[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (right) :

chr17:41,393,295-42,998,534

Best TWAS P=6.89e-14 · Best GWAS P=3.34e-17 conditioned to 1.51e-12

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex C17orf65 0.07 0.06 enet 15 0.07 4.5e-09 6.6 -6.6 4.5e-11 -0.19 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous ASB16-AS1 0.12 0.05 enet 16 0.05 3.7e-05 6.6 -6.7 2.0e-11 -0.16 0.39 0.03 FALSE
3 GTEx Adipose Visceral Omentum ASB16-AS1 0.14 0.12 lasso 5 0.10 9.8e-06 6.4 -6.5 8.2e-11 -0.21 0.88 0.02 FALSE
4 GTEx Brain Cerebellum ASB16-AS1 0.37 0.06 enet 32 0.19 3.1e-06 7.0 -5.6 2.5e-08 -0.19 0.20 0.08 FALSE
5 GTEx Breast Mammary Tissue (Female) ASB16-AS1 0.08 0.04 lasso 2 0.06 7.9e-03 6.4 -6.4 1.3e-10 -0.20 0.11 0.05 FALSE
6 GTEx Cells Transformed fibroblasts NAGS 0.07 0.00 enet 13 0.00 3.2e-01 6.8 5.2 1.6e-07 0.10 0.11 0.04 FALSE
7 GTEx Cells Transformed fibroblasts ASB16 0.14 0.14 lasso 3 0.12 2.0e-09 6.6 -6.6 4.1e-11 -0.20 1.00 0.00 FALSE
8 GTEx Cells Transformed fibroblasts ASB16-AS1 0.17 0.17 lasso 4 0.16 2.3e-12 6.6 -6.3 2.4e-10 -0.20 1.00 0.00 FALSE
9 GTEx Esophagus Gastroesophageal Junction ASB16-AS1 0.17 0.13 lasso 7 0.11 8.6e-05 5.0 -5.3 1.1e-07 -0.28 0.18 0.32 FALSE
10 GTEx Esophagus Mucosa HDAC5 0.06 0.05 lasso 3 0.02 9.2e-03 7.5 -7.5 6.9e-14 -0.20 0.22 0.50 TRUE
11 GTEx Esophagus Mucosa ASB16 0.10 0.10 lasso 4 0.08 8.2e-06 6.6 -6.6 3.3e-11 -0.20 0.92 0.01 FALSE
12 GTEx Esophagus Mucosa ASB16-AS1 0.11 0.08 enet 16 0.07 3.7e-05 7.0 -6.4 1.4e-10 -0.22 0.90 0.03 FALSE
13 GTEx Muscle Skeletal ASB16 0.07 0.06 lasso 3 0.06 2.9e-06 6.2 6.5 8.2e-11 0.20 0.96 0.02 FALSE
14 GTEx Nerve Tibial ASB16 0.12 0.07 lasso 5 0.07 7.5e-06 6.6 -6.5 7.2e-11 -0.20 0.99 0.00 FALSE
15 GTEx Nerve Tibial ASB16-AS1 0.17 0.15 lasso 5 0.16 1.4e-11 6.6 -6.2 4.2e-10 -0.17 1.00 0.00 FALSE
16 GTEx Pituitary ASB16-AS1 0.19 0.17 lasso 4 0.22 3.8e-06 6.5 -7.4 1.0e-13 -0.25 0.26 0.40 FALSE
17 GTEx Prostate RP5-882C2.2 0.17 -0.01 lasso 7 -0.01 5.9e-01 6.2 -5.8 7.6e-09 -0.40 0.04 0.26 FALSE
18 GTEx Skin Sun Exposed Lower leg ASB16-AS1 0.13 0.09 lasso 5 0.07 2.7e-06 6.7 -6.7 2.1e-11 -0.19 0.99 0.00 FALSE
19 GTEx Testis ASB16-AS1 0.35 0.25 lasso 5 0.23 1.0e-10 6.6 -6.5 7.4e-11 -0.19 1.00 0.00 FALSE
20 GTEx Thyroid RP5-882C2.2 0.10 0.07 lasso 3 0.07 2.9e-06 6.6 -6.5 9.7e-11 -0.21 0.80 0.01 FALSE
21 GTEx Thyroid ASB16-AS1 0.14 0.06 lasso 2 0.04 5.4e-04 6.6 -6.6 3.2e-11 -0.20 0.56 0.04 FALSE
22 GTEx Whole Blood ASB16-AS1 0.14 0.05 lasso 6 0.04 3.1e-04 6.6 -6.5 7.1e-11 -0.19 0.97 0.01 FALSE
23 YFS Blood G6PC3 0.02 0.01 bslmm 350 0.02 3.0e-06 2.7 5.9 3.7e-09 0.42 0.86 0.02 FALSE
24 The Cancer Genome Atlas Bladder Urothelial Carcinoma ASB16 0.03 0.01 enet 4 0.02 1.2e-02 6.7 -5.9 3.4e-09 -0.16 0.01 0.76 FALSE
25 The Cancer Genome Atlas Bladder Urothelial Carcinoma C17orf65 0.03 0.00 blup 37 0.01 2.3e-02 6.6 -6.0 2.0e-09 -0.16 0.02 0.88 FALSE
26 The Cancer Genome Atlas Breast Invasive Carcinoma C17orf65 0.02 0.01 blup 38 0.02 2.6e-04 6.3 -6.1 1.1e-09 -0.19 0.02 0.95 FALSE
27 The Cancer Genome Atlas Colon Adenocarcinoma ASB16 0.05 0.06 blup 40 0.05 4.6e-04 6.3 -6.7 2.0e-11 -0.20 0.02 0.96 FALSE
28 The Cancer Genome Atlas Colon Adenocarcinoma C17orf65 0.05 0.06 blup 38 0.05 4.2e-04 6.2 -6.6 5.7e-11 -0.19 0.02 0.96 FALSE
29 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ASB16 0.02 0.02 blup 39 0.02 3.8e-03 6.4 -5.6 1.8e-08 -0.14 0.01 0.53 FALSE
30 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma C17orf65 0.03 0.01 lasso 10 0.02 3.6e-03 3.3 -5.1 2.8e-07 -0.12 0.04 0.80 FALSE
31 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ASB16 0.02 0.03 blup 40 0.03 1.3e-04 6.7 -6.5 9.3e-11 -0.19 0.02 0.98 FALSE
32 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C17orf65 0.05 0.05 lasso 2 0.05 2.5e-06 6.2 -6.3 2.3e-10 -0.19 0.02 0.98 FALSE
33 The Cancer Genome Atlas Brain Lower Grade Glioma ASB16 0.03 0.03 lasso 3 0.03 3.2e-04 6.3 -6.3 2.3e-10 -0.19 0.02 0.96 FALSE
34 The Cancer Genome Atlas Brain Lower Grade Glioma C17orf65 0.04 0.04 blup 37 0.03 1.4e-04 6.6 -6.6 4.3e-11 -0.21 0.01 0.98 FALSE
35 The Cancer Genome Atlas Lung Adenocarcinoma ASB16 0.02 0.02 lasso 4 0.01 6.3e-03 6.6 -6.5 7.1e-11 -0.19 0.02 0.84 FALSE
36 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ASB16 0.04 0.04 lasso 4 0.03 1.8e-04 6.2 -6.4 2.0e-10 -0.18 0.01 0.98 FALSE
37 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C17orf65 0.07 0.05 lasso 6 0.05 3.1e-06 6.5 -6.1 8.4e-10 -0.18 0.01 0.99 FALSE
38 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma C17orf65 0.04 0.03 blup 39 0.03 2.7e-03 6.4 -6.6 4.6e-11 -0.19 0.02 0.84 FALSE
39 The Cancer Genome Atlas Pancreatic Adenocarcinoma C17orf65 0.09 0.02 blup 38 0.04 8.0e-03 6.6 -6.3 3.8e-10 -0.19 0.01 0.62 FALSE
40 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma C17orf65 0.09 0.09 enet 8 0.08 2.9e-04 6.2 -6.6 5.1e-11 -0.19 0.02 0.96 FALSE
41 The Cancer Genome Atlas Skin Cutaneous Melanoma C17orf65 0.15 0.05 blup 37 0.09 1.7e-03 6.6 -6.5 1.0e-10 -0.20 0.01 0.72 FALSE
42 The Cancer Genome Atlas Testicular Germ Cell Tumors C17orf65 0.07 0.02 blup 38 0.04 1.1e-02 6.3 -5.8 8.8e-09 -0.16 0.01 0.53 FALSE
43 The Cancer Genome Atlas Thyroid Carcinoma ASB16 0.07 0.01 blup 39 0.02 1.6e-03 6.3 -5.9 2.7e-09 -0.20 0.02 0.71 FALSE
44 The Cancer Genome Atlas Thyroid Carcinoma C17orf65 0.03 0.03 lasso 7 0.03 3.8e-04 6.6 -6.6 3.7e-11 -0.19 0.01 0.96 FALSE