TWAS hub - CEP89

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.098	0.0300	1.4e-05	0.005	0.047	0.034	0.046	0.026	6.6e-02	2.1e-06	5.0e-05	2.4e-06	3.5e-04
2	GTEx	Adipose Subcutaneous	0.202	0.0460	8.4e-09	0.188	NA	0.158	NA	0.160	3.1e-15	NA	6.1e-13	NA	5.0e-13
3	GTEx	Adipose Visceral Omentum	0.122	0.0500	5.1e-03	0.065	NA	0.027	NA	0.039	2.7e-04	NA	1.5e-02	NA	4.3e-03
4	GTEx	Artery Tibial	0.168	0.0557	9.3e-04	0.079	NA	0.034	NA	0.067	8.6e-07	NA	9.9e-04	NA	6.2e-06
5	GTEx	Breast Mammary Tissue	0.197	0.0530	6.8e-05	0.139	NA	0.149	NA	0.152	1.4e-07	NA	4.5e-08	NA	3.0e-08
6	GTEx	Breast Mammary Tissue (Male)	0.099	0.0843	1.5e-01	0.063	NA	0.025	NA	0.063	1.5e-02	NA	8.5e-02	NA	1.4e-02
7	GTEx	Cells Transformed fibroblasts	0.318	0.0630	2.2e-08	0.115	NA	0.130	NA	0.141	6.4e-09	NA	5.7e-10	NA	1.0e-10
8	GTEx	Colon Transverse	0.190	0.0790	8.0e-03	0.008	NA	0.100	NA	0.069	1.3e-01	NA	1.8e-05	NA	3.4e-04
9	GTEx	Esophagus Mucosa	0.145	0.0540	6.4e-04	0.045	NA	0.032	NA	0.044	5.9e-04	NA	3.1e-03	NA	6.1e-04
10	GTEx	Esophagus Muscularis	0.146	0.0460	1.8e-05	0.046	NA	0.068	NA	0.082	8.4e-04	NA	6.1e-05	NA	1.1e-05
11	GTEx	Lung	0.157	0.0508	6.4e-04	0.092	NA	0.060	NA	0.074	1.5e-07	NA	2.4e-05	NA	2.7e-06
12	GTEx	Nerve Tibial	0.316	0.0571	1.2e-08	0.031	NA	0.224	NA	0.209	2.6e-03	NA	7.1e-16	NA	9.0e-15
13	GTEx	Prostate	0.357	0.1030	9.8e-04	0.030	NA	0.005	NA	0.023	6.1e-02	NA	2.4e-01	NA	8.6e-02
14	GTEx	Skin Not Sun Exposed Suprapubic	0.208	0.0680	2.2e-04	0.051	NA	0.016	NA	0.068	8.9e-04	NA	4.3e-02	NA	1.4e-04
15	GTEx	Skin Sun Exposed Lower leg	0.111	0.0380	4.5e-04	0.119	NA	0.097	NA	0.110	4.6e-10	NA	1.9e-08	NA	2.3e-09
16	GTEx	Testis	0.236	0.0680	1.0e-04	0.204	NA	0.178	NA	0.187	2.0e-09	NA	2.6e-08	NA	1.0e-08
17	GTEx	Thyroid	0.137	0.0420	8.5e-05	0.085	NA	0.061	NA	0.073	4.8e-07	NA	1.9e-05	NA	3.1e-06
18	GTEx	Vagina	0.297	0.0860	4.5e-04	0.326	NA	0.238	NA	0.308	2.9e-08	NA	3.5e-06	NA	7.9e-08
19	METSIM	Adipose	0.102	0.0293	1.3e-06	0.051	0.046	0.059	0.052	0.057	3.9e-08	1.7e-07	3.3e-09	2.5e-08	6.9e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Heel bone mineral density (BMD) T-score, automated (left)	5.9	13.4	37.9	4.8	3.5	3.0	3.1	3.1	6.2	2.7	4.5	3.3	6.0	3.1	2.8	2.3	3.6	3.0	2.2	3.4	3.0	2.5
Medication: Bendroflumethiazide	5.9	9.0	16.0	-2.6	-3.1	-3.4	-3.1	-3.3	-2.9	-4.0	-2.4	-3.5	-0.4	-3.1	-2.4	-0.5	-3.3	-3.1	-3.2	-3.1	-3.1	-3.6
Heel bone mineral density (BMD) T-score, automated (right)	5.7	13.0	45.0	4.5	3.5	2.9	3.1	2.9	5.8	2.4	4.5	3.3	6.7	3.1	2.8	1.7	3.5	3.1	1.8	3.4	3.1	2.4
Heel T-Score	5.0	39.8	146.4	12.1	4.8	4.5	4.4	4.7	11.3	3.8	7.4	4.6	10.4	4.3	5.1	4.2	6.0	4.2	4.5	4.9	4.2	4.5
Age when periods started (menarche)	3.8	9.1	17.8	1.7	3.5	3.5	3.2	4.1	3.2	2.4	0.8	3.0	2.2	3.6	0.7	-0.6	4.2	3.6	2.2	3.6	3.6	3.6
Had menopause	3.6	4.5	7.0	-1.2	-2.6	-2.4	-2.3	-2.6	-2.5	-2.0	-1.3	-2.4	-2.1	-2.5	-0.9	0.7	-2.2	-2.5	-1.4	-2.6	-2.5	-1.5
Health satisfaction	3.2	4.2	6.9	1.0	2.1	2.1	2.2	2.4	2.5	2.1	1.5	2.3	2.6	2.0	2.3	0.5	1.9	2.0	2.0	2.0	2.0	2.1
Serious illness, injury or assault to yourself	3.1	3.7	5.8	1.4	2.3	2.4	2.1	2.1	2.2	2.3	1.5	2.4	1.0	2.3	1.1	0.2	1.2	2.3	2.2	2.2	2.3	1.7
Ever used hormone-replacement therapy (HRT)	3.0	3.8	5.5	0.1	-2.2	-2.3	-2.2	-2.0	-1.8	-1.6	-0.9	-2.0	-1.9	-2.3	-2.3	-1.9	-2.2	-2.3	-1.5	-2.2	-2.3	-1.1
Medication: Simvastatin	3.0	4.5	6.7	-2.2	-1.9	-2.4	-2.1	-2.4	-2.4	-2.6	-1.4	-2.1	0.3	-2.1	-1.1	-2.5	-2.1	-2.2	-2.5	-1.8	-2.2	-2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	3.0	3.9	7.1	0.4	2.1	2.2	1.9	2.4	2.1	2.5	1.8	2.3	1.4	1.9	1.3	-0.9	1.7	1.9	2.4	2.2	1.9	2.7
Osteoporosis (self-reported)	3.0	3.7	8.4	-1.5	-2.1	-1.8	-2.2	-2.0	-2.9	-1.5	-2.2	-2.0	-1.2	-2.0	-1.7	-1.7	-1.8	-2.0	-0.7	-2.0	-2.0	-2.1
Ovarian Cancer	2.9	3.8	7.1	-2.1	-2.1	-2.1	-2.4	-2.1	-1.8	-1.9	-2.7	-2.0	-0.2	-2.2	-2.1	0.1	-2.1	-2.2	-1.4	-2.0	-2.2	-1.4
Primary Biliary Cirrhosis	2.9	4.2	6.2	2.1	2.0	2.1	1.9	2.5	2.4	2.0	2.5	2.0	2.2	1.9	2.0	0.5	2.4	1.9	1.9	2.2	1.9	1.5
Alzheimer’s Disease (in mother)	2.6	3.1	5.6	1.8	1.9	2.1	1.7	2.0	1.5	2.1	0.5	2.0	1.4	1.8	0.7	0.0	1.9	1.8	2.4	1.7	1.8	2.2
Alzheimer’s Disease (including proxy)	2.6	3.8	7.8	2.1	2.2	2.5	1.8	1.8	1.8	2.6	0.7	2.2	1.7	2.1	0.9	0.3	1.7	1.9	2.8	1.9	1.9	2.3
Depression (Nagel 2018)	2.4	3.6	7.2	0.9	2.0	2.4	2.1	2.1	2.2	2.0	0.5	1.6	0.7	2.1	1.8	0.3	1.7	2.2	2.7	2.3	2.2	2.2
Severe depression (siblings)	2.4	2.7	4.7	-0.8	-1.9	-2.1	-2.2	-1.5	-1.0	-1.3	-1.9	-1.5	-1.0	-2.1	-2.1	0.1	-1.2	-2.1	-1.3	-1.9	-2.1	-1.2
Pulse rate, automated reading	2.4	7.7	12.9	3.5	2.9	2.9	2.7	3.6	3.5	2.7	2.5	3.1	1.5	3.0	2.0	-1.2	3.4	3.0	1.7	2.9	3.0	2.0
High cholesterol (Self-reported)	2.4	4.3	7.6	-0.4	-2.4	-2.4	-2.8	-2.3	-2.5	-1.6	-1.2	-2.0	-0.5	-2.6	-2.1	-1.4	-2.0	-2.6	-1.2	-2.4	-2.6	-1.9
Age started oral contraceptive pill	2.4	3.1	6.8	-0.6	2.0	1.7	2.0	2.2	1.5	1.0	1.8	1.5	1.4	1.9	2.6	-1.1	2.3	1.9	0.7	2.0	1.9	1.5
Frequency of tenseness / restlessness in last 2 weeks	2.3	3.6	7.6	-0.7	2.1	2.0	2.4	2.3	2.4	1.3	1.4	1.8	1.2	2.2	2.8	1.1	1.7	2.1	0.9	2.2	2.1	1.8
Medication: Ibuprofen	2.3	2.8	4.5	0.2	1.8	1.8	2.0	1.8	1.8	1.3	1.7	1.5	1.6	1.8	2.0	0.5	1.6	1.8	1.3	1.8	1.8	2.1
Waist Hip Ratio (WHR)	2.2	9.7	148.8	-4.0	0.1	-0.0	0.3	0.2	0.6	-0.3	2.2	0.0	-1.3	0.3	2.6	12.2	-0.5	0.3	-0.5	0.3	0.3	-2.2
Supplements: Zinc	2.2	2.4	5.7	1.5	1.5	1.6	1.3	1.9	1.3	2.1	-0.2	1.9	0.1	1.4	0.7	-0.1	2.1	1.5	2.1	1.5	1.5	2.4
Medication: Atenolol	2.2	2.7	6.1	-0.8	1.9	1.8	1.8	1.4	1.7	1.3	2.0	1.8	2.3	1.8	2.5	0.1	1.4	1.8	1.1	1.6	1.8	0.7
Medication: Lansoprazole	2.2	2.5	5.8	1.4	2.0	1.7	1.8	1.9	1.7	0.8	1.1	1.4	2.4	2.0	1.1	-0.4	0.9	2.0	0.7	2.1	2.0	1.0
Age at last live birth	2.2	3.2	7.5	-0.2	2.2	1.7	2.0	2.1	1.8	0.8	1.5	1.8	2.7	2.1	2.6	0.6	1.6	2.1	0.2	2.1	2.1	0.2
Type 2 Diabetes (T2D) (2012)	2.1	2.4	5.2	1.0	1.7	1.9	1.5	1.8	2.3	1.7	-0.5	1.6	0.2	1.8	0.5	-0.4	1.4	1.7	1.7	1.7	1.7	2.2
Alcohol usually taken with meals	2.1	3.4	7.5	-1.5	-1.9	-1.9	-2.0	-1.7	-2.7	-2.6	-2.3	-2.4	-1.4	-1.6	-1.9	-0.2	-1.6	-1.6	-1.6	-1.8	-1.6	-1.5
Eye problems/disorders: None of the above	2.0	2.3	5.2	-0.6	-1.5	-1.7	-1.5	-1.8	-2.3	-1.3	-0.5	-1.3	-1.8	-1.6	-0.5	0.3	-2.1	-1.6	-1.4	-1.6	-1.6	-1.7
Mineral and other dietary supplements	2.0	2.7	5.6	1.8	1.5	1.9	1.7	1.4	1.7	1.8	1.6	1.5	0.3	1.5	1.4	-0.7	2.0	1.6	2.4	1.6	1.6	2.0
Illnesses of siblings	1.8	2.5	5.8	0.6	1.6	1.4	1.6	1.7	1.6	1.6	2.4	1.8	1.5	1.5	2.2	1.2	0.9	1.5	1.6	1.6	1.5	1.3
Number of children fathered	1.7	1.9	4.4	-2.1	-1.5	-1.5	-1.6	-2.0	-1.9	-0.4	-0.7	-0.9	-0.0	-1.7	-0.4	0.2	-1.4	-1.7	-0.1	-1.7	-1.7	-1.7
Heart disease (mother)	1.7	2.1	3.6	0.4	-1.8	-1.5	-1.8	-1.4	-1.6	-0.6	-0.7	-1.6	-0.7	-1.9	-1.0	-1.7	-1.3	-1.9	-0.0	-1.8	-1.9	-1.5
Frequency of depressed mood in last 2 weeks	1.6	2.2	4.5	0.2	1.4	1.6	1.6	1.6	2.1	1.7	0.3	1.4	1.3	1.4	1.7	0.8	1.5	1.4	2.0	1.7	1.4	1.9
High blood pressure (mother)	1.6	2.2	8.0	-2.8	-1.3	-1.5	-1.3	-1.8	-1.5	-1.8	-0.8	-1.5	-1.1	-1.2	-1.4	-0.2	-1.0	-1.2	-2.0	-1.3	-1.2	-1.7
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	3.6	0.4	1.6	1.5	1.8	1.5	1.6	1.0	1.6	1.3	1.5	1.6	1.7	0.9	1.1	1.6	1.0	1.6	1.6	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	7.7	0.3	1.5	1.4	1.8	1.5	1.4	1.6	2.8	1.6	1.6	1.3	2.3	0.2	1.1	1.2	1.6	1.3	1.2	1.6
Medication: Amlodipine	1.6	2.3	3.7	-1.4	-1.7	-1.8	-1.4	-1.9	-1.3	-1.9	-0.7	-1.6	-1.3	-1.5	-0.8	-0.4	-1.9	-1.5	-1.8	-1.5	-1.5	-1.6
Qualifications: None of the above	1.5	3.2	6.3	-1.3	-2.3	-2.0	-2.3	-1.7	-1.7	-0.6	-2.0	-1.7	0.2	-2.5	-2.1	-1.2	-0.9	-2.5	0.1	-2.3	-2.5	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	4.7	1.3	1.0	1.3	1.3	1.0	1.7	1.5	1.9	1.3	0.4	1.0	2.2	1.2	0.6	1.1	1.7	1.1	1.1	1.7
Breast cancer (self-reported)	1.5	1.8	4.8	1.8	1.3	1.6	1.2	1.3	2.2	1.3	0.4	1.3	0.9	1.4	1.6	0.3	1.0	1.4	1.7	1.4	1.4	0.6
Cholesterol lowering medication	1.5	2.2	3.8	-0.9	-1.7	-1.8	-2.0	-1.5	-1.4	-1.7	-1.7	-1.8	-0.7	-1.8	-1.3	-0.9	-0.7	-1.8	-1.0	-1.6	-1.8	-1.3
Heart disease (siblings)	1.5	1.8	5.5	-0.7	-1.3	-1.5	-1.5	-2.4	-1.5	-0.9	-0.8	-1.1	-0.0	-1.6	-0.6	1.3	-1.9	-1.5	-0.8	-1.5	-1.5	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	7.3	2.3	2.2	2.5	2.0	2.7	2.2	2.6	1.9	2.3	0.4	2.2	0.0	1.5	1.4	2.2	2.5	2.2	2.2	2.4
Tense / ‘highly strung’	1.4	2.3	6.4	1.2	1.3	1.4	1.1	1.7	1.6	2.0	2.5	1.9	2.2	1.1	1.5	0.8	0.8	1.1	1.6	1.1	1.1	1.1
Forced vital capacity (FVC), Best measure	1.4	5.2	8.0	2.6	2.5	2.7	2.2	2.8	2.5	2.7	2.0	2.6	0.8	2.5	0.1	1.8	1.4	2.5	2.4	2.5	2.5	2.5
Medication: Blood pressure	1.4	2.4	4.7	-1.1	-1.2	-1.7	-1.5	-2.0	-1.5	-1.1	0.8	-0.7	1.8	-1.7	-1.2	-1.6	-2.2	-1.7	-1.5	-1.5	-1.7	-2.0
Unable to work because of sickness or disability	1.4	1.8	4.3	0.7	1.4	1.3	1.2	1.4	1.5	1.5	0.9	1.6	2.1	1.1	1.3	-1.4	1.5	1.2	1.2	1.4	1.2	1.1
LDL Cholesterol	1.3	2.1	4.3	1.3	1.7	1.6	1.5	2.1	1.7	1.1	1.3	1.4	-0.2	1.8	0.5	0.9	1.6	1.6	1.1	1.8	1.6	1.2
Blood Red Count	1.3	12.7	36.0	3.7	-4.2	-2.7	-3.8	-3.1	-3.0	-0.4	-6.0	-3.2	-4.3	-3.8	-3.0	-5.2	-2.1	-3.7	1.5	-4.2	-3.7	-1.3
Financial difficulties in last 2 years	1.3	1.8	5.5	1.0	1.1	1.5	1.3	1.5	1.6	1.2	0.4	1.0	1.6	1.2	1.0	-0.7	2.3	1.3	1.7	1.1	1.3	1.2
Depression (self-reported)	1.3	1.6	5.1	2.3	0.9	1.1	0.9	1.5	2.0	0.9	0.2	0.7	-0.0	1.0	0.4	-1.4	2.2	1.0	1.3	1.2	1.0	0.9
Illnesses of siblings: Diabetes	1.3	1.5	5.3	-0.7	-1.3	-1.1	-1.2	-1.4	-1.6	-1.1	-0.7	-1.6	-1.3	-1.2	-1.2	-2.3	-0.8	-1.2	-0.5	-1.3	-1.2	-0.6
Qualifications: nursing, teaching	1.3	2.0	4.1	1.1	1.6	1.5	1.6	2.0	1.5	0.5	1.1	0.9	-0.9	1.9	1.5	0.8	1.4	1.9	0.2	1.8	1.9	1.3
Supplements: Fish oil (including cod liver oil)	1.3	1.6	3.5	-1.8	-1.1	-1.5	-1.1	-1.3	-0.9	-1.7	-0.7	-1.5	0.5	-1.2	-0.2	0.6	-1.4	-1.3	-1.9	-1.2	-1.3	-1.7
Breast Cancer	1.2	2.9	4.8	-2.0	-1.8	-2.0	-1.9	-1.5	-1.2	-2.2	-1.8	-1.9	-1.5	-1.8	-1.4	-0.5	-0.8	-1.8	-2.2	-1.5	-1.8	-1.7
Chronotype (morning person)	1.2	2.7	5.7	-0.6	-1.5	-1.6	-2.0	-2.1	-1.5	-1.6	-1.5	-1.7	-0.6	-1.7	-2.4	-0.2	-2.3	-1.6	-1.1	-1.5	-1.6	-2.1
Time employed in main current job	1.2	1.3	2.6	-0.6	1.2	1.1	1.2	1.2	1.6	0.7	1.1	1.1	-0.5	1.4	1.1	1.2	1.4	1.3	0.7	1.3	1.3	1.3
Pulse rate	1.2	2.0	4.2	-0.8	1.8	1.5	1.5	1.9	1.6	0.9	1.2	1.5	2.0	1.6	1.2	-0.4	1.7	1.6	0.4	1.7	1.6	0.9
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	4.4	2.1	0.9	1.5	1.0	1.4	1.0	1.1	-1.2	0.4	-1.5	1.3	0.1	2.0	1.7	1.3	1.8	1.0	1.3	1.9
Mouth/teeth dental problems: Loose teeth	1.2	1.4	3.2	-0.1	-1.4	-1.1	-1.4	-1.2	-0.5	-1.2	-1.3	-1.8	-0.6	-1.4	-1.1	-1.1	-1.1	-1.4	-0.6	-1.2	-1.4	-1.3
Chest pain or discomfort	1.2	1.7	6.1	0.7	1.3	1.2	1.6	1.1	0.9	1.1	1.8	1.4	1.7	1.3	2.5	0.1	1.2	1.2	0.8	1.1	1.2	0.8
Eye problems/disorders: Glaucoma	1.2	1.4	3.8	1.9	1.2	1.2	1.0	1.1	2.0	0.5	-0.3	0.8	1.0	1.3	-0.3	-0.5	1.8	1.3	0.6	1.3	1.3	0.8
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	2.6	-0.2	-1.6	-1.5	-1.3	-1.4	-0.8	-1.5	-0.8	-1.4	-0.6	-1.5	-0.3	1.4	-1.1	-1.4	-1.1	-1.4	-1.4	-0.9
Hearing difficulty/problems with background noise	1.1	1.7	5.5	-2.1	-1.0	-1.5	-0.9	-1.9	-0.8	-2.1	-0.2	-1.4	0.2	-1.0	-0.2	-0.9	-0.7	-1.1	-2.3	-1.0	-1.1	-1.6
Prospective memory result	1.1	1.3	6.8	-2.6	-1.0	-1.1	-0.7	-0.9	-1.4	-1.7	0.0	-1.3	0.3	-0.9	-0.2	0.3	-0.8	-1.0	-1.8	-0.8	-1.0	-0.8
Number of full brothers	1.1	1.4	4.4	-2.1	-1.1	-1.2	-1.3	-1.6	-1.7	-0.6	-1.1	-0.7	0.1	-1.3	-1.4	0.6	-0.7	-1.3	-0.6	-1.3	-1.3	-0.3
Had major operations	1.1	1.3	3.6	-0.3	0.8	1.1	1.1	0.8	0.9	1.4	1.4	0.8	1.2	0.7	1.2	-0.6	1.4	0.8	1.7	1.0	0.8	1.9
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.5	-0.7	-1.2	-1.1	-1.0	-1.5	-0.9	-1.2	-0.9	-1.1	-0.7	-1.1	-1.0	-0.9	-1.6	-1.1	-1.1	-1.1	-1.1	-1.6
Smoking status: Previous	1.1	1.6	5.8	0.5	-1.2	-1.1	-1.2	-2.0	-1.2	-0.6	-0.8	-1.0	-1.2	-1.2	-1.9	0.8	-2.4	-1.2	-0.6	-1.4	-1.2	-0.9
Eye problems/disorders: Cataract	1.1	1.2	3.4	0.3	0.9	1.2	1.0	1.6	1.7	1.0	0.2	0.9	0.8	1.2	0.8	0.3	1.9	1.2	1.2	1.1	1.2	0.7
Irritability	1.1	1.9	5.9	-1.0	-1.4	-1.4	-1.3	-1.9	-1.3	-1.2	-0.0	-1.5	1.2	-1.5	-0.2	0.5	-2.4	-1.5	-0.8	-1.6	-1.5	-1.8
Alzheimer’s Disease (in father)	1.0	1.1	1.8	0.6	1.4	1.3	0.9	0.6	0.4	1.4	0.7	1.3	0.9	1.2	0.4	-0.4	1.0	1.2	1.3	1.1	1.2	1.4
Diabetes (mother)	1.0	1.3	3.3	-1.6	-1.3	-1.3	-1.0	-1.2	-1.0	-1.2	0.2	-1.1	0.1	-1.2	0.2	-1.8	-1.0	-1.2	-1.3	-1.4	-1.2	-1.0
High blood pressure	1.0	2.7	6.6	-1.8	-1.1	-1.7	-1.3	-1.6	-1.8	-1.9	0.4	-1.1	1.8	-1.4	-0.4	-2.5	-1.9	-1.4	-1.7	-1.3	-1.4	-2.6
Chronic bronchitis/emphysema (father)	1.0	1.1	9.2	-1.3	-0.9	-1.1	-0.8	-0.8	-0.5	-0.7	0.3	-0.7	-0.4	-1.0	0.5	3.0	-0.9	-0.9	-0.7	-0.7	-0.9	-1.1
Alcohol intake versus 10 years previously	1.0	1.5	3.9	2.0	1.4	1.3	1.0	1.3	1.1	1.3	-0.3	1.7	1.0	1.3	-0.3	-1.1	1.8	1.2	0.7	1.1	1.2	0.9
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	3.5	1.3	1.2	1.4	1.6	1.3	1.7	0.9	0.3	0.9	0.2	1.4	1.9	-1.1	1.4	1.4	1.3	1.4	1.4	1.4
Age at first live birth	1.0	1.7	3.2	0.9	1.8	1.3	1.4	1.6	1.1	0.3	0.3	1.5	1.7	1.8	1.5	-0.2	1.1	1.7	-0.5	1.8	1.7	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.2	4.6	1.7	1.6	1.6	1.3	1.7	0.9	2.1	2.0	2.0	0.8	1.4	-0.3	0.2	0.7	1.4	1.4	1.4	1.4	2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.0	4.5	2.1	1.5	1.8	1.1	1.9	1.4	1.8	0.6	1.3	0.2	1.5	-1.0	-0.1	1.1	1.5	2.1	1.5	1.5	0.6
Worry (Nagel 2018)	0.9	1.9	3.7	0.5	1.1	1.5	1.2	1.9	1.6	1.8	1.7	1.4	1.8	1.1	1.7	0.9	0.3	1.1	1.9	1.2	1.1	1.2
Angina	0.9	1.1	2.7	1.6	1.1	1.0	1.2	0.4	0.8	1.3	0.9	1.2	1.7	0.9	1.5	-0.9	0.6	0.9	0.9	0.9	0.9	-0.1
Medication for hormone replacement therapy	0.9	1.0	5.5	0.8	-1.0	-1.0	-0.8	-1.1	-0.7	-0.4	0.4	-1.0	-2.3	-0.9	-1.3	0.4	-1.2	-0.9	-0.7	-0.9	-0.9	-0.7
Current tobacco smoking	0.9	1.5	6.9	1.1	1.0	1.3	1.3	0.6	1.4	1.5	0.2	1.2	0.1	1.1	0.8	2.6	0.6	1.1	1.5	1.0	1.1	1.6
Hair/balding pattern: Pattern 2	0.9	1.2	3.3	0.7	1.3	1.2	0.9	0.9	1.4	1.8	1.0	1.5	0.5	1.1	0.4	0.9	1.0	1.1	1.4	1.0	1.1	0.4
Pulse wave Arterial Stiffness index	0.9	1.0	9.2	-2.2	-0.2	-0.7	-0.4	0.2	-0.2	-0.4	0.6	0.2	3.0	-0.7	0.9	-0.1	0.1	-0.7	-0.8	-0.4	-0.7	-0.8
Blood clot in the leg (DVT)	0.9	1.2	4.8	-0.6	0.8	1.2	1.2	0.9	1.2	1.0	0.7	0.9	-0.6	1.0	1.1	2.2	1.2	1.0	1.2	0.8	1.0	1.2
Glaucoma (self-reported)	0.9	1.0	2.4	1.5	1.0	1.1	0.8	0.8	1.4	0.9	-1.0	1.0	0.6	1.0	-1.0	-0.6	1.4	1.1	0.6	1.0	1.1	0.9
High blood pressure (siblings)	0.9	1.4	4.9	-0.6	-0.9	-1.0	-1.2	-0.8	-1.1	-1.2	-1.5	-0.9	-0.7	-0.9	-2.2	-1.6	0.1	-0.9	-1.7	-1.1	-0.9	-1.0
Wheeze or whistling in the chest in last year	0.9	1.5	3.7	-1.9	-1.1	-1.4	-0.7	-1.5	-1.0	-1.7	-0.2	-1.2	0.7	-1.1	1.2	0.2	-0.5	-1.1	-1.8	-1.2	-1.1	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	8.7	-0.8	-0.5	-0.9	-0.2	-0.7	-0.4	-0.8	1.4	-0.3	-1.1	-0.4	0.1	-3.0	-0.4	-0.5	-2.0	-0.4	-0.5	-0.8
Leg pain on walking	0.9	1.1	2.7	-1.1	1.0	0.7	1.0	1.1	0.8	1.0	0.8	1.3	1.6	0.8	1.3	0.5	1.2	0.8	0.7	1.1	0.8	1.6
Schizophrenia vs Biploar Disorder	0.8	1.1	4.9	-0.5	0.4	0.6	0.9	0.9	0.7	0.7	1.8	0.6	0.9	0.4	1.9	2.2	1.2	0.5	0.8	0.8	0.5	1.0
Coronary Artery Disease (CAD)	0.8	1.0	13.6	0.8	-0.4	-0.1	-0.3	-0.3	0.5	-0.5	0.5	-0.7	0.4	-0.3	0.7	3.7	-1.3	-0.2	0.4	-0.2	-0.2	-0.1
Mean Putamen Volume	0.8	0.9	1.6	0.9	-1.3	-1.1	-1.2	-0.7	-0.6	-1.2	-0.5	-1.3	-0.0	-1.2	-1.1	-0.1	-0.6	-1.0	-0.8	-1.0	-1.0	-0.6
HDL Cholesterol	0.8	1.3	3.8	-1.0	-1.0	-1.6	-1.3	-1.0	-1.1	-1.0	0.2	-0.8	0.6	-1.4	-0.8	1.4	-0.0	-1.4	-1.9	-1.1	-1.4	-1.0
Hand grip strength (left)	0.8	2.0	7.5	2.7	1.5	1.8	1.1	2.1	1.4	1.3	-0.2	1.3	-0.4	1.7	-0.9	-0.6	1.0	1.6	1.3	1.4	1.6	0.4
Pain all over the body in last month	0.8	0.8	3.5	0.3	1.0	0.7	0.8	0.2	0.5	0.7	0.4	1.0	1.8	0.8	0.8	-1.9	0.9	0.8	0.5	0.9	0.8	0.8
Lung cancer (father)	0.8	0.9	2.0	-0.7	-1.0	-1.1	-1.0	-0.5	-0.9	-1.2	-1.4	-0.9	-1.1	-0.9	-0.9	0.4	-0.6	-0.9	-1.3	-0.9	-0.9	-1.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	4.7	-0.1	0.8	0.3	0.7	1.1	0.5	0.8	2.2	1.2	1.8	0.5	1.9	-0.5	0.5	0.5	0.0	0.8	0.5	0.3
Comparative body size at age 10	0.8	2.3	4.7	-1.4	-1.4	-1.7	-1.7	-1.7	-1.9	-1.8	-1.3	-1.4	-1.1	-1.4	-1.5	2.2	-0.2	-1.5	-1.5	-1.5	-1.5	-1.5
Pulse wave peak to peak time	0.8	0.9	7.6	2.1	0.4	0.8	0.5	0.0	0.4	0.4	-0.5	0.0	-2.7	0.9	-0.9	0.3	-0.0	0.8	0.5	0.6	0.8	0.8
Shortness of breath walking on level ground	0.8	0.9	5.0	-2.2	-0.8	-1.1	-0.6	-0.8	-1.1	-0.9	0.0	-0.5	0.3	-1.0	0.5	0.6	-0.9	-0.9	-1.2	-0.8	-0.9	-0.8
Emphysema/chronic bronchitis	0.8	0.9	1.5	0.0	-1.0	-1.0	-1.2	-1.1	-1.2	-1.2	-1.0	-1.1	-0.4	-1.0	-0.5	-0.6	-1.0	-1.0	-0.5	-0.9	-1.0	-1.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	3.2	-0.4	-0.6	-1.0	-0.3	-1.4	0.1	-1.7	1.8	-1.0	0.5	-0.7	1.0	0.7	-0.8	-0.7	-1.6	-0.6	-0.7	-1.3
Number of operations (self-reported)	0.8	1.2	4.8	-1.0	0.5	0.6	0.9	0.9	1.0	0.6	2.2	0.5	1.5	0.5	1.9	1.5	1.1	0.5	0.8	0.7	0.5	1.0
Risk taking	0.8	1.2	5.1	-0.6	1.1	1.1	1.3	0.5	0.6	1.0	2.3	1.0	0.5	1.1	1.6	0.4	0.7	1.2	1.0	1.1	1.2	0.6
Vascular/heart problems diagnosed by doctor	0.8	2.3	6.4	2.0	0.9	1.4	1.1	1.5	1.6	1.7	-0.6	0.8	-1.9	1.1	0.1	2.5	1.6	1.1	1.7	1.1	1.1	2.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	3.4	-0.5	0.8	1.1	1.2	0.8	1.2	0.8	1.0	0.8	-0.6	1.0	1.2	1.9	1.2	1.0	1.0	0.8	1.0	1.0
Alcohol drinker status: Previous	0.8	0.9	3.0	1.7	0.5	0.5	0.6	0.8	1.6	0.3	1.2	0.4	1.1	0.4	0.7	-1.2	1.7	0.4	0.5	0.8	0.4	0.7
Ulcerative Colitis	0.7	1.1	2.1	0.8	-1.5	-1.3	-0.9	-0.8	-0.9	-0.9	0.7	-0.9	-1.2	-1.3	0.1	-0.5	-1.3	-1.1	-1.3	-1.2	-1.1	-0.7
Hearing difficulty/problems: Yes	0.7	1.0	2.8	-1.0	-0.9	-1.0	-0.5	-1.3	0.2	-0.6	1.1	-0.8	0.3	-1.0	1.7	1.6	-0.8	-1.0	-0.7	-0.9	-1.0	-1.3
Past tobacco smoking	0.7	1.2	4.8	-0.9	0.9	0.7	0.8	1.8	0.9	0.1	0.9	0.7	1.4	0.8	1.7	-1.4	2.2	0.8	0.2	1.0	0.8	0.4
Forced vital capacity (FVC)	0.7	2.5	7.5	2.7	1.7	1.7	1.2	1.9	1.8	2.0	1.6	1.9	0.5	1.5	-0.8	0.8	0.7	1.5	1.6	1.6	1.5	1.8
Mouth/teeth dental problems	0.7	1.0	10.2	0.9	-0.8	-0.2	-0.6	-0.7	-0.6	-0.4	-1.4	-0.9	-3.2	-0.3	-1.3	0.9	-0.6	-0.3	0.4	-0.7	-0.3	-0.0
Fluid intelligence score	0.7	1.4	2.4	0.9	1.5	0.9	1.5	0.8	1.1	0.0	1.4	1.0	0.2	1.6	1.5	-1.5	0.7	1.5	-1.1	1.5	1.5	0.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	7.2	2.7	1.4	1.7	1.1	1.9	1.6	2.0	1.7	1.7	-0.0	1.4	-0.6	1.0	0.8	1.4	2.0	1.4	1.4	1.8
Noisy workplace	0.7	0.8	5.0	-2.2	-0.6	-0.7	-0.6	-0.7	-0.6	-0.8	-1.3	-0.5	0.7	-0.7	-0.3	1.6	-0.0	-0.7	-0.8	-0.7	-0.7	0.1
Length of working week for main job	0.7	0.8	4.5	2.1	-0.7	-0.3	-0.8	-1.1	-0.2	-0.1	-0.8	-0.7	-1.3	-0.5	-1.5	-0.2	-1.2	-0.5	0.4	-0.8	-0.5	0.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	4.0	1.6	0.8	0.8	1.0	0.4	0.8	0.2	0.4	0.6	-2.0	1.1	1.6	2.0	-0.2	1.0	-0.2	0.9	1.0	0.5
Hypertension (Self-reported)	0.7	1.9	7.2	-1.4	-0.8	-1.3	-0.9	-1.2	-1.4	-1.6	0.4	-0.8	1.9	-1.0	-0.3	-2.7	-1.6	-1.0	-1.6	-1.0	-1.0	-2.1
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.8	-0.4	1.1	1.0	1.1	1.1	0.9	0.3	1.3	0.8	0.5	1.2	0.6	0.8	0.4	1.2	0.4	1.3	1.2	-0.4
Loneliness, isolation	0.7	0.9	7.3	-1.4	-0.7	-0.5	-0.5	-0.3	-0.3	0.3	0.5	-0.3	0.6	-0.9	1.4	2.7	-0.9	-0.8	0.9	-0.5	-0.8	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	3.3	-1.1	0.3	0.3	0.2	-0.3	0.2	1.2	1.8	0.7	1.7	-0.1	0.8	1.7	-0.2	-0.0	1.3	0.2	-0.0	0.2
Back pain experienced in last month	0.7	1.1	2.5	0.2	1.2	1.1	0.9	1.4	1.2	0.9	-0.1	1.1	1.6	1.1	0.7	-0.6	1.1	1.0	1.2	1.2	1.0	0.9
Smoking status: Current	0.7	1.0	8.2	0.8	0.6	0.9	0.9	0.3	1.0	1.1	0.1	0.8	-0.2	0.7	0.6	2.9	0.3	0.7	1.3	0.6	0.7	1.3
Number of self-reported non-cancer illnesses	0.7	1.2	4.8	-0.0	-1.3	-1.4	-1.0	-1.1	-0.6	-1.5	0.2	-1.2	0.1	-1.3	0.1	-2.2	-0.4	-1.2	-1.2	-1.2	-1.2	-1.1
Ever taken oral contraceptive pill	0.7	0.8	1.4	0.5	1.1	1.2	0.8	1.0	0.5	1.0	1.0	1.0	0.2	1.2	0.2	0.1	0.9	1.1	1.1	0.9	1.1	0.8
Lupus	0.6	0.9	1.8	0.6	1.0	1.2	1.0	1.2	0.9	1.4	0.6	1.2	-0.1	1.1	0.5	0.0	1.3	1.0	1.2	0.9	1.0	0.6
Smoking Status	0.6	1.3	9.4	1.5	-0.5	-0.2	-0.4	-1.4	-0.0	-0.0	-1.1	-0.4	-1.3	-0.4	-1.7	3.1	-2.1	-0.3	0.2	-0.6	-0.3	0.4
Cardiovascular Disease	0.6	2.1	5.6	-0.9	-1.2	-1.6	-1.5	-1.3	-1.5	-1.5	0.1	-0.9	1.1	-1.4	-0.7	-2.4	-1.8	-1.5	-1.5	-1.4	-1.5	-2.3
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.7	-0.1	-0.9	-1.0	-1.3	-0.7	-0.2	-0.8	-1.2	-1.0	1.4	-1.1	-1.6	-1.9	-1.2	-1.1	-0.4	-0.8	-1.1	-0.6
Taking other prescription medications	0.6	0.9	2.3	1.0	1.0	0.8	1.1	1.0	1.1	0.6	1.2	1.1	1.5	0.8	1.2	-0.4	0.5	0.9	0.7	1.0	0.9	0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.9	1.4	0.5	1.0	0.8	0.5	0.9	0.9	0.2	0.4	-0.1	0.6	0.9	0.7	0.6	0.6	1.3	0.9	0.6	1.2
Qualifications: CSEs or equivalent	0.6	0.8	5.5	0.3	-0.5	-0.4	-0.6	-0.6	0.5	-0.7	-2.3	-0.7	-1.4	-0.3	-1.7	-0.8	0.2	-0.2	-0.9	-0.3	-0.2	-0.3
Supplements: Glucosamine	0.6	0.8	3.4	-0.8	-0.8	-0.9	-1.2	-0.3	-1.0	-0.4	-1.1	-0.5	-0.1	-1.0	-1.8	0.7	-0.9	-0.9	-0.6	-0.8	-0.9	-0.6
Number of incorrect matches in round	0.6	1.0	6.7	-2.6	-1.1	-0.9	-0.6	-0.8	-0.5	-1.3	-0.1	-1.5	-0.6	-0.9	0.6	1.1	-0.3	-0.9	-0.5	-0.7	-0.9	-0.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.6	0.3	0.9	0.8	0.9	1.0	0.8	1.3	0.8	1.2	-0.3	0.8	0.7	0.3	0.5	0.8	0.8	0.8	0.8	1.1
Medication: Cholesterol lowering	0.6	1.0	2.7	-1.4	-0.8	-1.1	-0.8	-1.0	-0.9	-0.4	0.7	-0.3	0.7	-1.1	0.4	-1.6	-1.0	-1.1	-0.9	-0.9	-1.1	-1.5
Illnesses of mother	0.6	0.7	2.6	1.6	0.6	0.6	0.6	0.9	1.2	1.0	0.3	0.9	-0.2	0.6	0.0	1.3	0.3	0.6	0.8	0.8	0.6	1.3
Exposure to tobacco smoke at home	0.6	0.7	2.6	-0.9	0.8	0.8	0.5	0.3	0.1	1.3	-0.4	0.9	1.1	0.6	0.4	0.9	0.2	0.6	1.6	0.8	0.6	1.4
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.4	0.4	-1.1	-0.7	-1.0	-0.5	-0.8	-0.6	-1.0	-1.2	-0.8	-0.9	-0.5	0.6	-1.1	-0.8	0.2	-1.1	-0.8	-0.4
Angina (self-reported)	0.6	0.8	3.2	1.4	0.8	0.8	0.9	0.1	0.5	1.0	0.6	0.9	1.8	0.6	1.5	-0.6	0.4	0.6	0.8	0.5	0.6	-0.3
Medication: Omeprazole	0.6	0.8	3.4	-1.8	-1.1	-0.8	-0.5	-0.7	-0.6	-1.1	-0.5	-1.2	-0.1	-0.9	0.4	-0.2	-0.4	-0.9	-0.4	-1.0	-0.9	-1.1
Overall health rating	0.6	1.3	5.4	0.1	1.0	0.9	1.0	0.8	1.3	1.4	1.2	1.5	2.3	0.7	1.3	-0.4	1.5	0.7	0.9	0.8	0.7	1.0
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.9	-1.1	-0.8	-1.0	-0.9	-0.9	-0.6	-0.5	0.5	-0.7	0.3	-1.0	-0.2	-0.8	0.0	-1.0	-0.8	-0.9	-1.0	-1.4
Long-standing illness, disability or infirmity	0.6	0.9	4.2	0.2	0.7	0.7	0.8	0.8	0.8	1.0	1.0	0.9	2.0	0.5	1.8	0.3	0.6	0.5	1.3	0.6	0.5	1.1
Friendships satisfaction	0.6	0.7	3.7	-0.3	-0.7	-0.7	-0.9	-1.0	-0.6	-0.8	-1.9	-0.9	0.1	-0.7	-0.6	-0.4	-0.9	-0.7	-0.6	-0.9	-0.7	-1.4
Osteoarthritis (self-reported)	0.6	0.8	2.2	-0.6	-0.9	-1.0	-0.7	-0.4	-0.5	-1.4	-1.0	-1.1	-0.2	-0.9	-0.1	0.7	-0.6	-0.9	-1.0	-0.8	-0.9	-1.5
Guilty feelings	0.6	1.0	5.7	-2.1	0.2	-0.1	0.6	-0.3	0.0	-0.7	0.9	-0.1	2.2	0.1	2.4	-0.4	-0.1	0.1	-0.8	0.1	0.1	-0.8
Mother’s age at death	0.6	0.7	2.6	-1.3	-0.4	-0.3	-0.4	-0.4	-0.9	-0.7	-1.6	-0.7	-1.6	-0.2	-0.8	-1.3	-0.6	-0.2	-0.9	-0.2	-0.2	-0.6
Medication: Paracetamol	0.6	0.9	4.6	-2.1	0.0	-0.4	0.2	0.2	0.2	-0.6	1.2	0.2	1.9	-0.2	1.0	-1.7	1.1	-0.2	-1.3	0.0	-0.2	-0.3
Medication: Lisinopril	0.6	0.8	3.6	0.9	-0.7	-0.8	-1.3	-0.9	-0.4	-0.6	-1.2	-1.0	-0.2	-0.9	-1.9	-1.2	-0.8	-0.9	0.1	-0.7	-0.9	-0.1
Pain experienced in last month	0.6	1.1	8.0	-0.8	-1.0	-0.5	-0.6	-1.1	-0.7	-1.2	-0.5	-1.4	-2.8	-0.5	-1.1	0.5	-0.8	-0.5	-0.9	-0.7	-0.5	-0.6
Pack years of smoking	0.6	0.9	1.4	-1.1	-1.0	-1.1	-1.1	-0.9	-0.8	-1.1	-1.2	-1.0	0.7	-1.0	-0.1	-1.1	-0.9	-1.0	-0.8	-0.9	-1.0	-0.6
Hypothyroidism (self reported)	0.5	1.1	3.7	-0.8	1.1	0.8	1.2	1.1	1.1	0.8	1.9	1.4	0.9	1.1	1.5	0.6	0.5	1.1	0.0	0.9	1.1	0.6
Diabetes (father)	0.5	0.6	3.1	1.4	0.3	0.3	0.3	0.4	0.4	-0.4	-1.1	-0.1	-1.3	0.5	-1.0	-1.8	0.0	0.5	-0.3	0.5	0.5	0.8
Hand grip strength (right)	0.5	1.3	5.7	2.4	1.0	1.3	0.7	1.6	1.3	0.9	0.0	1.0	0.2	1.2	-1.0	-1.2	0.9	1.2	0.8	1.0	1.2	0.1
Multivitamins +/- minerals	0.5	0.7	1.3	-0.1	0.8	0.7	0.9	1.0	0.6	0.8	1.1	1.0	-0.8	0.9	1.0	-0.2	1.0	0.9	-0.0	0.9	0.9	0.8
Diabetes (self-reported)	0.5	0.7	3.9	-1.2	-0.5	-0.8	-0.8	-0.3	-0.1	-0.4	-0.2	-0.3	2.0	-0.9	-0.5	-1.5	-0.9	-0.8	-0.6	-0.6	-0.8	-0.7
Medication: Ramipril	0.5	0.6	2.8	-0.5	-0.5	-0.8	-0.4	-0.8	-1.0	-0.9	0.4	-0.3	-0.9	-0.5	-0.2	-0.7	-1.0	-0.5	-1.7	-0.6	-0.5	-0.9
Worrier / anxious feelings	0.5	0.9	3.3	0.3	0.8	0.9	1.0	1.0	0.9	1.4	1.0	1.3	1.2	0.7	1.8	-0.4	0.4	0.7	1.1	0.7	0.7	0.7
Number of live births	0.5	0.7	3.6	-1.9	0.7	0.3	0.8	0.8	0.1	-0.2	1.6	0.5	1.4	0.6	0.7	0.1	0.8	0.6	-0.8	0.6	0.6	-0.1
Mouth/teeth dental problems: Dentures	0.5	0.8	8.8	-1.1	0.6	0.0	0.6	0.4	0.5	-0.5	1.2	0.3	3.0	0.3	0.5	-0.7	0.7	0.3	-1.1	0.5	0.3	-0.1
Standing height	0.5	5.2	9.6	1.0	2.7	2.3	2.1	3.0	2.8	2.2	1.9	2.8	1.8	2.3	0.6	2.6	1.8	2.3	1.1	2.5	2.3	3.1
Loud music exposure frequency	0.5	0.6	3.2	0.9	-0.3	-0.1	-0.7	-0.0	0.2	0.9	-0.5	-0.0	0.2	-0.6	-1.3	1.8	-0.6	-0.5	1.2	-0.5	-0.5	0.0
Neck or shoulder pain in last month	0.5	0.7	4.9	-1.1	1.0	0.3	0.7	0.7	0.5	0.5	0.4	1.2	2.2	0.6	0.9	-0.7	0.5	0.5	-0.3	0.8	0.5	0.0
Medication: Allopurinol	0.5	0.7	3.7	-1.6	0.4	-0.4	-0.1	-0.4	-0.1	-1.2	-0.5	-0.1	1.5	0.1	-0.0	-0.7	-0.7	0.1	-1.9	0.3	0.1	-0.6
Illnesses of father: Heart disease	0.5	0.7	2.0	1.4	0.6	0.7	0.8	0.5	1.0	0.1	1.2	0.2	1.1	0.7	1.0	-0.6	1.0	0.7	0.8	0.9	0.7	0.4
Wears glasses or contact lenses	0.5	0.6	3.2	1.6	-0.7	-0.3	-0.1	-0.4	-0.3	-0.5	-0.2	-0.8	-1.3	-0.4	0.7	-1.8	-0.1	-0.4	-0.1	-0.6	-0.4	-1.1
Hearing aid user	0.5	0.6	3.1	1.2	0.2	0.3	0.4	1.0	1.8	0.4	1.0	0.1	-0.2	0.3	1.2	0.4	1.1	0.3	0.5	0.6	0.3	0.8
Medication: Blood pressure	0.5	1.0	4.3	-2.1	-0.5	-0.7	-0.5	-0.6	-1.1	-1.9	-0.7	-1.0	0.1	-0.4	-0.3	-0.1	-0.9	-0.4	-1.7	-0.5	-0.4	-1.6
Medication: Atorvastatin	0.5	0.6	1.6	0.1	-1.2	-0.8	-1.0	-0.9	-0.2	-0.1	0.3	-0.6	0.5	-1.3	0.1	0.0	-0.6	-1.2	0.6	-1.1	-1.2	-0.8
Ever smoked	0.5	0.9	5.2	1.5	-0.4	-0.3	-0.4	-1.4	-0.5	0.3	-0.4	-0.1	-1.0	-0.4	-0.8	2.1	-2.3	-0.4	0.2	-0.6	-0.4	0.3
Ever depressed for a whole week	0.5	0.7	3.8	1.9	0.8	0.6	0.6	0.6	0.6	1.1	-0.1	1.1	-0.7	0.7	-0.4	-0.9	0.2	0.7	0.4	0.7	0.7	0.9
Commuting to job workplace: Cycle	0.5	0.7	1.5	-0.2	-0.9	-0.6	-0.7	-1.2	-1.2	-1.1	-0.9	-1.2	-1.1	-0.7	-0.2	0.3	-1.0	-0.7	-0.1	-0.7	-0.7	-0.5
Myopia	0.5	0.8	5.8	2.4	0.0	0.1	-0.3	0.1	-0.0	1.1	-0.8	0.6	-0.8	-0.1	-0.3	-2.1	0.2	0.0	0.9	0.1	0.0	0.4
Schizophrenia (2018)	0.4	0.8	8.6	-1.3	0.1	0.4	0.1	0.4	0.5	0.2	1.0	-0.1	1.2	0.1	0.2	2.9	0.8	0.2	0.9	0.4	0.2	-0.4
Major Depression (MDD)	0.4	0.4	0.8	0.9	0.6	0.7	0.5	0.6	0.7	0.9	0.4	0.7	0.9	0.5	0.7	-0.3	0.6	0.4	0.8	0.7	0.4	0.7
Body Mass Index (BMI) (2010)	0.4	0.5	4.7	-2.2	0.6	0.3	0.4	0.3	0.1	-0.2	-0.7	0.3	1.1	0.5	0.1	1.2	0.6	0.4	-0.3	0.4	0.4	0.4
Triglycerides	0.4	0.6	2.3	-1.3	-0.5	-0.2	-0.3	-1.0	-0.6	-0.1	-0.5	-0.6	0.7	-0.5	0.8	1.5	-1.4	-0.3	0.7	-0.6	-0.3	-0.8
Systolic Blood Pressure	0.4	1.9	7.1	-2.1	-0.0	-0.9	-0.8	-0.4	-1.3	-1.3	-1.7	-0.1	0.5	-0.3	-2.2	-1.2	-2.1	-0.3	-2.7	-0.1	-0.3	-2.2
Neuroticism	0.4	1.0	4.8	0.2	0.6	0.9	0.8	0.9	1.0	1.2	1.0	0.9	2.2	0.6	2.0	0.2	0.1	0.6	1.4	0.6	0.6	0.6
Systolic blood pressure, automated reading	0.4	1.0	3.9	-2.0	-0.1	-0.6	-0.4	-0.4	-1.0	-0.9	-1.1	-0.2	-0.2	-0.2	-1.3	-1.7	-1.2	-0.2	-1.8	-0.2	-0.2	-1.6
Medication: Co-codamol	0.4	0.5	5.1	-0.4	0.5	0.2	0.3	0.4	0.0	0.3	-0.5	0.5	0.9	0.3	0.8	-2.3	0.7	0.3	0.2	0.5	0.3	-0.0
Trunk fat percentage	0.4	1.5	6.7	-2.4	-0.9	-1.3	-0.1	-0.5	-0.1	-1.2	0.3	-0.5	0.1	-0.9	1.2	-1.8	2.6	-0.9	-1.7	-0.9	-0.9	0.2
Maternal smoking around birth	0.4	0.5	1.8	-0.1	-0.8	-0.7	-0.3	-0.2	-0.5	-1.4	-0.7	-1.2	-1.0	-0.6	0.6	-0.6	0.3	-0.5	-0.9	-0.7	-0.5	-0.9
Fed-up feelings	0.4	0.7	4.0	-1.0	-0.8	-0.5	-0.4	-0.5	-0.5	-0.1	-0.9	-0.7	0.1	-0.8	1.3	2.0	-0.6	-0.8	0.5	-0.8	-0.8	-0.0
Stomach or abdominal pain in last month	0.4	0.5	3.2	-1.7	0.4	0.1	0.3	0.2	0.3	-0.1	0.4	0.2	1.8	0.1	0.9	1.2	-0.3	0.1	-0.1	0.3	0.1	0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.6	-1.2	0.2	0.2	0.6	-0.1	0.2	-1.0	0.2	-0.5	0.9	0.3	1.3	-1.0	0.5	0.3	-1.0	0.4	0.3	0.3
Sitting height	0.4	3.1	6.3	2.5	1.9	1.7	1.8	2.1	2.4	1.7	2.1	2.2	0.3	1.8	0.8	0.2	1.3	1.8	0.8	1.7	1.8	2.3
Hip circumference	0.4	1.6	22.9	-0.8	-0.4	-0.5	-0.1	-0.1	-0.1	-0.9	-1.2	-0.3	-0.3	-0.3	-0.5	-4.8	1.6	-0.3	-0.9	-0.3	-0.3	0.3
Falls in the last year	0.4	0.6	6.2	-2.5	-0.2	-0.2	0.3	-0.2	0.1	-1.1	0.7	-0.7	0.5	0.0	0.4	0.9	0.4	0.0	-0.9	-0.0	0.0	-0.2
Happiness	0.4	0.4	1.8	0.3	0.7	0.7	0.5	0.8	1.0	0.6	0.0	0.7	0.3	0.7	0.2	1.4	0.3	0.6	0.7	0.6	0.6	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.5	-1.0	-0.5	-0.6	-0.5	-0.3	-0.9	-0.6	-1.2	-0.5	-1.0	-0.4	-0.2	-1.2	-0.6	-0.4	-0.7	-0.5	-0.4	-0.7
Medication: Paracetamol	0.4	0.6	2.9	-1.4	0.4	0.1	0.5	0.5	0.8	-0.0	1.1	0.4	1.7	0.2	0.4	-1.1	1.4	0.3	-0.4	0.4	0.3	0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	5.1	-1.4	0.7	0.3	0.8	0.7	0.7	0.5	2.3	1.0	1.3	0.6	1.5	-0.4	0.9	0.6	-0.4	0.5	0.6	-0.1
Body fat percentage	0.4	1.4	6.7	-2.0	-0.9	-1.2	-0.1	-0.5	-0.2	-1.1	0.1	-0.5	-0.0	-0.9	1.1	-2.3	2.6	-0.8	-1.5	-0.9	-0.8	0.0
Leg fat percentage (right)	0.4	1.6	9.2	-1.7	-1.2	-1.3	-0.6	-0.7	-0.5	-1.3	-0.5	-1.0	0.2	-1.1	0.3	-3.0	2.0	-1.0	-1.3	-1.1	-1.0	-0.8
Comparative height size at age 10	0.4	2.1	4.6	-0.6	1.6	1.1	1.4	1.8	1.6	1.4	1.9	1.9	2.1	1.2	0.9	1.1	0.9	1.2	0.2	1.5	1.2	2.2
Suffer from ‘nerves’	0.4	0.6	3.5	0.4	0.2	0.5	0.4	0.7	0.7	0.9	0.7	0.3	1.1	0.1	1.4	1.9	-0.4	0.0	1.5	0.2	0.0	0.4
Knee pain experienced in last month	0.4	0.6	1.3	-0.9	-0.9	-0.9	-1.0	0.2	-0.9	-0.6	-1.1	-0.7	0.6	-0.9	-0.5	0.7	-0.2	-0.9	-0.3	-0.9	-0.9	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	2.6	-0.7	-0.3	-0.5	0.1	-0.3	-0.1	-0.2	1.6	0.0	0.4	-0.4	1.1	-1.4	0.2	-0.4	-0.7	-0.3	-0.4	-0.4
Arm fat percentage (left)	0.4	1.7	5.9	-1.9	-1.3	-1.5	-0.4	-1.0	-0.6	-1.3	-0.2	-0.9	-1.1	-1.1	0.8	-2.4	1.9	-1.1	-1.6	-1.3	-1.1	-0.4
Diabetes diagnosed by doctor	0.4	0.6	3.6	-0.4	-0.5	-0.6	-0.8	-0.3	0.2	-0.3	-0.5	-0.3	1.5	-0.7	-0.9	-1.9	-0.7	-0.7	-0.4	-0.5	-0.7	-0.6
Average weekly champagne plus white wine intake	0.4	0.6	3.5	-1.9	-0.2	-0.3	-0.1	-0.3	-0.7	-1.4	0.8	-0.7	0.3	-0.1	0.7	-1.0	-0.1	-0.2	-1.3	-0.2	-0.2	-0.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.0	-0.4	0.8	0.6	0.8	0.4	0.9	0.7	0.2	0.8	0.7	0.7	1.0	0.0	0.8	0.7	0.1	0.8	0.7	1.0
Leg fat percentage (left)	0.4	1.5	6.7	-2.1	-1.1	-1.2	-0.4	-0.6	-0.4	-1.4	-0.6	-0.9	0.3	-0.9	0.7	-2.6	1.9	-0.9	-1.4	-1.0	-0.9	-0.7
Ever had prostate specific antigen (PSA) test	0.4	0.4	2.0	-1.2	-0.6	-0.8	-0.6	-1.4	0.0	-0.0	-0.2	-0.1	-0.2	-0.8	-0.0	0.0	-0.6	-0.8	-0.4	-0.8	-0.8	-0.4
Basal cell carcinoma (self-reported)	0.4	0.5	2.1	-0.2	-0.6	-0.7	-0.6	-0.3	-0.6	-0.4	-1.1	-0.3	-0.0	-0.6	-1.1	-1.4	-0.9	-0.7	-0.7	-0.6	-0.7	-0.5
Neuroticism (Nagel 2018)	0.3	0.7	3.4	-0.3	0.3	0.7	0.5	0.6	0.6	1.2	0.9	0.4	1.5	0.2	1.6	0.7	-0.6	0.2	1.8	0.3	0.2	0.5
Ulcerative Colitis (UC)	0.3	0.5	2.5	1.6	-1.0	-0.9	-0.7	-0.3	-0.2	-0.8	0.8	-0.6	-0.4	-0.9	-0.0	-0.3	-0.3	-0.7	-0.8	-0.7	-0.7	-0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.2	0.1	-0.4	-0.8	-0.3	-1.0	-0.9	-1.1	0.2	-0.7	0.2	-0.5	0.2	-1.4	-0.5	-0.5	-1.5	-0.4	-0.5	-1.3
Prostate Cancer	0.3	0.4	2.6	0.2	-0.4	-0.3	-0.6	-0.5	-0.2	-0.6	-0.8	-0.8	-0.2	-0.4	-1.2	1.6	-0.5	-0.4	0.1	-0.6	-0.4	-0.2
Age at First Birth	0.3	0.5	5.2	-0.2	-0.1	-0.6	0.0	-0.2	-0.4	-0.4	2.3	0.0	0.0	-0.3	0.5	-0.9	-0.2	-0.4	-1.3	-0.2	-0.4	-0.5
Schizophrenia (2014)	0.3	0.6	4.7	-2.2	-0.2	0.1	-0.3	0.1	-0.0	-0.1	0.3	-0.4	1.4	-0.3	-0.2	2.1	0.1	-0.2	0.5	0.2	-0.2	-0.4
Blood White Count	0.3	2.1	6.0	1.3	1.1	1.8	1.2	1.3	1.6	1.6	0.4	1.2	2.2	1.2	1.9	-1.6	0.7	1.2	2.4	1.2	1.2	1.0
Allergy or Eczema	0.3	0.7	3.9	0.9	0.5	0.3	0.2	0.1	0.3	0.5	1.5	0.5	1.4	0.3	1.4	-2.0	0.7	0.3	0.9	0.6	0.3	-0.3
Lung FEV1/FVC ratio	0.3	1.6	3.3	-0.1	-1.6	-1.3	-1.3	-1.2	-1.4	-1.0	-1.5	-1.3	-1.8	-1.4	-1.0	0.7	-0.9	-1.3	-0.6	-1.5	-1.3	-1.5
Number of treatments/medications taken	0.3	0.6	2.5	-1.5	-0.1	-0.6	0.0	-0.3	0.2	-1.2	0.7	-0.3	1.2	-0.2	0.4	-1.5	-0.1	-0.2	-1.6	-0.1	-0.2	-0.8
Average weekly spirits intake	0.3	0.4	1.8	-1.2	-0.5	-0.6	-0.4	-0.8	-0.5	-0.4	0.1	-0.4	-0.8	-0.5	-0.5	1.3	-0.3	-0.5	-0.9	-0.5	-0.5	0.3
Relative age of first facial hair	0.3	0.5	5.8	0.4	-0.2	-0.6	-0.6	-0.4	-0.2	0.6	0.6	0.6	0.6	-0.7	-0.3	-2.4	0.1	-0.7	-0.1	-0.4	-0.7	-0.5
Ever had hysterectomy (womb removed)	0.3	0.3	2.2	-1.5	-0.4	-0.6	-0.4	-0.4	-0.3	-1.0	-0.2	-0.7	-0.1	-0.3	-0.4	0.1	-0.4	-0.4	-0.9	-0.4	-0.4	-0.5
Pack years adult smoking proportion	0.3	0.5	1.2	-0.5	-0.8	-0.8	-0.9	-0.7	-0.7	-0.8	-1.1	-0.7	0.4	-0.8	-0.1	-0.8	-0.7	-0.8	-0.4	-0.7	-0.8	-0.2
Townsend deprivation index at recruitment	0.3	0.4	2.7	0.5	-0.5	-0.2	-0.6	-0.5	-0.2	0.2	-0.7	-0.6	0.1	-0.5	-0.5	1.6	0.0	-0.6	1.1	-0.5	-0.6	0.4
Average weekly fortified wine intake	0.3	0.4	1.1	-0.8	0.9	0.6	0.5	0.6	0.2	0.4	-0.0	0.4	0.5	0.7	-0.5	-0.1	1.1	0.7	0.5	0.7	0.7	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.4	0.0	0.5	0.8	0.6	0.2	0.7	0.3	-0.6	0.3	0.1	0.6	1.2	0.9	0.5	0.6	1.1	0.5	0.6	0.9
Hayfever, allergic rhinitis or eczema	0.3	0.6	4.7	-0.0	0.1	-0.1	0.4	-0.3	-0.4	-0.2	1.8	0.2	0.8	0.0	2.2	-1.5	0.3	-0.1	-0.1	0.1	-0.1	-0.6
Body mass index (BMI)	0.3	1.4	11.6	-1.6	-0.9	-1.0	-0.2	-0.5	-0.4	-1.2	-1.0	-0.7	-0.9	-0.6	0.6	-3.4	1.3	-0.6	-1.3	-0.8	-0.6	-0.8
Nervous feelings	0.3	0.5	3.7	-1.2	-0.1	-0.1	0.0	0.2	0.7	-0.4	0.5	-0.2	1.4	-0.2	0.8	1.9	-0.8	-0.3	-0.5	-0.0	-0.3	-0.3
Neuroticism score	0.3	0.7	5.1	-0.9	-0.0	0.0	0.5	0.0	0.4	0.1	1.2	-0.0	1.8	-0.1	2.3	1.1	-0.5	-0.1	0.3	-0.1	-0.1	-0.1
Impedance of arm (right)	0.3	1.3	9.6	-1.0	0.5	0.2	0.6	0.1	0.4	0.6	2.0	0.6	1.5	0.1	0.9	3.1	1.6	0.1	0.0	0.4	0.1	1.7
Arm fat percentage (right)	0.3	1.3	5.1	-2.1	-0.9	-1.1	-0.0	-0.6	-0.2	-1.0	-0.1	-0.6	-0.7	-0.8	1.0	-2.3	2.2	-0.8	-1.3	-0.9	-0.8	0.1
Breastfed as a baby	0.3	0.4	3.6	1.1	-0.1	-0.0	-0.4	0.4	0.0	0.1	-0.7	-0.3	0.4	-0.1	-1.3	-1.9	-0.3	-0.1	0.5	-0.2	-0.1	-0.3
Peak expiratory flow (PEF)	0.3	0.6	4.9	2.2	0.3	0.6	0.1	0.8	0.5	0.8	0.0	0.3	-0.7	0.3	-1.4	0.5	-0.5	0.3	1.1	0.4	0.3	0.7
Pulse wave reflection index	0.3	0.3	1.3	-0.5	-0.4	-0.2	-0.5	-0.3	-0.4	0.8	-0.1	0.1	1.1	-0.6	0.1	0.7	-0.3	-0.6	1.1	-0.5	-0.6	0.1
Headache pain in last month	0.3	0.5	2.8	1.7	0.4	0.2	0.6	0.2	0.8	0.6	0.5	0.7	-0.3	0.3	0.5	-1.6	0.8	0.3	0.3	0.3	0.3	0.0
Gout (self-reported)	0.3	0.4	2.7	-1.0	0.5	-0.2	0.1	-0.1	0.1	-0.7	-0.3	0.2	1.6	0.2	0.0	-0.3	-0.5	0.2	-1.3	0.3	0.2	-0.3
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.7	-1.3	0.3	0.2	0.3	-0.1	-0.6	-0.8	-1.1	-0.2	-0.4	0.5	0.7	0.9	-0.1	0.5	-0.7	0.4	0.5	-0.6
Exposure to tobacco smoke outside home	0.3	0.4	5.2	-0.2	-0.2	0.1	-0.2	-0.0	0.1	0.1	-0.2	-0.5	0.1	-0.2	-0.2	2.3	0.3	-0.2	0.7	0.0	-0.2	1.1
Medication: Seretide 50 evohaler	0.3	0.4	3.5	0.1	0.3	0.4	0.4	0.8	0.7	-0.1	-0.2	-0.0	0.6	0.4	0.7	1.9	0.4	0.4	0.4	0.5	0.4	0.4
Whole body fat mass	0.3	1.0	6.4	-1.6	-0.6	-0.9	0.0	-0.1	0.2	-1.0	-0.1	-0.2	-0.2	-0.5	0.6	-2.5	2.3	-0.5	-1.5	-0.6	-0.5	0.0
Leg fat mass (right)	0.3	1.1	9.5	-1.3	-0.6	-0.8	-0.1	-0.1	0.2	-0.9	-0.3	-0.4	-0.1	-0.5	0.4	-3.1	2.1	-0.5	-1.3	-0.5	-0.5	-0.1
Number of full sisters	0.3	0.4	2.3	-0.6	-0.6	-0.4	-0.5	-0.3	-0.8	0.2	-0.9	-0.2	-1.5	-0.4	-1.2	-0.7	0.2	-0.4	-0.1	-0.5	-0.4	0.3
Ever had bowel cancer screening	0.3	0.3	2.5	-0.3	0.4	0.4	0.2	0.2	1.0	0.5	-0.6	0.3	1.6	0.2	-0.0	-0.7	0.4	0.2	0.6	0.4	0.2	0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.2	-1.1	0.3	0.3	0.6	0.2	0.1	0.1	1.2	0.4	1.5	0.3	1.5	-0.1	0.2	0.4	0.5	0.5	0.4	0.0
Medication for cholesterol	0.3	0.4	1.2	0.8	0.6	0.6	0.4	0.3	0.6	1.0	-0.5	0.8	1.1	0.4	0.2	0.3	0.4	0.4	1.1	0.4	0.4	0.9
Illnesses of father: None of the above (group 1)	0.3	0.4	1.1	-0.0	-0.7	-0.7	-0.6	-0.2	-0.6	-0.2	-0.8	-0.4	-1.0	-0.7	-0.4	0.3	-0.6	-0.7	-0.8	-0.8	-0.7	-1.0
Miserableness	0.3	0.5	3.1	0.4	0.5	0.3	0.7	-0.0	0.5	1.0	1.0	0.8	1.1	0.2	1.8	0.3	-0.0	0.2	0.7	0.3	0.2	0.2
Financial situation satisfaction	0.3	0.4	0.9	0.6	0.7	0.6	0.8	0.3	0.5	0.7	0.8	1.0	0.6	0.7	0.8	-0.9	0.3	0.7	-0.1	0.3	0.7	-0.2
Commuting to job workplace: Public transport	0.3	0.3	1.6	0.2	0.5	0.3	0.5	0.4	0.3	0.0	0.6	0.3	1.0	0.5	0.9	-1.3	0.1	0.4	0.0	0.6	0.4	0.3
Alcohol drinker status: Never	0.3	0.4	1.8	-1.1	-0.0	0.1	0.3	-0.4	-0.1	-0.2	1.0	-0.4	0.6	0.0	1.3	-1.3	0.3	0.0	0.3	0.1	0.0	-0.9
Arm fat-free mass (left)	0.3	1.4	3.9	0.1	1.3	1.3	1.3	2.0	1.6	0.8	-0.0	1.4	0.1	1.4	0.7	-1.2	1.3	1.4	0.5	1.3	1.4	1.2
Supplements: Calcium	0.3	0.3	1.2	0.5	-0.6	-0.5	-0.5	-0.2	-0.9	-0.2	-0.1	-0.4	-1.1	-0.5	0.2	1.0	-0.5	-0.5	-0.1	-0.5	-0.5	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.5	4.3	-0.9	0.1	0.4	-0.0	0.4	0.3	0.0	0.1	-0.1	1.4	0.1	-0.1	2.1	0.1	0.2	0.8	0.3	0.2	-0.5
Depressed Affect (Nagel 2018)	0.2	0.5	2.9	-0.4	-0.2	0.3	-0.1	-0.0	-0.0	1.0	0.1	-0.0	0.4	-0.3	1.0	1.6	-0.7	-0.3	1.7	-0.2	-0.3	0.7
Irritable Bowel Disease (IBD)	0.2	0.4	2.2	1.5	-0.4	-0.5	-0.0	0.3	0.4	-0.7	1.2	-0.2	0.4	-0.3	0.8	0.5	0.4	-0.3	-0.9	-0.2	-0.3	0.4
Bipolar Disorder (2011)	0.2	0.2	1.4	0.5	-0.1	-0.0	-0.4	0.0	-0.6	0.3	-0.7	0.1	0.3	-0.3	-0.6	-1.2	0.4	-0.2	0.6	-0.0	-0.2	-0.6
Fasting Glucose	0.2	0.2	2.6	-0.3	-0.0	-0.1	-0.1	0.5	-0.1	-0.6	0.3	-0.1	1.6	-0.0	0.8	-0.6	0.5	-0.1	0.2	0.1	-0.1	-0.2
Neuroticism (2016)	0.2	0.3	0.8	-0.5	0.3	0.5	0.4	0.4	0.3	0.9	-0.8	0.4	0.7	0.2	0.8	0.3	-0.1	0.2	0.9	0.3	0.2	-0.1
Blood Platelet Count	0.2	2.0	14.4	-3.8	-0.2	-0.1	0.1	0.5	0.0	-1.2	-0.2	-0.6	3.1	-0.1	2.2	2.1	1.2	-0.2	-0.5	-0.1	-0.2	-1.3
Height	0.2	4.3	12.5	-1.3	2.3	1.5	1.9	2.7	2.4	1.5	2.1	2.7	2.8	1.7	1.1	3.5	1.6	1.7	0.2	2.1	1.7	2.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.1	-0.3	-0.1	-0.3	-0.2	-0.0	0.5	-0.4	1.0	-0.1	0.8	-0.2	-0.2	-1.1	0.4	-0.2	-0.6	-0.1	-0.2	-0.6
Medication: Metformin	0.2	0.3	2.0	-0.3	-0.1	-0.4	-0.7	-0.0	0.2	0.3	-0.4	0.3	1.4	-0.5	-1.1	-0.9	-0.6	-0.5	-0.1	-0.4	-0.5	-0.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.5	-0.4	0.7	0.7	0.7	0.5	0.4	0.4	0.1	0.6	-0.4	0.7	0.2	0.4	-0.1	0.7	0.3	0.6	0.7	0.5
Medication: Levothyroxine sodium	0.2	0.3	2.3	-1.3	0.0	-0.2	0.1	0.1	-0.0	-0.2	1.5	0.0	0.7	-0.0	0.8	-0.2	0.3	-0.0	-0.3	-0.1	-0.0	-0.2
Impedance of leg (left)	0.2	1.0	5.6	0.0	0.6	0.5	0.4	0.5	-0.1	0.8	1.7	0.6	2.3	0.3	0.6	2.4	0.8	0.3	0.6	0.5	0.3	0.7
Trunk fat mass	0.2	1.0	6.4	-1.8	-0.5	-0.9	0.1	-0.0	0.4	-0.9	0.1	-0.2	0.1	-0.5	0.9	-2.0	2.5	-0.5	-1.4	-0.5	-0.5	0.4
Waist circumference	0.2	0.7	6.2	-2.5	-0.3	-0.5	0.2	0.1	0.4	-0.8	0.1	-0.2	-0.9	-0.1	1.1	0.3	1.6	-0.1	-1.0	-0.2	-0.1	-0.7
Heart attack	0.2	0.3	1.7	-0.5	-0.2	-0.0	0.1	-0.8	-0.1	-0.0	1.3	-0.0	0.7	-0.1	1.0	-0.6	-0.5	-0.1	-0.0	-0.1	-0.1	-0.2
Allergy	0.2	0.5	5.0	0.8	0.4	0.5	-0.1	0.9	0.9	0.5	-1.1	0.2	-0.2	0.4	-2.2	0.2	0.1	0.4	0.0	0.4	0.4	0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.8	-0.2	0.5	0.5	0.6	0.3	-0.2	0.0	0.5	0.4	0.8	0.5	0.9	-0.2	0.7	0.5	0.3	0.5	0.5	0.6
Weight	0.2	0.8	4.7	-1.0	0.4	0.1	0.8	0.9	1.0	-0.2	-0.1	0.6	-0.0	0.5	0.8	-2.0	2.2	0.5	-0.7	0.4	0.5	0.7
Trunk fat-free mass	0.2	1.1	2.8	0.9	1.2	1.2	1.0	1.7	1.5	1.0	-0.1	1.2	-0.2	1.2	-0.1	-0.9	0.6	1.2	0.8	1.2	1.2	1.1
Father’s age at death	0.2	0.3	1.1	0.6	-0.5	-0.5	-0.5	-0.3	-0.3	-0.3	-0.5	-0.5	-0.9	-0.5	-1.0	0.7	-0.1	-0.6	-0.6	-0.5	-0.6	0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.3	2.4	-0.0	-0.1	-0.6	-0.2	-0.5	-0.5	-0.6	0.1	-0.2	-0.8	-0.2	0.4	-0.4	-1.5	-0.2	-1.0	-0.3	-0.2	-0.7
Asthma	0.2	0.3	1.3	0.3	-0.5	-0.4	-0.2	-0.8	-0.6	-0.3	-0.5	-0.4	-0.7	-0.4	0.9	1.1	-0.5	-0.4	0.2	-0.6	-0.4	0.2
Impedance of arm (left)	0.2	0.9	7.7	-0.9	-0.2	-0.5	0.0	-0.5	-0.5	0.1	2.0	0.1	0.5	-0.5	0.5	2.8	1.1	-0.5	-0.5	-0.3	-0.5	0.9
Arm fat mass (right)	0.2	1.0	7.1	-1.7	-0.6	-0.7	0.1	-0.1	0.0	-0.7	-0.5	-0.3	-0.6	-0.5	0.7	-2.7	2.0	-0.4	-1.0	-0.6	-0.4	0.1
Trunk predicted mass	0.2	1.2	3.1	1.0	1.2	1.3	1.1	1.8	1.5	1.0	-0.1	1.3	-0.2	1.3	-0.0	-0.9	0.6	1.3	0.8	1.2	1.3	1.2
Medication: Ventolin 100micrograms inhaler	0.2	0.2	1.4	1.2	-0.1	-0.0	-0.1	-0.2	0.3	-0.0	-0.3	0.0	0.2	-0.1	1.0	0.1	0.9	-0.1	0.6	-0.2	-0.1	-0.5
Birth weight	0.2	0.5	2.2	0.2	-0.7	-0.4	0.0	-0.5	-0.6	-1.0	-0.6	-0.8	-1.4	-0.3	-0.2	1.5	0.7	-0.3	-0.7	-0.4	-0.3	0.0
Arm fat-free mass (right)	0.2	1.1	2.9	0.5	1.2	1.1	1.2	1.7	1.3	0.8	0.1	1.4	-0.1	1.3	0.5	-1.1	0.8	1.3	0.3	1.1	1.3	0.9
Worry too long after embarrassment	0.2	0.3	1.2	-0.2	-0.4	-0.5	0.1	-0.4	-0.2	-0.4	0.6	-0.1	-0.5	-0.2	0.9	-0.9	-0.4	-0.3	-1.1	-0.4	-0.3	-0.7
Medication for pain relief, constipation, heartburn	0.2	0.4	2.5	1.6	-0.3	-0.2	-0.6	-0.4	-0.8	0.1	-0.8	-0.1	-1.3	-0.3	-0.7	0.3	-0.4	-0.3	0.2	-0.3	-0.3	-0.8
Migraine (self-reported)	0.2	0.2	1.3	-0.0	-0.3	-0.3	0.3	0.2	0.3	0.0	1.1	-0.0	-1.1	-0.2	0.2	-0.1	0.4	-0.2	-0.3	-0.3	-0.2	0.8
Mean time to correctly identify matches	0.2	0.4	1.6	-1.2	-0.5	-0.6	-0.6	-0.9	-0.4	-0.0	0.1	-0.0	1.2	-0.8	-0.5	-0.2	-0.7	-0.8	0.1	-0.6	-0.8	0.3
Arm predicted mass (right)	0.2	1.1	2.8	0.6	1.2	1.1	1.1	1.7	1.3	0.7	-0.0	1.3	-0.1	1.3	0.5	-1.4	0.9	1.3	0.2	1.1	1.3	0.9
Alcohol intake frequency.	0.2	0.4	2.5	0.4	-0.2	0.0	-0.4	0.1	0.0	0.6	-0.8	0.1	1.2	-0.4	0.4	-0.9	1.6	-0.4	1.0	-0.3	-0.4	-0.7
Supplements: Vitamin C	0.2	0.3	0.7	-0.3	-0.5	-0.7	-0.9	-0.1	-0.6	-0.2	-0.4	-0.4	0.8	-0.7	-0.5	0.5	0.1	-0.7	0.1	-0.5	-0.7	0.2
Whole body fat-free mass	0.2	0.9	2.4	0.5	1.0	0.9	1.0	1.5	1.4	0.6	-0.1	1.1	-0.3	1.1	0.2	-1.0	0.9	1.1	0.3	1.0	1.1	1.2
Average weekly red wine intake	0.2	0.3	2.0	-1.0	-0.0	0.0	-0.3	-0.1	-0.5	0.2	0.8	-0.0	1.4	-0.1	0.2	-0.3	-0.8	-0.2	0.6	-0.1	-0.2	-0.2
Mood swings	0.2	0.4	2.6	0.3	-0.1	0.4	0.0	0.1	0.2	0.9	-0.2	0.1	1.1	-0.1	0.5	1.6	-0.4	-0.1	1.5	-0.2	-0.1	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.5	-0.9	-0.3	-0.2	0.2	0.0	-0.1	-0.7	0.8	-0.4	-0.4	-0.0	1.2	-0.2	0.5	-0.0	-0.4	0.0	-0.0	0.0
Asthma (self-reported)	0.2	0.3	1.1	-0.3	-0.5	-0.5	-0.2	-0.9	-0.9	-0.6	-0.5	-0.5	-0.2	-0.4	1.1	1.0	-0.5	-0.4	0.0	-0.6	-0.4	0.1
Medication: Aspirin	0.2	0.2	1.1	-0.7	-0.1	-0.1	0.2	-0.1	-0.0	-1.1	-0.1	-0.6	-0.0	0.1	-0.2	-1.0	0.1	0.1	-0.9	-0.0	0.1	-0.1
Medication: Gliclazide	0.2	0.2	1.3	0.8	-0.1	0.0	-0.4	-0.1	0.3	0.2	-0.7	-0.2	0.3	-0.1	-1.1	-0.2	-0.4	-0.2	0.6	-0.2	-0.2	0.6
Whole body water mass	0.2	1.0	2.5	0.5	1.0	1.0	1.0	1.6	1.4	0.7	-0.1	1.2	-0.4	1.1	0.2	-1.0	0.9	1.1	0.4	1.0	1.1	1.2
Arm fat mass (left)	0.2	1.0	6.6	-1.6	-0.7	-0.9	-0.1	-0.2	-0.1	-0.8	-0.4	-0.4	-0.7	-0.6	0.7	-2.6	1.9	-0.6	-1.1	-0.7	-0.6	-0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.6	0.3	0.3	-0.1	-0.1	0.4	-0.5	0.1	1.0	0.2	1.3	0.0	-0.2	-0.5	0.2	-0.0	-0.3	-0.1	-0.0	-0.5
Illnesses of father: High blood pressure	0.2	0.2	1.5	0.5	0.3	0.0	0.0	0.3	0.2	-0.1	-0.1	0.4	-0.9	0.3	-0.7	-1.2	0.4	0.3	-0.5	0.3	0.3	-0.3
Fractured/broken bones in last 5 years	0.2	0.2	1.7	-1.3	-0.1	0.2	-0.1	-0.1	0.1	0.1	0.2	-0.4	0.9	-0.1	-0.1	0.8	0.1	-0.2	0.8	-0.1	-0.2	0.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.0	-1.0	-0.6	-0.2	0.2	-0.1	-0.2	-0.7	0.2	-0.7	-1.0	-0.2	1.0	0.3	-0.3	-0.2	-0.4	-0.4	-0.2	-0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.2	1.6	-0.3	-0.1	0.1	0.2	-0.6	-0.0	0.1	1.3	0.0	0.7	-0.1	1.1	-0.1	-0.4	-0.0	0.3	-0.0	-0.0	-0.1
Impedance of whole body	0.2	1.1	7.4	-0.7	0.5	0.1	0.4	0.1	-0.2	0.6	2.3	0.6	1.8	0.0	0.8	2.7	1.3	0.1	-0.0	0.3	0.1	1.1
Leg fat mass (left)	0.2	0.9	7.5	-1.4	-0.4	-0.6	0.1	0.0	0.3	-0.8	-0.3	-0.2	0.2	-0.3	0.6	-2.7	2.1	-0.3	-1.2	-0.4	-0.3	-0.1
Arm predicted mass (left)	0.2	1.2	3.3	0.3	1.2	1.2	1.2	1.8	1.5	0.9	-0.2	1.4	0.1	1.3	0.6	-1.3	1.1	1.3	0.5	1.1	1.3	1.1
Bipolar Disorder (2018)	0.1	0.2	1.4	0.2	0.1	0.0	-0.2	0.2	-0.1	-0.2	-1.2	-0.0	0.8	0.1	-0.4	-0.3	-0.7	0.1	0.1	-0.0	0.1	-0.3
Intelligence (Savage-Jansen 2018)	0.1	0.4	3.1	0.2	0.5	0.0	0.3	-0.1	-0.3	-0.4	0.2	0.3	0.7	0.4	0.3	-1.8	-0.3	0.4	-1.0	0.5	0.4	-0.8
Crohns Disease (2017)	0.1	0.3	0.9	0.6	-0.1	-0.3	0.3	0.4	0.4	-0.6	0.1	-0.1	0.5	-0.0	0.9	0.9	0.6	-0.1	-0.9	-0.1	-0.1	0.8
Reaction Time	0.1	0.3	1.4	-0.3	0.4	0.3	0.3	0.2	0.2	0.8	0.6	0.9	1.2	0.2	-0.0	0.3	-0.0	0.2	0.6	0.3	0.2	0.9
Crohns Disease (2012)	0.1	0.1	1.0	0.4	-0.2	-0.4	-0.0	0.3	-0.1	-0.5	0.5	-0.0	-0.7	-0.1	-0.1	-0.0	0.2	-0.2	-1.0	-0.2	-0.2	0.1
HbA1C	0.1	0.2	1.0	0.4	-0.1	-0.2	-0.4	0.1	0.2	0.3	-0.3	0.0	-0.4	-0.2	-1.0	0.8	-0.7	-0.1	0.3	-0.1	-0.1	-0.0
Rheumatoid Arthritis	0.1	0.1	0.4	-0.6	0.1	-0.2	0.2	0.2	-0.2	0.1	-0.3	0.3	0.1	-0.0	0.5	0.1	0.3	-0.1	-0.3	-0.1	-0.1	0.4
Blood Eosinophil Count	0.1	0.8	2.3	1.2	-1.0	-0.5	-0.8	-0.3	0.1	-0.9	-0.7	-1.1	-1.2	-0.8	0.2	-1.5	0.1	-0.8	-0.3	-0.8	-0.8	-1.4
BMI	0.1	0.8	5.8	-1.1	-0.3	-0.2	0.4	0.3	0.6	-0.9	-0.2	-0.3	-0.1	0.1	0.7	-2.4	2.1	-0.1	-0.6	-0.3	-0.1	-0.5
Respiratory disease	0.1	0.3	1.4	-0.2	-0.6	-0.5	-0.4	-0.8	-0.5	-0.8	-0.0	-0.6	0.0	-0.4	1.2	0.3	-0.3	-0.5	-0.0	-0.5	-0.5	-0.3
Lung FVC	0.1	0.7	2.8	0.6	0.7	1.1	0.6	0.8	0.6	1.2	0.5	0.8	0.1	0.8	-0.6	0.3	0.1	0.9	1.7	0.7	0.9	0.7
Hair Pigment	0.1	1.7	5.8	1.7	0.9	1.4	1.1	1.2	1.0	1.5	0.4	1.1	-0.6	1.1	1.9	0.8	1.2	1.1	2.4	1.1	1.1	1.5
Tanning	0.1	0.7	8.4	1.1	-0.1	0.1	0.0	-0.2	0.4	0.2	0.4	-0.3	0.1	-0.1	0.8	2.9	-1.0	-0.1	0.7	-0.1	-0.1	-0.2
Sensitivity / hurt feelings	0.1	0.2	1.7	0.3	0.1	0.4	0.5	0.1	0.6	0.4	-0.5	0.1	0.3	0.2	0.8	1.3	-0.1	0.2	0.6	0.1	0.2	0.5
Vitamin and mineral supplements	0.1	0.1	0.5	0.7	0.4	0.5	0.3	0.1	0.5	0.3	-0.6	0.4	0.3	0.3	-0.2	0.0	-0.0	0.4	0.3	0.3	0.4	-0.1
Impedance of leg (right)	0.1	0.6	3.9	0.5	0.2	0.2	-0.1	0.1	-0.5	0.7	1.6	0.3	2.0	-0.2	-0.0	1.6	0.7	-0.2	0.6	0.1	-0.2	0.4
Leg fat-free mass (left)	0.1	0.4	2.1	-0.1	0.2	0.1	0.4	0.8	1.0	0.0	-0.3	0.5	-0.8	0.4	-0.1	-1.4	1.1	0.4	-0.6	0.3	0.4	0.8
Relative age voice broke	0.1	0.1	0.8	-0.5	0.1	-0.0	-0.3	-0.2	-0.1	0.9	0.3	0.6	0.7	-0.3	-0.1	-0.3	0.2	-0.3	0.5	0.1	-0.3	-0.1
Leg predicted mass (left)	0.1	0.5	1.9	-0.1	0.4	0.3	0.5	0.9	1.1	0.1	-0.2	0.7	-0.8	0.5	0.0	-1.4	1.2	0.5	-0.4	0.4	0.5	1.0
Had other major operations	0.1	0.2	0.6	-0.6	-0.3	-0.3	-0.2	-0.3	-0.4	0.6	0.6	0.1	-0.1	-0.5	0.6	0.1	-0.1	-0.4	0.8	-0.4	-0.4	0.1
Hair/balding pattern: Pattern 3	0.1	0.2	1.0	-0.5	0.2	0.2	0.4	0.4	0.2	-0.2	0.1	0.1	0.3	0.4	0.8	-1.0	0.7	0.4	-0.0	0.3	0.4	-0.1
Hair/balding pattern: Pattern 4	0.1	0.3	2.1	0.3	-0.0	-0.2	-0.2	-0.9	-1.2	-0.1	0.1	-0.1	0.7	-0.2	-0.7	-0.2	-1.4	-0.2	-0.3	-0.1	-0.2	-0.8
Birth weight of first child	0.1	0.3	1.1	0.2	-0.3	-0.2	0.2	-0.5	-0.5	-0.6	-0.5	-0.5	-1.0	-0.1	0.1	0.9	-1.0	-0.1	-0.6	-0.3	-0.1	0.2
Qualifications: College or University degree	0.1	0.2	1.1	-0.4	0.5	-0.2	-0.1	-0.0	-0.6	-1.0	-0.5	-0.1	0.4	0.3	-0.3	-0.4	-0.6	0.3	-1.1	0.3	0.3	-0.5
Family relationship satisfaction	0.1	0.2	1.0	-0.2	-0.3	-0.1	-0.2	-0.4	0.1	0.2	-0.2	-0.2	1.0	-0.4	0.3	0.4	-0.6	-0.3	0.6	-0.4	-0.3	-0.0
Medication: Aspirin	0.1	0.2	0.8	-0.5	0.2	0.2	0.5	0.1	0.3	-0.7	-0.3	-0.3	0.1	0.4	0.1	-0.9	0.5	0.4	-0.5	0.3	0.4	0.1
Leg fat-free mass (right)	0.1	0.6	1.8	-0.2	0.7	0.5	0.8	1.2	1.3	0.2	-0.1	0.9	-0.6	0.8	0.3	-0.8	1.2	0.8	-0.3	0.7	0.8	1.2
Commuting to job workplace: Walk	0.1	0.1	0.2	0.4	0.4	0.3	0.2	0.0	0.1	0.2	0.1	0.4	-0.2	0.3	-0.4	0.5	0.1	0.3	0.2	0.3	0.3	0.2
Leg predicted mass (right)	0.1	0.6	1.7	-0.2	0.7	0.6	0.8	1.2	1.3	0.2	-0.2	0.9	-0.7	0.8	0.3	-0.8	1.2	0.8	-0.3	0.7	0.8	1.2
Basal metabolic rate	0.1	0.7	1.9	0.1	0.8	0.7	0.9	1.4	1.3	0.5	-0.1	1.0	-0.3	0.9	0.3	-1.2	1.2	0.9	0.0	0.8	0.9	1.0
Average weekly beer plus cider intake	0.1	0.1	0.5	-0.3	0.1	0.4	0.2	-0.0	0.3	-0.2	-0.0	-0.1	-0.6	0.4	-0.7	0.1	-0.5	0.4	-0.4	0.2	0.4	0.5
Diastolic blood pressure, automated reading	0.1	0.3	1.5	-1.2	-0.1	0.1	0.2	0.6	-0.4	-0.3	-0.2	-0.3	-0.8	0.2	0.3	-1.0	0.7	0.2	-0.3	-0.2	0.2	-1.0

Hub : Genes

CEP89

Models

Trait associations