[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr20:32,819,871-34,556,216

Best TWAS P=3.11e-10 · Best GWAS P=1.18e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	EDEM2	0.09	0.09	enet	12	0.09	5.8e-11	6.0	-5.4	7.1e-08	-0.76	0.02	0.98	FALSE
2	GTEx	Adipose Subcutaneous	EDEM2	0.10	0.07	lasso	9	0.07	2.1e-06	6.0	-5.8	7.0e-09	-0.75	0.03	0.97	FALSE
3	GTEx	Adipose Subcutaneous	TRPC4AP	0.06	0.01	lasso	6	0.01	3.8e-02	-3.3	-5.4	6.2e-08	-0.80	0.03	0.87	FALSE
4	GTEx	Adipose Subcutaneous	PROCR	0.13	0.05	enet	4	0.05	8.2e-05	6.0	-5.7	1.2e-08	-0.81	0.02	0.97	FALSE
5	GTEx	Artery Aorta	MYH7B	0.22	0.08	lasso	6	0.09	1.3e-05	6.1	5.5	2.9e-08	0.92	0.01	0.99	FALSE
6	GTEx	Artery Aorta	EDEM2	0.13	0.08	enet	10	0.07	6.3e-05	5.1	-5.4	8.5e-08	-0.93	0.02	0.98	FALSE
7	GTEx	Artery Tibial	MYH7B	0.14	0.10	lasso	10	0.12	2.9e-09	6.1	5.4	5.9e-08	0.91	0.01	0.99	FALSE
8	GTEx	Artery Tibial	EDEM2	0.14	0.10	lasso	6	0.08	1.1e-06	6.0	-5.9	3.6e-09	-0.85	0.02	0.98	FALSE
9	GTEx	Brain Caudate basal ganglia	GSS	0.20	0.16	lasso	8	0.11	4.3e-04	6.1	5.9	3.0e-09	0.97	0.02	0.80	FALSE
10	GTEx	Brain Cerebellar Hemisphere	MYH7B	0.18	0.10	lasso	5	0.08	3.7e-03	6.1	6.3	3.1e-10	0.98	0.02	0.96	TRUE
11	GTEx	Brain Cerebellum	MYH7B	0.26	0.30	lasso	4	0.26	2.2e-08	6.1	6.2	6.6e-10	0.99	0.01	0.99	FALSE
12	GTEx	Brain Cerebellum	GSS	0.19	0.12	enet	15	0.19	2.9e-06	6.1	5.4	7.9e-08	0.90	0.02	0.93	FALSE
13	GTEx	Brain Cerebellum	PROCR	0.29	0.01	enet	34	0.13	1.1e-04	-1.7	5.3	1.5e-07	0.52	0.04	0.27	FALSE
14	GTEx	Cells EBV-transformed lymphocytes	EDEM2	0.15	0.17	lasso	4	0.15	1.3e-05	6.0	-6.0	2.6e-09	-0.82	0.02	0.96	FALSE
15	GTEx	Esophagus Mucosa	MYH7B	0.11	0.03	enet	20	0.03	2.2e-03	6.1	5.4	6.4e-08	0.86	0.01	0.96	FALSE
16	GTEx	Heart Left Ventricle	PROCR	0.10	0.04	enet	8	0.05	1.6e-03	6.0	-5.6	2.3e-08	-0.76	0.03	0.88	FALSE
17	GTEx	Lung	MYH7B	0.06	0.03	lasso	3	0.03	1.6e-03	4.4	5.1	3.0e-07	0.75	0.03	0.94	FALSE
18	GTEx	Nerve Tibial	MYH7B	0.21	0.12	lasso	8	0.12	9.7e-09	6.1	5.4	5.8e-08	0.92	0.01	0.99	FALSE
19	GTEx	Pancreas	EDEM2	0.20	0.23	lasso	8	0.23	3.5e-10	6.0	5.7	1.1e-08	0.83	0.02	0.98	FALSE
20	GTEx	Pancreas	PROCR	0.40	0.13	lasso	13	0.18	5.4e-08	6.0	5.4	6.3e-08	0.75	0.03	0.97	FALSE
21	GTEx	Spleen	PROCR	0.35	0.31	lasso	6	0.29	4.8e-08	6.0	6.1	1.2e-09	0.80	0.02	0.97	FALSE
22	GTEx	Thyroid	MYH7B	0.06	0.03	enet	15	0.06	3.6e-05	4.3	5.2	1.8e-07	0.77	0.07	0.92	FALSE
23	GTEx	Thyroid	EDEM2	0.13	0.04	enet	13	0.08	4.9e-07	6.1	-5.9	3.5e-09	-0.93	0.01	0.99	FALSE
24	METSIM	Adipose	EDEM2	0.04	0.05	lasso	2	0.04	3.9e-07	6.0	-6.0	2.5e-09	-0.82	0.02	0.98	FALSE
25	METSIM	Adipose	TRPC4AP	0.04	0.03	lasso	5	0.04	1.1e-06	6.1	-5.3	1.0e-07	-0.92	0.01	0.99	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	EDEM2	0.10	0.08	lasso	5	0.07	2.0e-09	6.0	-6.1	1.2e-09	-0.87	0.02	0.98	FALSE
27	YFS	Blood	EDEM2	0.08	0.09	lasso	4	0.10	1.2e-29	6.0	-5.2	1.7e-07	-0.88	0.02	0.98	FALSE