Best TWAS P=4.9e-25 · Best GWAS P=5.81e-41 conditioned to 0.00552
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | EPDR1 | 0.18 | 0.01 | lasso | 4 | 0.01 | 8.9e-02 | 7.3 | 6.2 | 5.0e-10 | 0.02 | 0.17 | 0.10 | FALSE |
| 2 | GTEx | Artery Tibial | EPDR1 | 0.27 | 0.15 | lasso | 12 | 0.16 | 3.4e-12 | 7.3 | 5.9 | 3.2e-09 | 0.09 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Nerve Tibial | EPDR1 | 0.29 | 0.14 | lasso | 4 | 0.23 | 2.7e-16 | 7.8 | 7.2 | 6.8e-13 | 0.10 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Pancreas | EPDR1 | 0.18 | 0.15 | lasso | 5 | 0.17 | 1.0e-07 | -8.3 | 8.5 | 1.3e-17 | 0.27 | 0.69 | 0.02 | FALSE |
| 5 | GTEx | Thyroid | EPDR1 | 0.19 | 0.06 | enet | 25 | 0.10 | 4.0e-08 | 7.3 | 8.3 | 7.1e-17 | 0.24 | 0.66 | 0.22 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | EPDR1 | 0.17 | 0.06 | lasso | 6 | 0.10 | 2.5e-13 | 4.8 | 7.0 | 1.9e-12 | 0.10 | 1.00 | 0.00 | TRUE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EPDR1 | 0.08 | 0.04 | enet | 3 | 0.05 | 5.4e-06 | 7.3 | 10.3 | 4.9e-25 | 0.34 | 0.33 | 0.62 | TRUE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | EPDR1 | 0.09 | 0.10 | lasso | 2 | 0.06 | 2.8e-03 | -5.6 | 5.8 | 5.5e-09 | 0.06 | 0.09 | 0.05 | TRUE |