[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) :

chr19:32,670,184-34,392,158

Best TWAS P=1.05e-45 · Best GWAS P=2.7e-45 conditioned to 0.00375

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex RHPN2 0.19 0.16 enet 18 0.18 5.7e-21 8.5 -12.0 3.6e-33 -0.68 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex WDR88 0.09 0.07 lasso 4 0.06 1.8e-07 6.8 7.2 4.5e-13 0.34 1.00 0.00 FALSE
3 GTEx Artery Aorta RHPN2 0.13 0.09 lasso 3 0.07 7.0e-05 12.3 -11.2 5.0e-29 -0.43 0.87 0.01 FALSE
4 GTEx Artery Tibial RHPN2 0.09 0.09 enet 17 0.11 5.1e-09 12.4 -11.0 5.0e-28 -0.50 0.99 0.00 FALSE
5 GTEx Brain Caudate basal ganglia RHPN2 0.20 -0.01 enet 18 0.03 4.8e-02 6.1 -8.9 6.1e-19 -0.52 0.06 0.38 FALSE
6 GTEx Brain Hippocampus RHPN2 0.22 -0.01 enet 9 0.00 3.3e-01 -4.2 -11.0 5.7e-28 -0.58 0.05 0.30 FALSE
7 GTEx Breast Mammary Tissue (Male) CEP89 0.10 0.06 lasso 2 0.06 1.4e-02 -3.1 6.2 7.5e-10 0.30 0.05 0.09 FALSE
8 GTEx Cells Transformed fibroblasts GPATCH1 0.08 0.12 lasso 3 0.12 5.3e-09 5.0 5.6 1.7e-08 0.00 1.00 0.00 FALSE
9 GTEx Cells Transformed fibroblasts RHPN2 0.08 0.00 enet 12 0.01 1.2e-01 4.9 -6.2 5.3e-10 -0.15 0.18 0.03 FALSE
10 GTEx Esophagus Muscularis CEP89 0.15 0.05 lasso 5 0.08 1.1e-05 -3.8 6.0 1.6e-09 0.23 0.89 0.02 FALSE
11 GTEx Muscle Skeletal GPATCH1 0.07 0.03 enet 13 0.02 1.7e-03 4.9 6.3 2.6e-10 -0.02 0.28 0.02 FALSE
12 GTEx Muscle Skeletal RHPN2 0.06 0.05 lasso 3 0.05 1.6e-05 8.7 -11.0 4.8e-28 -0.51 0.66 0.22 FALSE
13 GTEx Nerve Tibial RHPN2 0.17 0.09 enet 19 0.12 1.5e-08 8.8 -8.1 8.1e-16 -0.48 0.98 0.00 TRUE
14 GTEx Testis GPATCH1 0.21 0.04 enet 27 0.08 2.8e-04 8.5 8.2 2.3e-16 0.32 0.54 0.08 FALSE
15 GTEx Thyroid RHPN2 0.18 0.02 enet 25 0.05 1.2e-04 7.1 -6.8 1.5e-11 -0.44 0.38 0.41 FALSE
16 METSIM Adipose GPATCH1 0.12 0.12 lasso 11 0.11 9.7e-17 8.9 10.5 7.2e-26 0.49 1.00 0.00 FALSE
17 METSIM Adipose RHPN2 0.11 0.05 blup 478 0.11 1.5e-15 8.8 -7.9 2.5e-15 -0.32 1.00 0.00 FALSE
18 METSIM Adipose WDR88 0.07 0.06 lasso 7 0.08 2.1e-11 4.9 8.5 1.5e-17 0.46 0.99 0.01 FALSE
19 YFS Blood GPATCH1 0.05 0.01 blup 453 0.03 2.8e-09 8.6 6.7 2.2e-11 0.46 0.03 0.97 FALSE
20 YFS Blood LRP3 0.18 0.12 bslmm 431 0.16 7.1e-49 7.4 8.0 9.6e-16 0.38 1.00 0.00 FALSE
21 The Cancer Genome Atlas Bladder Urothelial Carcinoma GPATCH1 0.03 0.01 blup 63 0.01 2.3e-02 12.8 10.8 2.9e-27 0.47 0.19 0.04 FALSE
22 The Cancer Genome Atlas Breast Invasive Carcinoma RHPN2 0.02 0.01 blup 66 0.02 4.2e-05 14.1 -12.7 7.8e-37 -0.78 0.00 0.99 FALSE
23 The Cancer Genome Atlas Colon Adenocarcinoma GPATCH1 0.06 0.07 blup 63 0.05 7.5e-04 8.5 9.8 1.6e-22 0.51 0.25 0.08 FALSE
24 The Cancer Genome Atlas Colon Adenocarcinoma RHPN2 0.12 0.01 blup 66 0.05 7.5e-04 8.7 -8.6 9.4e-18 -0.54 0.05 0.11 FALSE
25 The Cancer Genome Atlas Glioblastoma Multiforme GPATCH1 0.10 0.11 blup 63 0.10 6.5e-04 12.7 12.8 2.1e-37 0.59 0.05 0.53 FALSE
26 The Cancer Genome Atlas Glioblastoma Multiforme RHPN2 0.11 0.01 blup 65 0.00 2.5e-01 12.8 -14.2 1.0e-45 -0.79 0.01 0.81 TRUE
27 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma GPATCH1 0.03 0.05 lasso 2 0.04 2.2e-05 8.8 9.2 4.7e-20 0.44 0.86 0.04 FALSE
28 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GPATCH1 0.07 0.11 lasso 6 0.10 2.3e-11 8.7 8.1 4.3e-16 0.30 1.00 0.00 FALSE
29 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RHPN2 0.05 0.01 blup 65 0.03 4.6e-04 12.7 -12.3 8.7e-35 -0.77 0.01 0.82 FALSE
30 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma WDR88 0.03 0.01 lasso 3 0.02 1.7e-03 8.0 7.2 8.0e-13 0.34 0.12 0.05 FALSE
31 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma RHPN2 0.21 0.02 blup 66 0.08 3.2e-05 8.5 -11.8 4.3e-32 -0.70 0.02 0.78 FALSE
32 The Cancer Genome Atlas Brain Lower Grade Glioma GPATCH1 0.05 0.05 enet 8 0.07 4.2e-08 5.0 7.3 3.4e-13 0.17 1.00 0.00 FALSE
33 The Cancer Genome Atlas Brain Lower Grade Glioma RHPN2 0.05 0.03 enet 11 0.05 3.5e-06 12.7 -13.4 5.8e-41 -0.74 0.14 0.85 TRUE
34 The Cancer Genome Atlas Liver Hepatocellular Carcinoma WDR88 0.08 0.05 enet 6 0.09 6.3e-05 6.3 8.5 1.9e-17 0.43 0.22 0.05 FALSE
35 The Cancer Genome Atlas Lung Adenocarcinoma GPATCH1 0.04 0.04 blup 63 0.05 2.9e-06 8.9 10.3 6.4e-25 0.40 0.98 0.00 FALSE
36 The Cancer Genome Atlas Lung Squamous Cell Carcinoma GPATCH1 0.03 0.01 blup 63 0.01 4.2e-02 4.9 5.1 2.7e-07 0.04 0.08 0.03 FALSE
37 The Cancer Genome Atlas Lung Squamous Cell Carcinoma RHPN2 0.04 0.02 blup 65 0.02 5.1e-03 14.1 -9.1 1.2e-19 -0.66 0.00 0.96 FALSE
38 The Cancer Genome Atlas Pancreatic Adenocarcinoma GPATCH1 0.07 0.05 blup 63 0.08 3.0e-04 4.1 9.8 7.3e-23 0.33 0.25 0.03 FALSE
39 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma GPATCH1 0.16 0.12 blup 63 0.13 8.4e-06 12.7 10.4 3.3e-25 0.36 0.78 0.04 FALSE
40 The Cancer Genome Atlas Prostate Adenocarcinoma GPATCH1 0.27 0.20 lasso 4 0.24 2.0e-25 8.8 9.0 3.3e-19 0.30 1.00 0.00 FALSE
41 The Cancer Genome Atlas Prostate Adenocarcinoma WDR88 0.05 0.03 blup 66 0.03 6.5e-04 6.8 5.2 1.8e-07 0.23 0.18 0.02 FALSE
42 The Cancer Genome Atlas Stomach Adenocarcinoma GPATCH1 0.05 0.04 blup 64 0.04 4.7e-04 8.2 9.4 5.4e-21 0.42 0.16 0.06 FALSE
43 The Cancer Genome Atlas Stomach Adenocarcinoma SLC7A10 0.08 0.00 blup 56 0.02 2.1e-02 6.8 -5.6 2.3e-08 -0.26 0.01 0.69 FALSE