[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr22:28,792,887-30,261,219

Best TWAS P=4.8e-23 · Best GWAS P=3.77e-23 conditioned to 1

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Thyroid	KREMEN1	0.10	0.09	lasso	3	0.08	1.3e-06	9.89	9.9	4.8e-23	1.00	0.00	1.00	TRUE
10	METSIM	Adipose	KREMEN1	0.12	0.12	lasso	8	0.11	1.7e-16	9.69	9.8	1.3e-22	0.97	0.00	1.00	FALSE
3	GTEx	Adrenal Gland	KREMEN1	0.38	0.26	lasso	3	0.22	1.7e-08	9.88	9.7	3.0e-22	0.98	0.00	1.00	FALSE
8	GTEx	Pancreas	KREMEN1	0.33	0.24	lasso	7	0.23	4.2e-10	9.90	9.6	5.4e-22	0.99	0.00	1.00	FALSE
6	GTEx	Heart Left Ventricle	KREMEN1	0.47	0.32	lasso	6	0.34	5.0e-19	8.39	9.2	3.9e-20	0.96	0.01	0.99	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KREMEN1	0.13	0.10	lasso	5	0.11	3.3e-12	8.39	9.2	4.5e-20	0.93	0.04	0.96	FALSE
7	GTEx	Ovary	KREMEN1	0.28	0.18	enet	5	0.19	1.7e-05	8.39	8.7	4.3e-18	0.86	0.04	0.82	FALSE
2	GTEx	Adipose Subcutaneous	KREMEN1	0.19	0.13	enet	22	0.13	9.2e-11	9.88	8.5	1.7e-17	0.87	0.00	1.00	FALSE
4	GTEx	Breast Mammary Tissue	KREMEN1	0.14	0.06	enet	10	0.10	6.9e-06	7.30	7.8	6.7e-15	0.85	0.01	0.98	FALSE
14	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ZNRF3	0.44	-0.01	blup	126	0.05	2.0e-02	-0.53	7.3	2.9e-13	0.61	0.01	0.24	FALSE
11	YFS	Blood	KREMEN1	0.10	0.10	enet	14	0.10	1.3e-32	7.06	-6.5	7.5e-11	-0.65	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KREMEN1	0.12	0.06	bslmm	410	0.08	2.8e-10	7.28	6.3	3.0e-10	0.64	0.18	0.82	FALSE
12	The Cancer Genome Atlas	Colon Adenocarcinoma	C22orf31	0.07	0.02	blup	64	0.06	2.7e-04	4.23	6.0	2.4e-09	0.64	0.04	0.50	FALSE
5	GTEx	Breast Mammary Tissue (Male)	KREMEN1	0.08	-0.01	enet	2	-0.01	4.9e-01	5.22	5.2	2.6e-07	0.62	0.03	0.29	FALSE