[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (right) : ← →

chr1:112,312,154-114,196,883

Best TWAS P=6.24e-16 · Best GWAS P=7.03e-15 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ST7L	0.25	0.33	bslmm	401	0.34	3.4e-43	4.7	6.0	2.3e-09	0.66	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	WNT2B	0.43	0.46	enet	44	0.47	7.4e-64	7.8	7.7	1.7e-14	0.95	0.00	1.00	FALSE
3	GTEx	Adipose Subcutaneous	ST7L	0.27	0.32	enet	17	0.34	2.6e-28	4.7	5.5	4.3e-08	0.63	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	ST7L	0.33	0.32	enet	29	0.32	4.2e-17	4.8	6.5	6.2e-11	0.76	0.94	0.06	FALSE
5	GTEx	Artery Tibial	ST7L	0.22	0.21	enet	13	0.21	3.8e-16	4.8	5.7	1.5e-08	0.63	1.00	0.00	FALSE
6	GTEx	Brain Cerebellar Hemisphere	ST7L	0.24	0.16	lasso	2	0.12	5.1e-04	4.3	5.2	2.3e-07	0.57	0.06	0.37	FALSE
7	GTEx	Brain Cortex	ST7L	0.29	0.18	lasso	5	0.20	3.1e-06	4.8	6.2	5.5e-10	0.75	0.06	0.88	FALSE
8	GTEx	Brain Cortex	WNT2B	0.36	0.19	lasso	5	0.23	5.5e-07	7.7	7.8	4.6e-15	0.94	0.01	0.99	FALSE
9	GTEx	Brain Frontal Cortex BA9	WNT2B	0.29	0.28	lasso	3	0.29	2.6e-08	7.7	7.8	4.1e-15	0.97	0.01	0.99	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	ST7L	0.31	0.10	lasso	7	0.05	2.1e-02	-4.8	5.2	1.7e-07	0.51	0.09	0.29	FALSE
11	GTEx	Cells Transformed fibroblasts	ST7L	0.54	0.64	enet	13	0.66	1.3e-64	4.8	5.6	2.2e-08	0.64	1.00	0.00	FALSE
12	GTEx	Colon Transverse	ST7L	0.22	0.19	enet	9	0.16	3.4e-08	4.8	5.8	6.7e-09	0.68	0.81	0.19	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	ST7L	0.32	0.30	enet	31	0.30	1.9e-11	4.8	5.5	5.0e-08	0.62	0.98	0.02	FALSE
14	GTEx	Esophagus Mucosa	ST7L	0.18	0.20	lasso	3	0.19	8.9e-13	4.8	5.6	2.1e-08	0.65	0.99	0.01	FALSE
15	GTEx	Heart Atrial Appendage	ST7L	0.25	0.08	enet	18	0.11	1.1e-05	4.7	5.9	3.1e-09	0.69	0.33	0.67	FALSE
16	GTEx	Pituitary	ST7L	0.31	0.18	lasso	7	0.18	3.0e-05	7.4	7.7	1.7e-14	0.83	0.01	0.97	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	ST7L	0.14	0.10	enet	8	0.06	2.6e-04	4.7	5.8	6.6e-09	0.64	0.85	0.10	FALSE
18	GTEx	Skin Not Sun Exposed Suprapubic	SLC16A1	0.12	0.00	lasso	5	0.04	5.0e-03	7.7	-6.8	1.4e-11	-0.82	0.01	0.92	FALSE
19	GTEx	Skin Sun Exposed Lower leg	MOV10	0.05	0.02	lasso	5	0.02	1.1e-02	7.7	7.0	1.9e-12	0.82	0.02	0.95	FALSE
20	GTEx	Stomach	ST7L	0.21	0.24	lasso	3	0.23	2.6e-11	4.7	5.6	1.9e-08	0.65	0.95	0.05	FALSE
21	METSIM	Adipose	ST7L	0.22	0.25	enet	11	0.25	1.0e-37	4.7	5.9	3.1e-09	0.67	1.00	0.00	FALSE
22	ROSMAP	Brain Pre-frontal Cortex	WNT2B	0.34	0.40	enet	30	0.42	1.5e-59	7.7	8.1	6.2e-16	0.96	0.00	1.00	TRUE
23	YFS	Blood	MOV10	0.07	0.04	blup	314	0.04	1.5e-12	7.6	6.3	2.8e-10	0.78	0.02	0.98	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ST7L	0.21	0.22	blup	56	0.21	1.7e-17	4.8	5.5	4.6e-08	0.55	1.00	0.00	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	ST7L	0.23	0.36	lasso	5	0.36	2.8e-76	4.8	5.3	1.1e-07	0.61	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Colon Adenocarcinoma	ST7L	0.33	0.19	lasso	3	0.21	1.7e-12	4.8	6.4	1.9e-10	0.75	0.90	0.10	FALSE
27	The Cancer Genome Atlas	Glioblastoma Multiforme	ST7L	0.27	0.20	blup	55	0.18	5.0e-06	4.7	5.3	9.9e-08	0.59	0.39	0.38	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ST7L	0.18	0.27	blup	56	0.28	2.4e-31	4.7	5.8	4.9e-09	0.65	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	ST7L	0.26	0.35	enet	17	0.36	2.6e-43	4.8	5.6	2.1e-08	0.63	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ST7L	0.39	0.36	lasso	7	0.35	1.8e-15	4.8	5.1	2.8e-07	0.59	1.00	0.00	FALSE
31	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ST7L	0.28	0.28	enet	12	0.26	1.0e-10	4.7	5.3	1.2e-07	0.60	0.99	0.01	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	MOV10	0.03	0.00	lasso	9	0.00	9.9e-02	7.6	6.2	5.5e-10	0.69	0.01	0.80	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	ST7L	0.31	0.43	enet	12	0.42	3.4e-47	4.8	5.6	2.3e-08	0.60	1.00	0.00	FALSE
34	The Cancer Genome Atlas	Soft Tissue Sarcoma	ST7L	0.11	0.13	lasso	7	0.12	1.5e-07	4.8	6.1	1.4e-09	0.70	0.44	0.56	FALSE
35	The Cancer Genome Atlas	Stomach Adenocarcinoma	ST7L	0.23	0.23	lasso	4	0.23	1.3e-16	4.8	5.4	7.4e-08	0.59	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	MOV10	0.06	0.06	lasso	7	0.05	9.4e-06	7.2	7.7	1.7e-14	0.93	0.01	0.99	FALSE