.3	2.6	2.4	-0.7	0.8	1.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	-0.7	0.9	-1.0	0.7	-0.2	0.3	-0.4
Ever had hysterectomy (womb removed)	0.0	0.0	0.2	-0.0	0.1	-0.2	0.4	0.1	0.1	-0.0
Systolic blood pressure, automated reading	0.3	0.9	3.3	0.7	1.8	-0.5	0.8	0.2	1.0	-0.9
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.5	0.8	0.1	-1.2	-1.0	-0.1	1.0	-1.2
Angina	0.6	0.8	2.0	0.9	0.6	1.4	1.1	-0.7	-0.8	0.7
Medication for hormone replacement therapy	0.8	0.9	3.9	-0.9	-0.6	0.2	2.0	0.2	0.8	0.6
Vitamin and mineral supplements	0.8	1.1	3.0	-0.5	-0.1	-1.6	-0.7	0.4	1.7	-1.2
Supplements: Zinc	0.2	0.2	0.5	-0.7	-0.2	-0.5	-0.2	0.1	-0.0	0.7
Medication: Co-codamol	0.5	0.6	1.5	1.2	0.4	0.4	0.9	-0.2	0.8	0.9
Medication: Metformin	1.3	1.9	5.2	-2.0	0.5	-2.3	-1.0	0.3	0.1	-1.6
Diabetes (father)	0.3	0.4	2.1	0.1	-0.1	0.2	0.2	-1.5	0.1	0.6
Diabetes (mother)	0.7	0.8	1.8	-1.1	-0.8	-0.4	-1.4	1.3	-0.4	-0.6
Severe depression (siblings)	1.4	1.6	7.3	-1.3	0.1	0.3	-0.4	1.2	-2.7	-0.3
Pack years adult smoking proportion	0.3	0.5	2.0	0.5	-0.0	-1.0	0.2	0.3	1.4	-0.3
Impedance of leg (right)	0.6	3.1	9.2	1.3	-1.1	2.5	3.0	-0.6	0.2	1.8
Leg fat-free mass (left)	2.0	10.6	24.1	-3.7	0.7	-3.8	-4.9	3.3	-2.0	-2.7
Trunk fat percentage	0.5	2.2	4.2	-1.4	2.0	-1.8	-0.2	2.0	-0.9	-1.1
Hand grip strength (right)	0.5	1.3	2.8	-1.2	-1.4	1.2	-0.5	1.1	-1.7	0.7
Townsend deprivation index at recruitment	0.6	0.8	1.9	-0.1	1.3	-1.4	-0.9	0.1	-0.3	-1.0
Current tobacco smoking	0.6	1.0	2.8	1.7	0.4	0.8	1.2	0.2	1.0	0.7
Average weekly fortified wine intake	0.3	0.4	1.0	0.4	1.0	0.4	0.7	-1.0	-0.2	0.2
Maternal smoking around birth	1.0	1.5	3.4	-0.1	1.8	-1.2	-1.3	0.2	-0.8	-1.8
Fed-up feelings	1.6	2.9	5.5	2.4	0.1	0.9	1.9	-2.3	2.0	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.7	0.8	-1.3	0.9	0.2	-0.0	0.1	0.0
Relative age voice broke	1.3	1.9	3.7	1.2	1.9	1.6	1.4	0.2	-0.8	1.7
Taking other prescription medications	1.2	1.8	5.3	0.5	-1.3	1.9	2.3	-0.7	0.6	1.0
Age when periods started (menarche)	0.6	1.4	3.1	-1.0	-1.8	0.9	-0.2	-0.3	-1.8	1.4
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	4.3	-0.6	1.1	-2.1	-0.3	0.7	1.5	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	15.4	35.0	66.5	-7.6	-0.4	-7.2	-8.2	6.0	-3.1	-4.8
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.5	-0.6	-1.9	-1.2	-0.5	-0.7	1.2	-0.5
Qualifications: CSEs or equivalent	1.1	1.4	3.1	1.2	-1.6	-0.1	0.4	-1.6	1.8	0.1
Serious illness, injury or assault to yourself	1.6	2.0	3.9	2.0	-1.0	1.4	1.4	-1.9	0.8	0.9
High blood pressure	0.2	0.5	1.9	0.5	0.3	-0.1	0.4	-1.4	0.7	-0.7
Hayfever, allergic rhinitis or eczema	1.3	2.9	9.0	-2.4	-0.5	-0.6	-1.7	1.4	-3.0	-0.1
Multivitamins +/- minerals	0.6	0.7	1.7	-0.1	0.3	1.1	0.9	0.3	-1.3	1.1
Stomach or abdominal pain in last month	4.3	5.3	9.4	2.1	-3.0	3.1	1.4	-2.4	0.5	2.6
Supplements: Glucosamine	0.2	0.2	0.7	-0.3	0.8	0.3	0.8	0.2	-0.2	-0.2
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.1	0.6	0.5	0.9	1.1	-0.3	0.7	0.2
Medication: Atenolol	0.6	0.8	3.1	-0.5	0.8	-1.1	-1.8	-0.1	-0.4	-0.2
Medication: Levothyroxine sodium	0.5	0.8	2.9	-1.0	0.3	0.7	-0.3	0.7	-1.7	0.5
Sitting height	1.3	9.2	22.1	-3.4	-1.2	-1.9	-4.7	3.3	-3.6	-1.3
Chronic bronchitis/emphysema (father)	0.7	0.8	3.1	-0.6	-1.8	0.2	1.0	-0.9	0.6	-0.3
High blood pressure (mother)	1.2	1.6	3.6	-1.9	-0.5	-1.5	-1.6	1.6	-0.3	-0.3
Body mass index (BMI)	0.6	2.5	6.2	-1.3	1.7	-2.5	-1.5	1.1	-0.0	-1.8
Impedance of leg (left)	0.6	2.9	7.2	0.8	-1.6	2.6	2.7	-0.3	-0.4	1.7
Leg predicted mass (left)	2.0	10.6	24.5	-3.7	0.7	-3.8	-4.9	3.2	-2.0	-2.7
Trunk fat mass	1.2	5.1	9.6	-2.5	1.7	-2.7	-1.8	3.1	-1.5	-1.9
Waist circumference	1.5	5.3	9.5	-2.4	1.4	-2.8	-1.7	2.8	-1.0	-3.1
Number of incorrect matches in round	1.2	2.0	5.4	0.2	1.0	-2.3	-0.8	0.6	2.0	-1.6
Past tobacco smoking	0.6	1.2	2.2	0.9	-1.3	-0.6	-0.6	-1.4	1.5	1.0
Alcohol usually taken with meals	0.3	0.4	0.8	0.7	-0.7	0.7	0.9	-0.2	0.7	0.5
Nervous feelings	2.4	4.5	11.9	2.2	-1.2	1.5	1.5	-3.4	2.4	1.7
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.1	4.4	1.8	1.0	2.1	2.0	-0.7	-0.2	0.9
Hearing difficulty/problems with background noise	1.7	2.7	8.0	1.4	0.0	1.6	2.8	-2.1	1.3	0.7
Hair/balding pattern: Pattern 2	0.3	0.4	0.8	0.2	0.7	-0.1	-0.9	0.6	-0.9	-0.6
Had menopause	1.2	1.5	3.7	1.7	0.6	-0.8	0.6	-1.9	1.6	-0.4
Had other major operations	1.1	1.4	4.0	2.0	-0.6	1.0	0.7	-1.4	0.8	1.1
Forced vital capacity (FVC)	0.4	1.5	4.5	-1.2	-0.3	-0.3	-2.1	0.7	-1.8	0.4
Heel bone mineral density (BMD) T-score, automated (right)	18.5	42.4	72.8	-8.0	1.0	-8.0	-8.5	7.3	-3.2	-5.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.5	0.7	-0.4	1.6	0.7	-0.7	-0.4	1.0
Qualifications: None of the above	1.9	4.1	9.5	0.3	1.9	-3.1	-1.8	0.5	1.9	-2.9
Financial difficulties in last 2 years	1.0	1.3	3.6	1.0	0.7	-0.3	1.4	-1.2	1.9	1.0
Mouth/teeth dental problems	0.3	0.4	1.3	-1.1	-0.5	-0.3	-0.3	0.1	-0.4	-1.2
Heart attack	0.3	0.3	1.1	-1.1	0.2	0.0	-0.2	0.0	-1.0	-0.5
Allergy	1.6	3.7	7.9	2.8	1.0	1.8	2.0	-2.1	2.0	1.4
Pain all over the body in last month	0.4	0.4	1.1	0.6	1.1	-0.1	0.7	-0.9	0.2	-0.0
Diabetes (self-reported)	0.5	0.8	2.1	0.1	1.0	-1.5	-0.5	-0.1	0.9	-1.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.9	0.3	-0.9	0.6	0.8	-0.6	-0.2	0.2
Medication: Ramipril	0.7	0.8	2.1	0.6	-0.2	0.5	1.4	-1.4	1.1	0.1
Medication: Simvastatin	0.3	0.4	0.9	0.0	0.5	0.8	0.7	-0.9	-0.3	0.4
Fluid intelligence score	0.3	0.5	1.4	-1.2	0.7	-0.5	0.2	1.0	0.8	-0.0
Illnesses of siblings	0.7	1.0	2.1	0.3	-1.4	1.2	-0.7	0.9	-1.1	1.0
Neuroticism score	1.8	3.8	7.6	1.9	-0.5	2.5	2.4	-2.8	1.1	1.4
Weight	1.9	9.6	16.5	-3.5	1.0	-3.6	-4.1	3.4	-2.1	-2.9
Impedance of arm (right)	0.6	2.7	5.6	1.7	0.5	1.9	2.4	-1.5	-0.2	2.0
Arm fat percentage (right)	0.4	1.4	4.0	-0.6	2.0	-1.9	-0.3	1.0	0.1	-1.1
Trunk fat-free mass	2.9	16.9	41.2	-4.7	-0.5	-4.1	-6.4	4.5	-2.5	-3.5
Hip circumference	1.1	4.8	8.1	-2.0	1.7	-2.2	-2.8	2.4	-2.0	-1.9
Time employed in main current job	0.6	0.7	3.4	-0.3	-1.8	-0.1	0.0	-0.8	0.8	0.4
Alcohol intake versus 10 years previously	4.9	7.3	14.9	3.9	-1.6	2.1	2.4	-3.4	3.0	1.7
Father’s age at death	0.8	1.1	1.5	1.0	-0.7	0.9	1.2	-1.1	1.2	1.0
Worrier / anxious feelings	0.9	1.6	4.4	0.8	-0.9	1.6	1.1	-2.1	0.5	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.9	1.1	-0.4	0.4	1.1	-0.9	1.4	0.5
Falls in the last year	1.4	1.9	4.0	2.0	1.7	0.5	1.6	-1.7	1.0	0.2
Hair/balding pattern: Pattern 3	0.3	0.5	1.6	-1.3	-0.2	-0.1	-0.8	0.6	-0.7	0.7
Number of live births	1.6	2.2	4.7	1.4	-1.3	1.6	1.8	-2.2	1.0	0.6
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	5.1	-0.8	0.4	0.4	-1.2	0.0	-2.3	1.1
Pulse rate	0.4	0.6	2.4	-0.8	-0.7	-0.7	-0.6	1.6	0.1	0.4
Happiness	0.9	1.1	3.3	0.8	0.6	1.8	1.1	0.3	-1.1	1.1
Noisy workplace	1.7	2.0	4.9	1.7	-1.3	0.5	0.7	-1.7	2.2	1.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.4	-0.6	0.6	0.5	0.7	-0.3	-0.4	-0.5
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	6.5	0.3	-1.7	2.0	1.1	-1.0	-0.6	2.6
Mouth/teeth dental problems: Dentures	0.4	0.6	1.9	1.3	1.4	0.0	-0.1	-0.1	0.6	0.5
Asthma	0.8	1.7	3.8	-1.6	-1.6	-1.3	-0.2	0.9	0.2	-1.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.8	1.1	-1.3	0.7	0.5	0.1	0.7	0.2
Medication: Cholesterol lowering	0.6	0.9	2.3	0.3	1.5	1.5	1.1	-0.3	-0.7	0.4
Depression (self-reported)	0.5	0.6	1.7	0.8	-0.6	0.4	0.9	-0.0	1.3	0.5
Medication: Lansoprazole	2.6	3.0	6.2	2.5	0.7	2.4	2.1	-1.0	0.6	1.6
Prospective memory result	1.0	1.2	4.3	0.1	-2.1	0.6	0.9	-1.4	0.7	0.9
Lung cancer (father)	0.7	0.8	2.1	-1.1	-0.2	-1.2	-0.2	0.8	0.1	-1.5
Illnesses of mother	1.1	1.3	2.8	1.6	1.6	0.5	1.7	-0.7	0.7	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	4.3	-0.2	1.3	1.1	0.0	-0.2	-2.1	1.3
Pulse wave Arterial Stiffness index	1.2	1.4	3.6	1.3	-0.3	1.1	1.9	-1.3	0.6	1.1
Impedance of arm (left)	0.5	2.3	6.6	1.0	0.6	1.9	2.6	-0.9	-0.8	1.7
Arm fat mass (right)	1.1	4.5	8.8	-2.1	1.8	-3.0	-2.2	2.2	-0.9	-2.2
Trunk predicted mass	2.9	16.7	41.0	-4.6	-0.5	-4.1	-6.4	4.5	-2.5	-3.5
Standing height	2.1	20.7	39.7	-5.7	-1.5	-3.1	-6.3	5.5	-4.9	-2.8
Length of working week for main job	0.5	0.5	2.9	0.5	-0.7	-0.1	0.0	-0.5	1.7	0.0
Exposure to tobacco smoke at home	1.0	1.1	2.8	1.1	0.8	-0.0	1.1	-1.1	1.7	-0.7
Breastfed as a baby	0.4	0.5	1.7	0.3	-0.6	0.8	0.7	-1.3	-0.2	0.3
Tense / ‘highly strung’	2.4	4.0	7.0	2.3	-1.1	1.4	2.2	-2.7	2.6	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.3	1.2	-0.0	1.4	1.2	-1.8	0.4	1.6
Hair/balding pattern: Pattern 4	0.7	1.8	6.0	-2.0	-0.7	0.7	-0.7	0.7	-2.5	0.7
Birth weight of first child	0.5	0.8	3.5	-0.1	-1.9	0.9	-0.3	-0.3	-1.1	0.1
Peak expiratory flow (PEF)	0.6	1.3	4.2	-2.0	0.5	-0.8	-0.9	0.8	-1.6	-0.2
Pulse wave reflection index	3.1	3.8	8.1	2.4	-0.1	2.1	2.2	-2.9	0.0	1.8
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.9	-1.4	-0.9	-0.9	-0.2	0.5	0.2	-1.3
Loud music exposure frequency	0.7	0.8	2.9	-0.5	-0.9	0.8	-0.7	-0.1	-1.7	-0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.4	-0.4	-0.9	0.8	0.9	-1.2	0.3	1.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.5	0.4	1.2	-0.5	-0.1	0.2	0.2	-0.2
Blood clot in the leg (DVT)	0.5	0.6	2.5	0.3	0.4	-0.6	-0.5	0.9	0.2	-1.6
Medication: Paracetamol	0.8	1.4	4.8	0.1	-0.7	-1.1	0.3	0.7	2.2	-1.6
Headache pain in last month	2.4	4.1	18.3	-0.2	-4.3	1.7	-0.0	-1.1	-0.5	2.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.6	1.8	-0.1	-0.1	-1.0	-1.3	0.3	-0.3	-1.0
Glaucoma (self-reported)	1.5	1.8	4.7	-1.6	0.7	-0.8	-0.3	2.2	-1.7	-1.0
Gout (self-reported)	0.4	0.6	1.9	0.9	-0.6	1.4	0.2	0.0	-0.4	0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.3	-0.3	-0.3	1.2	0.5	0.7	-0.5	0.9
Medication: Amlodipine	1.4	2.0	5.3	-2.3	1.3	-1.0	-1.1	1.4	-1.6	-0.3
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.5	-0.2	-1.6	-0.7	-0.4	0.2	0.8	-1.5
Birth weight	0.4	1.0	2.5	-0.7	-0.5	0.8	0.1	1.6	-1.1	1.2
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.1	-0.7	0.3	-1.4	-0.8	0.5	-0.3	-1.4
High blood pressure (siblings)	0.3	0.4	0.9	-0.9	0.5	-0.3	0.5	-0.9	-0.5	0.1
Forced vital capacity (FVC), Best measure	0.2	0.7	2.8	-0.8	0.2	0.3	-0.9	0.4	-1.7	0.6
Body fat percentage	0.5	1.8	4.2	-1.1	2.0	-1.7	0.0	1.7	-0.5	-1.1
Leg fat percentage (right)	0.2	0.9	2.4	-0.3	1.5	-1.3	0.5	0.9	0.7	-0.6
Arm fat-free mass (right)	2.9	15.0	28.3	-4.6	-0.0	-4.1	-5.3	4.5	-2.3	-3.6
Exposure to tobacco smoke outside home	0.3	0.4	1.7	0.6	1.3	0.6	0.2	-0.7	-0.4	0.2
Comparative body size at age 10	0.3	0.8	2.2	-0.2	1.5	-1.3	-0.8	-0.1	0.8	-0.7
Number of full brothers	0.8	1.0	2.3	-1.5	0.4	-1.5	-0.4	1.0	-0.2	-1.0
Worry too long after embarrassment	1.8	3.0	9.5	1.0	-1.6	3.1	1.4	-1.4	-0.1	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.4	6.1	2.5	-0.9	1.3	1.7	-2.4	2.0	1.7
Wheeze or whistling in the chest in last year	1.1	1.9	4.8	-0.9	-1.8	-1.7	-0.9	0.6	0.8	-2.2
Number of children fathered	0.4	0.5	0.9	-0.5	0.8	-0.9	0.1	0.9	0.7	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.9	-0.3	-0.7	0.9	0.7	-0.7	0.1	0.7
Age at first live birth	0.3	0.6	2.1	-0.5	0.8	0.9	-0.5	0.4	-1.5	0.0
Pulse wave peak to peak time	2.0	2.4	5.8	-1.7	0.2	-1.4	-2.4	1.6	-1.1	-1.4
Health satisfaction	0.6	0.8	3.0	-0.4	-0.4	0.7	0.8	1.7	-0.8	0.6
Shortness of breath walking on level ground	1.9	2.3	5.4	-2.3	-1.5	-1.7	-1.7	1.3	-0.1	-1.1
Qualifications: College or University degree	0.6	2.0	4.5	-0.3	-1.8	1.8	0.2	1.1	-2.1	1.1
Eye problems/disorders: None of the above	2.6	3.0	4.7	2.2	-0.7	1.7	1.8	-1.8	1.6	1.9
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.1	0.2	0.6	-1.3	0.4	-0.0	1.4	-0.7
Emphysema/chronic bronchitis	0.7	0.8	2.1	0.4	-1.5	0.8	1.0	-0.5	0.9	0.6
Medication for pain relief, constipation, heartburn	1.4	2.5	4.6	-1.4	1.8	-1.9	-2.1	1.3	-1.3	-0.3
Neck or shoulder pain in last month	0.1	0.2	0.6	0.2	0.3	0.8	0.1	-0.0	-0.5	-0.4
Medication: Blood pressure	0.1	0.2	0.5	0.1	-0.3	0.4	0.7	-0.2	0.5	0.7
Angina (self-reported)	0.4	0.5	1.2	0.6	0.5	1.1	0.7	-0.4	-0.9	0.5
Migraine (self-reported)	1.2	1.5	2.6	0.5	-1.5	1.4	1.0	-1.6	-0.1	1.5
Medication: Ibuprofen	0.3	0.4	1.0	1.0	-0.7	1.0	0.2	0.1	-0.1	0.6
Medication: Allopurinol	0.9	1.2	2.9	0.4	-0.4	1.7	-0.2	-0.5	-1.4	1.6
Medication: Omeprazole	1.1	1.3	4.2	0.7	-0.3	2.1	1.8	0.7	0.5	0.7
Medication: Seretide 50 evohaler	5.6	6.5	15.5	-3.3	-1.4	-1.8	-2.1	3.9	-2.1	-2.1
Mean time to correctly identify matches	1.5	2.9	6.5	2.5	1.3	1.4	2.0	-1.6	0.8	1.6
Heart disease (mother)	0.2	0.3	0.8	0.4	-0.0	0.9	0.9	-0.2	-0.1	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.3	6.5	-1.5	-0.0	-1.7	-1.7	1.0	-0.7	-2.5
Whole body fat mass	1.1	4.8	7.8	-2.2	1.9	-2.8	-1.9	2.8	-1.1	-2.1
Leg fat mass (right)	1.0	3.7	7.4	-1.9	1.3	-2.7	-1.7	2.5	-0.4	-2.0
Arm predicted mass (right)	2.9	15.1	31.5	-4.5	-0.1	-4.0	-5.6	4.5	-2.5	-3.5
Pulse rate, automated reading	0.2	0.7	1.9	-1.2	-1.4	-0.2	-0.3	1.1	0.0	-0.7
Alcohol intake frequency.	1.2	2.7	5.0	2.2	-1.1	1.3	1.6	-2.1	1.6	1.4
Comparative height size at age 10	1.2	6.4	12.2	-2.4	0.7	-2.9	-3.2	3.5	-1.2	-2.5
Number of full sisters	1.5	1.8	5.1	1.0	-0.9	-0.1	1.4	-1.8	2.3	0.6
Suffer from ‘nerves’	0.7	1.1	2.2	1.1	0.2	1.5	1.4	-1.1	0.4	1.2
Overall health rating	1.0	2.2	7.9	1.8	-0.4	0.4	1.5	-0.7	2.8	1.0
Chest pain or discomfort	0.5	0.7	2.5	-0.9	-0.0	-1.1	0.0	-0.2	0.6	-1.6
Had major operations	0.6	0.7	3.0	0.8	-0.4	1.7	1.0	-0.1	-0.3	0.3
Age at last live birth	0.7	1.0	3.9	1.0	-0.2	2.0	1.1	-0.8	-0.6	0.2
Family relationship satisfaction	0.8	1.0	2.3	1.1	1.3	1.5	1.0	0.0	-0.8	0.6
Leg pain on walking	0.9	1.1	2.5	1.0	-0.8	0.2	1.1	-1.6	1.6	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.7	0.4	0.5	1.1	-0.1	0.6	-1.3	1.3
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.9	-0.5	0.9	-0.6	-0.0	0.3	0.6	-0.9
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	4.5	-1.4	1.5	-0.4	-1.1	2.1	-1.2	-1.9
Medication: Aspirin	1.1	1.4	3.6	0.8	-1.0	1.6	1.2	-1.9	0.6	0.6
Supplements: Vitamin C	0.5	0.6	3.5	0.1	-1.9	0.5	-0.2	-0.1	-0.6	0.6
Knee pain experienced in last month	1.2	1.8	5.9	1.3	2.4	0.3	1.8	-0.4	1.3	-0.1
Hypertension (Self-reported)	0.2	0.5	2.3	0.3	0.2	0.3	0.7	-1.5	0.4	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.0	3.5	11.0	1.4	0.8	3.3	2.6	-0.4	-0.7	1.8
Illnesses of father: Heart disease	1.7	2.3	6.5	1.6	-0.1	2.5	1.2	-1.4	-0.5	1.9
Illnesses of siblings: Diabetes	1.8	2.2	7.5	-0.4	1.0	-2.7	-1.2	-0.1	1.5	-1.9
Smoking status: Previous	0.7	1.0	2.3	-1.1	0.7	0.3	0.5	1.2	-1.5	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.0	7.3	-2.7	-1.4	-1.2	-2.2	1.8	-1.5	-0.7
Whole body fat-free mass	2.6	15.1	36.1	-4.4	0.0	-4.1	-6.0	4.2	-2.4	-3.3
Leg fat-free mass (right)	2.0	10.7	25.1	-3.8	0.5	-3.5	-5.0	3.3	-2.2	-2.6
Arm fat percentage (left)	0.5	2.0	4.9	-0.9	2.2	-2.0	-0.2	1.5	-0.2	-1.3
Average weekly red wine intake	1.2	1.8	3.1	-1.8	0.4	-1.5	-1.1	1.7	-0.8	-1.6
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.4	0.7	-0.7	1.2	0.7	-0.2	-0.1	0.4
Mood swings	1.8	3.2	5.8	1.9	-0.2	2.4	2.4	-2.1	0.9	1.4
Loneliness, isolation	0.4	0.6	2.8	0.6	0.3	-0.5	-0.2	-0.1	0.8	-1.7
Long-standing illness, disability or infirmity	0.7	1.0	3.3	0.8	0.0	1.2	1.8	-1.0	0.6	0.3
Ever had bowel cancer screening	0.7	0.8	4.5	0.1	2.1	-0.3	0.6	0.1	-0.4	-0.7
Diabetes diagnosed by doctor	0.3	0.5	1.4	-0.5	0.3	-1.2	-0.3	0.2	0.5	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	2.6	2.8	9.3	1.9	0.2	1.5	3.0	-1.2	1.6	0.6
Friendships satisfaction	0.6	0.7	2.2	-0.1	-0.2	1.5	0.4	0.6	-1.3	0.6
Qualifications: nursing, teaching	0.7	1.1	4.2	0.3	0.9	0.7	2.0	-1.3	0.6	0.6
Commuting to job workplace: Walk	2.1	2.3	9.6	-1.3	0.4	-0.3	-1.5	1.4	-3.1	-0.5
Eye problems/disorders: Cataract	1.6	1.8	3.4	-1.5	0.4	-1.1	-1.5	1.6	-0.9	-1.8
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	4.2	0.8	-2.1	2.1	1.5	-1.3	-0.1	1.7
Medication for cholesterol	0.3	0.5	1.3	0.2	1.1	0.0	-0.6	1.1	-0.8	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	1.2	1.1	-0.2	0.0	-0.3	-0.2	0.1	-0.3
Back pain experienced in last month	0.3	0.4	0.9	0.5	-0.6	0.8	0.9	-0.0	-0.2	0.9
Mineral and other dietary supplements	0.4	0.5	2.1	0.6	-0.1	0.0	0.8	-0.5	1.4	0.2
Breast cancer (self-reported)	1.5	1.8	5.1	2.3	-0.4	0.1	1.4	-0.7	2.2	-0.0
Asthma (self-reported)	0.8	1.6	3.7	-1.5	-1.6	-1.4	-0.2	0.9	0.5	-1.9
Osteoporosis (self-reported)	0.3	0.4	1.6	0.2	0.9	0.6	0.0	0.2	-1.3	0.3
Osteoarthritis (self-reported)	1.1	1.4	5.0	-0.4	2.2	-1.3	0.3	0.7	1.2	-0.9
Medication: Aspirin	1.5	2.0	6.2	1.0	-0.8	1.9	1.1	-2.5	0.4	1.1
Medication: Gliclazide	2.0	2.2	4.9	-0.5	2.0	-2.2	-0.3	0.1	1.7	-1.9
Illnesses of father: None of the above (group 1)	2.8	3.5	7.2	-2.4	0.6	-1.7	-1.5	2.7	-1.3	-2.0
Smoking status: Current	0.5	0.8	1.7	1.3	0.1	1.0	1.3	0.4	0.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.9	6.4	2.0	2.2	1.8	2.4	-2.5	-0.1	1.6
Whole body water mass	2.6	14.7	34.3	-4.3	0.0	-4.0	-5.9	4.2	-2.3	-3.3
Leg predicted mass (right)	1.9	10.3	24.3	-3.7	0.5	-3.5	-4.9	3.2	-2.1	-2.6
Arm fat mass (left)	1.2	5.1	8.9	-2.2	1.9	-3.0	-2.2	2.6	-1.1	-2.3
Number of self-reported non-cancer illnesses	1.1	2.0	7.1	1.2	-0.2	1.9	2.7	-0.9	0.6	0.3
Average weekly champagne plus white wine intake	0.9	1.2	3.1	-0.1	0.7	1.8	0.6	1.0	-1.7	0.9
Miserableness	1.4	2.4	4.6	1.8	0.2	2.1	2.1	-1.4	0.8	1.5
Guilty feelings	1.5	2.3	6.3	0.7	-0.6	1.8	0.8	-2.5	-0.5	2.2
Wears glasses or contact lenses	1.5	1.7	5.1	-1.3	1.0	-0.1	-1.1	0.7	-2.2	-1.5
Ever taken oral contraceptive pill	0.3	0.4	1.0	-0.3	-0.6	0.8	1.0	-0.2	-0.3	0.6
Hearing aid user	1.1	1.2	3.8	1.3	1.1	0.3	1.1	-0.5	1.9	-0.4
Mother’s age at death	0.7	0.8	2.3	-1.5	-1.3	-1.0	0.0	0.8	0.6	0.1
Financial situation satisfaction	0.2	0.3	1.0	-0.4	-0.7	0.0	0.6	1.0	-0.1	0.1
Tinnitus: Yes, now most or all of the time	1.3	1.6	3.9	1.3	-1.0	0.4	0.2	-1.7	2.0	1.1
Commuting to job workplace: Public transport	1.7	2.0	7.6	-1.2	-0.8	-0.0	-1.5	1.4	-2.8	0.5
Eye problems/disorders: Glaucoma	1.8	2.1	4.3	-1.6	1.1	-1.2	-0.6	2.0	-2.1	-0.8
Medication: Blood pressure	0.0	0.1	0.2	-0.2	0.2	-0.2	-0.3	-0.3	-0.3	-0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.9	0.2	-0.6	0.5	0.3	-1.0	0.3	0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.8	-0.2	0.1	-0.7	-0.9	0.8	-0.7	-0.7
High cholesterol (Self-reported)	1.7	3.0	7.6	1.4	-0.2	1.8	2.2	-2.8	1.1	1.5
Medication: Bendroflumethiazide	1.1	1.7	3.1	-1.7	0.2	-0.7	-1.2	1.2	-1.8	-1.6
Medication: Paracetamol	0.4	0.6	2.4	0.2	-0.7	-0.6	-0.1	0.1	1.6	-0.9
Medication: Lisinopril	1.3	1.7	5.3	-1.7	-0.4	-1.1	-2.3	0.5	-1.1	-0.9
Medication: Atorvastatin	0.7	0.8	2.4	1.4	0.5	0.9	0.6	-1.6	0.4	0.0
Illnesses of father: High blood pressure	0.9	1.1	2.2	0.3	-1.4	1.5	0.5	-1.3	-0.5	1.2
Alcohol drinker status: Never	0.7	0.8	3.2	1.0	0.6	0.9	1.8	-0.1	0.5	-0.2
Ever smoked	0.5	0.8	2.5	-0.1	1.6	0.8	1.0	0.9	-0.5	-0.7
Basal metabolic rate	2.5	14.0	31.4	-4.3	0.3	-4.0	-5.6	4.0	-2.4	-3.2
Leg fat percentage (left)	0.3	1.0	2.2	-0.8	1.3	-1.5	0.1	1.3	0.3	-0.8
Arm fat-free mass (left)	2.9	14.8	32.1	-4.4	0.0	-4.1	-5.7	4.2	-2.4	-3.5
Number of operations (self-reported)	1.4	2.0	3.5	1.5	-1.8	1.7	1.9	-0.8	1.0	0.8
Average weekly beer plus cider intake	1.0	1.5	6.4	0.8	2.5	0.9	0.3	-0.5	-1.2	0.9
Irritability	0.6	1.0	2.8	0.3	0.1	1.4	1.7	-1.2	-0.4	0.2
Risk taking	0.7	1.1	3.6	0.1	0.8	0.8	1.1	-0.8	-0.9	1.9
Ever had prostate specific antigen (PSA) test	2.2	2.5	7.0	0.9	-0.7	2.2	2.6	-0.2	0.2	2.1
Fractured/broken bones in last 5 years	0.6	0.7	1.6	1.1	1.3	0.9	-0.1	0.5	-0.8	0.6
Age started oral contraceptive pill	1.4	1.8	3.4	0.9	-0.4	1.6	-0.4	-1.7	-1.8	1.5
Diastolic blood pressure, automated reading	0.2	0.6	2.1	0.5	0.8	1.1	1.4	0.5	-0.3	0.1
Ever depressed for a whole week	0.1	0.1	0.5	-0.2	0.0	0.3	-0.1	-0.6	-0.7	0.1
Unable to work because of sickness or disability	0.4	0.6	1.5	0.5	-0.1	-0.8	-0.7	1.2	0.5	-0.9
Commuting to job workplace: Cycle	0.7	0.9	2.0	1.4	0.9	-0.2	0.1	-1.3	1.2	-0.6
Myopia	2.9	4.2	8.2	-2.9	-2.5	-1.9	-2.9	0.2	-1.3	-1.1
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.9	-0.6	-0.1	-0.3	-0.6	1.7	-0.3	0.3
Cholesterol lowering medication	1.3	2.0	9.5	1.0	-1.2	0.7	0.6	-3.1	0.9	0.5
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	5.9	1.1	-0.6	2.4	2.4	-0.2	1.2	1.3
Pain experienced in last month	1.0	1.7	5.7	-0.8	0.1	-2.4	-1.0	1.0	1.1	-1.5
Supplements: Calcium	1.1	1.2	4.0	1.4	0.6	1.3	2.0	-0.6	-0.1	0.3
Basal cell carcinoma (self-reported)	3.0	3.5	7.4	1.8	-2.2	2.2	0.7	-2.0	0.0	2.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.0	-1.0	-0.0	0.4	-0.3	0.1	-1.4	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.5	0.4	0.6	-0.6	-0.5	1.0	0.1	-1.6
Heart disease (siblings)	1.1	1.4	4.0	0.8	-0.8	0.6	1.4	-1.2	2.0	0.9
Alcohol drinker status: Previous	1.1	1.2	2.1	0.6	0.6	1.5	1.1	-1.4	-0.6	1.4
Pack years of smoking	0.3	0.4	1.2	0.3	0.1	-1.0	-0.0	0.3	1.1	-0.5
Impedance of whole body	0.7	3.4	10.0	1.0	-0.6	2.7	3.2	-0.8	-0.6	2.1
Leg fat mass (left)	1.0	3.9	7.4	-2.2	1.0	-2.7	-1.9	2.5	-0.6	-2.0
Arm predicted mass (left)	2.6	13.0	30.3	-4.0	-0.2	-3.8	-5.5	3.9	-2.2	-3.2