[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr1:112,312,154-114,196,883

Best TWAS P=1.39e-14 · Best GWAS P=1.43e-14 conditioned to 0.0102

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
7	GTEx	Brain Cortex	WNT2B	0.36	0.19	lasso	5	0.23	5.5e-07	7.5	7.7	1.4e-14	0.80	0.01	0.98	TRUE
8	GTEx	Brain Frontal Cortex BA9	WNT2B	0.29	0.28	lasso	3	0.29	2.6e-08	7.5	7.7	1.7e-14	0.82	0.02	0.98	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	MOV10	0.06	0.06	lasso	7	0.05	9.4e-06	7.1	7.6	2.5e-14	0.83	0.01	0.99	FALSE
15	GTEx	Pituitary	ST7L	0.31	0.18	lasso	7	0.18	3.0e-05	7.5	7.6	3.1e-14	0.86	0.01	0.98	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	WNT2B	0.34	0.40	enet	30	0.42	1.5e-59	7.5	7.5	4.3e-14	0.77	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	WNT2B	0.43	0.46	enet	44	0.47	7.4e-64	7.5	7.4	1.3e-13	0.69	0.02	0.98	FALSE
18	GTEx	Skin Sun Exposed Lower leg	MOV10	0.05	0.02	lasso	5	0.02	1.1e-02	7.5	7.2	6.6e-13	0.85	0.01	0.96	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	SLC16A1	0.12	0.00	lasso	5	0.04	5.0e-03	7.5	-7.0	2.6e-12	-0.74	0.01	0.92	FALSE
4	GTEx	Adipose Visceral Omentum	ST7L	0.33	0.32	enet	29	0.32	4.2e-17	4.4	6.2	7.8e-10	0.56	0.96	0.04	FALSE
25	The Cancer Genome Atlas	Colon Adenocarcinoma	ST7L	0.33	0.19	lasso	3	0.21	1.7e-12	4.4	6.0	1.5e-09	0.57	0.95	0.05	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	WNT2B	0.10	0.04	blup	46	0.03	2.7e-03	2.6	6.0	2.0e-09	0.36	0.61	0.05	FALSE
6	GTEx	Brain Cortex	ST7L	0.29	0.18	lasso	5	0.20	3.1e-06	4.4	5.9	4.0e-09	0.53	0.08	0.82	FALSE
13	GTEx	Heart Atrial Appendage	ST7L	0.25	0.08	enet	18	0.11	1.1e-05	4.3	5.9	4.7e-09	0.56	0.40	0.59	FALSE
22	YFS	Blood	MOV10	0.07	0.04	blup	314	0.04	1.5e-12	7.5	5.8	6.2e-09	0.59	0.02	0.98	FALSE
30	The Cancer Genome Atlas	Soft Tissue Sarcoma	ST7L	0.11	0.13	lasso	7	0.12	1.5e-07	4.4	5.7	1.3e-08	0.51	0.63	0.36	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	ST7L	0.14	0.10	enet	8	0.06	2.6e-04	4.3	5.7	1.4e-08	0.53	0.78	0.18	FALSE
14	GTEx	Ovary	ST7L	0.53	0.05	enet	33	0.15	1.7e-04	-4.5	5.6	2.7e-08	0.33	0.09	0.30	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ST7L	0.18	0.27	blup	56	0.28	2.4e-31	4.3	5.5	3.0e-08	0.57	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ST7L	0.25	0.33	bslmm	401	0.34	3.4e-43	4.3	5.5	3.8e-08	0.48	1.00	0.00	FALSE
20	METSIM	Adipose	ST7L	0.22	0.25	enet	11	0.25	1.0e-37	4.3	5.5	5.1e-08	0.50	1.00	0.00	FALSE
23	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ST7L	0.21	0.22	blup	56	0.21	1.7e-17	4.4	5.4	6.3e-08	0.42	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	MOV10	0.03	0.00	lasso	9	0.00	9.9e-02	7.5	5.4	6.4e-08	0.47	0.01	0.80	FALSE
10	GTEx	Colon Transverse	ST7L	0.22	0.19	enet	9	0.16	3.4e-08	4.4	5.4	7.1e-08	0.47	0.85	0.15	FALSE
5	GTEx	Artery Tibial	ST7L	0.22	0.21	enet	13	0.21	3.8e-16	4.4	5.4	7.8e-08	0.49	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Prostate Adenocarcinoma	ST7L	0.31	0.43	enet	12	0.42	3.4e-47	4.4	5.3	9.4e-08	0.44	1.00	0.00	FALSE
27	The Cancer Genome Atlas	Lung Adenocarcinoma	ST7L	0.26	0.35	enet	17	0.36	2.6e-43	4.4	5.3	1.4e-07	0.50	1.00	0.00	FALSE
9	GTEx	Cells Transformed fibroblasts	ST7L	0.54	0.64	enet	13	0.66	1.3e-64	4.4	5.3	1.5e-07	0.48	1.00	0.00	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	ST7L	0.32	0.30	enet	31	0.30	1.9e-11	4.4	5.2	1.5e-07	0.44	0.99	0.01	FALSE
12	GTEx	Esophagus Mucosa	ST7L	0.18	0.20	lasso	3	0.19	8.9e-13	4.4	5.2	1.7e-07	0.47	1.00	0.00	FALSE
19	GTEx	Stomach	ST7L	0.21	0.24	lasso	3	0.23	2.6e-11	4.3	5.2	1.7e-07	0.47	0.98	0.02	FALSE
3	GTEx	Adipose Subcutaneous	ST7L	0.27	0.32	enet	17	0.34	2.6e-28	4.3	5.2	2.1e-07	0.45	1.00	0.00	FALSE