Hub : Genes

TRPC4AP

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.0560 0.0320 0.00610 0.014 NA 0.009 NA 0.011 2.2e-02 NA 5.6e-02 NA 3.9e-02
2 GTEx Breast Mammary Tissue (Female) 0.1827 0.0900 0.01600 0.004 NA 0.018 NA -0.003 2.3e-01 NA 9.5e-02 NA 3.9e-01
3 GTEx Cells Transformed fibroblasts 0.0570 0.0310 0.00920 0.010 NA 0.000 NA 0.012 5.4e-02 NA 3.4e-01 NA 4.2e-02
4 GTEx Lung 0.0727 0.0345 0.00620 -0.003 NA -0.004 NA -0.003 6.8e-01 NA 9.6e-01 NA 6.6e-01
5 GTEx Thyroid 0.0980 0.0490 0.00440 0.054 NA 0.020 NA 0.042 5.9e-05 NA 1.1e-02 NA 3.7e-04
6 GTEx Whole Blood 0.0960 0.0490 0.00780 0.033 NA 0.011 NA 0.018 4.5e-04 NA 3.3e-02 NA 7.9e-03
7 METSIM Adipose 0.0420 0.0178 0.00002 0.032 0.038 0.034 0.039 0.040 1.3e-05 1.9e-06 6.8e-06 1.6e-06 1.1e-06
8 ROSMAP Brain Pre-frontal Cortex 0.0536 0.0244 0.00220 0.029 0.027 0.022 0.029 0.030 1.1e-04 1.8e-04 7.0e-04 1.1e-04 8.7e-05
9 YFS Blood 0.2118 0.0409 0.00000 0.158 0.212 0.216 0.217 0.217 3.0e-49 2.2e-67 7.2e-69 2.5e-69 2.8e-69
10 TCGA Head and Neck Squamous Cell Carcinoma 0.0457 0.0274 0.00026 0.028 0.028 0.035 NA 0.030 3.9e-04 3.8e-04 7.1e-05 NA 2.6e-04
11 TCGA Thyroid Carcinoma 0.0390 0.0240 0.00470 0.028 0.023 0.018 NA 0.022 8.0e-04 2.6e-03 7.0e-03 NA 3.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 4.4 7.0 18.8 -3.4 -1.6 -3.5 -1.1 -2.4 -0.4 -4.3 -0.1 3.4 -3.2 -1.6
Bipolar Disorder or Schizophrenia 3.1 7.6 23.1 -4.3 -1.7 -2.9 -0.4 -1.0 0.7 -4.8 1.0 3.8 -2.8 -2.4
Depressed Affect (Nagel 2018) 0.6 1.3 3.3 -0.1 1.5 1.3 1.8 1.4 1.1 0.6 1.4 0.2 0.9 -0.8
Depression (Nagel 2018) 1.9 2.9 6.4 -0.6 2.5 2.0 2.2 2.5 1.4 0.5 1.8 0.5 1.8 -1.0
Intelligence (Savage-Jansen 2018) 0.8 2.3 8.2 -2.9 2.8 -0.7 -0.1 0.3 0.3 -2.1 0.3 1.8 -1.0 -0.8
Neuroticism (Nagel 2018) 1.3 3.1 8.8 -0.6 1.8 2.8 2.0 3.0 0.8 1.3 1.1 -0.6 2.4 0.0
Schizophrenia (2018) 1.3 2.6 7.7 -2.8 -0.9 -0.9 0.4 0.6 1.2 -2.7 1.4 2.1 -1.0 -1.8
Schizophrenia vs Biploar Disorder 1.0 1.4 2.7 0.5 -1.4 1.6 0.3 1.6 0.3 1.4 0.1 -1.6 1.6 0.6
Worry (Nagel 2018) 1.5 3.1 11.4 -2.0 1.3 2.9 0.6 3.4 -0.4 0.2 -0.3 -0.8 2.5 1.0
Alzheimer’s Disease (in mother) 0.3 0.4 1.4 -1.1 0.3 0.9 0.6 1.2 0.2 -0.3 0.2 0.1 0.6 -0.0
Alzheimer’s Disease (in father) 1.9 2.1 5.8 0.2 -2.4 -0.8 -1.6 -1.4 -2.1 0.1 -1.9 -1.2 -0.5 1.4
Alzheimer’s Disease (including proxy) 0.9 1.4 3.1 0.2 -1.2 0.2 -1.2 -0.5 -1.8 0.5 -1.7 -1.7 0.4 1.6
Crohns Disease (2017) 0.2 0.4 1.7 0.9 0.2 -0.8 -0.3 -1.2 0.3 -0.1 -0.1 0.2 -1.3 -0.3
Irritable Bowel Disease (IBD) 0.4 1.0 2.8 -1.3 -0.0 -0.7 -1.7 -0.5 -1.0 -1.4 -1.4 0.3 -0.6 0.8
Ulcerative Colitis (UC) 1.4 2.6 7.7 -2.8 -0.6 -0.5 -2.3 0.4 -1.8 -2.3 -2.1 0.3 -0.1 1.4
Major Depression (MDD) 1.1 1.3 3.5 -0.3 0.1 0.5 1.9 1.1 1.6 -0.2 1.7 1.0 0.3 -1.6
Reaction Time 0.5 0.9 1.7 1.1 -1.2 -0.1 1.1 -0.7 0.8 1.2 1.3 0.0 -0.3 -1.1
Verbal and Numeric Reasoning (VNR) 1.2 3.0 12.9 -3.6 1.3 -0.7 -0.0 0.8 0.6 -3.1 0.3 2.3 -1.0 -1.0
Breast Cancer 0.5 1.2 4.3 1.0 1.1 -1.7 -0.1 -2.1 0.5 0.0 0.4 0.3 -1.9 -0.6
Ovarian Cancer 0.2 0.3 1.1 0.5 0.2 -0.7 0.0 -0.9 -0.5 0.0 -0.3 -0.2 -1.1 -0.1
Prostate Cancer 2.5 3.5 7.6 2.6 -0.6 2.5 1.8 1.8 0.7 2.8 1.0 -1.8 2.4 0.0
Age at First Birth 0.9 1.3 6.9 -2.6 -0.8 0.2 -0.9 1.2 -0.3 -1.8 -0.6 0.6 0.4 0.4
Bipolar Disorder (2011) 7.4 7.2 18.4 -3.2 -0.3 -3.9 -2.1 -2.9 -0.9 -4.3 -1.2 2.9 -3.3 -0.8
Body Mass Index (BMI) (2010) 0.7 1.0 1.8 -1.0 -0.7 0.1 1.1 0.9 1.3 -1.3 1.2 0.8 -0.8 -1.1
Coronary Artery Disease (CAD) 4.0 4.8 10.1 -3.2 -0.2 -0.6 2.5 1.6 3.0 -1.7 2.7 2.5 -0.3 -2.7
Crohns Disease (2012) 0.3 0.4 1.8 -0.0 0.5 -0.7 -0.6 -0.7 -0.4 -0.5 -0.7 0.2 -1.3 0.2
Mean Putamen Volume 0.6 0.7 2.8 -0.8 -1.1 -1.0 -0.9 -0.3 -0.5 -1.7 -0.6 0.5 -0.8 -0.1
Fasting Glucose 0.7 0.8 1.9 -0.9 -0.4 -1.0 -1.3 -0.4 -1.1 -1.4 -0.9 0.1 -0.8 0.7
HbA1C 0.7 0.8 3.2 0.9 -0.1 -1.3 -0.6 -1.8 -0.1 0.0 -0.3 0.1 -1.5 -0.2
HDL Cholesterol 1.3 2.1 12.5 3.5 0.2 -0.0 0.3 -1.2 0.4 2.7 0.5 -1.1 0.2 0.1
LDL Cholesterol 0.5 0.7 5.6 0.7 -2.4 -0.4 -0.1 -1.1 0.0 0.3 -0.0 -0.1 -0.6 -0.2
Lupus 1.1 1.6 5.2 -1.0 -0.8 -0.2 -2.3 0.1 -1.5 -0.9 -2.1 -0.5 0.9 1.6
Neuroticism (2016) 1.0 1.4 3.6 0.1 0.9 1.9 1.5 1.7 0.6 1.1 1.0 -0.1 1.8 -0.4
Primary Biliary Cirrhosis 0.9 1.2 2.9 0.7 0.1 0.5 -1.0 0.1 -1.7 0.8 -1.5 -1.6 1.0 1.6
Rheumatoid Arthritis 3.0 4.1 13.5 3.0 0.6 2.1 0.2 0.7 0.1 3.7 -0.1 -2.8 2.8 1.4
Schizophrenia (2014) 1.1 2.3 7.6 -2.5 -0.7 -1.8 -0.5 -0.4 0.3 -2.8 0.6 1.9 -1.5 -1.2
Triglycerides 1.3 2.0 5.4 -0.6 -2.3 -1.7 -1.4 -1.9 -1.3 -1.6 -1.1 0.0 -1.6 0.4
Type 2 Diabetes (T2D) (2012) 1.4 1.6 5.4 -2.3 0.0 -1.5 -0.9 -0.2 -1.1 -2.1 -1.3 1.2 -0.7 0.2
Ulcerative Colitis 1.5 2.2 5.4 -1.9 -0.1 -0.6 -2.3 -0.3 -2.2 -1.7 -2.0 0.2 -0.5 1.4
Blood Eosinophil Count 0.3 2.4 5.7 -0.6 0.9 -1.5 1.0 -0.1 1.5 -1.7 1.6 1.9 -2.4 -2.1
Blood Platelet Count 0.3 3.9 11.7 -2.9 1.6 -2.3 -1.1 -0.5 -1.1 -3.4 -1.0 2.4 -2.5 -0.3
Blood Red Count 0.3 3.2 17.7 -4.2 -0.9 -0.3 -0.4 1.7 -0.6 -3.1 -0.4 1.7 -0.3 -0.3
Blood White Count 0.4 2.7 8.0 -2.8 -1.7 0.7 1.5 2.3 0.8 -2.5 1.3 1.3 0.2 -1.0
Heel T-Score 4.2 33.4 121.0 -11.0 -2.1 -4.2 0.6 1.0 1.7 -10.4 1.9 7.8 -5.2 -4.5
BMI 2.0 11.4 24.1 -1.7 -0.3 -2.9 3.3 -1.2 3.9 -3.0 4.3 4.7 -3.6 -4.9
Height 5.8 111.8 252.8 -15.9 6.8 6.4 -12.7 10.6 -10.4 -11.1 -13.3 -2.9 7.3 12.1
Waist Hip Ratio (WHR) 1.7 7.9 26.8 5.2 0.5 2.6 2.2 1.0 0.3 5.1 0.8 -3.3 2.9 0.8
Systolic Blood Pressure 1.3 6.6 13.1 -2.1 1.6 -3.6 -3.1 -2.8 -1.8 -3.4 -2.1 1.7 -3.4 0.5
Smoking Status 1.3 3.0 10.7 3.0 0.1 1.8 1.4 0.6 0.7 3.3 0.6 -1.7 2.0 0.3
Allergy or Eczema 0.7 1.8 4.5 -2.1 0.5 -0.6 -1.8 -0.2 -1.6 -2.1 -1.5 0.1 -0.4 1.4
Cardiovascular Disease 1.1 3.8 11.4 0.5 1.0 0.3 2.7 0.7 3.4 -0.1 3.2 1.6 -0.2 -2.7
Hypothyroidism (self reported) 0.7 1.5 5.5 0.7 -2.4 -0.8 -1.4 -1.2 -1.6 -0.4 -0.8 -1.0 -1.1 1.1
Respiratory disease 0.4 0.9 2.3 -1.2 0.7 0.2 -1.2 0.2 -1.0 -0.8 -1.3 -0.7 0.3 1.5
Type 2 Diabetes (T2D) (2018) 0.3 0.6 2.5 -0.3 1.6 -1.0 0.1 -0.7 0.3 -0.8 0.2 0.8 -1.1 -0.6
Lung FEV1/FVC ratio 1.6 7.9 15.1 -3.2 -2.2 1.0 -3.5 2.5 -3.6 -2.8 -3.9 -1.5 1.8 3.5
Lung FVC 5.8 29.3 79.9 7.8 -3.5 6.6 4.7 3.8 1.1 8.9 2.2 -6.2 6.6 1.1
Neuroticism 1.5 3.6 10.7 -1.1 1.8 2.9 2.2 3.3 1.2 1.0 1.6 0.1 2.5 -0.6
Chronotype (morning person) 1.4 3.2 8.5 -1.7 -0.4 0.2 -2.5 0.6 -2.8 -1.4 -2.9 -1.2 0.3 2.4
Hair Pigment 17.8 508.6 1623.8 -1.0 7.1 37.3 22.5 40.3 11.1 22.8 11.5 -13.8 32.6 0.7
Tanning 36.0 440.0 1346.9 0.2 -5.7 -34.0 -23.0 -36.7 -12.4 -21.6 -12.7 11.3 -29.4 1.1
Hand grip strength (left) 3.3 8.8 30.8 -5.5 -0.4 0.0 -3.7 1.3 -2.9 -4.9 -3.5 0.7 -0.6 2.3
Number of treatments/medications taken 1.1 2.0 6.1 -0.1 -0.3 2.4 1.3 2.5 -0.1 0.8 0.9 -1.5 2.0 0.8
Average weekly spirits intake 0.5 0.6 1.5 -0.3 -1.2 0.9 1.2 1.2 0.6 0.1 0.9 0.1 0.5 -0.5
Sensitivity / hurt feelings 3.2 5.4 14.1 1.0 -1.4 3.8 2.1 3.3 0.3 2.8 0.9 -2.1 3.7 0.7
Frequency of depressed mood in last 2 weeks 2.6 3.7 8.1 1.1 2.4 2.4 2.9 2.0 1.4 2.0 2.1 -0.4 2.0 -0.9
Hearing difficulty/problems: Yes 0.6 0.9 1.8 -0.9 -0.2 0.7 -0.8 0.9 -1.3 -0.1 -1.2 -0.7 1.0 1.3
Relative age of first facial hair 1.4 2.9 13.3 3.6 -0.4 0.9 0.7 0.0 0.5 3.3 0.4 -1.8 1.6 0.5
Other serious medical condition/disability diagnosed by doctor 5.1 6.6 17.1 0.7 -2.2 4.0 1.6 4.0 -0.0 2.4 0.7 -2.8 4.1 1.3
Ever used hormone-replacement therapy (HRT) 0.5 0.6 2.0 -1.2 -1.4 0.2 -0.2 0.8 -1.2 -1.0 -0.3 -0.1 0.0 0.2
Ever had hysterectomy (womb removed) 0.2 0.2 1.0 1.0 -0.8 0.4 0.2 -0.4 -0.5 0.2 0.2 -0.6 -0.1 -0.0
Systolic blood pressure, automated reading 2.6 7.6 22.1 -4.1 -0.1 -3.3 -2.8 -1.5 -2.2 -4.7 -2.0 2.1 -3.3 0.4
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.4 0.9 1.6 1.2 1.0 0.6 0.3 1.3 0.5 -0.6 1.1 -0.0
Angina 1.7 2.2 4.6 -1.0 0.7 -0.2 2.1 0.7 2.1 -1.5 2.2 1.6 -0.9 -1.8
Medication for hormone replacement therapy 0.2 0.2 0.8 0.4 -0.5 -0.5 -0.6 -0.4 -0.9 -0.3 -0.4 -0.2 -0.4 0.4
Vitamin and mineral supplements 1.3 1.8 3.2 1.1 1.3 -0.9 1.3 -1.6 1.8 1.0 1.7 1.3 -0.9 -1.6
Supplements: Zinc 3.2 3.4 8.5 -1.3 0.8 -2.8 -1.8 -2.2 -1.3 -2.6 -1.2 1.2 -2.9 -0.0
Medication: Co-codamol 2.3 2.7 6.1 1.1 0.1 2.4 2.2 2.5 0.7 2.0 1.4 -1.0 2.1 -0.1
Medication: Metformin 0.4 0.6 2.6 0.1 1.6 -0.8 -0.2 -1.0 0.0 -0.4 0.1 0.5 -1.3 -0.3
Diabetes (father) 2.0 2.5 7.0 -0.4 0.2 -2.6 -0.7 -2.5 -0.1 -1.7 -0.2 1.9 -2.5 -1.0
Diabetes (mother) 1.8 2.3 7.7 -2.8 -0.1 -1.4 -1.2 -0.4 -1.6 -2.7 -1.0 1.2 -1.4 0.1
Severe depression (siblings) 1.3 1.5 6.7 -1.9 -2.6 0.1 -0.3 0.8 -1.4 -1.5 -0.6 0.3 0.8 0.5
Pack years adult smoking proportion 1.7 2.6 7.2 -1.0 -1.4 1.9 -0.9 2.1 -1.3 -0.1 -1.2 -1.5 2.7 2.0
Impedance of leg (right) 0.8 3.9 9.2 2.7 -1.3 2.0 2.6 1.2 1.9 3.0 2.0 -1.2 1.6 -0.9
Leg fat-free mass (left) 2.9 15.6 57.8 -7.6 2.8 -0.6 -4.7 1.7 -2.9 -6.8 -4.0 1.8 -0.4 2.6
Trunk fat percentage 1.4 5.7 14.5 -1.2 -0.0 2.0 3.8 3.2 3.2 -0.2 3.7 1.3 0.9 -2.5
Hand grip strength (right) 3.8 10.3 37.1 -6.1 0.1 -0.3 -4.1 1.1 -2.9 -5.3 -3.7 1.1 -0.8 2.4
Townsend deprivation index at recruitment 2.6 3.7 12.9 3.6 -0.4 1.4 2.2 0.6 0.9 3.5 1.5 -1.3 1.8 -0.4
Current tobacco smoking 1.6 2.6 6.9 2.5 0.4 1.9 1.7 1.2 0.6 2.6 0.8 -1.3 2.1 0.1
Average weekly fortified wine intake 1.4 1.7 4.5 -1.0 -0.6 -1.0 -1.9 -1.3 -2.1 -0.7 -1.8 -0.2 -1.0 1.3
Maternal smoking around birth 3.3 4.7 11.7 3.0 -0.9 2.7 0.6 1.6 0.3 3.4 0.1 -3.0 3.1 1.2
Fed-up feelings 1.7 3.1 8.5 0.4 2.3 0.8 2.9 0.8 2.3 0.8 2.6 1.2 0.4 -2.2
Frequency of unenthusiasm / disinterest in last 2 weeks 3.3 4.4 10.7 0.2 2.1 3.0 2.7 3.3 1.4 1.5 1.9 -0.2 2.8 -0.9
Relative age voice broke 0.9 1.4 4.4 1.5 -0.8 1.4 0.7 0.6 0.2 2.1 0.2 -1.3 1.8 0.4
Taking other prescription medications 0.5 0.7 1.8 0.5 -0.2 0.8 -0.2 0.0 -1.3 0.7 -0.4 -1.3 1.0 1.3
Age when periods started (menarche) 1.6 3.8 10.0 0.8 0.4 -0.0 -3.1 -0.4 -2.4 0.8 -3.2 -2.0 1.4 3.0
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 2.1 0.7 0.1 -0.8 -0.4 -1.4 -0.7 0.3 -0.1 -0.3 -0.6 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 5.1 11.6 29.3 -5.4 0.1 -3.7 0.1 -1.1 1.7 -5.3 1.3 5.0 -4.0 -3.2
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 3.2 -0.5 -1.0 1.8 -0.2 1.7 -0.3 0.6 -0.4 -1.1 1.8 0.7
Qualifications: CSEs or equivalent 1.2 1.6 7.8 2.8 -1.4 0.5 0.6 -0.4 0.5 2.2 0.4 -1.1 0.6 -0.1
Serious illness, injury or assault to yourself 1.1 1.4 3.4 0.5 0.2 1.3 1.8 1.1 1.4 1.3 1.7 0.0 1.3 -0.9
High blood pressure 0.4 1.2 2.9 1.2 1.5 0.3 1.3 0.1 1.6 1.0 1.7 0.2 0.3 -1.1
Hayfever, allergic rhinitis or eczema 0.4 0.8 2.0 -1.3 0.7 -0.4 -1.2 -0.2 -0.9 -1.4 -1.0 0.1 -0.2 1.0
Multivitamins +/- minerals 1.7 2.1 5.7 -2.1 -1.1 -1.1 -1.6 -0.1 -1.8 -2.4 -1.6 0.1 -1.3 0.9
Stomach or abdominal pain in last month 0.5 0.7 1.6 -0.6 -1.1 0.5 1.3 1.1 0.8 -0.1 1.1 0.5 -0.0 -0.7
Supplements: Glucosamine 1.6 2.1 9.7 -3.1 -1.6 0.5 0.7 2.0 0.4 -2.0 0.8 0.8 -0.1 -0.4
Diverticular disease/diverticulitis (self-reported) 1.3 1.6 3.1 0.4 -1.6 1.7 1.5 1.7 1.2 1.1 1.2 -0.5 1.4 -0.4
Medication: Atenolol 2.0 2.5 5.5 -0.5 1.8 -1.1 1.6 -0.2 2.3 -0.9 2.0 2.0 -1.6 -1.9
Medication: Levothyroxine sodium 0.3 0.4 1.1 0.1 -1.1 0.7 -0.3 0.7 -0.7 -0.1 -0.2 -0.9 0.5 1.0
Sitting height 7.7 54.4 179.6 -13.4 4.5 -1.2 -9.9 2.3 -6.0 -12.1 -8.6 2.4 -1.1 5.5
Chronic bronchitis/emphysema (father) 1.0 1.2 2.9 1.0 -1.0 0.8 -0.5 0.1 -1.4 1.2 -0.7 -1.7 1.1 1.4
High blood pressure (mother) 1.3 1.8 4.3 -0.9 -1.0 -2.1 -0.8 -1.5 -0.1 -2.0 -0.2 1.8 -1.8 -0.7
Body mass index (BMI) 1.8 7.8 17.3 -1.4 -0.1 -1.7 3.4 -0.2 3.5 -2.0 4.1 3.7 -2.4 -4.2
Impedance of leg (left) 0.9 4.5 11.9 3.0 -1.0 2.2 2.7 1.2 1.8 3.5 2.1 -1.4 1.8 -1.0
Leg predicted mass (left) 2.9 15.6 56.7 -7.5 2.7 -0.6 -4.8 1.7 -3.0 -6.8 -4.1 1.7 -0.3 2.7
Trunk fat mass 0.9 4.0 12.6 -3.5 0.9 1.4 1.6 3.1 1.6 -2.5 1.7 1.7 0.6 -1.2
Waist circumference 0.7 2.5 4.8 -1.4 1.6 0.3 2.1 1.5 1.9 -1.3 2.2 1.7 0.0 -1.7
Number of incorrect matches in round 1.1 1.8 7.5 0.2 -2.7 0.4 -1.3 -0.1 -1.9 0.3 -1.4 -1.4 0.5 1.5
Past tobacco smoking 3.2 5.9 22.3 -4.2 -0.9 -2.3 -1.8 -0.9 -0.9 -4.7 -0.9 2.5 -2.6 -0.6
Alcohol usually taken with meals 1.5 2.3 10.9 -0.9 3.3 -1.4 0.2 -1.2 1.0 -1.3 0.5 1.7 -2.0 -1.0
Nervous feelings 2.1 4.0 13.9 -1.0 0.8 3.3 1.5 3.7 0.4 1.3 0.5 -1.2 3.4 0.8
Frequency of tenseness / restlessness in last 2 weeks 4.0 6.3 14.2 0.7 1.0 3.5 3.8 3.4 1.9 2.4 2.9 -0.4 3.1 -1.3
Hearing difficulty/problems with background noise 1.8 2.9 5.5 -1.3 -0.8 1.9 -1.3 2.0 -2.2 -0.3 -2.0 -1.4 2.1 2.3
Hair/balding pattern: Pattern 2 2.1 2.7 7.9 0.5 0.2 2.0 2.8 2.4 1.4 1.4 1.8 0.2 1.8 -1.1
Had menopause 0.7 0.9 2.5 -1.6 0.1 0.6 -0.8 1.5 -0.9 -1.4 -0.7 0.1 0.5 0.4
Had other major operations 1.3 1.5 5.0 -0.5 0.2 1.9 1.6 2.2 1.2 0.0 1.2 0.2 1.2 -0.9
Forced vital capacity (FVC) 2.6 10.0 25.5 0.7 0.9 5.0 -0.7 3.9 -1.9 2.2 -2.2 -4.0 4.9 3.7
Heel bone mineral density (BMD) T-score, automated (right) 4.8 10.9 30.9 -5.5 -0.6 -3.7 -0.4 -0.9 0.7 -5.6 0.5 4.8 -3.8 -2.5
Ever unenthusiastic/disinterested for a whole week 1.7 2.1 4.4 0.1 0.1 1.8 2.1 2.0 1.6 0.9 1.9 0.3 1.7 -1.2
Qualifications: None of the above 1.2 2.5 9.9 3.1 -0.7 0.4 1.6 -0.9 1.2 2.6 1.7 -0.7 1.0 -0.9
Financial difficulties in last 2 years 1.7 2.3 5.7 1.3 1.7 1.7 2.4 1.5 1.0 2.0 1.8 -0.6 1.1 -0.8
Mouth/teeth dental problems 1.2 1.9 4.1 -1.9 -0.1 -1.2 -2.0 -0.7 -1.5 -1.9 -1.7 0.5 -1.3 0.7
Heart attack 2.3 2.9 7.8 -1.4 0.0 1.5 2.8 2.3 2.1 -0.5 2.6 0.8 0.6 -1.6
Allergy 1.3 3.1 7.1 2.0 0.1 0.5 2.7 0.5 2.6 1.9 2.5 0.5 0.2 -2.3
Pain all over the body in last month 1.0 1.1 3.8 -0.4 -0.1 1.8 1.1 1.9 -0.0 0.1 0.3 -0.4 2.0 -0.1
Diabetes (self-reported) 0.2 0.3 3.2 -0.3 1.8 0.0 0.2 0.3 0.2 -0.3 0.3 0.2 -0.2 -0.2
Hayfever/allergic rhinitis (self-reported) 1.8 2.4 6.6 -0.9 -0.1 -1.9 -2.6 -1.9 -1.6 -1.8 -1.7 0.4 -1.3 1.0
Medication: Ramipril 1.3 1.7 5.4 0.7 2.3 1.0 1.8 1.3 1.6 0.7 1.6 -0.1 0.6 -0.7
Medication: Simvastatin 0.1 0.1 0.3 0.2 -0.1 -0.2 -0.2 -0.3 -0.4 -0.4 -0.2 -0.2 -0.2 0.6
Fluid intelligence score 2.0 4.1 8.0 -2.8 2.4 -0.3 1.4 1.1 2.5 -2.0 2.0 2.7 -1.2 -2.2
Illnesses of siblings 1.0 1.5 6.0 1.9 1.1 1.0 -0.3 0.1 0.2 2.4 -0.4 -1.7 0.8 0.7
Neuroticism score 2.5 5.3 11.8 0.4 2.5 3.4 2.7 3.3 1.2 2.5 1.8 -0.8 3.2 -0.4
Weight 1.6 8.1 38.6 -6.2 2.1 -0.1 -1.5 2.3 -0.2 -5.6 -0.9 2.5 -0.5 0.1
Impedance of arm (right) 2.6 12.2 28.0 2.6 -0.7 5.3 0.7 4.0 -0.9 5.0 -0.7 -4.7 5.1 2.7
Arm fat percentage (right) 1.4 5.6 16.7 -0.6 -0.5 0.8 4.1 2.1 3.2 -0.0 4.1 1.7 0.0 -3.1
Trunk fat-free mass 4.8 27.3 86.3 -9.3 3.6 -1.1 -6.9 1.4 -4.5 -8.7 -6.0 1.9 -0.7 4.0
Hip circumference 1.6 7.0 25.6 -5.1 1.9 -0.7 0.4 1.6 1.6 -4.7 1.3 3.5 -1.4 -2.0
Time employed in main current job 0.1 0.1 0.5 -0.3 -0.7 0.1 -0.4 0.1 0.3 -0.5 0.0 0.3 -0.3 -0.3
Alcohol intake versus 10 years previously 0.3 0.5 1.3 0.3 1.1 -0.1 -0.6 -0.1 -1.0 0.1 -0.9 -0.7 -0.0 1.1
Father’s age at death 1.6 2.1 5.0 -0.2 0.1 -1.5 -2.1 -2.2 -1.8 -0.7 -1.8 0.1 -1.9 0.9
Worrier / anxious feelings 1.5 2.9 7.1 -1.0 1.1 2.7 -0.6 2.4 -1.4 0.6 -1.1 -1.7 2.4 1.8
Frequency of tiredness / lethargy in last 2 weeks 2.3 3.8 7.6 -2.2 1.1 1.4 2.7 2.6 2.0 -1.0 2.4 1.7 1.0 -2.1
Falls in the last year 0.0 0.0 0.1 -0.0 0.2 0.2 0.0 0.0 0.0 -0.1 0.0 -0.3 0.2 0.4
Hair/balding pattern: Pattern 3 3.5 5.2 13.1 -3.2 -0.6 -2.4 -2.9 -1.7 -1.8 -3.6 -2.1 1.4 -2.4 0.9
Number of live births 0.3 0.4 2.4 0.8 -1.5 -0.1 0.2 0.0 0.6 0.2 0.4 0.1 -0.2 -0.7
Forced expiratory volume in 1-second (FEV1) 2.8 9.4 25.3 0.6 0.6 5.0 -0.5 4.1 -1.5 2.0 -1.8 -3.9 4.9 3.4
Pulse rate 3.2 5.5 13.5 3.0 -1.8 2.3 -0.7 0.8 -1.6 3.3 -1.3 -3.7 2.9 2.3
Happiness 1.5 1.8 6.9 0.2 2.6 0.5 2.0 0.9 1.4 0.7 1.8 0.7 0.1 -1.0
Noisy workplace 1.0 1.2 2.4 0.2 -1.6 1.4 0.3 1.2 -0.7 1.2 -0.2 -1.5 1.4 0.9
Qualifications: A levels/AS levels or equivalent 0.9 2.0 10.8 -3.3 0.5 -0.5 -0.4 0.6 0.4 -2.5 -0.1 1.8 -0.5 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 1.9 0.2 1.4 -0.2 -0.4 -0.4 0.1 0.4 -0.1 0.0 -0.2 0.1
Mouth/teeth dental problems: Dentures 0.4 0.6 1.5 0.5 -0.7 -0.4 -1.2 -0.8 -0.9 -0.2 -1.1 -0.8 0.1 0.9
Asthma 0.3 0.5 2.8 -0.4 1.7 0.3 -0.7 -0.0 -0.7 -0.3 -0.8 -0.3 0.0 1.0
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.6 0.2 1.6 1.3 1.1 1.2 0.8 0.8 0.7 -0.4 1.0 -0.1
Medication: Cholesterol lowering 0.3 0.5 1.5 0.8 -0.9 0.3 1.2 0.3 0.9 0.4 1.1 0.1 0.6 -0.1
Depression (self-reported) 4.6 5.5 13.6 3.5 2.6 1.3 3.2 -0.0 1.9 3.7 2.9 -0.4 1.3 -1.5
Medication: Lansoprazole 2.7 3.1 8.5 0.9 -0.4 2.6 2.1 2.9 0.9 1.9 1.1 -1.2 2.4 -0.1
Prospective memory result 0.7 0.9 2.3 0.7 -1.5 0.8 -0.4 0.4 -1.0 0.6 -0.7 -1.2 1.5 0.9
Lung cancer (father) 1.6 1.9 4.7 -0.9 -2.2 0.3 -1.5 0.8 -1.9 -0.6 -1.7 -0.8 1.1 1.8
Illnesses of mother 0.8 0.9 2.4 1.2 1.1 0.7 -0.7 0.3 -0.6 1.2 -0.7 -1.5 0.8 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 2.8 8.9 24.0 0.3 -0.2 4.4 -1.2 3.6 -1.9 1.6 -2.3 -3.8 4.9 3.7
Pulse wave Arterial Stiffness index 0.8 0.9 3.6 -1.9 -0.9 -0.3 0.2 0.7 0.4 -1.8 0.4 0.9 -0.7 -0.6
Impedance of arm (left) 2.8 12.8 28.9 2.9 -0.7 5.4 0.9 4.0 -0.6 5.4 -0.5 -4.9 5.2 2.6
Arm fat mass (right) 1.1 4.4 9.5 -3.1 0.5 -0.1 2.1 1.7 2.2 -2.7 2.5 2.7 -0.8 -2.4
Trunk predicted mass 4.7 27.0 83.5 -9.1 3.6 -1.1 -6.9 1.3 -4.5 -8.6 -6.1 1.8 -0.7 4.0
Standing height 6.0 59.7 135.5 -11.6 4.7 3.1 -10.6 5.6 -7.8 -8.9 -10.5 -1.7 3.7 9.0
Length of working week for main job 0.7 0.7 3.0 -0.4 1.7 -0.9 -0.3 -1.0 0.2 -0.5 -0.2 0.7 -1.4 -0.4
Exposure to tobacco smoke at home 0.9 1.0 2.1 1.1 1.0 1.1 0.1 0.8 -0.8 1.4 -0.5 -1.3 1.2 0.8
Breastfed as a baby 2.3 2.9 8.2 2.0 2.6 1.7 0.5 1.0 -0.4 2.9 -0.2 -2.0 2.1 0.9
Tense / ‘highly strung’ 2.5 4.1 9.9 0.3 2.2 3.1 1.7 3.1 0.6 2.3 0.8 -1.3 3.1 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.1 4.2 -0.6 2.0 1.1 2.0 1.6 1.7 0.2 2.0 0.9 1.3 -1.3
Hair/balding pattern: Pattern 4 2.9 7.0 30.5 -5.5 -2.6 -1.5 -1.4 0.7 -0.8 -5.0 -0.9 2.2 -1.9 -0.5
Birth weight of first child 3.1 5.7 17.3 1.3 -0.8 3.9 1.2 3.4 1.0 2.6 0.7 -2.4 4.2 1.0
Peak expiratory flow (PEF) 2.5 5.7 14.6 -2.4 0.9 3.4 -1.5 3.8 -1.6 -1.1 -2.1 -1.6 3.3 2.6
Pulse wave reflection index 2.3 2.8 8.0 -2.3 -1.0 -2.1 -0.5 -0.9 -0.0 -2.8 0.1 2.1 -2.3 -0.9
Ever highly irritable/argumentative for 2 days 2.7 3.3 8.8 1.5 -0.1 3.0 1.3 2.5 0.8 2.2 0.7 -1.7 2.9 0.7
Loud music exposure frequency 2.8 3.1 8.8 0.8 0.1 2.9 1.5 2.6 -0.6 1.9 0.2 -1.6 3.0 0.7
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.6 -1.3 0.9 0.2 0.7 0.7 0.8 -1.1 0.7 1.2 -0.1 -0.9
Mouth/teeth dental problems: Bleeding gums 2.9 3.8 10.7 1.5 0.8 1.3 3.3 1.1 2.8 1.9 3.0 0.5 1.0 -1.9
Blood clot in the leg (DVT) 9.1 11.7 30.7 -2.3 -2.3 -1.0 -5.5 -1.2 -5.5 -2.6 -5.2 -1.9 -0.0 4.2
Medication: Paracetamol 0.5 0.9 2.9 0.5 0.5 0.1 1.7 0.2 1.4 0.4 1.7 0.4 -0.2 -1.0
Headache pain in last month 0.4 0.7 4.0 1.1 2.0 0.3 0.1 -0.0 0.5 1.2 0.1 -0.6 0.4 0.2
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.5 -1.2 0.4 -0.1 -0.8 0.1 -1.1 -0.8 -0.9 0.2 -0.3 0.1
Glaucoma (self-reported) 0.6 0.7 3.4 0.9 -0.8 -1.1 -0.6 -1.8 0.0 -0.1 -0.3 0.4 -0.8 0.0
Gout (self-reported) 0.3 0.4 1.0 -0.1 -0.8 0.7 -0.5 0.4 -0.6 0.2 -0.8 -1.0 0.6 1.0
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 1.1 0.4 -1.0 -0.1 -0.3 -0.1 -0.8 -0.2 -0.0 -0.6 -0.4 0.7
Medication: Amlodipine 1.2 1.6 4.8 2.2 0.7 1.3 -0.3 -0.1 -0.6 1.9 -0.5 -2.1 0.7 1.3
Medication: Ventolin 100micrograms inhaler 0.6 0.8 4.6 0.3 2.1 0.8 -0.0 0.5 -0.8 0.6 -0.4 -0.7 0.6 0.8
Birth weight 3.7 8.1 22.3 0.2 -1.7 3.6 -1.8 2.9 -2.1 1.6 -2.6 -3.4 4.7 3.7
Chronic bronchitis/emphysema (mother) 1.5 1.7 4.8 1.9 -0.1 1.3 0.7 0.8 0.4 2.2 0.5 -1.6 2.0 0.6
High blood pressure (siblings) 2.6 3.8 9.2 -2.0 -0.1 -2.8 -0.2 -1.9 0.6 -3.0 0.6 2.7 -2.6 -1.5
Forced vital capacity (FVC), Best measure 2.9 10.5 28.3 0.4 0.3 4.9 -1.1 3.9 -2.0 2.1 -2.4 -4.1 5.3 3.9
Body fat percentage 1.7 6.9 19.7 -0.7 -0.3 0.9 4.4 2.2 3.8 -0.2 4.4 2.0 -0.1 -3.5
Leg fat percentage (right) 3.1 11.3 31.7 -0.1 -0.7 -1.0 5.1 0.2 4.8 -0.7 5.6 3.5 -2.0 -5.0
Arm fat-free mass (right) 3.8 19.3 67.7 -8.2 2.8 -1.7 -5.2 0.6 -2.8 -8.2 -4.1 2.8 -1.4 2.2
Exposure to tobacco smoke outside home 1.7 2.3 5.8 0.9 2.1 2.0 1.6 1.3 0.9 2.4 1.1 -0.8 1.7 -0.1
Comparative body size at age 10 0.4 1.2 5.2 -0.1 -2.3 0.1 1.6 0.1 1.2 -0.5 1.5 0.6 0.2 -1.1
Number of full brothers 2.7 3.5 7.8 0.4 -1.8 0.8 -2.3 0.3 -2.6 0.5 -2.8 -2.5 1.4 2.4
Worry too long after embarrassment 1.9 3.2 7.3 -0.4 1.4 2.7 2.2 2.6 1.3 1.8 1.5 -0.5 2.6 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 3.7 1.8 1.9 1.2 1.9 0.8 0.6 1.6 1.2 -0.7 0.8 -0.2
Wheeze or whistling in the chest in last year 0.5 1.0 4.0 0.1 2.0 -1.0 -1.0 -1.3 -0.9 -0.6 -0.8 0.0 -0.6 0.8
Number of children fathered 0.3 0.4 1.2 -0.4 0.2 1.0 0.7 1.1 0.8 0.0 0.5 -0.2 0.4 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.8 6.0 -2.5 -1.6 -0.1 -1.3 0.2 -2.2 -1.6 -1.2 0.5 0.1 0.7
Age at first live birth 0.6 1.1 2.8 -1.7 0.5 -0.9 -0.0 -0.4 1.2 -1.5 0.4 1.6 -0.9 -0.8
Pulse wave peak to peak time 0.6 0.7 1.2 1.0 1.0 0.6 -0.6 -0.1 -0.7 1.1 -0.9 -0.9 1.0 1.0
Health satisfaction 0.7 1.0 4.0 -1.3 0.2 1.3 1.1 2.0 0.7 -0.2 1.0 0.1 0.7 -0.3
Shortness of breath walking on level ground 1.0 1.2 3.0 1.1 -0.0 0.9 1.7 0.4 1.4 1.5 1.7 -0.3 0.7 -0.8
Qualifications: College or University degree 2.8 8.7 21.7 -4.4 0.5 -3.1 -3.5 -2.0 -2.3 -4.7 -2.8 2.2 -2.9 1.1
Eye problems/disorders: None of the above 0.1 0.1 0.5 -0.2 0.7 0.0 -0.2 -0.1 -0.5 0.3 -0.4 -0.1 -0.1 0.1
Mouth/teeth dental problems: Loose teeth 1.1 1.3 3.3 -1.6 -0.4 -1.6 -0.2 -0.5 -0.2 -1.8 -0.0 1.7 -1.5 -0.8
Emphysema/chronic bronchitis 0.6 0.7 1.8 0.8 -0.5 1.0 0.2 0.6 -0.7 1.0 -0.3 -1.4 1.0 0.9
Medication for pain relief, constipation, heartburn 1.1 1.8 6.4 -0.7 -0.6 -1.2 -2.5 -1.0 -1.8 -1.1 -2.1 0.1 -0.8 0.8
Neck or shoulder pain in last month 0.8 1.1 5.2 -2.3 -0.2 -0.1 -0.1 1.0 0.4 -1.9 0.2 1.2 -0.1 -0.4
Medication: Blood pressure 0.4 0.6 1.9 0.9 1.0 -0.4 0.7 -0.4 1.4 0.5 1.1 0.3 -0.4 -0.7
Angina (self-reported) 2.2 2.8 4.9 -1.4 0.8 -0.5 2.1 0.6 2.1 -2.0 2.2 2.1 -1.2 -2.1
Migraine (self-reported) 0.9 1.1 3.9 1.2 2.0 -0.9 0.6 -1.3 0.7 0.5 0.6 0.9 -1.0 -1.0
Medication: Ibuprofen 0.4 0.5 2.4 -0.2 1.6 0.8 0.6 1.0 0.4 0.2 0.4 -0.2 0.6 0.1
Medication: Allopurinol 0.2 0.3 1.3 -0.1 -1.1 0.6 0.2 0.5 -0.0 0.1 -0.1 -0.6 0.5 0.5
Medication: Omeprazole 0.1 0.1 0.3 -0.2 -0.5 -0.0 -0.1 -0.2 -0.1 -0.1 -0.0 -0.2 -0.1 0.5
Medication: Seretide 50 evohaler 0.9 1.0 2.1 -0.3 1.3 -1.1 -1.5 -1.2 -1.3 -0.8 -1.1 0.2 -1.0 0.6
Mean time to correctly identify matches 0.5 0.9 2.6 0.3 -1.6 -0.7 0.7 -1.1 0.7 0.3 1.2 0.6 -1.1 -1.2
Heart disease (mother) 1.1 1.3 3.8 -1.0 -0.7 1.3 1.9 1.7 1.0 -0.4 1.5 0.3 0.8 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 2.3 0.1 -1.5 -0.7 -1.0 -0.8 -0.9 -0.6 -0.6 -0.1 -0.6 0.4
Whole body fat mass 1.0 4.1 10.1 -3.2 0.9 0.4 1.9 2.1 2.1 -2.6 2.2 2.4 -0.3 -2.0
Leg fat mass (right) 1.7 6.6 12.5 -2.7 0.4 -1.0 2.7 0.8 3.1 -2.8 3.4 3.5 -1.7 -3.3
Arm predicted mass (right) 3.6 18.3 62.4 -7.9 3.1 -1.7 -5.1 0.5 -2.8 -7.9 -4.1 2.6 -1.4 2.3
Pulse rate, automated reading 2.1 6.8 16.6 3.8 -0.9 2.2 -1.0 0.3 -1.9 4.1 -1.6 -3.9 3.1 2.5
Alcohol intake frequency. 0.4 0.9 2.2 0.7 1.5 1.0 0.9 1.3 0.3 1.0 0.5 -0.5 1.3 0.0
Comparative height size at age 10 3.8 20.9 51.3 -7.2 3.0 4.8 -3.9 6.5 -3.0 -4.2 -4.5 -1.3 4.5 4.6
Number of full sisters 0.5 0.6 1.6 0.5 -0.8 -0.1 1.3 0.4 0.6 0.7 1.1 0.5 0.6 -1.0
Suffer from ‘nerves’ 0.7 1.1 4.8 -0.4 2.2 1.5 0.6 1.4 -0.1 0.5 0.2 -0.3 1.3 0.2
Overall health rating 1.0 2.1 6.9 -0.8 0.2 1.3 2.6 2.1 1.4 0.3 2.0 0.5 1.0 -1.2
Chest pain or discomfort 0.6 0.9 3.3 -1.4 1.8 0.5 0.7 1.1 0.0 -1.2 0.6 1.0 0.4 -0.4
Had major operations 1.5 1.8 4.7 1.8 0.1 1.7 0.6 0.9 0.4 2.2 0.4 -1.8 2.0 0.7
Age at last live birth 0.7 1.0 2.2 -1.2 0.9 -1.3 -0.3 -0.8 0.4 -1.3 0.1 1.5 -1.3 -0.6
Family relationship satisfaction 1.2 1.5 3.2 -1.0 1.2 -1.3 0.8 -0.9 0.5 -0.9 1.2 1.8 -1.8 -1.3
Leg pain on walking 2.2 2.8 6.6 1.5 -0.4 2.6 0.9 1.9 -0.1 2.5 0.1 -2.1 2.4 1.1
Qualifications: NVQ or HND or HNC or equivalent 1.9 2.2 5.1 1.4 -0.6 2.2 0.7 1.6 0.1 2.2 0.0 -1.9 2.3 0.8
Commuting to job workplace: Car/motor vehicle 0.9 1.1 3.0 -0.7 -0.9 0.8 1.7 1.4 0.8 -0.2 1.4 0.5 0.4 -1.4
Illness, injury, bereavement, stress in last 2 years 1.4 1.8 4.4 -1.3 -1.3 -2.1 -0.8 -1.3 -0.7 -2.0 -0.6 1.3 -1.7 -0.1
Medication: Aspirin 1.4 1.9 4.1 -1.0 -0.5 -1.2 1.6 -0.6 1.5 -1.1 2.0 1.8 -1.2 -1.5
Supplements: Vitamin C 1.0 1.2 3.0 0.3 0.2 1.6 -0.3 1.7 -0.4 0.7 -0.5 -1.6 1.7 1.0
Knee pain experienced in last month 4.8 7.4 13.8 2.1 -1.7 3.6 3.6 3.0 1.8 3.7 2.6 -2.3 3.1 -0.3
Hypertension (Self-reported) 0.7 1.9 4.8 1.4 1.5 0.5 1.7 0.3 2.2 1.2 2.2 0.4 0.3 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 2.3 0.2 0.6 0.3 -0.5 0.0 -1.5 0.9 -0.9 -0.9 0.4 1.2
Illnesses of father: Heart disease 2.1 3.0 7.6 -1.5 -0.1 1.0 2.8 1.9 2.3 -1.0 2.5 1.3 0.1 -1.8
Illnesses of siblings: Diabetes 1.2 1.5 5.1 -2.2 -0.4 -0.5 0.5 1.0 -0.2 -2.3 0.7 1.6 -1.0 -0.9
Smoking status: Previous 2.0 3.0 12.1 3.0 0.4 1.5 1.0 0.3 0.2 3.5 0.2 -2.1 1.8 0.7
Forced expiratory volume in 1-second (FEV1), predicted 2.7 5.5 10.5 -3.2 1.3 1.2 -3.1 1.6 -2.7 -2.2 -3.2 -0.8 2.1 2.8
Whole body fat-free mass 4.0 22.9 77.1 -8.8 3.4 -1.0 -6.1 1.4 -3.8 -8.1 -5.2 2.0 -0.7 3.4
Leg fat-free mass (right) 3.0 16.1 54.8 -7.4 2.9 -0.5 -5.0 1.6 -3.4 -6.6 -4.4 1.4 -0.2 3.0
Arm fat percentage (left) 1.5 5.8 17.8 -0.3 -0.6 0.8 4.2 1.9 3.4 0.3 4.2 1.6 0.0 -3.2
Average weekly red wine intake 0.6 0.9 3.6 -1.6 0.3 0.9 0.6 1.9 0.6 -1.4 0.3 0.6 0.4 0.0
Handedness (chirality/laterality): Left-handed 2.4 2.9 5.0 -0.5 -0.1 1.9 -1.4 1.9 -2.1 0.2 -1.9 -2.0 2.2 2.2
Mood swings 1.0 1.8 3.7 1.0 1.8 1.5 1.9 1.3 1.3 1.3 1.4 0.1 1.2 -1.0
Loneliness, isolation 1.6 2.2 6.1 1.5 1.1 1.3 2.5 0.5 1.3 2.1 1.9 -0.2 1.3 -1.0
Long-standing illness, disability or infirmity 0.5 0.7 2.3 -1.2 -0.0 1.2 0.9 1.5 0.3 -0.3 0.6 -0.3 0.9 0.3
Ever had bowel cancer screening 0.3 0.3 2.0 -1.4 0.2 0.3 0.2 0.7 -0.4 -0.9 -0.2 0.3 0.1 0.1
Diabetes diagnosed by doctor 0.1 0.2 1.4 -0.2 1.2 0.1 0.3 0.3 0.3 -0.3 0.3 0.2 0.0 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 2.1 2.3 4.2 -0.2 0.8 -1.8 1.5 -1.5 1.4 -0.4 1.6 2.0 -2.0 -1.9
Friendships satisfaction 1.6 2.0 4.9 -0.5 0.5 -1.5 1.5 -1.1 1.2 -0.7 1.8 2.2 -1.6 -1.9
Qualifications: nursing, teaching 0.8 1.3 3.6 -1.1 0.3 -1.3 0.3 -1.1 0.7 -1.2 0.9 1.4 -1.9 -1.2
Commuting to job workplace: Walk 1.3 1.4 4.0 -0.1 1.3 -1.0 -2.0 -1.8 -0.9 -0.8 -1.6 -0.0 -0.7 1.2
Eye problems/disorders: Cataract 0.7 0.9 2.2 -1.0 0.3 -1.4 -0.7 -1.0 0.3 -1.5 -0.1 1.0 -1.3 -0.2
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 5.0 2.0 0.7 1.5 0.9 0.6 0.7 2.2 0.6 -1.3 1.5 0.4
Medication for cholesterol 0.9 1.3 3.6 0.3 -1.4 -0.3 -1.7 -0.7 -1.5 0.3 -1.9 -0.8 0.5 1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.8 0.3 -0.2 0.5 -0.3 0.1 -0.9 0.8 -0.6 -0.8 0.5 0.8
Back pain experienced in last month 6.1 9.0 27.2 1.6 -2.3 4.3 -0.0 3.8 -0.9 2.9 -1.0 -3.6 5.2 2.7
Mineral and other dietary supplements 0.2 0.2 0.8 0.9 0.4 -0.6 -0.4 -0.8 0.3 0.2 -0.1 0.5 -0.4 -0.3
Breast cancer (self-reported) 1.2 1.5 4.7 -0.5 0.6 0.9 2.2 1.1 1.8 0.5 1.7 0.6 0.4 -1.4
Asthma (self-reported) 0.3 0.5 2.4 0.0 1.6 0.5 -0.5 0.0 -0.7 0.1 -0.7 -0.6 0.1 1.1
Osteoporosis (self-reported) 1.1 1.4 4.0 1.6 -2.0 1.0 0.0 0.2 0.1 1.6 -0.0 -1.5 1.5 0.7
Osteoarthritis (self-reported) 1.6 2.1 7.3 0.5 -0.4 1.5 2.7 1.8 1.5 1.0 2.2 0.0 0.8 -1.2
Medication: Aspirin 0.9 1.2 3.4 -0.8 -0.7 -0.6 1.6 -0.2 1.4 -0.8 1.9 1.3 -0.7 -1.1
Medication: Gliclazide 1.1 1.2 3.3 -1.7 -0.0 -1.2 -0.9 -0.9 -0.1 -1.8 -0.3 1.1 -1.7 -0.3
Illnesses of father: None of the above (group 1) 1.3 1.6 3.5 0.3 -0.8 0.7 -1.9 0.4 -1.7 0.5 -1.7 -1.5 0.9 1.9
Smoking status: Current 1.7 2.6 7.5 2.5 0.4 2.0 1.4 1.1 0.2 2.7 0.5 -1.6 2.3 0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.1 6.7 16.9 1.7 -0.3 4.1 2.0 3.5 0.5 3.3 0.8 -2.9 4.1 1.1
Whole body water mass 3.9 22.3 74.3 -8.6 3.3 -1.0 -6.0 1.3 -3.8 -8.1 -5.2 2.0 -0.7 3.3
Leg predicted mass (right) 3.0 15.9 54.5 -7.4 2.9 -0.4 -5.0 1.6 -3.4 -6.5 -4.4 1.4 -0.1 3.0
Arm fat mass (left) 1.0 3.9 8.8 -3.0 0.4 -0.0 1.9 1.7 2.1 -2.6 2.3 2.5 -0.7 -2.1
Number of self-reported non-cancer illnesses 0.9 1.5 4.9 0.5 -0.9 1.9 0.8 1.4 -0.2 1.3 0.6 -1.4 2.2 0.8
Average weekly champagne plus white wine intake 0.3 0.5 1.1 -0.6 0.3 -0.3 -1.0 -0.4 -1.0 -0.4 -1.0 -0.0 -0.6 0.8
Miserableness 1.9 3.2 9.2 1.8 1.1 1.7 3.0 1.6 1.7 2.0 2.4 -0.1 1.4 -1.3
Guilty feelings 1.6 2.4 6.6 1.8 1.7 1.8 1.0 1.0 -0.5 2.6 0.2 -1.6 2.2 1.1
Wears glasses or contact lenses 0.6 0.7 3.5 -1.9 0.0 0.3 0.2 1.1 0.5 -1.3 0.0 0.4 -0.2 -0.1
Ever taken oral contraceptive pill 0.4 0.5 1.4 0.2 -0.5 0.0 1.2 0.1 1.1 0.4 0.9 0.8 -0.3 -0.8
Hearing aid user 1.2 1.3 2.9 -0.9 -1.6 0.4 -1.7 0.3 -1.7 -0.6 -1.5 -0.8 0.5 1.4
Mother’s age at death 0.6 0.7 2.3 -1.5 -0.5 -0.7 -1.1 -0.1 -0.8 -1.1 -1.0 0.8 -0.6 0.2
Financial situation satisfaction 2.3 2.9 7.8 1.9 0.9 2.2 1.8 1.7 0.0 2.8 0.8 -1.6 2.2 0.6
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.6 -1.3 0.3 0.4 -0.4 1.0 -1.0 -0.9 -0.8 -0.1 0.0 1.0
Commuting to job workplace: Public transport 1.5 1.8 5.0 -0.2 1.1 -0.8 -2.1 -0.9 -1.8 -0.7 -2.2 -0.8 -0.8 1.7
Eye problems/disorders: Glaucoma 0.4 0.5 2.4 1.4 -0.5 -0.6 0.0 -1.6 0.3 0.7 0.2 0.1 -0.5 -0.2
Medication: Blood pressure 1.0 1.9 7.5 0.3 2.7 -0.1 1.4 0.0 1.9 0.0 1.9 0.9 -0.9 -1.6
Pain type(s) experienced in last month: Hip pain 1.7 2.1 4.7 -1.6 -0.3 0.0 2.2 1.1 1.3 -1.2 1.9 1.8 -0.8 -1.7
Supplements: Fish oil (including cod liver oil) 0.5 0.6 2.0 -1.4 -0.2 -0.4 -0.6 -0.2 -1.0 -1.3 -0.7 0.2 -1.0 0.2
High cholesterol (Self-reported) 0.6 1.1 2.9 -0.3 -0.3 -1.4 0.5 -0.9 0.5 -1.5 0.7 1.3 -1.7 -1.0
Medication: Bendroflumethiazide 0.2 0.3 1.8 0.7 1.3 -0.4 -0.5 -0.8 0.4 0.2 0.2 0.1 -0.2 -0.4
Medication: Paracetamol 0.4 0.6 1.5 -0.1 0.6 -0.5 1.2 -0.3 1.0 -0.4 1.2 0.6 -1.0 -0.9
Medication: Lisinopril 0.7 0.9 2.4 0.0 0.6 -0.4 1.3 -0.6 1.4 0.1 1.6 0.9 -0.6 -1.2
Medication: Atorvastatin 0.1 0.2 0.8 0.1 -0.9 0.4 0.5 0.3 -0.0 0.0 0.3 -0.6 0.2 0.3
Illnesses of father: High blood pressure 0.8 0.9 2.6 0.1 1.0 -1.4 0.6 -1.3 0.5 -0.3 0.4 1.1 -1.6 -1.0
Alcohol drinker status: Never 0.9 1.1 2.4 1.2 -1.0 0.6 -0.8 0.1 -1.1 0.9 -1.1 -1.5 1.1 1.4
Ever smoked 1.7 2.9 10.7 3.0 1.0 1.5 1.2 0.6 0.4 3.3 0.4 -1.8 1.8 0.5
Basal metabolic rate 3.4 18.6 68.9 -8.3 3.0 -0.8 -5.0 1.7 -3.0 -7.7 -4.2 2.2 -0.6 2.6
Leg fat percentage (left) 3.0 10.8 31.2 -0.1 -0.4 -1.0 5.0 0.2 4.6 -0.6 5.6 3.4 -1.9 -5.0
Arm fat-free mass (left) 3.6 18.4 67.8 -8.2 3.0 -1.4 -4.8 1.0 -2.6 -8.0 -3.8 2.8 -1.3 2.0
Number of operations (self-reported) 1.9 2.8 6.0 1.1 0.2 2.2 1.9 2.4 1.4 2.0 1.7 -0.9 2.4 -0.7
Average weekly beer plus cider intake 1.0 1.5 3.8 1.8 -1.6 1.2 1.2 0.8 0.6 1.9 0.5 -1.1 1.3 0.0
Irritability 3.6 6.0 13.4 -0.2 3.4 1.7 3.5 2.0 3.7 1.6 3.3 1.4 1.3 -2.3
Risk taking 0.6 0.9 3.2 -1.7 -0.6 -0.7 -0.6 -0.5 -0.5 -1.8 -0.4 0.8 -1.1 -0.1
Ever had prostate specific antigen (PSA) test 0.5 0.6 2.5 -1.6 1.3 0.1 -0.4 0.9 -0.2 -0.9 -0.1 0.3 0.0 0.4
Fractured/broken bones in last 5 years 0.5 0.7 2.2 1.5 0.3 0.1 -0.3 -0.8 -0.6 1.3 -0.6 -1.0 0.4 0.7
Age started oral contraceptive pill 1.5 1.9 3.5 -1.7 0.2 1.6 -1.2 1.9 -1.2 -0.7 -1.7 -1.3 1.3 1.7
Diastolic blood pressure, automated reading 0.4 1.3 3.8 0.1 0.5 0.8 1.9 1.0 1.6 0.3 1.9 0.5 0.3 -1.5
Ever depressed for a whole week 0.8 1.0 3.3 0.1 -1.8 1.3 0.9 1.6 0.3 0.5 0.7 -0.3 1.4 0.1
Unable to work because of sickness or disability 3.0 3.9 9.1 2.0 -0.9 1.9 3.0 1.8 2.1 2.4 2.3 -0.3 2.2 -1.3
Commuting to job workplace: Cycle 0.5 0.6 1.5 0.8 0.2 -0.1 -1.2 -0.9 -0.7 0.6 -1.1 -0.7 0.0 1.1
Myopia 1.1 1.6 6.9 -0.5 2.6 -1.2 -1.4 -1.1 -1.1 -1.1 -1.4 0.6 -0.8 0.7
Vascular/heart problems diagnosed by doctor 1.2 3.1 9.3 -0.7 -1.6 -0.0 -2.4 -0.3 -3.0 -0.5 -3.1 -1.2 0.2 2.3
Cholesterol lowering medication 0.2 0.3 1.1 -0.7 0.6 -0.4 0.5 -0.2 0.2 -1.0 0.5 0.5 -0.9 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 -0.4 -0.4 0.2 0.4 0.2 0.0 -0.2 0.3 -0.1 -0.5 0.2
Pain experienced in last month 1.9 3.1 8.2 -1.2 1.1 -2.9 -1.6 -2.4 -0.8 -1.9 -0.9 1.7 -2.7 -0.3
Supplements: Calcium 0.3 0.3 0.8 0.1 -0.2 0.9 0.8 0.6 0.6 0.6 0.5 -0.3 0.8 -0.1
Basal cell carcinoma (self-reported) 2.7 3.2 15.4 -2.6 0.0 2.4 1.6 3.9 0.6 -0.4 0.9 0.5 1.9 -0.4
Heart attack/myocardial infarction (self-reported) 1.8 2.3 5.9 -1.1 -0.2 1.7 2.4 2.3 1.7 -0.2 2.2 0.4 0.9 -1.1
Deep venous thrombosis (DVT) (self-reported) 9.8 12.6 32.7 -2.5 -2.5 -1.0 -5.7 -1.1 -5.7 -2.6 -5.4 -1.9 0.2 4.4
Heart disease (siblings) 2.8 3.5 9.6 -0.6 -1.7 2.9 2.3 3.1 1.0 0.4 1.4 -0.6 2.8 -0.3
Alcohol drinker status: Previous 0.8 0.9 2.4 -0.2 0.0 -0.8 -1.5 -0.9 -1.5 -0.8 -1.3 0.1 -0.3 0.9
Pack years of smoking 1.8 2.6 6.4 -1.5 -1.4 1.9 -0.9 2.3 -1.3 -0.5 -1.2 -1.3 2.5 1.9
Impedance of whole body 1.7 8.8 23.0 3.0 -0.9 4.4 1.9 3.2 0.6 4.8 0.7 -3.5 4.1 1.1
Leg fat mass (left) 1.6 6.3 11.8 -2.8 0.6 -0.9 2.7 0.9 3.0 -2.8 3.3 3.4 -1.6 -3.2
Arm predicted mass (left) 3.8 19.2 69.7 -8.3 3.0 -1.6 -4.9 0.8 -2.7 -8.2 -3.9 2.9 -1.6 1.9