Best TWAS P=4.7e-10 · Best GWAS P=2.62e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | L3MBTL2 | 0.14 | 0.01 | lasso | 6 | 0.04 | 1.8e-03 | -5.1 | 5.5 | 3.1e-08 | -0.66 | 0.03 | 0.88 | FALSE |
| 2 | GTEx | Artery Tibial | L3MBTL2 | 0.05 | 0.06 | lasso | 3 | 0.05 | 1.0e-04 | -6.2 | 6.2 | 7.3e-10 | -0.99 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | L3MBTL2 | 0.12 | 0.08 | lasso | 6 | 0.05 | 1.0e-02 | -6.3 | -6.2 | 4.7e-10 | 0.98 | 0.01 | 0.93 | TRUE |
| 4 | YFS | Blood | EP300 | 0.05 | 0.04 | blup | 284 | 0.05 | 5.2e-15 | -6.3 | 6.0 | 1.6e-09 | -0.79 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | L3MBTL2 | 0.05 | 0.03 | enet | 9 | 0.04 | 1.8e-04 | 4.7 | 5.4 | 7.8e-08 | -0.58 | 0.24 | 0.27 | FALSE |