[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (right) : ← →

chr17:41,393,295-42,998,534

Best TWAS P=6.89e-14 · Best GWAS P=3.34e-17 conditioned to 1.51e-12

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C17orf65	0.07	0.06	enet	15	0.07	4.5e-09	6.6	-6.6	4.5e-11	-0.19	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	ASB16-AS1	0.12	0.05	enet	16	0.05	3.7e-05	6.6	-6.7	2.0e-11	-0.16	0.39	0.03	FALSE
3	GTEx	Adipose Visceral Omentum	ASB16-AS1	0.14	0.12	lasso	5	0.10	9.8e-06	6.4	-6.5	8.2e-11	-0.21	0.88	0.02	FALSE
4	GTEx	Brain Cerebellum	ASB16-AS1	0.37	0.06	enet	32	0.19	3.1e-06	7.0	-5.6	2.5e-08	-0.19	0.20	0.08	FALSE
5	GTEx	Breast Mammary Tissue (Female)	ASB16-AS1	0.08	0.04	lasso	2	0.06	7.9e-03	6.4	-6.4	1.3e-10	-0.20	0.11	0.05	FALSE
6	GTEx	Cells Transformed fibroblasts	NAGS	0.07	0.00	enet	13	0.00	3.2e-01	6.8	5.2	1.6e-07	0.10	0.11	0.04	FALSE
7	GTEx	Cells Transformed fibroblasts	ASB16	0.14	0.14	lasso	3	0.12	2.0e-09	6.6	-6.6	4.1e-11	-0.20	1.00	0.00	FALSE
8	GTEx	Cells Transformed fibroblasts	ASB16-AS1	0.17	0.17	lasso	4	0.16	2.3e-12	6.6	-6.3	2.4e-10	-0.20	1.00	0.00	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	ASB16-AS1	0.17	0.13	lasso	7	0.11	8.6e-05	5.0	-5.3	1.1e-07	-0.28	0.18	0.32	FALSE
10	GTEx	Esophagus Mucosa	HDAC5	0.06	0.05	lasso	3	0.02	9.2e-03	7.5	-7.5	6.9e-14	-0.20	0.22	0.50	TRUE
11	GTEx	Esophagus Mucosa	ASB16	0.10	0.10	lasso	4	0.08	8.2e-06	6.6	-6.6	3.3e-11	-0.20	0.92	0.01	FALSE
12	GTEx	Esophagus Mucosa	ASB16-AS1	0.11	0.08	enet	16	0.07	3.7e-05	7.0	-6.4	1.4e-10	-0.22	0.90	0.03	FALSE
13	GTEx	Muscle Skeletal	ASB16	0.07	0.06	lasso	3	0.06	2.9e-06	6.2	6.5	8.2e-11	0.20	0.96	0.02	FALSE
14	GTEx	Nerve Tibial	ASB16	0.12	0.07	lasso	5	0.07	7.5e-06	6.6	-6.5	7.2e-11	-0.20	0.99	0.00	FALSE
15	GTEx	Nerve Tibial	ASB16-AS1	0.17	0.15	lasso	5	0.16	1.4e-11	6.6	-6.2	4.2e-10	-0.17	1.00	0.00	FALSE
16	GTEx	Pituitary	ASB16-AS1	0.19	0.17	lasso	4	0.22	3.8e-06	6.5	-7.4	1.0e-13	-0.25	0.26	0.40	FALSE
17	GTEx	Prostate	RP5-882C2.2	0.17	-0.01	lasso	7	-0.01	5.9e-01	6.2	-5.8	7.6e-09	-0.40	0.04	0.26	FALSE
18	GTEx	Skin Sun Exposed Lower leg	ASB16-AS1	0.13	0.09	lasso	5	0.07	2.7e-06	6.7	-6.7	2.1e-11	-0.19	0.99	0.00	FALSE
19	GTEx	Testis	ASB16-AS1	0.35	0.25	lasso	5	0.23	1.0e-10	6.6	-6.5	7.4e-11	-0.19	1.00	0.00	FALSE
20	GTEx	Thyroid	RP5-882C2.2	0.10	0.07	lasso	3	0.07	2.9e-06	6.6	-6.5	9.7e-11	-0.21	0.80	0.01	FALSE
21	GTEx	Thyroid	ASB16-AS1	0.14	0.06	lasso	2	0.04	5.4e-04	6.6	-6.6	3.2e-11	-0.20	0.56	0.04	FALSE
22	GTEx	Whole Blood	ASB16-AS1	0.14	0.05	lasso	6	0.04	3.1e-04	6.6	-6.5	7.1e-11	-0.19	0.97	0.01	FALSE
23	YFS	Blood	G6PC3	0.02	0.01	bslmm	350	0.02	3.0e-06	2.7	5.9	3.7e-09	0.42	0.86	0.02	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ASB16	0.03	0.01	enet	4	0.02	1.2e-02	6.7	-5.9	3.4e-09	-0.16	0.01	0.76	FALSE
25	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C17orf65	0.03	0.00	blup	37	0.01	2.3e-02	6.6	-6.0	2.0e-09	-0.16	0.02	0.88	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	C17orf65	0.02	0.01	blup	38	0.02	2.6e-04	6.3	-6.1	1.1e-09	-0.19	0.02	0.95	FALSE
27	The Cancer Genome Atlas	Colon Adenocarcinoma	ASB16	0.05	0.06	blup	40	0.05	4.6e-04	6.3	-6.7	2.0e-11	-0.20	0.02	0.96	FALSE
28	The Cancer Genome Atlas	Colon Adenocarcinoma	C17orf65	0.05	0.06	blup	38	0.05	4.2e-04	6.2	-6.6	5.7e-11	-0.19	0.02	0.96	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ASB16	0.02	0.02	blup	39	0.02	3.8e-03	6.4	-5.6	1.8e-08	-0.14	0.01	0.53	FALSE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C17orf65	0.03	0.01	lasso	10	0.02	3.6e-03	3.3	-5.1	2.8e-07	-0.12	0.04	0.80	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ASB16	0.02	0.03	blup	40	0.03	1.3e-04	6.7	-6.5	9.3e-11	-0.19	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C17orf65	0.05	0.05	lasso	2	0.05	2.5e-06	6.2	-6.3	2.3e-10	-0.19	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	ASB16	0.03	0.03	lasso	3	0.03	3.2e-04	6.3	-6.3	2.3e-10	-0.19	0.02	0.96	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	C17orf65	0.04	0.04	blup	37	0.03	1.4e-04	6.6	-6.6	4.3e-11	-0.21	0.01	0.98	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	ASB16	0.02	0.02	lasso	4	0.01	6.3e-03	6.6	-6.5	7.1e-11	-0.19	0.02	0.84	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ASB16	0.04	0.04	lasso	4	0.03	1.8e-04	6.2	-6.4	2.0e-10	-0.18	0.01	0.98	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C17orf65	0.07	0.05	lasso	6	0.05	3.1e-06	6.5	-6.1	8.4e-10	-0.18	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C17orf65	0.04	0.03	blup	39	0.03	2.7e-03	6.4	-6.6	4.6e-11	-0.19	0.02	0.84	FALSE
39	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C17orf65	0.09	0.02	blup	38	0.04	8.0e-03	6.6	-6.3	3.8e-10	-0.19	0.01	0.62	FALSE
40	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C17orf65	0.09	0.09	enet	8	0.08	2.9e-04	6.2	-6.6	5.1e-11	-0.19	0.02	0.96	FALSE
41	The Cancer Genome Atlas	Skin Cutaneous Melanoma	C17orf65	0.15	0.05	blup	37	0.09	1.7e-03	6.6	-6.5	1.0e-10	-0.20	0.01	0.72	FALSE
42	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C17orf65	0.07	0.02	blup	38	0.04	1.1e-02	6.3	-5.8	8.8e-09	-0.16	0.01	0.53	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	ASB16	0.07	0.01	blup	39	0.02	1.6e-03	6.3	-5.9	2.7e-09	-0.20	0.02	0.71	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	C17orf65	0.03	0.03	lasso	7	0.03	3.8e-04	6.6	-6.6	3.7e-11	-0.19	0.01	0.96	FALSE