[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr22:28,792,887-30,261,219

Best TWAS P=4.8e-23 · Best GWAS P=3.77e-23 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex KREMEN1 0.12 0.06 bslmm 410 0.08 2.8e-10 7.28 6.3 3.0e-10 0.64 0.18 0.82 FALSE
2 GTEx Adipose Subcutaneous KREMEN1 0.19 0.13 enet 22 0.13 9.2e-11 9.88 8.5 1.7e-17 0.87 0.00 1.00 FALSE
3 GTEx Adrenal Gland KREMEN1 0.38 0.26 lasso 3 0.22 1.7e-08 9.88 9.7 3.0e-22 0.98 0.00 1.00 FALSE
4 GTEx Breast Mammary Tissue KREMEN1 0.14 0.06 enet 10 0.10 6.9e-06 7.30 7.8 6.7e-15 0.85 0.01 0.98 FALSE
5 GTEx Breast Mammary Tissue (Male) KREMEN1 0.08 -0.01 enet 2 -0.01 4.9e-01 5.22 5.2 2.6e-07 0.62 0.03 0.29 FALSE
6 GTEx Heart Left Ventricle KREMEN1 0.47 0.32 lasso 6 0.34 5.0e-19 8.39 9.2 3.9e-20 0.96 0.01 0.99 FALSE
7 GTEx Ovary KREMEN1 0.28 0.18 enet 5 0.19 1.7e-05 8.39 8.7 4.3e-18 0.86 0.04 0.82 FALSE
8 GTEx Pancreas KREMEN1 0.33 0.24 lasso 7 0.23 4.2e-10 9.90 9.6 5.4e-22 0.99 0.00 1.00 FALSE
9 GTEx Thyroid KREMEN1 0.10 0.09 lasso 3 0.08 1.3e-06 9.89 9.9 4.8e-23 1.00 0.00 1.00 TRUE
10 METSIM Adipose KREMEN1 0.12 0.12 lasso 8 0.11 1.7e-16 9.69 9.8 1.3e-22 0.97 0.00 1.00 FALSE
11 YFS Blood KREMEN1 0.10 0.10 enet 14 0.10 1.3e-32 7.06 -6.5 7.5e-11 -0.65 1.00 0.00 FALSE
12 The Cancer Genome Atlas Colon Adenocarcinoma C22orf31 0.07 0.02 blup 64 0.06 2.7e-04 4.23 6.0 2.4e-09 0.64 0.04 0.50 FALSE
13 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma KREMEN1 0.13 0.10 lasso 5 0.11 3.3e-12 8.39 9.2 4.5e-20 0.93 0.04 0.96 FALSE
14 The Cancer Genome Atlas Skin Cutaneous Melanoma ZNRF3 0.44 -0.01 blup 126 0.05 2.0e-02 -0.53 7.3 2.9e-13 0.61 0.01 0.24 FALSE