Best TWAS P=1.86e-08 · Best GWAS P=3.72e-07 conditioned to 0.707
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | FHL3 | 0.35 | 0.22 | lasso | 4 | 0.27 | 3.9e-15 | -4.5 | -5.1 | 2.9e-07 | -0.91 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Coronary | FHL3 | 0.31 | 0.22 | lasso | 5 | 0.18 | 1.3e-06 | -4.5 | -5.3 | 1.0e-07 | -0.70 | 0.03 | 0.94 | FALSE |
| 3 | GTEx | Pancreas | FHL3 | 0.17 | 0.05 | lasso | 3 | 0.10 | 6.6e-05 | 5.1 | -5.3 | 9.0e-08 | -0.91 | 0.00 | 0.99 | FALSE |
| 4 | METSIM | Adipose | FHL3 | 0.15 | 0.12 | lasso | 5 | 0.14 | 6.3e-20 | 5.1 | -5.6 | 1.9e-08 | -0.93 | 0.00 | 1.00 | TRUE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FHL3 | 0.06 | 0.01 | enet | 10 | 0.01 | 4.2e-04 | 5.1 | -5.5 | 4.3e-08 | -0.82 | 0.00 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | FHL3 | 0.10 | 0.05 | lasso | 2 | 0.06 | 2.9e-04 | -4.7 | -5.2 | 2.1e-07 | -0.92 | 0.00 | 0.95 | FALSE |