[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr19:32,670,184-34,392,158

Best TWAS P=1.05e-45 · Best GWAS P=2.7e-45 conditioned to 0.00375

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
26	The Cancer Genome Atlas	Glioblastoma Multiforme	RHPN2	0.11	0.01	blup	65	0.00	2.5e-01	12.8	-14.2	1.0e-45	-0.79	0.01	0.81	TRUE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	RHPN2	0.05	0.03	enet	11	0.05	3.5e-06	12.7	-13.4	5.8e-41	-0.74	0.14	0.85	TRUE
13	GTEx	Nerve Tibial	RHPN2	0.17	0.09	enet	19	0.12	1.5e-08	8.8	-8.1	8.1e-16	-0.48	0.98	0.00	TRUE
25	The Cancer Genome Atlas	Glioblastoma Multiforme	GPATCH1	0.10	0.11	blup	63	0.10	6.5e-04	12.7	12.8	2.1e-37	0.59	0.05	0.53	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	RHPN2	0.02	0.01	blup	66	0.02	4.2e-05	14.1	-12.7	7.8e-37	-0.78	0.00	0.99	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RHPN2	0.05	0.01	blup	65	0.03	4.6e-04	12.7	-12.3	8.7e-35	-0.77	0.01	0.82	FALSE
1	CommonMind	Brain Pre-frontal Cortex	RHPN2	0.19	0.16	enet	18	0.18	5.7e-21	8.5	-12.0	3.6e-33	-0.68	1.00	0.00	FALSE
31	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RHPN2	0.21	0.02	blup	66	0.08	3.2e-05	8.5	-11.8	4.3e-32	-0.70	0.02	0.78	FALSE
3	GTEx	Artery Aorta	RHPN2	0.13	0.09	lasso	3	0.07	7.0e-05	12.3	-11.2	5.0e-29	-0.43	0.87	0.01	FALSE
12	GTEx	Muscle Skeletal	RHPN2	0.06	0.05	lasso	3	0.05	1.6e-05	8.7	-11.0	4.8e-28	-0.51	0.66	0.22	FALSE
4	GTEx	Artery Tibial	RHPN2	0.09	0.09	enet	17	0.11	5.1e-09	12.4	-11.0	5.0e-28	-0.50	0.99	0.00	FALSE
6	GTEx	Brain Hippocampus	RHPN2	0.22	-0.01	enet	9	0.00	3.3e-01	-4.2	-11.0	5.7e-28	-0.58	0.05	0.30	FALSE
21	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	GPATCH1	0.03	0.01	blup	63	0.01	2.3e-02	12.8	10.8	2.9e-27	0.47	0.19	0.04	FALSE
16	METSIM	Adipose	GPATCH1	0.12	0.12	lasso	11	0.11	9.7e-17	8.9	10.5	7.2e-26	0.49	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GPATCH1	0.16	0.12	blup	63	0.13	8.4e-06	12.7	10.4	3.3e-25	0.36	0.78	0.04	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	GPATCH1	0.04	0.04	blup	63	0.05	2.9e-06	8.9	10.3	6.4e-25	0.40	0.98	0.00	FALSE
38	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GPATCH1	0.07	0.05	blup	63	0.08	3.0e-04	4.1	9.8	7.3e-23	0.33	0.25	0.03	FALSE
23	The Cancer Genome Atlas	Colon Adenocarcinoma	GPATCH1	0.06	0.07	blup	63	0.05	7.5e-04	8.5	9.8	1.6e-22	0.51	0.25	0.08	FALSE
42	The Cancer Genome Atlas	Stomach Adenocarcinoma	GPATCH1	0.05	0.04	blup	64	0.04	4.7e-04	8.2	9.4	5.4e-21	0.42	0.16	0.06	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GPATCH1	0.03	0.05	lasso	2	0.04	2.2e-05	8.8	9.2	4.7e-20	0.44	0.86	0.04	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RHPN2	0.04	0.02	blup	65	0.02	5.1e-03	14.1	-9.1	1.2e-19	-0.66	0.00	0.96	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	GPATCH1	0.27	0.20	lasso	4	0.24	2.0e-25	8.8	9.0	3.3e-19	0.30	1.00	0.00	FALSE
5	GTEx	Brain Caudate basal ganglia	RHPN2	0.20	-0.01	enet	18	0.03	4.8e-02	6.1	-8.9	6.1e-19	-0.52	0.06	0.38	FALSE
24	The Cancer Genome Atlas	Colon Adenocarcinoma	RHPN2	0.12	0.01	blup	66	0.05	7.5e-04	8.7	-8.6	9.4e-18	-0.54	0.05	0.11	FALSE
18	METSIM	Adipose	WDR88	0.07	0.06	lasso	7	0.08	2.1e-11	4.9	8.5	1.5e-17	0.46	0.99	0.01	FALSE
34	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	WDR88	0.08	0.05	enet	6	0.09	6.3e-05	6.3	8.5	1.9e-17	0.43	0.22	0.05	FALSE
14	GTEx	Testis	GPATCH1	0.21	0.04	enet	27	0.08	2.8e-04	8.5	8.2	2.3e-16	0.32	0.54	0.08	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GPATCH1	0.07	0.11	lasso	6	0.10	2.3e-11	8.7	8.1	4.3e-16	0.30	1.00	0.00	FALSE
20	YFS	Blood	LRP3	0.18	0.12	bslmm	431	0.16	7.1e-49	7.4	8.0	9.6e-16	0.38	1.00	0.00	FALSE
17	METSIM	Adipose	RHPN2	0.11	0.05	blup	478	0.11	1.5e-15	8.8	-7.9	2.5e-15	-0.32	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	GPATCH1	0.05	0.05	enet	8	0.07	4.2e-08	5.0	7.3	3.4e-13	0.17	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	WDR88	0.09	0.07	lasso	4	0.06	1.8e-07	6.8	7.2	4.5e-13	0.34	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	WDR88	0.03	0.01	lasso	3	0.02	1.7e-03	8.0	7.2	8.0e-13	0.34	0.12	0.05	FALSE
15	GTEx	Thyroid	RHPN2	0.18	0.02	enet	25	0.05	1.2e-04	7.1	-6.8	1.5e-11	-0.44	0.38	0.41	FALSE
19	YFS	Blood	GPATCH1	0.05	0.01	blup	453	0.03	2.8e-09	8.6	6.7	2.2e-11	0.46	0.03	0.97	FALSE
11	GTEx	Muscle Skeletal	GPATCH1	0.07	0.03	enet	13	0.02	1.7e-03	4.9	6.3	2.6e-10	-0.02	0.28	0.02	FALSE
9	GTEx	Cells Transformed fibroblasts	RHPN2	0.08	0.00	enet	12	0.01	1.2e-01	4.9	-6.2	5.3e-10	-0.15	0.18	0.03	FALSE
7	GTEx	Breast Mammary Tissue (Male)	CEP89	0.10	0.06	lasso	2	0.06	1.4e-02	-3.1	6.2	7.5e-10	0.30	0.05	0.09	FALSE
10	GTEx	Esophagus Muscularis	CEP89	0.15	0.05	lasso	5	0.08	1.1e-05	-3.8	6.0	1.6e-09	0.23	0.89	0.02	FALSE
8	GTEx	Cells Transformed fibroblasts	GPATCH1	0.08	0.12	lasso	3	0.12	5.3e-09	5.0	5.6	1.7e-08	0.00	1.00	0.00	FALSE
43	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC7A10	0.08	0.00	blup	56	0.02	2.1e-02	6.8	-5.6	2.3e-08	-0.26	0.01	0.69	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	WDR88	0.05	0.03	blup	66	0.03	6.5e-04	6.8	5.2	1.8e-07	0.23	0.18	0.02	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GPATCH1	0.03	0.01	blup	63	0.01	4.2e-02	4.9	5.1	2.7e-07	0.04	0.08	0.03	FALSE