Hub : Genes

L3MBTL2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1410 0.0500 8.6e-05 0.012 NA 0.038 NA 0.044 7.0e-02 NA 3.5e-03 NA 1.8e-03
2 GTEx Artery Tibial 0.0544 0.0271 6.0e-03 0.062 NA 0.039 NA 0.049 1.3e-05 NA 5.2e-04 NA 1.0e-04
3 GTEx Cells EBV-transformed lymphocytes 0.1200 0.0550 2.5e-03 0.076 NA 0.019 NA 0.050 1.8e-03 NA 7.9e-02 NA 1.0e-02
4 GTEx Esophagus Mucosa 0.1560 0.0700 1.6e-06 0.106 NA 0.117 NA 0.112 1.5e-07 NA 3.4e-08 NA 6.3e-08
5 GTEx Liver 0.1250 0.0680 7.1e-03 0.085 NA 0.087 NA 0.095 2.3e-03 NA 2.1e-03 NA 1.3e-03
6 GTEx Pituitary 0.1890 0.0760 2.2e-04 0.146 NA 0.191 NA 0.171 1.7e-04 NA 1.6e-05 NA 4.5e-05
7 GTEx Skin Not Sun Exposed Suprapubic 0.0790 0.0400 5.9e-03 0.000 NA 0.016 NA 0.022 3.1e-01 NA 4.2e-02 NA 2.2e-02
8 GTEx Skin Sun Exposed Lower leg 0.0810 0.0310 1.7e-04 0.028 NA 0.056 NA 0.047 2.2e-03 NA 2.1e-05 NA 9.2e-05
9 TCGA Thyroid Carcinoma 0.0450 0.0260 4.7e-04 0.035 0.034 0.036 NA 0.033 2.5e-04 0.00028 1.8e-04 NA 3.1e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 3.0 4.7 13.8 3.7 1.8 -1.7 0.4 0.1 1.2 3.6 1.4 2.5
Bipolar Disorder or Schizophrenia 5.2 12.8 38.1 6.2 3.0 -3.1 2.0 1.3 2.2 4.6 1.5 5.0
Depressed Affect (Nagel 2018) 4.4 9.2 18.6 2.5 0.7 -1.7 4.0 3.1 4.2 2.5 2.1 4.3
Depression (Nagel 2018) 1.0 1.5 2.7 1.4 0.3 -0.7 1.6 1.3 1.5 1.4 1.2 1.2
Intelligence (Savage-Jansen 2018) 4.9 15.0 30.5 -2.2 1.6 -1.0 -5.5 -4.8 -5.4 -4.0 -4.1 -3.2
Neuroticism (Nagel 2018) 10.1 23.8 51.2 5.9 2.5 -3.6 5.3 3.9 5.9 4.5 3.4 7.2
Schizophrenia (2018) 4.1 8.5 24.4 4.9 2.4 -2.6 2.2 1.6 1.9 3.0 0.8 4.3
Schizophrenia vs Biploar Disorder 0.3 0.3 1.7 0.6 0.1 -0.3 1.3 0.7 0.5 -0.3 -0.3 0.2
Worry (Nagel 2018) 8.8 18.6 39.7 5.7 2.4 -3.1 4.0 2.6 5.2 4.2 3.6 6.3
Alzheimer’s Disease (in mother) 0.8 1.0 3.4 1.8 1.0 -1.3 0.4 -0.2 0.8 1.0 0.0 0.9
Alzheimer’s Disease (in father) 1.5 1.6 3.6 1.3 1.4 -1.6 1.0 0.3 1.0 1.2 -0.7 1.9
Alzheimer’s Disease (including proxy) 3.4 5.0 12.7 3.6 2.0 -2.4 1.8 1.1 2.0 2.3 0.1 2.9
Crohns Disease (2017) 1.7 3.8 9.4 1.8 1.3 -2.0 2.8 1.4 1.5 1.9 -0.1 3.1
Irritable Bowel Disease (IBD) 1.7 4.0 9.2 2.4 2.4 -2.8 2.1 0.3 1.2 1.1 -0.8 3.0
Ulcerative Colitis (UC) 1.5 2.7 6.7 2.0 2.5 -2.6 0.9 -0.7 0.7 0.0 -1.1 2.2
Major Depression (MDD) 1.6 1.9 6.0 2.5 2.0 -1.1 -0.5 -0.5 0.6 -0.1 0.8 2.1
Reaction Time 1.4 2.7 7.7 -0.0 1.2 -0.4 -2.2 -2.1 -1.6 -2.8 -1.6 -0.6
Verbal and Numeric Reasoning (VNR) 5.1 12.3 22.2 -0.9 2.2 -1.5 -4.5 -4.7 -4.5 -3.9 -4.2 -2.6
Breast Cancer 1.2 2.8 7.9 -1.3 -2.2 1.4 -0.1 2.3 0.8 2.8 1.6 -0.4
Ovarian Cancer 0.3 0.4 1.1 -0.1 0.6 -0.3 -0.8 -0.8 1.1 -0.7 -0.4 -0.0
Prostate Cancer 1.6 2.2 5.5 2.4 2.2 -2.3 0.9 -0.4 0.8 -0.1 -0.4 1.7
Age at First Birth 1.3 1.9 5.8 2.4 1.8 -2.1 0.4 -0.4 -0.3 1.4 -0.7 1.0
Bipolar Disorder (2011) 0.9 0.9 3.7 1.1 -0.0 0.0 0.6 0.9 0.7 1.9 0.6 0.9
Body Mass Index (BMI) (2010) 2.8 3.9 7.4 1.3 -0.5 -0.1 2.4 2.7 2.4 2.6 1.9 2.1
Coronary Artery Disease (CAD) 0.9 1.1 3.5 -1.0 -1.5 1.6 0.2 0.1 -0.4 -0.7 0.1 -1.9
Crohns Disease (2012) 1.6 2.6 5.6 2.0 1.5 -2.0 1.9 0.6 0.8 1.5 -0.8 2.4
Mean Putamen Volume 0.3 0.4 0.9 -0.1 -0.8 0.3 0.7 0.6 0.4 0.7 0.1 -1.0
Fasting Glucose 0.7 0.9 4.1 -0.8 -0.8 0.2 2.0 1.3 0.7 0.1 0.1 0.2
HbA1C 0.7 0.8 2.4 -0.2 -0.6 0.2 0.5 1.4 1.0 0.0 1.5 0.9
HDL Cholesterol 0.3 0.4 1.1 0.2 -0.2 0.5 -0.9 -0.8 -0.9 -0.3 0.0 -1.0
LDL Cholesterol 0.1 0.2 0.6 0.6 -0.5 0.4 0.2 0.7 -0.4 -0.2 0.6 -0.4
Lupus 0.4 0.6 1.6 0.3 -0.7 0.5 1.1 1.0 0.7 0.6 1.3 0.4
Neuroticism (2016) 6.5 9.4 18.0 3.9 1.6 -2.2 2.4 2.0 4.1 3.3 2.5 4.2
Primary Biliary Cirrhosis 1.4 1.9 4.2 1.3 1.4 -2.0 1.5 0.7 1.3 0.7 -0.8 2.0
Rheumatoid Arthritis 2.1 2.9 5.8 -2.1 -1.7 2.0 -0.7 -0.4 -1.7 -2.4 -0.2 -2.4
Schizophrenia (2014) 4.0 8.7 26.4 5.1 2.0 -2.4 2.2 1.9 1.8 3.6 1.1 4.0
Triglycerides 0.8 1.3 3.6 1.5 1.2 -1.3 1.1 0.3 1.1 0.4 0.0 1.9
Type 2 Diabetes (T2D) (2012) 1.5 1.7 4.9 -0.8 -2.2 1.9 0.8 1.4 1.3 0.6 1.2 -0.6
Ulcerative Colitis 0.6 0.9 1.6 1.2 0.9 -1.1 1.1 0.4 0.8 0.7 -0.4 1.3
Blood Eosinophil Count 3.7 28.5 68.4 7.2 6.7 -8.3 4.3 0.4 2.9 2.2 -1.7 7.6
Blood Platelet Count 0.4 4.1 19.9 -1.3 -0.9 1.4 -4.5 -1.2 -2.4 0.6 0.4 -2.2
Blood Red Count 0.1 0.9 2.6 -1.6 -0.2 -0.2 -1.6 -0.6 -0.9 -0.3 -1.2 -0.4
Blood White Count 0.1 0.4 1.7 -1.3 -0.6 0.6 -0.7 0.3 0.4 -0.3 0.2 -0.2
Heel T-Score 5.2 41.7 106.1 7.5 10.3 -10.2 -0.3 -5.2 -0.1 -2.2 -5.7 6.7
BMI 2.1 12.4 26.9 -2.4 -4.4 3.5 4.2 5.2 3.2 1.7 4.0 0.3
Height 0.2 4.4 10.2 1.8 1.5 -2.4 2.5 2.0 0.8 3.2 -1.2 2.4
Waist Hip Ratio (WHR) 0.5 2.2 8.8 -1.4 1.1 -1.3 0.4 -0.5 -0.4 -2.4 -3.0 0.4
Systolic Blood Pressure 1.1 5.7 9.6 -0.3 -3.0 3.0 2.4 3.1 2.3 2.1 2.8 0.0
Smoking Status 4.2 10.0 22.0 -1.7 0.8 0.4 -4.7 -4.5 -3.4 -4.0 -2.5 -3.1
Allergy or Eczema 5.0 13.1 30.3 5.0 3.4 -4.3 3.4 1.8 2.9 3.0 0.7 5.5
Cardiovascular Disease 2.1 6.9 12.6 0.5 -2.2 1.5 3.1 3.6 3.4 2.6 3.4 1.5
Hypothyroidism (self reported) 2.9 6.6 13.1 -0.7 0.8 0.0 -3.4 -3.0 -3.6 -2.5 -3.0 -3.0
Respiratory disease 2.5 5.5 14.0 1.0 2.4 -3.5 3.1 0.5 2.0 -0.5 -1.4 3.7
Type 2 Diabetes (T2D) (2018) 3.5 6.6 13.1 -0.7 -2.7 2.0 3.6 3.6 3.0 2.1 2.5 1.2
Lung FEV1/FVC ratio 5.1 26.0 52.7 -0.8 -5.4 4.2 4.4 6.3 6.3 5.8 7.3 1.3
Lung FVC 1.0 5.0 21.2 -1.2 0.5 -0.0 -4.6 -3.2 -2.3 -1.3 -1.2 -1.9
Neuroticism 7.2 17.4 37.7 4.3 1.6 -2.6 4.3 3.6 5.5 4.1 3.3 6.1
Chronotype (morning person) 2.5 5.7 13.1 -0.6 -2.2 1.6 3.6 3.3 2.7 1.9 2.7 1.1
Hair Pigment 0.6 15.7 29.1 -5.4 -1.8 2.7 -4.3 -3.6 -3.9 -4.5 -2.8 -5.3
Tanning 0.3 4.2 7.5 -2.6 -0.8 1.3 -1.9 -1.6 -2.4 -2.5 -1.6 -2.7
Hand grip strength (left) 1.1 2.8 6.4 -2.0 -2.5 2.5 -0.0 1.7 0.2 1.3 1.2 -1.7
Number of treatments/medications taken 2.6 4.7 12.5 2.3 1.0 -1.7 2.4 2.3 2.4 1.9 1.0 3.5
Average weekly spirits intake 1.1 1.3 3.5 -1.1 -0.1 0.6 -1.9 -0.7 -1.6 -1.0 -1.2 -1.4
Sensitivity / hurt feelings 2.6 4.4 8.2 2.1 0.4 -0.9 2.4 2.4 2.4 2.3 1.7 2.9
Frequency of depressed mood in last 2 weeks 1.3 1.8 4.0 2.0 1.2 -1.6 1.1 0.7 0.8 1.4 0.6 1.9
Hearing difficulty/problems: Yes 0.5 0.8 2.2 0.3 0.7 -0.5 -1.5 -0.9 -0.9 -0.6 -1.3 -0.8
Relative age of first facial hair 0.4 0.8 2.7 -0.0 -0.0 -0.7 0.9 0.8 1.7 0.4 0.4 1.3
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 0.7 0.8 0.8 -0.7 0.9 -0.1 0.7 -0.8 -0.3 0.8
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.7 0.0 0.7 -0.7 -0.7 -1.2 -1.1 -1.4 -1.6 -0.4
Ever had hysterectomy (womb removed) 0.3 0.4 0.8 0.7 -0.2 -0.1 0.9 0.5 0.8 0.1 0.7 0.8
Systolic blood pressure, automated reading 1.6 4.7 9.4 -1.0 -3.0 3.1 2.1 2.7 1.5 1.0 2.7 -0.5
Eye problems/disorders: Diabetes related eye disease 2.8 3.1 8.4 1.3 -0.9 0.5 1.2 2.1 1.9 2.9 2.4 1.1
Angina 0.5 0.7 1.9 1.0 0.9 -1.4 0.5 0.3 0.0 0.9 -0.6 1.1
Medication for hormone replacement therapy 0.1 0.2 0.4 -0.5 -0.3 0.7 0.6 0.4 -0.2 -0.2 0.1 -0.2
Vitamin and mineral supplements 1.2 1.7 3.9 -1.1 -1.1 1.4 -1.8 -1.2 -0.5 -1.4 0.3 -2.0
Supplements: Zinc 1.9 2.1 3.4 -0.7 -1.7 1.3 1.6 1.8 1.7 1.2 1.8 0.1
Medication: Co-codamol 1.3 1.5 3.1 1.7 1.8 -1.6 -1.4 -1.1 -0.5 0.3 -0.8 0.8
Medication: Metformin 1.6 2.3 5.1 -0.7 -2.3 2.2 1.6 1.6 0.8 0.4 1.7 -1.0
Diabetes (father) 1.4 1.7 4.0 -0.6 -0.9 0.6 1.8 1.7 2.0 1.5 1.0 0.4
Diabetes (mother) 1.9 2.4 7.4 -1.4 -1.4 2.0 -0.8 -0.7 -1.4 -1.7 -0.5 -2.7
Severe depression (siblings) 0.5 0.6 1.4 -0.7 -1.2 0.9 -0.1 0.4 0.6 0.9 0.8 -0.7
Pack years adult smoking proportion 1.6 2.5 5.8 -2.1 -2.3 2.4 -0.8 0.4 -0.9 -0.9 0.2 -2.2
Impedance of leg (right) 1.7 8.4 22.0 2.1 4.5 -4.7 -0.5 -2.9 -1.1 -1.2 -3.6 2.2
Leg fat-free mass (left) 1.8 9.5 19.6 -0.1 -3.0 2.2 3.4 4.4 3.0 3.9 3.9 1.0
Trunk fat percentage 3.1 12.4 28.2 1.5 -0.3 -1.1 5.3 4.2 4.8 3.3 3.0 4.4
Hand grip strength (right) 1.0 2.6 6.4 -1.7 -2.3 2.5 0.4 1.5 -0.0 1.4 0.9 -1.9
Townsend deprivation index at recruitment 0.3 0.5 1.2 -0.9 -0.5 0.5 -0.9 -0.7 -0.3 -0.5 -0.3 -1.1
Current tobacco smoking 5.6 9.2 18.9 -2.0 -0.4 1.5 -4.3 -3.9 -2.8 -3.7 -2.1 -4.1
Average weekly fortified wine intake 1.1 1.3 4.1 0.2 1.0 -0.9 -0.1 -1.3 -1.4 -1.2 -2.0 -0.8
Maternal smoking around birth 2.9 4.2 10.0 -1.5 0.2 0.7 -3.2 -2.0 -2.5 -2.6 -1.7 -2.4
Fed-up feelings 2.5 4.6 9.4 1.5 0.3 -1.4 2.2 2.3 2.8 2.6 1.5 3.1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.7 5.8 0.3 -1.0 0.4 2.4 2.3 1.6 2.0 2.2 0.9
Relative age voice broke 0.1 0.2 0.7 -0.3 -0.4 0.2 0.8 0.6 0.8 -0.0 0.1 0.0
Taking other prescription medications 3.6 5.5 14.4 3.5 2.1 -2.5 1.9 1.2 2.2 1.4 1.2 3.8
Age when periods started (menarche) 2.9 6.9 17.4 3.8 4.2 -3.6 -1.6 -2.3 -1.9 0.5 -2.1 1.2
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.8 -1.4 -1.2 1.1 0.6 0.6 0.3 -0.2 0.3 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 7.1 16.1 38.8 5.5 6.2 -6.2 0.3 -1.9 1.4 0.1 -1.7 5.4
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.2 -0.0 -0.6 0.7 0.4 1.1 0.4 0.4 1.1 0.1
Qualifications: CSEs or equivalent 1.9 2.5 5.5 -2.0 -2.3 2.0 1.7 1.5 0.9 -0.6 1.1 -1.5
Serious illness, injury or assault to yourself 1.1 1.3 2.3 1.4 1.1 -1.5 1.1 0.4 1.1 1.2 -0.4 1.5
High blood pressure 0.8 2.2 4.4 1.0 -1.4 1.1 1.1 1.9 1.5 1.8 2.1 0.5
Hayfever, allergic rhinitis or eczema 2.9 6.4 13.8 3.6 2.3 -3.1 2.6 1.3 1.9 1.9 0.3 3.7
Multivitamins +/- minerals 1.2 1.6 3.7 0.7 0.3 -0.8 1.9 1.8 1.1 1.1 0.4 1.9
Stomach or abdominal pain in last month 1.8 2.3 5.6 1.8 2.4 -2.4 -1.0 -0.6 -0.1 0.2 -0.7 2.1
Supplements: Glucosamine 0.7 0.9 1.8 -0.4 0.5 -0.1 -0.9 -0.8 -1.3 -1.3 -1.3 -1.1
Diverticular disease/diverticulitis (self-reported) 1.1 1.4 4.4 -0.2 0.9 -0.6 -2.1 -1.6 -1.1 -1.3 -1.1 0.2
Medication: Atenolol 1.0 1.3 3.2 -1.8 -1.7 1.7 0.3 1.1 0.6 0.3 0.2 -0.9
Medication: Levothyroxine sodium 2.1 3.6 6.3 0.8 1.3 -0.5 -2.5 -2.3 -2.5 -2.2 -2.2 -1.6
Sitting height 0.1 0.8 5.8 0.4 -0.3 -0.0 0.1 1.1 -0.0 2.4 0.0 0.2
Chronic bronchitis/emphysema (father) 0.7 0.8 2.2 -0.9 0.9 -0.7 -0.0 -0.3 -0.8 -1.5 -1.2 0.8
High blood pressure (mother) 1.4 1.9 5.4 -2.3 -2.0 1.9 0.1 0.5 0.8 -0.4 0.8 -1.5
Body mass index (BMI) 2.2 9.3 19.8 -0.8 -3.4 2.6 3.3 4.5 3.3 2.3 4.1 0.8
Impedance of leg (left) 1.6 7.9 21.7 2.3 4.4 -4.7 -0.4 -2.7 -0.8 -0.8 -3.4 2.3
Leg predicted mass (left) 1.7 9.2 19.0 -0.1 -2.9 2.1 3.4 4.4 3.0 3.8 3.8 1.0
Trunk fat mass 2.8 12.2 25.5 1.3 -1.0 -0.3 5.1 4.6 4.5 3.7 3.5 3.8
Waist circumference 1.6 5.9 12.9 0.1 -1.7 0.8 3.5 3.6 3.2 1.8 2.7 1.7
Number of incorrect matches in round 3.5 5.9 12.0 2.6 -0.4 0.2 2.4 2.6 2.9 2.9 3.5 2.2
Past tobacco smoking 0.6 1.2 3.0 -0.9 -1.7 1.5 0.2 0.7 0.2 1.2 0.5 -1.5
Alcohol usually taken with meals 0.6 0.9 2.7 0.8 1.1 -1.3 0.4 0.3 0.8 0.9 -0.5 1.6
Nervous feelings 5.0 9.3 26.0 5.1 3.3 -3.6 1.2 0.5 2.1 2.0 1.2 4.7
Frequency of tenseness / restlessness in last 2 weeks 1.8 2.7 7.9 2.1 1.9 -2.3 0.8 -0.0 1.4 0.7 0.3 2.8
Hearing difficulty/problems with background noise 0.4 0.7 2.6 0.4 -0.6 0.7 0.8 1.6 0.7 0.7 0.9 0.4
Hair/balding pattern: Pattern 2 0.2 0.3 0.8 -0.6 -0.4 0.3 0.6 0.7 0.9 -0.2 -0.2 0.1
Had menopause 1.1 1.3 2.2 -0.5 0.3 -0.2 -1.5 -1.4 -1.3 -1.5 -1.5 -1.1
Had other major operations 0.4 0.5 1.2 0.2 -0.2 0.2 1.1 1.0 0.7 -0.3 0.6 1.1
Forced vital capacity (FVC) 0.2 0.8 1.8 0.6 1.1 -1.3 -0.8 -0.9 -0.4 0.9 -0.8 0.6
Heel bone mineral density (BMD) T-score, automated (right) 5.3 12.2 28.4 5.0 5.3 -5.3 0.2 -1.9 1.0 0.0 -1.0 4.8
Ever unenthusiastic/disinterested for a whole week 3.0 3.7 8.9 0.1 -1.4 1.1 2.5 3.0 2.3 1.5 2.2 1.7
Qualifications: None of the above 0.2 0.4 1.7 -0.8 -0.3 0.6 -0.6 -0.5 -0.6 -1.3 0.2 -0.5
Financial difficulties in last 2 years 1.3 1.8 3.8 -0.5 0.5 -0.4 -1.9 -1.6 -1.9 -1.7 -1.3 -1.0
Mouth/teeth dental problems 1.5 2.3 6.5 -0.2 -1.9 1.9 2.5 1.6 0.8 1.2 1.0 -0.8
Heart attack 1.7 2.2 6.2 1.9 2.2 -2.5 -0.5 -0.7 -0.8 -0.2 -1.3 1.5
Allergy 3.9 8.9 22.2 -3.5 -3.2 4.3 -3.0 -1.3 -2.0 -1.4 0.7 -4.7
Pain all over the body in last month 0.3 0.3 1.3 0.2 0.7 -0.6 0.2 -0.0 0.1 -0.2 0.1 1.2
Diabetes (self-reported) 1.4 2.2 5.0 0.2 -1.4 1.3 2.2 2.0 1.8 1.1 1.6 0.6
Hayfever/allergic rhinitis (self-reported) 1.2 1.7 5.0 1.3 1.3 -1.7 1.3 1.0 0.8 0.3 -0.1 2.2
Medication: Ramipril 0.7 0.9 2.6 0.9 0.0 -0.5 0.5 1.2 0.9 1.5 0.4 1.6
Medication: Simvastatin 0.4 0.6 1.8 -0.8 -1.2 1.3 -0.1 0.7 0.4 -0.2 1.0 -0.1
Fluid intelligence score 2.6 5.4 11.0 -0.6 1.4 -0.9 -3.3 -3.1 -3.3 -2.3 -2.5 -1.4
Illnesses of siblings 0.2 0.3 0.7 0.6 0.6 0.0 -0.1 -0.8 -0.8 -0.5 -0.4 -0.6
Neuroticism score 7.4 15.3 33.1 4.2 1.2 -2.2 3.8 3.5 4.9 4.0 3.7 5.8
Weight 2.2 10.7 22.8 0.5 -2.3 1.3 4.1 4.8 3.8 3.8 3.9 2.1
Impedance of arm (right) 2.2 10.3 29.5 2.4 4.5 -5.4 2.1 -1.2 1.1 -0.1 -2.6 4.7
Arm fat percentage (right) 2.5 10.0 21.7 0.2 -1.5 0.3 4.7 4.4 4.2 2.6 3.3 3.3
Trunk fat-free mass 0.8 4.5 9.6 -0.3 -2.6 2.3 1.4 3.1 1.0 2.9 2.7 -0.4
Hip circumference 2.5 10.8 19.0 1.6 -1.6 0.8 4.2 4.2 4.1 3.7 4.4 2.5
Time employed in main current job 2.0 2.3 6.4 2.4 -0.6 0.7 0.7 1.0 0.6 2.4 2.5 0.1
Alcohol intake versus 10 years previously 0.6 0.9 2.5 -0.8 -0.9 0.5 1.1 1.6 1.3 0.6 0.5 0.4
Father’s age at death 0.8 1.0 2.3 0.3 1.4 -1.0 -0.6 -1.5 -0.5 -1.1 -1.4 0.1
Worrier / anxious feelings 6.3 11.8 22.3 4.2 1.4 -2.1 3.9 2.9 4.0 3.2 3.2 4.7
Frequency of tiredness / lethargy in last 2 weeks 5.6 9.1 20.1 2.4 0.7 -1.7 3.1 3.2 4.0 3.4 2.4 4.5
Falls in the last year 0.5 0.6 1.3 1.0 0.4 -0.4 1.1 0.7 1.1 0.3 0.6 1.1
Hair/balding pattern: Pattern 3 1.0 1.5 4.7 1.0 0.3 -0.3 0.8 1.3 1.4 2.2 1.3 1.5
Number of live births 0.6 0.8 2.5 -1.6 0.3 -0.5 -0.9 -0.8 -0.6 -1.5 -0.6 -0.1
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 5.0 0.1 -0.5 -0.1 0.7 0.9 1.3 2.2 0.9 1.0
Pulse rate 0.4 0.7 2.2 0.8 0.6 -0.7 -0.6 0.2 -0.6 1.5 0.6 1.1
Happiness 2.6 3.1 6.4 2.0 0.3 -0.7 1.7 2.2 1.5 2.4 1.1 2.5
Noisy workplace 0.2 0.2 0.6 0.1 -0.5 0.5 0.3 0.5 0.4 0.3 0.5 -0.8
Qualifications: A levels/AS levels or equivalent 0.7 1.6 5.2 0.7 1.2 -0.8 -1.8 -2.3 -1.0 -0.2 -1.2 -0.9
Serious illness, injury or assault of a close relative in last 2 years 3.8 4.4 11.4 -1.0 1.4 -0.6 -2.0 -2.1 -3.0 -2.3 -3.4 -1.2
Mouth/teeth dental problems: Dentures 3.3 5.5 9.2 -1.6 1.1 -0.8 -3.0 -2.6 -2.9 -3.0 -3.0 -1.8
Asthma 3.0 5.9 15.8 2.1 3.1 -4.0 2.4 0.2 1.6 -0.2 -1.2 3.7
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.2 2.7 1.0 1.6 -1.7 -0.7 -0.5 -0.9 0.5 -1.3 1.1
Medication: Cholesterol lowering 0.6 1.0 2.6 -0.4 -1.6 1.6 0.2 1.2 0.0 0.2 1.4 -0.5
Depression (self-reported) 2.6 3.1 9.3 2.0 1.9 -2.1 0.9 0.4 1.9 1.5 0.6 3.0
Medication: Lansoprazole 1.4 1.6 4.8 1.5 1.0 -1.3 1.3 0.9 1.4 0.7 0.2 2.2
Prospective memory result 0.4 0.5 1.2 0.8 -0.2 -0.1 0.1 0.5 1.0 0.8 1.1 0.8
Lung cancer (father) 1.3 1.5 3.3 0.3 0.8 -0.4 -1.8 -1.4 -1.2 -1.3 -1.6 -1.3
Illnesses of mother 1.3 1.7 6.0 0.2 1.0 -0.6 -1.3 -1.4 -2.5 -0.8 -1.7 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 8.6 0.8 -0.2 -0.5 0.9 1.5 1.3 2.9 1.2 1.5
Pulse wave Arterial Stiffness index 1.7 2.0 5.8 0.3 -0.8 0.4 1.2 2.4 2.0 2.1 1.1 0.6
Impedance of arm (left) 2.3 10.7 27.5 2.3 4.2 -5.2 3.0 -0.6 2.0 0.5 -2.4 5.2
Arm fat mass (right) 2.7 11.0 23.3 0.2 -2.1 0.9 4.6 4.8 4.1 3.2 3.8 2.7
Trunk predicted mass 0.8 4.7 9.9 -0.4 -2.6 2.4 1.5 3.2 1.1 2.9 2.8 -0.4
Standing height 0.5 4.8 12.0 2.6 1.6 -2.4 2.3 1.4 1.4 3.5 0.0 2.8
Length of working week for main job 0.3 0.3 0.9 -0.6 -0.6 0.6 0.6 1.0 0.5 0.6 -0.0 0.2
Exposure to tobacco smoke at home 0.9 1.0 4.2 2.1 1.4 -1.0 -0.7 -1.0 -0.5 0.1 -0.3 0.1
Breastfed as a baby 1.0 1.2 2.8 0.7 1.5 -1.6 0.9 -0.3 0.8 0.3 -1.7 1.2
Tense / ‘highly strung’ 7.5 12.4 29.6 3.3 1.0 -2.0 3.3 3.4 4.1 4.0 3.2 5.4
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.7 8.9 2.7 1.4 -1.7 1.6 1.4 1.7 2.0 1.1 3.0
Hair/balding pattern: Pattern 4 1.6 3.9 10.4 -0.8 -0.7 1.5 -1.8 -2.4 -2.2 -2.7 -0.2 -3.2
Birth weight of first child 0.8 1.4 3.5 0.3 -1.0 0.5 0.9 1.9 1.0 1.7 1.6 0.6
Peak expiratory flow (PEF) 1.0 2.2 4.1 -0.8 -2.0 1.5 1.2 2.0 1.2 1.6 1.8 -0.0
Pulse wave reflection index 1.0 1.3 3.6 -0.2 -1.0 0.8 0.7 1.9 1.5 1.6 0.8 0.1
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.7 0.7 0.4 -0.5 1.1 0.5 1.1 -0.1 0.2 1.3
Loud music exposure frequency 2.4 2.6 4.7 0.6 1.8 -1.9 -1.6 -2.2 -1.9 -1.3 -1.9 -0.0
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 2.1 0.5 0.8 -0.7 -0.0 -0.8 -0.8 -0.6 -1.4 -0.7
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 3.8 0.9 0.1 -0.3 1.1 1.4 1.8 1.5 1.7 2.0
Blood clot in the leg (DVT) 1.0 1.3 3.1 -1.0 -1.8 1.5 0.1 1.4 0.4 0.5 1.7 -0.1
Medication: Paracetamol 1.4 2.3 6.0 2.5 0.4 -0.8 1.0 1.3 1.5 2.0 1.5 1.8
Headache pain in last month 1.1 1.9 7.2 -0.0 -0.6 -0.2 1.3 2.7 1.4 2.0 0.4 1.3
Medication for cholesterol, blood pressure or diabetes 1.7 2.8 7.6 -0.2 2.1 -1.9 -1.1 -2.2 -1.1 -1.7 -2.8 -0.1
Glaucoma (self-reported) 3.3 3.9 9.1 3.0 3.0 -3.0 0.8 -0.4 0.0 -0.1 -0.4 2.7
Gout (self-reported) 1.3 1.8 4.2 2.0 2.1 -2.0 0.0 -1.0 0.3 -0.6 -0.9 1.2
Hypothyroidism/myxoedema (self-reported) 1.8 3.6 8.4 -0.3 0.9 -0.1 -2.3 -1.9 -2.9 -2.0 -2.4 -2.0
Medication: Amlodipine 1.1 1.6 4.8 -0.9 -2.0 2.2 -0.2 0.6 0.4 0.7 1.0 -1.7
Medication: Ventolin 100micrograms inhaler 4.2 5.4 14.0 2.5 3.1 -3.7 2.0 0.1 1.5 1.0 -1.2 3.2
Birth weight 0.3 0.7 2.6 0.8 1.0 -1.0 -0.3 0.3 0.5 1.6 0.1 1.1
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.7 -0.7 -0.5 0.1 1.2 1.3 1.3 1.1 0.5 0.7
High blood pressure (siblings) 0.2 0.2 0.6 0.6 0.1 -0.4 0.1 0.2 0.8 0.4 0.5 0.7
Forced vital capacity (FVC), Best measure 0.2 0.7 1.5 0.7 1.1 -1.2 -0.9 -0.4 -0.6 1.1 -0.6 0.7
Body fat percentage 2.7 10.6 22.3 1.1 -0.8 -0.5 4.7 4.1 4.5 3.0 3.2 3.8
Leg fat percentage (right) 1.4 5.1 9.8 0.4 -1.1 0.3 3.0 3.1 3.1 1.8 2.8 2.2
Arm fat-free mass (right) 1.2 6.0 11.4 -0.6 -3.1 2.8 1.7 3.4 1.5 3.1 3.1 -0.7
Exposure to tobacco smoke outside home 4.5 5.9 10.7 0.8 2.3 -1.8 -3.3 -2.9 -3.1 -3.0 -2.4 -0.7
Comparative body size at age 10 2.9 8.0 22.8 -1.4 -4.3 4.8 -0.1 1.4 0.6 0.8 3.6 -3.7
Number of full brothers 2.2 2.7 6.2 -1.6 0.5 -0.2 -2.2 -2.2 -1.6 -2.5 -1.5 -0.9
Worry too long after embarrassment 2.1 3.6 8.6 2.4 1.1 -1.3 2.1 1.3 2.1 1.2 1.6 2.9
Seen a psychiatrist for nerves, anxiety, tension or depression 5.2 6.7 17.1 3.0 1.7 -2.3 2.4 2.2 2.5 2.8 1.4 4.1
Wheeze or whistling in the chest in last year 1.4 2.5 6.2 1.5 2.1 -2.5 1.2 -0.1 1.1 -0.5 -1.0 2.5
Number of children fathered 1.0 1.1 2.8 -1.7 -1.4 1.6 -0.4 0.5 0.7 0.0 1.0 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.9 1.7 0.5 -0.1 0.3 -0.7 0.7 0.8 0.8 0.0
Age at first live birth 1.5 2.7 7.1 2.7 0.8 -0.9 1.2 1.4 1.6 2.3 1.2 1.8
Pulse wave peak to peak time 1.1 1.3 4.2 -0.0 0.8 -0.4 -0.8 -2.1 -1.6 -1.7 -0.7 -0.3
Health satisfaction 0.9 1.2 3.9 1.1 0.1 -0.3 1.3 1.5 0.9 0.6 0.5 2.0
Shortness of breath walking on level ground 0.3 0.3 1.5 1.2 0.4 -0.7 0.3 0.0 0.5 0.1 -0.1 0.7
Qualifications: College or University degree 0.4 1.4 2.8 1.5 1.7 -1.4 -1.1 -0.8 -0.5 1.2 -1.2 0.7
Eye problems/disorders: None of the above 3.6 4.2 8.3 0.1 2.0 -1.6 -1.4 -2.4 -2.5 -2.9 -2.8 -1.0
Mouth/teeth dental problems: Loose teeth 2.6 3.0 6.3 -1.7 -1.1 1.7 -2.5 -1.3 -2.2 -1.3 -0.4 -2.4
Emphysema/chronic bronchitis 1.3 1.5 3.6 0.4 1.9 -1.9 -0.2 -0.5 -0.2 -1.0 -1.2 1.7
Medication for pain relief, constipation, heartburn 3.2 5.5 13.4 -3.2 -2.2 2.8 -1.2 -1.2 -1.7 -2.8 -0.4 -3.7
Neck or shoulder pain in last month 2.3 3.3 8.6 2.2 2.1 -2.3 1.5 1.1 1.2 1.2 -0.1 2.9
Medication: Blood pressure 1.0 1.7 4.4 1.0 -1.3 1.1 1.0 1.4 0.7 1.9 2.1 0.5
Angina (self-reported) 0.4 0.5 1.4 0.7 0.8 -1.2 0.2 -0.0 -0.3 0.6 -0.8 0.8
Migraine (self-reported) 2.8 3.5 8.5 0.2 -1.0 0.5 2.0 2.9 2.2 2.8 1.8 1.4
Medication: Ibuprofen 2.9 3.4 8.1 1.6 2.7 -2.9 -1.3 -1.4 -1.3 -0.3 -2.2 1.6
Medication: Allopurinol 1.6 2.1 4.3 1.8 2.0 -2.1 1.5 0.0 0.7 0.3 -0.8 1.8
Medication: Omeprazole 3.3 3.9 9.7 2.3 3.1 -3.1 -0.9 -1.4 -0.8 -0.5 -1.9 1.9
Medication: Seretide 50 evohaler 0.6 0.7 2.5 0.4 0.2 -0.6 1.5 0.6 1.6 -0.2 0.3 0.7
Mean time to correctly identify matches 2.2 4.2 12.6 -0.0 1.4 -0.3 -2.6 -2.7 -2.1 -3.5 -2.0 -1.2
Heart disease (mother) 0.4 0.4 1.3 -0.5 -0.9 0.6 -0.0 0.5 1.1 0.3 0.9 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 2.3 1.1 1.4 -1.0 0.9 -0.5 -0.3 -1.5 -0.8 0.7
Whole body fat mass 2.6 10.7 21.1 1.0 -1.4 0.2 4.6 4.4 4.3 3.3 3.6 3.1
Leg fat mass (right) 1.9 7.4 15.2 0.3 -2.0 1.1 3.5 3.9 3.3 2.7 3.5 1.8
Arm predicted mass (right) 1.2 6.4 11.6 -0.5 -3.2 3.0 1.7 3.4 1.6 3.2 3.2 -0.7
Pulse rate, automated reading 0.4 1.2 4.0 1.7 0.4 -0.7 -0.5 0.8 -0.1 2.0 1.1 1.2
Alcohol intake frequency. 2.9 6.7 14.1 1.5 -0.0 -1.0 3.1 3.2 3.1 2.8 2.4 3.8
Comparative height size at age 10 0.1 0.6 2.0 -0.7 -0.8 0.5 1.0 1.4 -0.2 0.9 0.0 0.4
Number of full sisters 5.3 6.5 12.5 -1.0 0.9 0.1 -2.9 -3.5 -3.0 -3.3 -2.7 -2.8
Suffer from ‘nerves’ 3.0 4.8 10.4 2.8 1.3 -1.3 2.1 1.4 2.9 1.5 2.1 3.2
Overall health rating 1.4 2.9 7.3 0.9 -0.1 -0.4 2.3 2.3 1.9 1.2 1.4 2.7
Chest pain or discomfort 1.7 2.5 6.6 2.2 1.0 -1.5 1.0 1.5 0.3 2.0 0.2 2.6
Had major operations 0.7 0.8 2.9 -0.9 0.3 -0.1 -0.9 -0.9 -1.7 -1.0 -1.0 -0.4
Age at last live birth 2.2 3.1 6.8 1.5 -0.1 -0.3 1.7 2.0 2.2 2.6 1.8 1.9
Family relationship satisfaction 1.9 2.3 4.9 1.1 0.2 -0.6 1.9 2.0 1.6 1.8 0.8 2.2
Leg pain on walking 0.3 0.4 1.6 0.2 0.6 -0.5 -0.1 -0.9 0.4 -1.3 -0.4 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.9 0.3 0.3 0.1 -0.6 -0.1 -0.9 -0.2 -0.8 -0.3
Commuting to job workplace: Car/motor vehicle 0.2 0.3 1.0 -1.0 -0.5 0.6 0.3 0.6 0.4 -0.3 -0.4 -0.1
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 5.7 0.4 -1.1 1.1 1.1 1.0 1.4 0.7 2.4 -0.0
Medication: Aspirin 0.6 0.7 2.0 0.9 1.4 -1.3 -0.8 -0.6 -0.4 0.1 -0.5 0.9
Supplements: Vitamin C 0.1 0.1 0.5 -0.3 0.1 -0.1 0.6 0.1 -0.1 0.2 -0.7 -0.2
Knee pain experienced in last month 0.3 0.4 1.2 -1.1 -0.3 0.3 0.4 0.6 0.8 -0.6 0.0 0.8
Hypertension (Self-reported) 0.7 1.9 3.6 1.0 -1.0 0.7 1.2 1.8 1.6 1.7 1.9 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.7 0.0 0.8 -0.8 0.1 -0.1 -0.2 -0.7 -0.8 0.8
Illnesses of father: Heart disease 0.8 1.1 2.6 -0.3 -1.3 1.1 0.7 1.6 0.6 1.3 1.4 0.1
Illnesses of siblings: Diabetes 1.9 2.3 5.4 -0.8 -1.6 1.3 1.4 2.3 1.6 1.7 1.5 0.8
Smoking status: Previous 0.9 1.3 4.9 0.9 0.8 -0.9 1.4 1.2 0.9 0.3 0.7 2.2
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.4 6.5 -0.1 -1.3 0.6 2.2 2.2 1.4 2.6 0.9 0.6
Whole body fat-free mass 1.2 6.9 14.7 -0.3 -3.0 2.5 2.3 3.8 1.9 3.5 3.4 0.0
Leg fat-free mass (right) 1.8 9.6 19.6 -0.1 -3.1 2.3 3.3 4.4 3.1 4.0 3.9 0.9
Arm fat percentage (left) 2.9 11.5 25.4 0.1 -1.7 0.4 5.0 4.7 4.6 2.9 3.4 3.4
Average weekly red wine intake 1.5 2.3 5.3 -1.4 -0.1 0.5 -2.3 -1.6 -1.6 -1.4 -1.7 -1.8
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.7 0.0 -0.2 0.1 -1.1 0.3 -0.6 1.3 0.3 0.2
Mood swings 10.0 18.1 38.9 5.7 2.5 -3.4 3.9 3.3 4.6 4.3 2.9 6.2
Loneliness, isolation 0.4 0.5 2.0 -0.5 -0.0 -0.5 -0.0 0.6 1.1 0.5 0.6 1.4
Long-standing illness, disability or infirmity 1.8 2.8 4.9 1.7 0.1 -0.3 2.2 2.0 2.1 1.4 1.4 2.1
Ever had bowel cancer screening 0.8 0.9 1.9 0.8 0.2 -0.5 0.2 0.9 1.4 1.1 1.3 1.3
Diabetes diagnosed by doctor 2.8 4.5 9.0 0.3 -1.9 1.6 3.0 2.8 2.7 1.7 2.5 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 1.4 -1.2 -0.7 0.6 0.1 -0.3 0.6 -0.9 0.7 -0.4
Friendships satisfaction 0.4 0.5 1.4 0.6 0.4 -0.2 1.0 1.0 0.1 -0.4 -0.1 1.2
Qualifications: nursing, teaching 0.3 0.5 1.1 -0.7 -0.3 -0.3 0.3 0.9 1.0 0.9 0.2 1.0
Commuting to job workplace: Walk 1.1 1.1 2.8 1.5 1.7 -1.5 -0.6 -1.0 -0.3 -0.1 -1.1 0.6
Eye problems/disorders: Cataract 4.6 5.3 9.3 -0.5 -2.4 2.0 2.2 2.6 3.0 3.0 2.8 0.8
Mouth/teeth dental problems: Mouth ulcers 2.4 3.8 10.6 3.3 2.8 -2.9 -0.8 -0.9 0.0 0.8 0.0 2.4
Medication for cholesterol 0.4 0.7 1.8 -0.1 0.5 -0.5 -0.8 -1.2 -1.3 -0.5 -0.9 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.6 1.3 0.4 -0.5 0.7 0.6 1.2 0.8 0.8 1.2
Back pain experienced in last month 1.7 2.5 6.2 2.5 2.4 -2.3 0.3 -0.2 0.6 1.0 -0.6 1.8
Mineral and other dietary supplements 0.3 0.4 0.7 -0.1 -0.6 0.7 -0.8 -0.8 0.3 -0.2 0.8 -0.6
Breast cancer (self-reported) 0.6 0.7 2.6 0.3 0.6 -0.2 1.6 0.7 0.7 -1.3 -0.2 0.9
Asthma (self-reported) 2.6 5.2 12.8 1.9 2.7 -3.6 2.5 0.4 1.9 -0.0 -1.0 3.5
Osteoporosis (self-reported) 0.6 0.8 2.2 1.5 1.0 -1.3 0.1 0.5 0.4 0.7 -0.2 1.2
Osteoarthritis (self-reported) 1.4 1.8 4.3 1.4 2.0 -2.1 0.3 0.0 -0.5 -0.3 -1.1 2.0
Medication: Aspirin 0.7 1.0 2.5 1.0 1.6 -1.4 -0.9 -0.9 -0.6 -0.2 -0.8 0.8
Medication: Gliclazide 0.1 0.1 0.3 0.4 0.1 0.3 0.5 0.2 0.2 -0.5 0.6 -0.0
Illnesses of father: None of the above (group 1) 1.6 1.9 6.2 -0.2 0.5 -0.0 -2.5 -2.1 -1.3 -1.4 -0.8 -1.4
Smoking status: Current 5.0 8.0 18.4 -1.2 0.3 0.7 -4.3 -4.0 -2.6 -3.3 -2.2 -3.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.7 -0.3 -0.1 -0.1 -0.5 -0.1 0.4 0.8 0.5 0.6
Whole body water mass 1.1 6.4 13.3 -0.2 -2.8 2.4 2.2 3.7 1.9 3.4 3.3 0.0
Leg predicted mass (right) 1.8 9.6 19.6 -0.1 -3.0 2.3 3.3 4.4 3.1 4.0 3.9 0.9
Arm fat mass (left) 2.8 11.4 24.2 0.1 -2.2 1.1 4.8 4.9 4.2 3.2 3.8 2.7
Number of self-reported non-cancer illnesses 4.2 7.2 14.8 1.7 -0.1 -0.9 3.8 3.4 3.3 2.4 2.0 3.8
Average weekly champagne plus white wine intake 0.3 0.4 1.1 -0.3 0.3 -0.6 0.6 0.6 0.6 0.9 -0.5 1.0
Miserableness 1.8 3.1 7.3 1.4 0.1 -0.7 2.0 1.9 2.7 1.2 1.8 2.4
Guilty feelings 3.2 4.9 10.1 2.6 0.9 -1.5 1.3 1.8 2.5 2.5 2.6 3.2
Wears glasses or contact lenses 3.1 3.6 6.7 1.2 -0.0 -0.2 1.8 2.6 2.5 2.5 1.9 2.0
Ever taken oral contraceptive pill 2.0 2.3 5.7 0.6 1.3 -0.6 -2.3 -2.4 -1.2 -1.7 -1.2 -1.0
Hearing aid user 0.8 0.9 1.7 -1.2 -1.3 1.3 -0.5 0.9 0.0 0.0 0.9 -1.0
Mother’s age at death 1.4 1.8 3.9 -0.0 0.9 -0.7 -1.5 -1.9 -1.3 -2.0 -1.4 -1.0
Financial situation satisfaction 0.3 0.4 1.8 -0.1 0.2 -0.7 -0.1 1.1 0.3 0.5 0.1 1.3
Tinnitus: Yes, now most or all of the time 0.2 0.2 0.3 0.6 0.4 -0.3 0.5 0.4 0.0 0.5 -0.6 0.3
Commuting to job workplace: Public transport 4.4 5.2 11.6 0.8 1.5 -0.9 -3.4 -3.4 -3.0 -2.3 -1.8 -1.7
Eye problems/disorders: Glaucoma 4.8 5.6 15.0 3.2 3.9 -3.8 0.1 -1.5 -0.3 -0.9 -1.1 2.7
Medication: Blood pressure 0.3 0.5 1.1 0.2 -0.9 0.5 0.1 0.8 1.0 0.9 1.0 0.1
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.9 1.0 1.4 -1.1 -1.1 -0.9 -0.2 -0.3 -1.0 0.0
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.8 0.0 0.9 -1.1 1.2 1.0 -0.1 -0.0 -0.9 1.3
High cholesterol (Self-reported) 1.0 1.8 4.9 -0.4 -1.9 2.2 0.5 1.2 1.2 -0.5 2.0 -0.5
Medication: Bendroflumethiazide 0.2 0.3 0.7 -0.6 -0.8 0.6 -0.7 -0.4 0.3 -0.2 0.7 -0.3
Medication: Paracetamol 1.0 1.5 4.3 2.1 0.8 -1.1 0.6 0.7 0.9 1.5 0.9 1.8
Medication: Lisinopril 0.3 0.3 0.9 0.9 0.5 -0.7 -0.4 -0.6 0.7 0.3 0.1 0.5
Medication: Atorvastatin 1.1 1.3 2.7 -0.3 -1.6 1.6 1.6 1.0 0.6 0.0 1.6 -0.4
Illnesses of father: High blood pressure 1.2 1.4 3.6 1.9 -0.1 -0.3 1.1 0.9 1.0 1.8 1.4 1.0
Alcohol drinker status: Never 1.7 2.1 4.2 2.1 0.3 -0.7 0.9 1.3 1.0 2.0 1.6 1.9
Ever smoked 0.9 1.6 4.2 0.2 1.7 -1.4 -1.0 -1.3 -0.3 -2.1 -1.1 1.0
Basal metabolic rate 1.5 8.2 17.6 -0.0 -2.9 2.2 3.0 4.2 2.5 3.7 3.6 0.6
Leg fat percentage (left) 1.5 5.6 10.9 0.5 -1.2 0.3 3.1 3.2 3.3 2.0 2.9 2.3
Arm fat-free mass (left) 1.3 6.5 13.5 -0.1 -3.0 2.6 2.0 3.7 1.7 3.3 3.5 -0.2
Number of operations (self-reported) 0.3 0.4 2.7 -0.7 0.2 -0.1 0.1 -0.3 -0.4 -1.7 -0.4 0.2
Average weekly beer plus cider intake 3.0 4.3 8.3 -2.3 -0.5 0.9 -1.9 -1.9 -2.6 -2.8 -1.7 -2.9
Irritability 7.4 12.5 23.4 3.8 1.1 -2.2 3.7 3.8 4.0 4.2 2.5 4.8
Risk taking 0.7 1.1 2.2 -1.1 -0.3 0.4 -0.9 -1.3 -0.9 -1.5 -0.6 -1.5
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.3 0.4 0.1 0.0 1.1 1.1 0.7 0.6 0.7 0.6
Fractured/broken bones in last 5 years 0.3 0.3 0.8 -0.0 -0.8 0.5 0.6 0.9 -0.6 0.5 0.4 -0.4
Age started oral contraceptive pill 0.6 0.8 1.7 -1.2 -1.2 0.9 0.3 0.8 1.3 -0.2 0.9 -0.1
Diastolic blood pressure, automated reading 2.0 6.3 13.5 -0.0 -2.5 2.0 2.0 3.7 2.7 3.2 3.1 1.0
Ever depressed for a whole week 1.9 2.4 3.6 1.7 0.0 -0.1 1.7 1.9 1.8 1.7 1.4 1.9
Unable to work because of sickness or disability 0.3 0.4 1.0 1.0 1.0 -0.7 -0.7 -0.5 -0.5 -0.1 -0.5 0.5
Commuting to job workplace: Cycle 0.9 1.1 2.1 -0.8 -1.4 1.1 1.1 1.1 1.0 0.9 1.0 -0.3
Myopia 3.1 4.4 9.1 -0.4 1.5 -1.1 -3.0 -3.0 -2.8 -1.6 -2.4 -1.5
Vascular/heart problems diagnosed by doctor 0.6 1.8 3.6 -0.6 1.4 -1.1 -0.8 -1.8 -1.2 -1.7 -1.9 -0.5
Cholesterol lowering medication 1.3 1.9 4.6 -0.2 -1.0 0.9 1.7 1.9 2.2 0.6 1.3 1.4
Medication: Omeprazole (e.g. Zanprol) 3.2 4.0 10.2 2.5 3.0 -3.2 0.1 -0.7 -0.1 -0.1 -1.4 2.8
Pain experienced in last month 0.4 0.7 2.0 -1.0 -1.4 1.1 -0.2 -0.4 0.1 -0.4 0.4 -1.4
Supplements: Calcium 1.4 1.6 4.4 1.0 1.3 -1.8 1.4 0.8 1.0 0.2 -0.5 2.1
Basal cell carcinoma (self-reported) 5.4 6.4 13.3 3.4 2.5 -3.1 2.0 0.4 2.9 1.6 1.4 3.6
Heart attack/myocardial infarction (self-reported) 2.0 2.6 7.3 1.7 2.4 -2.7 -0.7 -1.0 -1.0 -0.5 -1.7 1.4
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.2 -0.7 -1.4 1.4 -0.2 0.8 0.1 0.1 1.5 -0.4
Heart disease (siblings) 0.2 0.3 1.5 -0.8 -0.0 -0.3 -1.2 -0.3 0.2 -0.0 -0.1 0.1
Alcohol drinker status: Previous 0.6 0.7 2.2 0.7 1.1 -1.3 -0.6 0.4 0.2 0.5 0.0 1.5
Pack years of smoking 1.8 2.7 6.0 -2.2 -2.3 2.5 -0.8 0.4 -0.9 -1.0 0.2 -2.3
Impedance of whole body 2.3 11.7 33.8 2.8 5.0 -5.8 1.7 -1.9 1.0 -0.2 -3.2 4.5
Leg fat mass (left) 2.0 8.0 16.0 0.4 -2.0 1.1 3.6 4.0 3.5 2.9 3.7 1.9
Arm predicted mass (left) 1.1 5.4 11.3 -0.3 -2.7 2.4 1.7 3.4 1.5 3.0 3.2 -0.2