[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (right) :

chr1:112,312,154-114,196,883

Best TWAS P=6.24e-16 · Best GWAS P=7.03e-15 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ST7L 0.25 0.33 bslmm 401 0.34 3.4e-43 4.7 6.0 2.3e-09 0.66 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex WNT2B 0.43 0.46 enet 44 0.47 7.4e-64 7.8 7.7 1.7e-14 0.95 0.00 1.00 FALSE
3 GTEx Adipose Subcutaneous ST7L 0.27 0.32 enet 17 0.34 2.6e-28 4.7 5.5 4.3e-08 0.63 1.00 0.00 FALSE
4 GTEx Adipose Visceral Omentum ST7L 0.33 0.32 enet 29 0.32 4.2e-17 4.8 6.5 6.2e-11 0.76 0.94 0.06 FALSE
5 GTEx Artery Tibial ST7L 0.22 0.21 enet 13 0.21 3.8e-16 4.8 5.7 1.5e-08 0.63 1.00 0.00 FALSE
6 GTEx Brain Cerebellar Hemisphere ST7L 0.24 0.16 lasso 2 0.12 5.1e-04 4.3 5.2 2.3e-07 0.57 0.06 0.37 FALSE
7 GTEx Brain Cortex ST7L 0.29 0.18 lasso 5 0.20 3.1e-06 4.8 6.2 5.5e-10 0.75 0.06 0.88 FALSE
8 GTEx Brain Cortex WNT2B 0.36 0.19 lasso 5 0.23 5.5e-07 7.7 7.8 4.6e-15 0.94 0.01 0.99 FALSE
9 GTEx Brain Frontal Cortex BA9 WNT2B 0.29 0.28 lasso 3 0.29 2.6e-08 7.7 7.8 4.1e-15 0.97 0.01 0.99 FALSE
10 GTEx Brain Nucleus accumbens basal ganglia ST7L 0.31 0.10 lasso 7 0.05 2.1e-02 -4.8 5.2 1.7e-07 0.51 0.09 0.29 FALSE
11 GTEx Cells Transformed fibroblasts ST7L 0.54 0.64 enet 13 0.66 1.3e-64 4.8 5.6 2.2e-08 0.64 1.00 0.00 FALSE
12 GTEx Colon Transverse ST7L 0.22 0.19 enet 9 0.16 3.4e-08 4.8 5.8 6.7e-09 0.68 0.81 0.19 FALSE
13 GTEx Esophagus Gastroesophageal Junction ST7L 0.32 0.30 enet 31 0.30 1.9e-11 4.8 5.5 5.0e-08 0.62 0.98 0.02 FALSE
14 GTEx Esophagus Mucosa ST7L 0.18 0.20 lasso 3 0.19 8.9e-13 4.8 5.6 2.1e-08 0.65 0.99 0.01 FALSE
15 GTEx Heart Atrial Appendage ST7L 0.25 0.08 enet 18 0.11 1.1e-05 4.7 5.9 3.1e-09 0.69 0.33 0.67 FALSE
16 GTEx Pituitary ST7L 0.31 0.18 lasso 7 0.18 3.0e-05 7.4 7.7 1.7e-14 0.83 0.01 0.97 FALSE
17 GTEx Skin Not Sun Exposed Suprapubic ST7L 0.14 0.10 enet 8 0.06 2.6e-04 4.7 5.8 6.6e-09 0.64 0.85 0.10 FALSE
18 GTEx Skin Not Sun Exposed Suprapubic SLC16A1 0.12 0.00 lasso 5 0.04 5.0e-03 7.7 -6.8 1.4e-11 -0.82 0.01 0.92 FALSE
19 GTEx Skin Sun Exposed Lower leg MOV10 0.05 0.02 lasso 5 0.02 1.1e-02 7.7 7.0 1.9e-12 0.82 0.02 0.95 FALSE
20 GTEx Stomach ST7L 0.21 0.24 lasso 3 0.23 2.6e-11 4.7 5.6 1.9e-08 0.65 0.95 0.05 FALSE
21 METSIM Adipose ST7L 0.22 0.25 enet 11 0.25 1.0e-37 4.7 5.9 3.1e-09 0.67 1.00 0.00 FALSE
22 ROSMAP Brain Pre-frontal Cortex WNT2B 0.34 0.40 enet 30 0.42 1.5e-59 7.7 8.1 6.2e-16 0.96 0.00 1.00 TRUE
23 YFS Blood MOV10 0.07 0.04 blup 314 0.04 1.5e-12 7.6 6.3 2.8e-10 0.78 0.02 0.98 FALSE
24 The Cancer Genome Atlas Bladder Urothelial Carcinoma ST7L 0.21 0.22 blup 56 0.21 1.7e-17 4.8 5.5 4.6e-08 0.55 1.00 0.00 FALSE
25 The Cancer Genome Atlas Breast Invasive Carcinoma ST7L 0.23 0.36 lasso 5 0.36 2.8e-76 4.8 5.3 1.1e-07 0.61 1.00 0.00 FALSE
26 The Cancer Genome Atlas Colon Adenocarcinoma ST7L 0.33 0.19 lasso 3 0.21 1.7e-12 4.8 6.4 1.9e-10 0.75 0.90 0.10 FALSE
27 The Cancer Genome Atlas Glioblastoma Multiforme ST7L 0.27 0.20 blup 55 0.18 5.0e-06 4.7 5.3 9.9e-08 0.59 0.39 0.38 FALSE
28 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ST7L 0.18 0.27 blup 56 0.28 2.4e-31 4.7 5.8 4.9e-09 0.65 1.00 0.00 FALSE
29 The Cancer Genome Atlas Lung Adenocarcinoma ST7L 0.26 0.35 enet 17 0.36 2.6e-43 4.8 5.6 2.1e-08 0.63 1.00 0.00 FALSE
30 The Cancer Genome Atlas Pancreatic Adenocarcinoma ST7L 0.39 0.36 lasso 7 0.35 1.8e-15 4.8 5.1 2.8e-07 0.59 1.00 0.00 FALSE
31 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ST7L 0.28 0.28 enet 12 0.26 1.0e-10 4.7 5.3 1.2e-07 0.60 0.99 0.01 FALSE
32 The Cancer Genome Atlas Prostate Adenocarcinoma MOV10 0.03 0.00 lasso 9 0.00 9.9e-02 7.6 6.2 5.5e-10 0.69 0.01 0.80 FALSE
33 The Cancer Genome Atlas Prostate Adenocarcinoma ST7L 0.31 0.43 enet 12 0.42 3.4e-47 4.8 5.6 2.3e-08 0.60 1.00 0.00 FALSE
34 The Cancer Genome Atlas Soft Tissue Sarcoma ST7L 0.11 0.13 lasso 7 0.12 1.5e-07 4.8 6.1 1.4e-09 0.70 0.44 0.56 FALSE
35 The Cancer Genome Atlas Stomach Adenocarcinoma ST7L 0.23 0.23 lasso 4 0.23 1.3e-16 4.8 5.4 7.4e-08 0.59 1.00 0.00 FALSE
36 The Cancer Genome Atlas Thyroid Carcinoma MOV10 0.06 0.06 lasso 7 0.05 9.4e-06 7.2 7.7 1.7e-14 0.93 0.01 0.99 FALSE