Hub : Genes

SLC16A1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Muscularis	0.1090	0.0470	4.7e-03	0.028	NA	0.036	NA	0.036	7.9e-03	NA	2.9e-03	NA	2.9e-03
2	GTEx	Heart Left Ventricle	0.0778	0.0326	4.5e-03	0.046	NA	0.019	NA	0.033	1.7e-03	NA	3.2e-02	NA	7.3e-03
3	GTEx	Skin Not Sun Exposed Suprapubic	0.1170	0.0450	1.3e-03	0.001	NA	0.022	NA	0.035	2.7e-01	NA	2.0e-02	NA	5.0e-03
4	GTEx	Skin Sun Exposed Lower leg	0.0730	0.0290	2.8e-03	0.028	NA	0.018	NA	0.022	2.3e-03	NA	1.1e-02	NA	5.7e-03
5	GTEx	Spleen	0.1600	0.0640	5.0e-03	0.083	NA	0.035	NA	0.068	3.7e-03	NA	4.5e-02	NA	8.3e-03
6	GTEx	Testis	0.3080	0.0670	4.7e-08	0.104	NA	0.204	NA	0.188	2.3e-05	NA	1.9e-09	NA	9.0e-09
7	METSIM	Adipose	0.0977	0.0255	2.4e-10	0.101	0.092	0.096	0.096	0.097	8.0e-15	1.0e-13	3.9e-14	3.9e-14	2.5e-14
8	TCGA	Brain Lower Grade Glioma	0.0379	0.0272	3.4e-03	0.011	0.017	0.001	NA	0.009	2.0e-02	4.6e-03	2.5e-01	NA	3.1e-02
9	TCGA	Lung Adenocarcinoma	0.0553	0.0414	7.0e-03	0.011	0.021	0.020	NA	0.015	1.7e-02	1.5e-03	2.1e-03	NA	6.9e-03
10	TCGA	Ovarian Serous Cystadenocarcinoma	0.1470	0.1060	3.3e-04	0.047	0.051	0.043	NA	0.050	4.1e-04	2.4e-04	7.1e-04	NA	2.6e-04
11	TCGA	Prostate Adenocarcinoma	0.0895	0.0395	2.2e-10	0.109	0.105	0.101	NA	0.107	1.9e-11	4.8e-11	1.1e-10	NA	3.0e-11
12	TCGA	Thyroid Carcinoma	0.2460	0.0830	2.6e-05	0.075	0.058	0.059	NA	0.067	8.2e-08	2.3e-06	2.1e-06	NA	4.1e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.5	0.8	3.3	-0.3	-0.0	0.5	-1.8	0.1	1.1	-0.7	1.3	-0.6	0.0	-0.6	1.5
Bipolar Disorder or Schizophrenia	0.5	1.3	9.1	-0.5	-0.8	3.0	-0.2	-0.9	0.1	0.2	0.3	0.3	1.4	0.3	1.5
Depressed Affect (Nagel 2018)	0.3	0.6	1.7	1.0	0.4	0.9	-0.2	0.9	-0.7	-0.4	-0.2	-0.7	-1.3	-0.4	-1.3
Depression (Nagel 2018)	0.3	0.5	1.7	0.4	0.5	0.8	-0.4	0.6	-1.3	-0.8	0.2	-0.5	-1.0	-0.5	-0.7
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.8	-0.3	-0.6	0.8	1.7	-0.8	0.0	1.4	-1.3	0.1	0.8	1.0	-1.4
Neuroticism (Nagel 2018)	0.2	0.4	1.3	1.1	0.4	0.3	-0.0	0.7	-0.4	-0.3	-0.5	-0.5	-1.0	-0.5	-0.7
Schizophrenia (2018)	0.9	1.9	11.8	-0.4	-1.0	3.4	1.1	-1.2	-0.7	0.8	-0.7	0.9	1.8	0.8	0.7
Schizophrenia vs Biploar Disorder	1.6	2.1	6.5	0.2	-0.5	2.5	2.3	-0.8	-1.3	1.1	-1.9	1.1	1.7	1.2	0.3
Worry (Nagel 2018)	0.1	0.3	1.1	0.6	0.2	-0.5	-0.0	0.4	-0.4	-0.3	-0.1	-0.7	-1.1	-0.3	-0.9
Alzheimer’s Disease (in mother)	0.3	0.4	2.0	-0.1	-0.3	0.8	0.0	-0.1	-1.4	0.1	-0.2	0.7	0.5	0.3	1.0
Alzheimer’s Disease (in father)	2.1	2.3	3.8	1.1	1.5	-1.4	-1.8	1.6	-1.2	-1.6	0.1	-1.9	-1.9	-1.6	-1.3
Alzheimer’s Disease (including proxy)	0.4	0.5	1.6	0.6	0.3	-0.2	-1.3	0.9	-1.0	-0.7	-0.2	-0.7	-0.9	-0.7	-0.4
Crohns Disease (2017)	0.6	1.2	12.2	0.3	0.6	-3.5	-0.8	0.5	0.4	-0.4	0.4	-0.5	-0.5	-0.3	-0.5
Irritable Bowel Disease (IBD)	0.6	1.5	14.2	-0.6	-0.2	-3.8	-0.8	-0.3	1.2	0.1	1.2	0.3	-0.2	0.3	0.2
Ulcerative Colitis (UC)	0.5	0.9	3.8	-1.1	-0.7	-1.9	-0.3	-0.9	1.3	0.7	1.3	0.7	0.0	0.7	0.1
Major Depression (MDD)	0.7	0.8	2.2	0.4	0.2	0.7	-1.0	1.0	-1.2	-1.3	0.7	-0.1	-0.5	-1.2	1.5
Reaction Time	0.4	0.9	3.5	-0.5	1.9	-1.3	-0.9	0.4	-0.2	-0.7	1.1	-0.8	-0.9	-0.7	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.5	1.2	0.9	0.3	0.2	0.8	-0.9	-0.6	-1.0	-0.5	-0.4	-0.7	-0.3
Breast Cancer	0.5	1.2	3.4	-1.8	0.3	-1.4	-0.8	-0.7	1.2	0.7	1.6	-0.4	-0.4	0.4	-1.6
Ovarian Cancer	0.3	0.3	1.2	0.1	0.1	-1.1	0.8	-0.1	-0.8	0.1	-0.7	0.8	0.1	0.1	0.8
Prostate Cancer	0.6	0.8	1.8	-0.9	-0.3	1.1	0.4	-1.0	0.6	0.7	0.7	1.1	1.2	0.9	1.4
Age at First Birth	0.3	0.4	2.2	-0.3	0.5	-1.1	-0.2	0.3	-0.2	0.3	-0.2	-1.2	0.2	-0.1	-1.5
Bipolar Disorder (2011)	0.4	0.4	2.5	-0.4	-1.6	0.9	0.2	-1.0	-0.3	0.7	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.8	0.2	-0.7	1.3	0.5	-0.4	-0.4	0.1	-0.2	-0.1	-0.6	0.1	-1.0
Coronary Artery Disease (CAD)	0.8	1.0	2.7	-0.7	-1.4	1.0	0.8	-1.1	-0.5	1.3	-0.3	0.1	0.2	1.6	-1.2
Crohns Disease (2012)	0.7	1.1	6.6	0.1	0.7	-2.6	-1.3	0.6	0.6	-0.8	0.9	-0.8	-0.9	-0.7	-0.5
Mean Putamen Volume	0.3	0.4	2.4	-0.5	0.3	0.2	-0.2	-0.2	0.5	0.6	0.3	-0.7	-0.6	0.4	-1.5
Fasting Glucose	1.7	2.1	4.6	-2.0	-1.2	-0.8	-0.7	-1.9	1.8	1.1	2.2	1.8	0.3	1.2	1.0
HbA1C	0.1	0.1	0.3	0.4	-0.4	0.6	0.0	0.0	0.2	-0.3	-0.3	-0.2	0.2	-0.4	0.1
HDL Cholesterol	0.1	0.2	0.9	-0.4	-0.0	0.8	0.1	-0.1	-0.1	0.4	0.1	0.1	1.0	-0.1	0.5
LDL Cholesterol	0.4	0.7	3.3	-0.5	-0.8	1.8	0.5	-0.6	-0.6	0.6	-0.0	0.7	1.1	0.5	1.0
Lupus	0.3	0.4	1.1	-1.0	-0.5	0.1	0.0	-1.0	0.1	0.3	1.0	0.3	0.5	0.6	0.8
Neuroticism (2016)	0.8	1.2	4.3	1.1	0.5	0.3	-0.2	1.1	-1.1	-0.9	-1.1	-1.1	-1.5	-1.1	-2.1
Primary Biliary Cirrhosis	0.3	0.4	0.8	0.3	0.7	0.6	-0.8	0.6	0.9	-0.7	0.6	-0.0	-0.3	-0.7	0.5
Rheumatoid Arthritis	0.6	0.8	5.6	-0.3	-2.4	-0.4	1.0	-0.6	0.1	0.7	-0.3	0.9	0.4	0.7	-0.4
Schizophrenia (2014)	0.6	1.3	8.7	0.3	0.1	2.9	0.8	-0.4	-0.6	-0.1	-1.2	0.5	1.7	0.2	1.3
Triglycerides	0.5	0.8	2.0	-1.2	-0.6	0.8	-0.3	-0.8	1.4	0.7	1.2	0.2	-0.2	0.7	-1.2
Type 2 Diabetes (T2D) (2012)	1.1	1.3	2.5	1.5	1.3	0.7	-0.7	1.5	-1.5	-1.6	-0.4	-0.6	-1.0	-1.4	0.0
Ulcerative Colitis	0.7	1.0	2.7	-1.1	-1.0	-1.6	0.1	-1.1	1.1	1.0	0.8	0.9	0.8	1.0	0.9
Blood Eosinophil Count	0.1	0.8	2.7	0.1	0.4	1.6	-1.0	0.5	0.6	-0.6	0.3	-1.2	-0.5	-0.5	-1.5
Blood Platelet Count	0.5	6.2	71.6	-0.1	0.0	-8.5	-0.3	-0.6	-0.8	-0.3	0.3	0.7	-0.0	0.2	1.2
Blood Red Count	0.2	1.6	4.2	1.5	1.0	1.4	-0.6	1.2	-1.1	-1.1	-1.5	-2.0	-0.8	-1.2	-1.2
Blood White Count	0.4	3.3	10.4	-2.3	-0.4	-1.1	0.2	-2.4	3.2	1.8	1.9	1.8	1.2	1.9	1.3
Heel T-Score	2.4	18.8	198.8	-1.8	-0.7	-14.1	-3.0	-0.1	1.4	-0.5	3.0	-0.2	0.4	-0.2	1.4
BMI	0.3	1.6	5.0	0.3	0.5	0.4	-2.0	0.7	-0.5	-1.8	1.6	-1.0	-2.2	-1.5	-0.4
Height	0.9	17.4	125.4	4.4	1.8	11.2	1.9	2.6	-4.2	-2.1	-4.5	-1.8	-1.0	-1.9	-1.0
Waist Hip Ratio (WHR)	0.9	4.1	16.9	2.5	0.5	4.1	2.5	0.8	-1.9	-0.1	-3.8	0.0	0.4	-0.3	-0.2
Systolic Blood Pressure	5.7	28.3	49.8	-6.5	-5.5	-7.1	3.5	-6.8	2.7	6.1	2.5	5.8	5.3	6.2	2.9
Smoking Status	0.3	0.8	7.3	-0.3	0.5	2.7	-0.7	0.1	0.3	-0.4	0.7	-0.5	-0.1	-0.5	-0.4
Allergy or Eczema	0.4	1.0	5.9	0.5	1.0	-2.4	-0.9	0.5	0.8	-1.0	0.4	-0.5	-0.7	-0.9	0.6
Cardiovascular Disease	2.6	8.7	16.4	-3.1	-3.7	-2.6	3.0	-4.0	1.3	3.8	0.6	3.2	2.5	4.0	0.3
Hypothyroidism (self reported)	0.5	1.1	7.5	0.4	-2.7	1.8	0.7	-0.2	-1.0	0.0	0.0	0.5	-0.6	-0.0	-0.3
Respiratory disease	0.1	0.2	0.5	-0.6	-0.2	-0.7	0.2	-0.2	0.1	0.5	0.4	0.4	0.3	0.3	0.2
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.8	1.2	-0.1	1.1	0.1	0.6	-1.7	-0.6	-1.5	-0.8	-1.0	-0.6	-1.1
Lung FEV1/FVC ratio	0.1	0.7	4.8	-0.1	1.0	2.2	-0.2	0.7	1.0	-0.4	0.1	0.3	-0.1	-0.3	0.7
Lung FVC	0.8	4.2	22.3	-2.4	-1.9	-4.7	-0.1	-2.1	1.0	1.7	2.0	1.2	1.2	1.7	0.1
Neuroticism	0.6	1.5	5.2	0.9	1.1	0.5	-1.0	1.2	-0.2	-0.9	0.0	-1.7	-1.8	-1.0	-2.3
Chronotype (morning person)	1.3	2.9	8.0	-2.4	-2.8	0.5	0.4	-2.4	0.2	2.0	1.7	1.6	1.0	2.0	0.3
Hair Pigment	0.1	2.0	6.6	-0.8	-1.9	0.3	2.6	-1.0	-0.8	1.3	-1.6	1.7	1.6	1.2	0.7
Tanning	0.3	3.1	6.0	-2.4	-1.9	0.6	1.5	-1.9	1.3	2.4	0.8	2.0	1.8	2.4	0.3
Hand grip strength (left)	1.4	3.7	16.1	0.4	-0.7	4.0	2.7	-1.3	-1.8	1.2	-2.1	1.2	2.3	1.4	1.2
Number of treatments/medications taken	1.4	2.4	15.6	-1.9	-1.1	-4.0	-0.7	-0.9	0.3	0.8	2.1	1.1	0.0	1.0	0.6
Average weekly spirits intake	5.4	6.7	11.4	3.3	3.1	0.6	-2.2	2.8	-1.8	-3.4	-1.2	-3.1	-3.0	-3.2	-1.3
Sensitivity / hurt feelings	1.5	2.6	6.2	2.5	2.2	0.8	0.1	2.1	-1.3	-1.6	-1.7	-1.2	-1.5	-1.6	-1.1
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.3	-0.4	1.1	0.9	-0.8	0.1	-0.3	-0.5	0.8	-0.6	-0.5	-0.4	-1.0
Hearing difficulty/problems: Yes	1.3	2.0	4.0	1.3	0.8	-0.8	-1.5	1.9	-0.8	-1.9	-0.0	-1.8	-2.0	-1.8	-0.7
Relative age of first facial hair	0.8	1.6	3.0	1.3	1.5	1.3	-0.7	1.7	-1.7	-1.3	-0.7	-1.2	-1.0	-1.4	-0.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	2.2	-0.1	-1.5	0.6	1.0	-0.5	-0.9	1.2	-0.6	0.8	0.8	1.1	0.3
Ever used hormone-replacement therapy (HRT)	1.5	1.9	5.9	-1.8	-0.5	-0.5	0.6	-1.4	2.4	1.1	1.4	1.8	1.2	1.2	1.3
Ever had hysterectomy (womb removed)	0.3	0.3	0.8	0.5	0.7	0.6	-0.5	0.3	0.9	-0.9	0.1	-0.2	-0.3	-0.6	0.5
Systolic blood pressure, automated reading	6.7	19.4	34.3	-5.9	-4.4	-4.9	1.9	-5.5	3.5	4.8	3.5	4.9	4.2	4.9	3.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.4	-0.2	-0.9	-0.7	0.8	-0.3	0.2	0.6	-0.6	-0.2	-0.2	0.4	-1.2
Angina	1.2	1.6	3.8	-1.8	-1.6	-0.2	0.1	-1.9	1.2	1.6	0.9	0.8	0.6	1.8	0.1
Medication for hormone replacement therapy	0.9	1.0	2.4	-1.5	-0.4	-0.9	0.2	-1.2	1.1	0.5	1.6	1.2	0.6	0.8	1.0
Vitamin and mineral supplements	0.1	0.2	0.5	0.3	-0.7	-0.3	0.6	0.0	-0.2	-0.2	-0.7	0.2	0.3	-0.3	0.3
Supplements: Zinc	0.2	0.3	1.0	-0.7	-0.1	-1.0	-0.4	0.3	-0.1	0.2	0.8	0.3	0.2	0.2	0.6
Medication: Co-codamol	0.3	0.4	1.1	-0.6	-0.6	-0.4	-0.9	0.0	-0.2	-0.0	1.1	0.6	-0.2	0.2	0.9
Medication: Metformin	0.2	0.3	1.0	0.4	-1.0	0.3	0.4	-0.1	-0.9	0.3	-0.8	-0.2	-0.3	0.3	-0.6
Diabetes (father)	0.6	0.7	7.0	-0.1	-0.3	2.6	0.7	-0.3	0.2	0.5	-0.3	-0.0	0.2	0.4	-0.6
Diabetes (mother)	0.2	0.2	1.1	-1.0	0.3	0.4	0.0	-0.7	-0.0	0.5	0.5	0.6	0.3	0.3	0.2
Severe depression (siblings)	4.7	5.2	10.4	2.3	2.5	0.6	-1.3	3.2	-2.3	-2.8	-1.3	-2.6	-2.3	-2.9	-1.9
Pack years adult smoking proportion	2.6	4.0	9.1	-2.1	-2.5	1.4	1.2	-2.1	1.3	1.4	0.9	3.0	2.3	1.8	2.7
Impedance of leg (right)	1.3	6.4	46.0	1.0	-0.2	6.8	3.0	-0.3	-0.6	1.4	-3.1	0.9	2.5	1.2	0.9
Leg fat-free mass (left)	0.8	4.2	9.5	1.3	2.1	1.1	-2.6	1.9	-0.9	-3.1	1.4	-2.1	-2.8	-2.7	-0.7
Trunk fat percentage	2.9	11.4	26.0	3.0	3.3	5.1	-2.6	3.7	-2.2	-4.0	-0.2	-3.7	-4.1	-3.9	-2.3
Hand grip strength (right)	1.6	4.3	18.5	0.4	-1.3	4.3	3.0	-1.4	-0.9	1.5	-2.4	1.2	2.6	1.6	1.1
Townsend deprivation index at recruitment	0.3	0.4	1.9	-0.8	-1.4	0.1	-0.5	-0.7	-0.9	0.2	0.6	-0.1	-0.3	0.2	-0.4
Current tobacco smoking	1.2	1.9	3.5	0.8	1.6	1.5	-1.5	1.4	-0.7	-1.2	0.0	-1.9	-1.6	-1.4	-1.8
Average weekly fortified wine intake	0.7	0.9	2.6	1.2	1.4	0.8	0.8	1.2	-1.0	-0.4	-1.6	-0.2	-0.2	-0.4	0.1
Maternal smoking around birth	0.3	0.5	1.4	0.8	0.4	0.8	-0.2	1.2	-0.9	-0.8	-0.8	-0.5	-0.5	-0.7	0.0
Fed-up feelings	0.2	0.3	1.1	0.5	0.2	0.2	0.5	0.1	-1.0	0.4	-0.7	0.3	-0.5	0.4	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.8	-0.2	-0.4	1.3	-0.1	-0.1	-0.9	0.1	-0.0	-0.3	-0.2	0.2	-0.7
Relative age voice broke	0.2	0.3	1.1	0.6	-0.2	1.0	0.3	0.7	-0.5	0.1	-0.9	-0.2	0.3	-0.0	0.2
Taking other prescription medications	0.4	0.5	3.2	-0.5	-1.8	-0.4	-0.2	-0.3	-0.8	0.3	0.7	0.2	-0.9	0.5	-0.7
Age when periods started (menarche)	0.3	0.8	2.1	-0.9	-0.4	1.0	0.4	-0.9	1.5	0.8	0.4	0.6	1.1	0.9	1.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	1.6	-0.3	0.1	0.9	-0.5	-0.1	1.3	-0.0	0.5	0.2	0.5	-0.0	0.3
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.5	49.0	-0.7	-0.0	-7.0	-0.7	-0.1	0.6	0.3	1.0	0.8	0.3	0.3	1.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.8	-0.4	-0.2	-1.1	-1.3	0.3	0.4	-0.2	1.1	0.3	-0.5	-0.4	0.3
Qualifications: CSEs or equivalent	0.5	0.6	1.8	-0.7	-1.0	0.1	0.1	-0.7	-0.1	0.9	0.5	1.1	1.0	0.9	1.4
Serious illness, injury or assault to yourself	2.1	2.6	4.7	-1.0	-1.8	2.1	1.3	-2.0	-0.1	1.9	-0.3	1.5	2.0	2.2	1.5
High blood pressure	3.4	9.5	18.9	-3.8	-3.1	-4.3	2.1	-3.7	1.8	3.9	1.6	3.5	2.1	3.9	0.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.0	1.0	1.0	-1.4	-0.4	0.7	-0.3	-0.9	-0.5	-0.8	-0.8	-0.9	-0.2
Multivitamins +/- minerals	0.2	0.2	1.2	-0.1	0.3	1.1	-0.2	0.1	0.3	0.5	-0.1	-0.1	0.3	0.4	-0.6
Stomach or abdominal pain in last month	0.5	0.6	2.6	0.7	-0.4	1.6	0.7	0.5	-0.7	-0.1	-0.9	0.2	0.7	0.1	1.0
Supplements: Glucosamine	0.4	0.5	1.7	0.1	1.2	-1.2	0.0	0.6	-0.5	-0.3	-0.2	0.3	0.5	-0.2	1.3
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.5	-1.4	-0.7	-2.0	-1.4	-0.6	1.6	0.6	2.1	0.1	0.3	0.6	0.6
Medication: Atenolol	0.8	1.0	9.2	-0.8	-0.5	-3.0	0.1	-0.4	0.7	0.5	0.7	0.2	-0.0	0.4	0.0
Medication: Levothyroxine sodium	0.5	0.9	6.0	-0.2	-2.4	1.7	0.8	-0.6	-0.1	0.6	0.1	0.6	-0.1	0.4	-0.7
Sitting height	0.3	2.2	4.5	1.8	1.3	1.2	-1.3	1.8	-0.5	-2.1	-0.5	-1.9	-1.5	-1.8	-0.6
Chronic bronchitis/emphysema (father)	0.6	0.7	2.7	0.1	0.4	-0.1	-1.6	0.4	-0.2	-1.2	1.1	-0.6	-1.2	-0.8	0.8
High blood pressure (mother)	2.7	3.8	8.0	-2.4	-2.3	-1.1	1.2	-2.8	0.5	2.5	1.3	2.3	1.6	2.7	0.8
Body mass index (BMI)	0.6	2.8	6.8	0.5	1.5	0.2	-2.6	1.3	-0.3	-2.4	2.1	-1.0	-2.6	-2.0	0.2
Impedance of leg (left)	1.6	7.6	52.0	1.2	-0.4	7.2	3.6	-0.4	-1.1	1.5	-3.7	0.9	2.2	1.2	0.4
Leg predicted mass (left)	0.8	4.1	9.1	1.2	2.0	1.1	-2.6	1.9	-0.8	-3.0	1.5	-2.1	-2.8	-2.7	-0.7
Trunk fat mass	2.6	11.2	27.5	3.0	3.4	5.2	-2.6	3.6	-2.3	-4.1	-0.1	-3.5	-3.9	-3.9	-1.8
Waist circumference	1.2	4.5	9.2	2.2	2.6	3.0	-1.4	2.4	-1.2	-3.0	-0.2	-1.6	-2.4	-2.8	-0.2
Number of incorrect matches in round	0.4	0.7	3.4	-0.5	-0.6	-1.8	-1.2	0.1	0.0	-0.6	1.2	-0.2	-0.7	-0.4	0.4
Past tobacco smoking	0.3	0.5	2.3	0.5	-0.1	-1.4	-0.1	0.4	-1.5	0.1	-0.8	-0.4	0.1	0.1	-0.3
Alcohol usually taken with meals	0.7	1.1	3.2	-1.2	-1.1	-1.8	0.1	-1.1	0.6	0.2	1.4	1.3	0.2	0.7	1.0
Nervous feelings	0.2	0.3	1.0	-0.7	0.1	-1.0	-0.5	-0.1	0.5	-0.1	1.0	-0.1	-0.6	-0.2	-0.5
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	5.2	0.6	1.2	-0.2	-2.0	1.4	-0.7	-1.4	0.8	-2.3	-1.8	-1.5	-2.0
Hearing difficulty/problems with background noise	0.7	1.1	2.0	-0.4	0.8	-0.8	-1.4	1.1	1.2	-0.8	1.3	-1.0	-1.4	-0.9	-0.7
Hair/balding pattern: Pattern 2	0.3	0.4	2.4	-0.3	-0.4	1.6	0.7	-0.4	0.4	0.6	-0.0	0.7	0.3	0.4	-0.4
Had menopause	0.9	1.2	3.8	-1.1	0.2	0.1	0.3	-0.8	2.0	0.7	1.1	1.4	1.0	0.6	1.8
Had other major operations	0.2	0.3	1.7	0.1	1.3	-0.6	-0.6	0.5	0.3	-0.3	0.8	0.3	-0.3	-0.3	0.3
Forced vital capacity (FVC)	0.1	0.6	2.7	-0.1	-0.4	1.6	0.8	-0.7	-0.8	0.7	-0.6	-0.0	0.8	0.6	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.7	4.0	45.7	0.6	0.4	-6.8	-0.3	0.7	-0.7	-0.4	-0.3	0.2	0.1	-0.3	0.6
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	2.5	0.5	-0.2	0.5	-0.3	0.6	-1.6	-0.2	-0.7	-0.2	0.4	-0.1	0.6
Qualifications: None of the above	0.8	1.7	6.2	-2.3	-0.7	0.3	-0.9	-1.3	1.4	1.1	2.5	0.9	0.6	0.9	0.8
Financial difficulties in last 2 years	0.6	0.9	3.6	0.9	-0.0	1.4	0.2	0.5	-1.9	-0.7	-0.6	-0.6	-1.0	-0.9	-0.8
Mouth/teeth dental problems	2.6	4.0	8.5	-2.3	-1.3	1.6	1.9	-2.7	1.1	2.9	0.2	1.7	2.6	2.7	-0.2
Heart attack	1.4	1.8	4.9	-1.8	-1.8	0.5	0.3	-2.2	0.9	1.5	1.3	1.2	0.7	1.8	1.0
Allergy	0.2	0.5	1.0	0.6	0.9	1.0	-0.3	1.0	-0.3	-0.6	-0.4	-0.8	-0.4	-0.8	-0.9
Pain all over the body in last month	0.5	0.6	2.3	0.4	0.4	0.2	-0.5	0.8	-0.9	-0.3	-0.2	-0.6	-1.1	-0.7	-1.5
Diabetes (self-reported)	0.4	0.6	2.2	0.7	-1.4	0.2	0.8	0.2	-1.1	0.3	-1.5	-0.0	-0.3	0.2	-0.7
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	5.7	0.3	0.5	-2.4	-1.3	0.2	-0.2	-0.3	0.3	-1.7	-0.8	-0.4	-1.8
Medication: Ramipril	0.4	0.5	3.5	0.1	0.1	-1.9	0.0	-0.2	-1.1	0.2	-0.6	-0.5	0.1	0.3	-0.3
Medication: Simvastatin	2.6	3.8	8.4	-2.2	-2.6	0.1	1.1	-2.9	1.8	2.3	1.1	1.7	1.7	2.6	1.1
Fluid intelligence score	1.2	2.5	5.0	2.0	2.2	0.1	-0.0	2.0	-1.6	-1.3	-1.9	-1.4	-1.5	-1.6	-1.4
Illnesses of siblings	0.9	1.2	7.1	1.3	0.5	2.7	-0.0	1.1	-0.6	-1.0	-0.9	-0.7	0.1	-1.1	0.9
Neuroticism score	0.5	1.1	2.6	1.3	0.9	0.9	0.3	1.1	-1.2	-0.4	-1.2	-1.0	-1.1	-0.5	-1.6
Weight	0.9	4.3	14.2	1.6	2.0	3.8	-1.8	1.8	-1.3	-2.8	0.7	-1.7	-2.4	-2.4	-0.1
Impedance of arm (right)	0.8	3.7	21.7	1.5	0.6	4.7	1.2	1.1	-1.1	0.2	-2.5	-1.9	-0.3	-0.3	-2.6
Arm fat percentage (right)	2.2	8.6	17.6	2.2	3.2	2.0	-3.2	3.3	-1.7	-3.7	0.8	-3.2	-4.2	-3.6	-1.9
Trunk fat-free mass	0.2	1.1	2.8	0.6	1.2	1.7	-1.0	0.5	-0.4	-1.6	0.9	-0.2	-0.7	-1.2	1.2
Hip circumference	0.8	3.3	7.0	1.2	1.9	2.4	-1.9	1.7	-0.8	-2.6	0.9	-1.6	-2.4	-2.3	-0.5
Time employed in main current job	0.8	0.9	2.8	1.3	1.2	0.4	-0.4	1.7	0.1	-1.0	-0.6	-0.8	-0.9	-1.0	-0.7
Alcohol intake versus 10 years previously	0.6	1.0	2.8	1.0	1.5	0.9	-0.2	1.4	-1.7	-0.9	-0.3	-0.3	-0.5	-1.1	0.5
Father’s age at death	2.1	2.8	5.1	1.6	1.6	-1.1	-2.2	2.2	0.4	-2.1	0.2	-2.1	-1.9	-2.1	-0.4
Worrier / anxious feelings	0.2	0.5	1.9	0.4	0.4	-0.2	-0.0	0.3	-1.3	0.1	-0.5	-0.5	-0.9	-0.0	-1.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.4	0.8	0.6	-0.0	-1.0	1.2	-0.6	-1.2	0.3	-0.7	-1.5	-1.3	-0.7
Falls in the last year	0.9	1.2	3.2	-1.8	-0.9	-0.1	-0.5	-1.0	1.5	0.8	1.8	1.2	0.6	0.8	0.9
Hair/balding pattern: Pattern 3	0.6	0.8	2.6	0.8	1.2	-0.8	-0.6	1.1	-1.6	-1.0	-0.3	-0.7	-0.8	-0.8	-0.4
Number of live births	0.3	0.5	1.3	-0.6	0.3	-1.2	-0.7	-0.2	1.0	-0.1	1.0	-0.4	-0.5	-0.3	-0.8
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	1.9	-0.1	-0.3	1.4	0.6	-0.5	-0.5	0.6	-0.3	0.0	0.6	0.5	-0.4
Pulse rate	1.0	1.7	4.0	-1.7	-1.4	2.0	0.5	-2.0	1.4	1.2	1.0	0.3	1.0	1.1	-0.2
Happiness	1.3	1.6	3.2	-0.9	-1.3	1.6	1.6	-1.4	-0.0	1.8	-0.5	0.6	1.0	1.8	-1.1
Noisy workplace	4.2	5.2	12.1	-2.3	-3.5	2.0	1.7	-2.6	1.5	2.2	1.0	2.9	2.1	2.5	2.1
Qualifications: A levels/AS levels or equivalent	1.5	3.3	6.2	0.3	2.4	-2.1	-2.5	1.8	0.1	-1.7	1.4	-2.1	-1.9	-1.9	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	3.8	0.4	-0.1	-0.4	1.3	-0.6	-0.7	0.2	-1.2	1.1	1.7	0.5	2.0
Mouth/teeth dental problems: Dentures	2.5	4.3	8.2	1.2	2.4	-1.4	-2.4	2.9	-0.9	-2.6	0.5	-2.1	-2.7	-2.8	-0.9
Asthma	0.5	1.0	1.9	-0.5	-1.2	0.5	1.4	-0.9	-0.5	1.4	-0.8	0.8	1.3	1.3	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.7	0.4	0.7	-0.9	-0.2	0.9	1.3	-0.4	0.0	-0.3	-0.4	-0.6	-0.3
Medication: Cholesterol lowering	0.4	0.6	2.5	-0.8	-1.6	-0.2	-0.7	-1.2	-0.2	0.7	0.6	-0.6	0.4	0.8	-0.6
Depression (self-reported)	0.1	0.2	0.6	-0.2	-0.2	0.8	-0.7	-0.5	-0.0	-0.0	0.7	-0.2	-0.1	0.1	0.1
Medication: Lansoprazole	0.1	0.1	0.3	0.3	0.3	-0.3	0.2	0.5	0.0	0.1	-0.3	-0.0	0.4	0.0	0.1
Prospective memory result	2.2	2.7	5.3	-1.9	-2.3	-0.8	1.4	-2.1	1.0	1.9	0.6	2.1	1.5	2.1	0.8
Lung cancer (father)	0.4	0.4	1.6	0.1	0.2	1.1	1.0	0.1	-0.8	0.0	-0.3	0.7	0.5	0.1	1.2
Illnesses of mother	1.7	2.0	4.5	2.1	1.1	1.8	-0.0	1.8	-0.7	-1.4	-1.5	-1.6	-1.3	-1.6	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.7	0.8	0.8	0.6	-0.1	0.6	-1.3	-0.6	-0.5	-0.8	-0.4	-0.5	-0.9
Pulse wave Arterial Stiffness index	0.4	0.5	1.8	-1.0	-0.0	-1.3	0.5	-0.6	0.8	0.5	0.7	0.1	0.3	0.5	-0.7
Impedance of arm (left)	1.0	4.6	19.8	2.1	1.0	4.5	1.0	1.6	-1.7	-0.3	-2.8	-2.5	-0.7	-0.9	-3.0
Arm fat mass (right)	1.4	5.8	11.3	1.9	2.6	2.5	-2.7	2.5	-1.5	-3.4	1.0	-2.2	-3.4	-2.9	-0.6
Trunk predicted mass	0.2	1.1	2.8	0.5	1.2	1.7	-1.1	0.5	-0.4	-1.7	0.9	-0.1	-0.7	-1.2	1.2
Standing height	0.7	7.4	59.1	2.5	1.4	7.7	1.1	1.4	-2.2	-1.3	-2.7	-1.6	-0.1	-1.2	-0.7
Length of working week for main job	0.2	0.3	1.4	0.1	-0.2	0.1	0.5	0.0	-0.3	0.0	-0.2	0.4	-1.1	0.0	-1.2
Exposure to tobacco smoke at home	0.3	0.4	1.6	-1.0	-0.5	0.3	-0.7	-0.1	0.9	-0.1	1.3	-0.1	-0.4	-0.2	-0.4
Breastfed as a baby	0.3	0.4	1.8	0.5	0.5	0.8	1.3	-0.0	0.2	-0.1	-1.1	0.2	-0.2	-0.2	-0.6
Tense / ‘highly strung’	0.1	0.2	0.5	0.2	0.1	0.0	0.7	0.2	-0.6	0.2	-0.6	-0.2	-0.2	0.1	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.8	0.2	1.9	-0.0	-1.6	1.2	-0.5	-1.0	0.8	-1.3	-1.5	-1.2	-1.2
Hair/balding pattern: Pattern 4	0.4	0.9	4.5	1.4	0.2	1.1	1.0	0.8	-1.0	-0.2	-2.1	-0.7	0.2	-0.2	-0.4
Birth weight of first child	0.6	1.0	2.7	0.7	1.5	1.6	-1.2	1.0	-0.6	-1.2	0.4	-0.6	-0.8	-1.1	0.4
Peak expiratory flow (PEF)	0.1	0.1	0.3	-0.2	0.3	0.4	-0.3	-0.0	0.4	-0.4	0.5	-0.5	-0.4	-0.3	-0.5
Pulse wave reflection index	1.8	2.2	8.5	0.7	1.8	-2.9	-1.9	1.6	0.0	-1.6	1.0	-0.9	-1.4	-1.3	0.1
Ever highly irritable/argumentative for 2 days	0.8	1.0	9.0	0.2	0.7	3.0	-0.4	0.7	-0.8	-0.7	0.3	0.0	-0.5	-0.6	-0.3
Loud music exposure frequency	0.6	0.6	2.1	-0.3	-0.5	1.4	0.3	-0.7	0.1	-0.2	0.6	1.4	0.4	0.3	1.4
Qualifications: O levels/GCSEs or equivalent	1.8	2.8	5.0	2.0	2.0	-1.6	-1.6	1.8	-0.8	-2.2	-0.1	-1.6	-2.2	-2.0	-0.7
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.1	1.6	-0.5	-0.2	1.0	0.7	-1.0	-0.7	-1.8	0.3	0.2	-0.3	0.8
Blood clot in the leg (DVT)	2.7	3.5	7.8	-2.2	-1.8	0.6	1.4	-2.8	1.7	1.8	1.4	2.7	1.6	2.1	1.3
Medication: Paracetamol	1.7	2.8	12.6	0.4	2.1	-3.5	-1.9	2.0	0.8	-1.2	0.9	-1.2	-1.5	-1.3	-0.4
Headache pain in last month	1.0	1.7	2.8	0.9	1.1	-1.6	-1.7	1.6	-1.4	-1.6	0.6	-1.2	-1.5	-1.5	-0.0
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.7	1.2	1.5	1.6	1.0	0.8	0.2	-0.5	-1.2	0.8	0.1	-0.5	1.2
Glaucoma (self-reported)	0.9	1.0	3.6	0.9	0.6	-1.9	-0.5	0.2	-1.9	-1.1	-0.2	-0.1	-0.7	-0.6	1.2
Gout (self-reported)	0.7	0.9	3.6	1.2	1.1	0.2	-0.2	1.4	-1.9	-0.5	-1.2	-0.7	0.1	-0.7	0.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	7.0	0.1	-2.6	1.7	1.1	-0.4	-1.1	0.4	-0.2	0.8	-0.2	0.2	-0.5
Medication: Amlodipine	1.4	2.0	9.7	-1.7	-0.9	-3.1	-1.2	-0.7	0.8	0.6	1.7	-0.9	-0.6	0.5	-1.8
Medication: Ventolin 100micrograms inhaler	0.8	1.0	5.1	1.4	0.1	0.5	0.8	1.0	-1.5	0.0	-2.2	-0.5	0.4	-0.3	-0.4
Birth weight	2.6	5.6	17.4	0.3	2.1	-2.6	-4.2	1.8	0.3	-2.9	2.7	-2.2	-2.9	-2.5	-0.2
Chronic bronchitis/emphysema (mother)	0.5	0.5	2.8	-0.6	0.1	-1.7	-0.6	0.1	-0.2	-0.4	1.0	0.5	-0.3	-0.4	0.9
High blood pressure (siblings)	0.6	0.9	5.2	-1.0	0.3	-2.3	-0.2	-0.9	0.1	1.1	0.5	0.4	0.4	1.1	-0.6
Forced vital capacity (FVC), Best measure	0.1	0.5	2.3	0.8	0.6	0.5	0.0	0.4	-1.5	-0.4	-0.7	-0.8	-0.2	-0.5	-0.9
Body fat percentage	2.3	9.1	20.2	2.6	3.1	4.5	-2.5	3.3	-1.9	-3.6	0.1	-3.0	-3.8	-3.5	-1.6
Leg fat percentage (right)	1.1	4.1	14.5	1.5	2.3	3.8	-1.8	2.0	-0.9	-2.6	0.8	-1.2	-2.4	-2.2	0.3
Arm fat-free mass (right)	0.4	2.1	5.3	0.9	1.7	2.0	-1.6	1.1	-0.8	-2.3	1.0	-0.7	-1.3	-1.9	0.9
Exposure to tobacco smoke outside home	0.2	0.3	2.1	-0.3	-0.7	1.4	0.1	-0.9	-0.3	0.0	0.3	0.1	-0.2	0.3	0.0
Comparative body size at age 10	1.0	2.7	21.6	-0.9	-0.7	-4.7	-1.4	-0.9	0.8	0.2	2.1	0.2	-0.9	0.2	-0.8
Number of full brothers	0.5	0.7	1.9	0.9	0.9	1.0	-0.2	1.4	-0.8	-0.9	-0.7	-0.7	-0.7	-0.9	-0.0
Worry too long after embarrassment	0.3	0.5	1.9	0.3	0.9	-1.4	-0.3	0.4	0.9	-0.4	0.0	-0.6	-0.4	-0.5	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.8	1.9	0.9	1.0	0.3	-1.2	0.8	-1.0	-1.0	-0.1	-1.4	-1.1	-0.9	-0.6
Wheeze or whistling in the chest in last year	1.1	2.0	4.7	1.0	1.0	0.1	-2.1	1.6	-0.8	-2.2	0.8	-1.4	-1.9	-1.8	0.5
Number of children fathered	0.1	0.1	0.6	-0.2	0.8	0.2	-0.3	0.1	0.4	-0.2	0.6	0.4	-0.2	0.0	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.9	-0.6	0.5	-0.1	-1.1	0.3	0.8	-0.7	1.7	0.5	-0.1	-0.5	1.7
Age at first live birth	4.5	8.0	14.7	3.8	3.2	0.4	-0.8	3.3	-3.5	-2.6	-2.9	-3.7	-1.9	-2.8	-2.4
Pulse wave peak to peak time	0.6	0.7	3.5	1.1	0.2	1.9	-0.5	0.7	-0.9	-0.6	-0.7	-0.3	-0.4	-0.6	0.5
Health satisfaction	0.6	0.7	3.1	0.6	-0.2	1.8	1.0	0.3	-1.3	0.1	-0.9	0.6	0.4	0.3	1.0
Shortness of breath walking on level ground	0.6	0.7	2.0	-0.5	-0.9	-1.2	0.2	-0.7	0.5	0.6	0.5	1.0	0.7	0.8	1.4
Qualifications: College or University degree	0.5	1.4	4.1	0.8	1.4	-1.1	-1.0	0.9	-0.7	-1.2	0.2	-2.0	-0.9	-1.4	-1.6
Eye problems/disorders: None of the above	0.5	0.6	1.5	-0.3	0.2	-1.0	-1.2	0.5	1.1	-0.6	1.0	-0.6	-0.7	-0.8	-0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.4	2.8	-0.1	-0.8	1.7	-0.6	0.1	0.3	-0.0	0.6	-0.1	-0.2	-0.1	0.0
Emphysema/chronic bronchitis	0.7	0.8	2.1	0.1	-1.1	0.3	1.2	-0.9	-1.4	0.6	-0.7	1.0	0.9	0.7	1.1
Medication for pain relief, constipation, heartburn	0.6	1.0	5.6	0.4	-0.7	2.4	1.1	-1.0	-1.1	0.0	-1.0	0.4	0.7	0.2	0.5
Neck or shoulder pain in last month	1.0	1.4	2.7	-0.1	1.4	1.6	-1.3	1.1	1.5	-1.1	1.6	-0.2	-0.5	-0.9	1.5
Medication: Blood pressure	0.6	1.1	5.6	-1.0	-1.5	-2.4	0.2	-1.1	-0.9	0.8	0.6	0.1	0.2	0.8	-0.7
Angina (self-reported)	1.4	1.9	4.4	-2.0	-1.6	0.2	0.1	-2.1	1.4	1.8	1.1	0.9	0.7	1.9	0.3
Migraine (self-reported)	1.8	2.2	5.2	1.8	2.1	-1.0	-0.6	2.3	-1.1	-1.6	-0.9	-1.1	-1.7	-1.8	-0.9
Medication: Ibuprofen	0.4	0.5	2.8	-0.5	-0.3	-1.3	0.1	0.1	1.7	0.5	0.3	0.1	0.4	0.2	-0.2
Medication: Allopurinol	0.4	0.5	3.5	0.6	0.3	-0.4	0.2	0.4	-1.9	0.3	-1.2	-0.2	0.7	-0.0	0.0
Medication: Omeprazole	1.5	1.7	8.4	1.6	0.3	-0.4	0.1	1.6	-2.9	-1.1	-1.5	-0.9	-1.3	-1.1	-0.4
Medication: Seretide 50 evohaler	1.2	1.4	3.4	-1.8	-0.8	-0.2	0.7	-1.2	1.3	1.4	0.6	1.6	1.1	1.4	1.1
Mean time to correctly identify matches	0.9	1.7	5.4	-0.6	2.3	-1.9	-1.8	0.8	0.5	-0.9	1.7	-0.8	-1.1	-0.9	0.2
Heart disease (mother)	4.1	5.0	13.5	-3.7	-1.6	-0.1	-0.3	-2.8	3.1	2.3	2.9	1.9	2.0	2.2	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.1	1.4	1.0	0.7	-0.3	1.4	-0.4	-1.1	-0.9	-0.8	-0.4	-1.0	0.0
Whole body fat mass	1.9	7.9	19.3	2.3	3.0	4.4	-2.4	2.9	-1.8	-3.6	0.3	-2.6	-3.4	-3.3	-1.1
Leg fat mass (right)	1.4	5.3	13.4	1.6	2.5	3.7	-2.4	2.2	-1.2	-3.1	1.0	-1.7	-2.8	-2.7	-0.1
Arm predicted mass (right)	0.4	2.1	5.5	1.0	1.8	2.1	-1.5	1.1	-0.7	-2.4	0.9	-0.6	-1.3	-1.9	1.0
Pulse rate, automated reading	1.8	5.9	12.0	-2.8	-2.7	2.0	2.1	-3.5	2.7	2.7	0.7	2.3	2.6	2.7	0.8
Alcohol intake frequency.	0.3	0.7	3.9	0.1	-0.5	1.7	-0.4	0.4	-2.0	-0.5	0.4	-0.3	-0.2	-0.3	0.2
Comparative height size at age 10	0.7	3.9	31.4	1.5	1.2	5.6	0.3	1.2	-1.6	-1.4	-1.1	-1.3	-0.5	-1.5	-1.1
Number of full sisters	0.5	0.6	1.9	-0.9	-1.0	1.4	0.7	-0.4	0.4	0.5	0.3	0.8	0.9	0.4	1.0
Suffer from ‘nerves’	0.6	0.9	2.7	0.2	-0.1	1.2	1.6	-0.0	-1.2	1.0	-1.6	0.6	0.7	0.8	-0.5
Overall health rating	0.1	0.3	1.9	-0.3	-1.4	0.6	0.3	-0.4	-0.4	0.5	0.3	0.2	-0.1	0.5	-0.3
Chest pain or discomfort	1.7	2.4	4.9	1.4	0.5	-0.2	-1.0	1.9	-2.2	-1.6	-0.8	-1.9	-2.1	-1.6	-2.0
Had major operations	1.4	1.6	6.1	-0.4	1.0	-0.2	-2.5	1.1	0.1	-1.3	1.8	-1.7	-1.2	-1.3	-0.8
Age at last live birth	4.9	7.1	13.3	3.6	2.8	-0.7	-1.0	3.2	-3.6	-2.5	-2.8	-3.6	-1.3	-2.7	-1.9
Family relationship satisfaction	0.3	0.4	1.4	-0.8	-0.5	0.8	-0.1	-0.2	0.8	0.8	0.4	-0.2	-0.0	0.6	-1.2
Leg pain on walking	1.8	2.2	8.2	0.0	1.3	-0.3	-2.9	1.4	0.9	-1.9	2.0	-1.1	-1.5	-1.7	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.3	1.5	1.0	0.9	0.1	1.3	0.0	-0.7	-1.5	-0.7	-0.0	-0.7	-0.1
Commuting to job workplace: Car/motor vehicle	1.4	1.6	4.3	2.1	1.4	0.8	0.7	1.0	-1.8	-0.4	-1.9	-1.3	-0.6	-0.6	-1.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	3.6	0.2	0.6	-0.4	-0.6	0.7	0.6	-0.2	-0.1	-1.2	-1.5	-0.5	-1.9
Medication: Aspirin	1.1	1.5	3.2	-1.8	-1.2	-0.8	-0.2	-1.8	1.4	1.3	1.8	0.3	0.0	1.4	-0.6
Supplements: Vitamin C	0.5	0.6	2.2	-0.9	-0.1	-0.0	-0.2	-0.4	1.5	0.4	1.3	0.8	0.1	0.7	0.7
Knee pain experienced in last month	0.3	0.4	1.1	0.4	0.5	-0.2	-0.5	1.0	-0.9	-0.6	-0.4	-1.0	-0.2	-0.8	0.1
Hypertension (Self-reported)	3.1	8.7	16.2	-3.5	-2.9	-4.0	2.4	-3.5	1.5	3.8	1.3	3.5	2.1	3.8	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	3.2	0.1	-0.8	1.8	0.5	-0.1	-0.6	-0.2	0.1	0.5	-0.1	0.2	0.7
Illnesses of father: Heart disease	5.5	7.6	14.0	-3.5	-3.7	0.2	1.9	-3.6	2.8	3.7	1.5	2.8	1.9	3.5	-0.5
Illnesses of siblings: Diabetes	0.4	0.5	2.4	0.4	0.1	-0.3	0.6	0.2	-1.1	-0.0	-0.4	0.1	-1.1	-0.1	-1.6
Smoking status: Previous	0.9	1.4	3.3	-1.1	-0.9	0.8	1.1	-1.3	1.6	0.8	0.8	1.8	1.0	0.9	1.6
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.9	10.7	2.4	1.5	3.3	0.5	1.2	-2.1	-1.5	-2.0	-1.1	-0.3	-1.2	0.4
Whole body fat-free mass	0.3	1.8	4.8	0.9	1.5	1.7	-1.6	1.1	-0.7	-2.2	1.0	-0.9	-1.5	-1.8	0.4
Leg fat-free mass (right)	0.6	3.3	7.2	1.0	1.7	1.0	-2.2	1.6	-0.9	-2.7	1.3	-1.9	-2.7	-2.4	-1.1
Arm fat percentage (left)	2.4	9.7	19.4	2.5	3.4	2.0	-3.2	3.6	-2.1	-4.0	0.6	-3.5	-4.4	-3.8	-2.1
Average weekly red wine intake	0.1	0.2	0.8	-0.3	-0.9	0.1	0.4	-0.2	-0.2	-0.0	0.3	0.9	-0.3	0.2	0.1
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.6	1.0	0.6	-1.1	-0.8	1.2	-0.7	-1.3	0.3	-0.7	-1.6	-1.2	-0.6
Mood swings	0.6	1.1	1.9	1.0	1.3	1.4	-0.6	1.4	-0.6	-1.4	0.1	-0.8	-1.2	-1.3	-0.5
Loneliness, isolation	1.7	2.4	11.2	0.6	-0.2	3.3	0.7	0.5	-1.4	0.5	-1.4	-1.4	-0.6	0.2	-3.1
Long-standing illness, disability or infirmity	1.0	1.5	5.2	-1.4	-2.3	0.8	1.0	-1.4	-0.4	1.4	0.2	1.3	1.1	1.5	0.6
Ever had bowel cancer screening	0.5	0.6	3.1	-0.6	-0.6	-1.8	-1.0	0.2	0.8	0.1	1.0	-0.5	-0.1	0.0	-0.1
Diabetes diagnosed by doctor	0.6	0.9	2.3	1.3	-0.7	0.7	0.1	0.9	-1.5	-0.6	-1.5	-0.7	-1.1	-0.6	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	0.2	0.4	-0.9	-0.6	0.3	1.0	-0.6	0.5	-0.1	-0.3	-0.6	0.3
Friendships satisfaction	0.7	0.9	4.2	-1.5	-0.2	0.4	-1.0	-0.6	1.5	0.1	2.1	0.1	-0.0	0.1	-0.2
Qualifications: nursing, teaching	0.4	0.7	2.2	0.1	1.0	-0.9	-0.5	0.5	-0.6	-0.7	0.3	-0.7	-1.2	-0.8	-1.5
Commuting to job workplace: Walk	1.3	1.4	2.4	-1.5	-1.6	0.7	1.0	-1.5	1.2	1.5	0.1	1.0	0.9	1.4	-0.7
Eye problems/disorders: Cataract	1.2	1.4	4.3	-1.5	-0.7	0.4	1.2	-1.3	0.7	2.1	0.4	1.1	1.2	1.8	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.6	1.9	0.7	-1.8	-0.6	1.4	-1.1	-1.4	-1.0	-1.5	-1.7	-1.4	-1.3
Medication for cholesterol	3.7	5.6	16.2	3.0	1.9	4.0	-1.0	2.5	-2.0	-1.9	-2.5	-3.1	-0.7	-2.3	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.6	-0.8	0.1	-0.2	-0.4	-0.5	0.1	0.7	0.7	0.1	0.8	0.7	0.4
Back pain experienced in last month	0.6	0.9	4.1	0.9	0.8	2.0	-0.7	1.0	-0.5	-1.1	-0.4	-0.8	-0.6	-1.0	0.1
Mineral and other dietary supplements	1.0	1.3	3.0	1.7	0.6	1.5	0.6	1.0	-0.8	-1.1	-1.5	-1.1	-0.5	-1.3	-1.0
Breast cancer (self-reported)	0.3	0.4	1.4	0.9	-0.7	0.3	0.1	-0.0	-0.8	0.5	-1.2	-0.4	0.6	0.3	-0.2
Asthma (self-reported)	0.5	1.0	2.1	-0.8	-1.2	0.4	1.3	-1.0	-0.2	1.4	-0.6	0.9	1.4	1.4	0.6
Osteoporosis (self-reported)	0.7	0.9	3.1	-0.9	-0.1	1.8	-0.3	-0.7	1.3	0.2	1.3	0.8	0.6	0.3	1.2
Osteoarthritis (self-reported)	2.3	3.0	15.1	-1.9	0.5	-0.8	-2.7	-0.3	2.2	-0.9	3.9	0.6	-0.8	-0.6	1.2
Medication: Aspirin	0.8	1.0	2.7	-1.4	-0.8	-1.1	-0.4	-1.4	1.1	0.9	1.6	-0.0	-0.2	1.0	-0.6
Medication: Gliclazide	0.1	0.1	0.6	0.1	-0.8	-0.4	0.3	-0.0	-0.2	0.3	-0.2	0.4	-0.3	0.1	-0.3
Illnesses of father: None of the above (group 1)	1.6	2.0	3.8	1.6	1.8	1.6	-0.1	1.9	-1.6	-1.4	-1.3	-1.4	-0.9	-1.6	-0.5
Smoking status: Current	1.2	2.0	4.7	0.6	1.5	1.6	-1.6	1.2	-0.6	-1.1	0.2	-1.9	-1.6	-1.3	-2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.7	5.3	-0.7	-0.4	-2.3	-0.8	-0.3	0.3	0.2	1.0	-0.0	-0.4	0.3	-1.0
Whole body water mass	0.3	1.9	5.0	0.8	1.5	1.6	-1.7	1.1	-0.7	-2.2	1.1	-0.9	-1.6	-1.8	0.3
Leg predicted mass (right)	0.6	3.4	7.5	1.0	1.7	1.0	-2.3	1.6	-0.9	-2.7	1.4	-2.0	-2.7	-2.4	-1.1
Arm fat mass (left)	1.4	5.8	11.1	1.8	2.6	2.3	-2.7	2.5	-1.4	-3.3	1.0	-2.3	-3.3	-3.0	-0.8
Number of self-reported non-cancer illnesses	0.8	1.4	3.1	-1.4	-1.7	-1.8	0.8	-1.4	-0.0	1.2	1.0	1.2	-0.1	1.4	-0.5
Average weekly champagne plus white wine intake	1.8	2.4	5.2	1.7	1.5	-1.4	-1.8	1.8	-0.1	-2.3	0.1	-1.5	-2.0	-2.0	-0.3
Miserableness	0.3	0.5	1.9	0.9	-0.2	0.9	0.4	0.7	-1.4	-0.2	-0.7	-0.0	-0.7	-0.1	-0.6
Guilty feelings	1.5	2.3	5.0	2.2	1.1	-0.3	-0.7	2.0	-1.6	-1.5	-1.4	-2.1	-1.3	-1.6	-1.1
Wears glasses or contact lenses	0.5	0.6	2.2	-0.4	-0.5	0.9	1.5	-0.6	0.6	0.6	-0.5	0.8	1.0	0.8	0.4
Ever taken oral contraceptive pill	0.1	0.1	0.4	0.3	-0.4	0.5	0.6	-0.0	0.3	-0.1	-0.6	0.3	-0.1	0.0	-0.0
Hearing aid user	2.1	2.4	4.2	1.6	2.0	0.2	-1.0	1.8	-1.5	-2.0	-0.7	-1.5	-2.0	-1.9	-0.9
Mother’s age at death	0.1	0.1	0.2	0.2	0.5	-0.3	0.3	-0.0	0.3	-0.2	0.1	0.1	-0.4	-0.0	-0.3
Financial situation satisfaction	1.2	1.5	3.4	-1.8	-1.6	1.8	0.3	-1.5	0.7	1.2	1.1	1.1	0.7	1.2	0.5
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.8	0.3	0.0	-1.0	-1.9	0.9	0.1	-1.3	1.2	-1.2	-1.9	-1.2	-1.1
Commuting to job workplace: Public transport	0.2	0.3	0.7	0.5	-0.5	0.6	0.5	0.3	-0.7	-0.2	-0.9	0.5	-0.0	0.0	0.5
Eye problems/disorders: Glaucoma	0.4	0.4	2.6	0.4	0.3	-1.6	-0.2	0.0	-1.1	-0.5	-0.2	-0.2	-0.5	-0.2	0.5
Medication: Blood pressure	3.3	6.4	29.0	-3.0	-1.8	-5.4	1.0	-2.4	1.9	2.3	2.0	2.8	0.7	2.5	0.6
Pain type(s) experienced in last month: Hip pain	0.3	0.4	2.5	-0.9	-0.0	0.4	-1.1	-0.0	-0.0	-0.3	1.6	-0.1	-0.4	-0.2	0.1
Supplements: Fish oil (including cod liver oil)	3.1	4.1	8.5	-2.9	-1.9	-0.9	0.4	-2.4	1.9	2.4	1.9	2.3	1.5	2.6	1.6
High cholesterol (Self-reported)	1.5	2.7	5.8	-2.2	-1.8	0.8	1.3	-2.4	1.2	2.1	0.8	1.5	1.6	2.2	0.3
Medication: Bendroflumethiazide	3.0	4.6	8.1	-1.6	-2.8	-1.6	2.8	-2.1	-0.2	2.2	-0.3	2.8	2.3	2.4	2.3
Medication: Paracetamol	1.4	2.1	10.6	-0.9	1.2	-3.3	-1.8	0.9	1.9	-0.2	1.7	-0.9	-0.8	-0.4	-0.5
Medication: Lisinopril	0.8	1.0	4.9	-1.0	0.2	-2.2	-1.1	0.2	0.6	-0.6	1.7	0.4	-0.6	-0.5	0.5
Medication: Atorvastatin	0.9	1.2	3.2	0.9	0.7	-0.6	-0.8	1.0	-1.8	-0.9	-0.4	-1.3	-1.4	-1.0	-1.4
Illnesses of father: High blood pressure	0.6	0.8	3.2	1.3	-0.1	0.2	0.7	0.3	-1.7	0.0	-1.8	-0.1	0.7	0.0	0.3
Alcohol drinker status: Never	1.4	1.7	6.0	-1.2	0.4	-1.9	-2.5	0.3	1.1	-0.6	2.4	-0.5	-1.1	-0.5	-0.4
Ever smoked	0.6	1.0	2.1	0.3	1.1	1.5	-1.0	0.6	0.8	-1.2	0.8	-0.8	-1.5	-1.2	-0.6
Basal metabolic rate	0.5	2.7	6.4	1.1	1.7	2.4	-1.8	1.3	-0.9	-2.5	1.0	-1.2	-1.9	-2.1	0.2
Leg fat percentage (left)	1.0	3.7	16.0	1.5	2.1	4.0	-1.3	1.7	-1.1	-2.3	0.4	-0.9	-2.3	-2.0	0.1
Arm fat-free mass (left)	0.3	1.5	5.4	0.5	1.3	2.3	-1.3	0.6	-0.2	-1.9	1.2	-0.1	-0.8	-1.3	1.4
Number of operations (self-reported)	0.4	0.6	1.6	0.4	1.0	0.6	-1.0	0.8	-0.3	-1.1	0.9	-0.5	-1.3	-0.9	0.1
Average weekly beer plus cider intake	1.7	2.5	4.8	-1.1	-1.1	1.8	2.0	-1.5	0.4	2.1	-0.7	1.6	2.2	2.1	1.1
Irritability	0.2	0.3	1.2	-0.2	0.5	1.1	-0.5	0.8	0.7	-0.3	0.3	-0.6	-0.1	-0.4	-0.4
Risk taking	0.4	0.6	2.6	0.5	-0.3	-1.1	-0.3	0.4	-0.1	-1.1	0.4	0.7	-0.7	-0.9	1.6
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.5	0.9	0.8	0.6	-0.6	1.6	-0.2	-1.0	-0.4	-0.5	-0.8	-0.9	0.2
Fractured/broken bones in last 5 years	2.1	2.7	6.2	-1.4	-2.4	2.5	0.9	-2.0	1.6	1.8	0.4	1.4	1.3	1.9	0.9
Age started oral contraceptive pill	0.5	0.6	2.8	0.3	1.7	-1.1	-0.7	0.5	0.3	-0.8	0.5	-0.7	-0.8	-0.6	-0.0
Diastolic blood pressure, automated reading	9.7	30.2	49.8	-6.4	-6.2	-5.4	4.0	-7.1	3.6	6.8	2.2	6.2	5.5	7.0	2.4
Ever depressed for a whole week	0.2	0.3	0.9	0.2	-0.7	1.0	0.6	0.1	-0.5	0.5	-0.8	0.3	0.6	0.4	0.2
Unable to work because of sickness or disability	1.7	2.2	3.8	-1.7	-1.7	0.8	0.9	-1.8	0.0	1.9	0.5	1.9	1.9	1.9	1.2
Commuting to job workplace: Cycle	1.1	1.3	4.2	-0.9	0.9	-0.3	-2.0	0.4	1.8	-0.9	2.1	-0.6	-0.7	-0.9	0.2
Myopia	1.4	2.0	16.4	0.5	-0.5	4.0	1.8	-0.1	-1.1	0.5	-1.4	0.1	0.1	0.5	-0.4
Vascular/heart problems diagnosed by doctor	3.6	9.9	17.4	4.0	3.3	4.2	-1.9	4.0	-1.7	-3.9	-1.9	-3.5	-2.1	-4.0	-0.4
Cholesterol lowering medication	4.7	6.9	12.3	-3.4	-2.5	-1.0	2.0	-3.5	2.6	3.1	2.0	3.5	1.7	3.3	1.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	6.7	0.8	-0.5	-0.5	0.6	0.7	-2.6	-0.1	-1.2	-0.1	-0.2	-0.1	0.1
Pain experienced in last month	0.4	0.6	1.4	0.1	-0.9	-0.1	1.1	-1.2	0.1	0.8	-0.7	1.0	0.7	0.9	0.6
Supplements: Calcium	1.3	1.5	4.1	-0.7	-1.5	1.8	1.0	-0.6	-0.6	0.8	0.2	2.0	0.7	1.1	1.9
Basal cell carcinoma (self-reported)	0.6	0.7	2.6	1.0	1.0	-0.2	-0.3	1.1	-1.6	-0.8	-0.7	-0.8	-0.0	-0.9	0.3
Heart attack/myocardial infarction (self-reported)	1.1	1.5	4.2	-1.6	-1.7	0.5	0.2	-2.0	0.7	1.3	1.2	1.0	0.5	1.5	0.8
Deep venous thrombosis (DVT) (self-reported)	2.4	3.1	7.1	-2.1	-1.4	0.4	1.1	-2.7	2.0	1.6	1.6	2.5	1.4	1.9	1.2
Heart disease (siblings)	2.1	2.6	5.8	-2.4	-1.8	-1.6	0.3	-1.7	2.1	1.8	1.6	1.6	0.7	1.7	0.1
Alcohol drinker status: Previous	0.8	0.9	3.0	-1.4	-0.8	1.7	0.0	-1.3	-0.2	0.4	1.3	0.4	0.6	0.7	0.8
Pack years of smoking	2.9	4.3	9.1	-2.4	-2.4	1.5	1.2	-2.3	1.6	1.5	1.2	3.0	2.3	1.9	2.5
Impedance of whole body	1.1	5.4	35.9	2.0	0.6	6.0	2.1	1.0	-1.6	0.3	-3.5	-1.2	0.6	-0.2	-1.6
Leg fat mass (left)	1.3	5.2	14.6	1.7	2.4	3.8	-2.1	2.1	-1.3	-3.1	0.8	-1.7	-2.8	-2.7	-0.2
Arm predicted mass (left)	0.4	1.8	4.6	0.6	1.5	2.1	-1.5	0.8	-0.2	-2.1	1.2	-0.3	-1.0	-1.6	1.4