[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (right) : ← →

chr1:7,686,056-9,571,422

Best TWAS P=1.99e-14 · Best GWAS P=6.79e-12 conditioned to 0.316

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SLC45A1	0.04	0.05	enet	9	0.02	1.8e-03	5.2	6.0	1.6e-09	-0.64	0.48	0.47	FALSE
2	GTEx	Adipose Subcutaneous	RERE	0.20	0.23	lasso	2	0.24	1.7e-19	-6.6	-7.0	2.4e-12	0.94	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	RP5-1115A15.1	0.14	0.07	enet	20	0.10	2.6e-08	6.4	-7.4	1.6e-13	0.78	0.06	0.94	FALSE
4	GTEx	Adipose Visceral Omentum	RERE	0.22	0.17	lasso	5	0.17	5.2e-09	6.5	-7.1	1.2e-12	0.60	0.08	0.92	FALSE
5	GTEx	Breast Mammary Tissue	RERE	0.19	0.08	enet	10	0.14	8.0e-08	-6.7	-7.7	2.0e-14	0.82	0.02	0.97	TRUE
6	GTEx	Breast Mammary Tissue	RP5-1115A15.1	0.10	0.07	lasso	2	0.03	7.0e-03	-6.6	-6.6	4.3e-11	0.96	0.02	0.98	FALSE
7	GTEx	Breast Mammary Tissue (Male)	RP5-1115A15.1	0.18	0.07	lasso	3	0.06	1.7e-02	2.9	-5.5	5.0e-08	0.72	0.03	0.55	FALSE
8	GTEx	Breast Mammary Tissue (Female)	RERE	0.14	0.12	lasso	3	0.08	2.4e-03	5.4	-5.8	7.2e-09	0.40	0.08	0.53	FALSE
9	GTEx	Cells Transformed fibroblasts	RERE	0.12	0.08	lasso	4	0.05	6.0e-05	-6.8	-7.0	2.3e-12	0.95	0.01	0.99	FALSE
10	GTEx	Esophagus Mucosa	RERE	0.13	0.16	lasso	3	0.16	7.2e-11	6.5	-6.5	7.0e-11	0.59	0.05	0.95	FALSE
11	GTEx	Esophagus Mucosa	RP5-1115A15.1	0.06	0.06	lasso	4	0.05	3.0e-04	6.5	-6.0	1.8e-09	0.64	0.05	0.88	FALSE
12	GTEx	Lung	RERE	0.07	0.05	lasso	4	0.05	2.0e-04	5.3	-5.6	2.0e-08	0.57	0.47	0.48	FALSE
13	GTEx	Lung	RP5-1115A15.1	0.05	0.08	lasso	1	0.07	1.0e-05	6.4	-6.4	1.7e-10	0.61	0.10	0.84	FALSE
14	GTEx	Nerve Tibial	RERE	0.12	0.09	enet	16	0.11	5.6e-08	-6.8	-6.7	1.9e-11	0.92	0.01	0.99	FALSE
15	GTEx	Pancreas	RERE	0.11	0.12	lasso	4	0.07	5.9e-04	-6.8	-7.0	2.7e-12	0.95	0.01	0.96	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	RP5-1115A15.1	0.08	0.04	enet	8	0.04	3.0e-03	5.8	-6.2	7.8e-10	0.57	0.18	0.59	FALSE
17	GTEx	Skin Sun Exposed Lower leg	RERE	0.14	0.05	lasso	8	0.08	4.3e-07	6.5	-6.0	1.7e-09	0.53	0.14	0.86	FALSE
18	GTEx	Skin Sun Exposed Lower leg	RP5-1115A15.1	0.07	0.03	enet	13	0.03	1.5e-03	6.5	-6.6	4.7e-11	0.54	0.12	0.81	FALSE
19	GTEx	Thyroid	RP5-1115A15.1	0.09	0.12	lasso	2	0.09	1.5e-07	6.4	-6.6	3.7e-11	0.64	0.10	0.90	FALSE
20	GTEx	Whole Blood	RERE	0.19	0.15	lasso	4	0.13	2.7e-12	6.5	-6.7	2.0e-11	0.64	0.05	0.95	FALSE
21	METSIM	Adipose	RERE	0.08	0.12	lasso	17	0.13	1.8e-19	-6.6	-7.1	1.1e-12	0.89	0.01	0.99	FALSE
22	NTR	Blood	RERE	0.04	0.04	lasso	8	0.03	2.0e-11	5.8	-6.5	1.0e-10	0.68	0.65	0.35	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	RERE	0.15	0.15	lasso	7	0.15	1.5e-18	-6.6	-7.1	1.5e-12	0.94	0.01	0.99	FALSE
24	YFS	Blood	RERE	0.09	0.15	lasso	4	0.16	5.7e-49	6.6	-7.0	2.1e-12	0.70	0.04	0.96	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	RERE	0.02	0.03	lasso	2	0.03	4.7e-07	6.6	-6.6	3.9e-11	0.60	0.05	0.95	FALSE
26	The Cancer Genome Atlas	Esophageal Carcinoma	RERE	0.10	0.07	blup	154	0.06	5.2e-03	4.1	-5.2	1.6e-07	0.41	0.07	0.17	FALSE
27	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RERE	0.22	0.04	lasso	10	0.08	4.1e-04	6.5	-7.2	5.8e-13	0.82	0.02	0.94	FALSE