TWAS hub - HDAC5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.0560	0.0240	0.0029	0.045	NA	0.016	NA	0.024	0.00055	NA	0.027	NA	0.0092
2	GTEx	Muscle Skeletal	0.0785	0.0309	0.0028	0.010	NA	0.010	NA	0.013	0.03300	NA	0.029	NA	0.0170

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Heel T-Score	18.9	150.3	299.3	-17.3	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	15.9	36.0	70.0	-8.4	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	13.1	30.0	56.1	-7.5	-2.0
Fractured/broken bones in last 5 years	10.0	12.9	24.2	4.9	1.3
Supplements: Glucosamine	4.8	6.3	12.5	-3.5	-0.2
Trunk fat percentage	4.4	17.7	29.7	-5.4	2.4
Diverticular disease/diverticulitis (self-reported)	4.2	5.0	9.9	-3.2	0.1
Body fat percentage	4.2	16.4	24.4	-4.9	2.9
Mean Putamen Volume	4.0	4.5	6.6	2.6	-1.6
Arm fat percentage (left)	3.9	15.7	21.3	-4.6	3.2
Arm fat percentage (right)	3.8	14.9	20.6	-4.5	3.0
Bipolar Disorder (2018)	3.7	5.9	11.5	-3.4	0.5
Blood Platelet Count	3.6	41.3	79.2	-8.9	1.9
Mouth/teeth dental problems	3.6	5.5	10.4	-0.7	-3.2
Osteoarthritis (self-reported)	3.6	4.6	8.4	-2.9	0.9
Serious illness, injury or assault to yourself	3.5	4.2	7.6	2.8	-0.9
Pulse wave peak to peak time	3.4	4.1	6.0	-2.4	1.5
Ever used hormone-replacement therapy (HRT)	3.3	4.2	8.2	-0.4	-2.9
Trunk fat mass	3.3	14.2	25.7	-5.1	1.6
Asthma	3.3	6.5	11.6	-1.2	3.4
Number of incorrect matches in round	3.2	5.3	9.3	1.1	-3.0
Mouth/teeth dental problems: Dentures	3.1	5.2	7.8	2.8	1.6
Headache pain in last month	3.1	5.3	9.7	1.0	3.1
Whole body fat mass	3.1	13.0	21.9	-4.7	2.0
Ever had prostate specific antigen (PSA) test	3.1	3.5	5.6	-2.4	1.2
Eye problems/disorders: Diabetes related eye disease	3.0	3.2	4.9	2.2	-1.2
Pulse wave Arterial Stiffness index	3.0	3.5	4.5	2.1	-1.6
Medication: Aspirin	2.9	3.9	6.9	0.9	-2.6
Mouth/teeth dental problems: Mouth ulcers	2.9	4.7	7.7	-1.3	2.8
Qualifications: nursing, teaching	2.8	4.4	7.4	-2.7	1.2
Number of operations (self-reported)	2.8	4.2	6.2	-1.4	2.5
Asthma (self-reported)	2.7	5.3	9.4	-1.1	3.1
Osteoporosis (self-reported)	2.7	3.3	4.5	2.1	1.5
Coronary Artery Disease (CAD)	2.6	3.1	6.2	2.5	-0.1
Arm fat mass (right)	2.6	10.8	18.1	-4.2	1.9
Chronic bronchitis/emphysema (mother)	2.6	3.0	5.9	2.4	-0.4
Pulse rate	2.5	4.2	8.2	2.9	0.4
Wheeze or whistling in the chest in last year	2.5	4.4	8.8	-0.2	3.0
Medication: Seretide 50 evohaler	2.5	2.9	3.9	-1.4	2.0
Arm fat mass (left)	2.5	10.2	16.7	-4.1	1.9
Schizophrenia vs Biploar Disorder	2.4	3.2	5.8	2.4	-0.8
Happiness	2.4	2.9	3.0	1.7	1.7
Leg fat percentage (right)	2.4	8.7	10.7	-3.3	2.6
Medication: Aspirin	2.4	3.2	5.8	0.7	-2.4
Basal cell carcinoma (self-reported)	2.4	2.9	3.5	-1.9	-1.5
Prospective memory result	2.3	2.9	3.6	-1.5	1.9
Hair/balding pattern: Pattern 4	2.2	5.3	10.0	3.2	0.7
Hearing aid user	2.2	2.5	4.3	-0.8	2.1
Age started oral contraceptive pill	2.2	2.8	4.8	0.9	-2.2
Type 2 Diabetes (T2D) (2018)	2.1	4.0	7.9	2.8	0.1
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	5.3	2.3	0.1
Sitting height	2.1	15.1	19.1	3.3	-4.4
Hypothyroidism/myxoedema (self-reported)	2.1	4.2	7.7	2.8	-0.8
Leg fat mass (right)	2.1	8.1	12.9	-3.6	1.8
Guilty feelings	2.1	3.2	4.5	-1.3	2.1
Leg fat percentage (left)	2.1	7.4	9.6	-3.1	2.3
Leg fat mass (left)	2.1	8.0	13.4	-3.7	1.6
Major Depression (MDD)	2.0	2.4	4.7	0.4	2.2
Waist circumference	2.0	7.2	12.9	-3.6	1.2
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	4.6	0.4	2.1
Diabetes diagnosed by doctor	2.0	3.3	5.7	2.4	-1.0
Maternal smoking around birth	1.9	2.7	5.3	2.3	-0.3
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	3.8	0.9	1.9
Diabetes (self-reported)	1.9	2.9	4.7	2.2	-1.1
Impedance of arm (right)	1.9	9.0	13.1	-3.6	2.2
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	5.0	-1.0	2.2
Knee pain experienced in last month	1.9	3.0	3.8	-2.0	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.0	3.6	0.6	1.9
Waist Hip Ratio (WHR)	1.8	8.2	16.3	-4.0	-0.4
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	3.7	0.3	1.9
Had menopause	1.8	2.3	2.8	1.3	-1.7
Illnesses of siblings	1.8	2.5	5.0	-2.2	-0.0
Length of working week for main job	1.8	1.9	3.9	-2.0	-0.2
Family relationship satisfaction	1.8	2.2	2.3	1.4	1.5
Average weekly champagne plus white wine intake	1.8	2.5	4.7	-2.2	-0.5
Myopia	1.8	2.5	4.9	-2.2	0.4
Alzheimer’s Disease (including proxy)	1.7	2.5	2.9	-1.7	1.5
Qualifications: None of the above	1.7	3.7	6.6	2.6	-0.8
Qualifications: A levels/AS levels or equivalent	1.7	3.8	7.5	-2.7	0.3
Impedance of arm (left)	1.7	7.7	12.1	-3.5	1.8
Pulse wave reflection index	1.7	2.1	2.9	1.1	-1.7
Heart disease (mother)	1.7	2.0	3.7	1.9	-0.6
Handedness (chirality/laterality): Left-handed	1.7	2.1	3.4	-1.8	-0.9
Medication: Bendroflumethiazide	1.7	2.5	4.8	2.2	-0.5
Alzheimer’s Disease (in mother)	1.6	1.8	2.0	-1.3	1.4
Fed-up feelings	1.6	2.9	3.0	1.6	1.7
Pulse rate, automated reading	1.6	5.2	10.3	3.2	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	2.5	-1.6	1.1
Respiratory disease	1.5	3.4	6.5	-0.5	2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	3.1	1.0	1.8
Loud music exposure frequency	1.5	1.6	1.9	1.4	1.2
Health satisfaction	1.5	1.9	2.5	1.6	-1.1
Mean time to correctly identify matches	1.5	2.8	3.7	1.4	-1.9
Loneliness, isolation	1.5	2.0	2.7	1.2	1.6
Medication: Paracetamol	1.5	2.3	2.5	-1.4	1.6
Diastolic blood pressure, automated reading	1.5	4.6	8.0	2.8	-1.1
Heart disease (siblings)	1.5	1.8	2.2	1.2	-1.5
Crohns Disease (2012)	1.4	2.3	3.1	1.8	-1.2
Medication for hormone replacement therapy	1.4	1.6	1.6	-1.3	-1.3
Medication: Metformin	1.4	1.9	2.3	1.2	-1.5
Chronic bronchitis/emphysema (father)	1.4	1.6	3.1	1.8	0.2
Ever highly irritable/argumentative for 2 days	1.4	1.7	2.1	-1.1	1.4
Illnesses of father: Heart disease	1.4	2.0	4.0	0.2	2.0
Commuting to job workplace: Walk	1.4	1.5	2.9	0.3	1.7
Primary Biliary Cirrhosis	1.3	1.9	3.0	-0.9	1.7
Hypothyroidism (self reported)	1.3	2.9	5.2	2.3	-0.7
Diabetes (mother)	1.3	1.7	3.3	1.8	-0.2
Medication: Levothyroxine sodium	1.3	2.2	4.0	2.0	-0.7
Financial difficulties in last 2 years	1.3	1.7	2.1	1.4	1.2
Father’s age at death	1.3	1.7	2.1	-1.2	-1.4
Leg pain on walking	1.3	1.6	1.9	-1.1	1.4
Back pain experienced in last month	1.3	1.9	2.2	1.5	-1.2
Prostate Cancer	1.2	1.7	2.6	-0.9	-1.6
Alcohol intake versus 10 years previously	1.2	1.8	3.1	1.8	0.6
Gout (self-reported)	1.2	1.7	3.3	-1.8	0.2
Had major operations	1.2	1.5	1.5	-1.2	1.2
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.6	1.6	-0.7
Crohns Disease (2017)	1.1	2.4	2.7	1.6	-1.4
Reaction Time	1.1	2.0	2.3	1.3	-1.5
Ulcerative Colitis	1.1	1.5	1.7	1.3	-1.2
Blood Red Count	1.1	11.1	21.9	4.7	0.5
BMI	1.1	6.6	11.1	-3.3	1.4
Frequency of depressed mood in last 2 weeks	1.1	1.5	2.0	1.0	1.4
Multivitamins +/- minerals	1.1	1.4	2.6	-0.5	-1.6
Hearing difficulty/problems with background noise	1.1	1.8	3.0	1.7	-0.7
Weight	1.1	5.5	10.9	-3.3	0.2
Breastfed as a baby	1.1	1.4	2.5	-0.5	-1.6
High blood pressure (siblings)	1.1	1.5	3.1	1.8	0.0
Alcohol intake frequency.	1.1	2.7	5.1	0.5	2.3
Age at last live birth	1.1	1.6	3.3	-1.8	-0.1
Supplements: Vitamin C	1.1	1.4	2.6	-1.6	0.2
Average weekly red wine intake	1.1	1.6	1.9	-1.2	-1.4
Depressed Affect (Nagel 2018)	1.0	2.1	3.6	1.9	0.8
Ovarian Cancer	1.0	1.3	2.1	1.5	-0.7
Supplements: Zinc	1.0	1.1	1.4	-0.8	-1.2
Body mass index (BMI)	1.0	4.2	5.8	-2.4	1.6
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	3.0	-0.5	1.7
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	1.9	1.1	1.4
Medication: Paracetamol	1.0	1.6	2.3	-0.9	1.5
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	1.9	-1.4	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.2	2.0	0.7	1.4
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.2	0.4	1.5
Illnesses of father: None of the above (group 1)	1.0	1.3	2.2	0.6	-1.5
Impedance of whole body	1.0	5.2	7.8	-2.8	1.6
Bipolar Disorder or Schizophrenia	0.9	2.2	3.9	-2.0	0.7
Hearing difficulty/problems: Yes	0.9	1.3	2.1	0.7	-1.5
Vitamin and mineral supplements	0.9	1.2	2.1	1.5	0.6
Average weekly fortified wine intake	0.9	1.1	1.4	-0.9	-1.2
Age when periods started (menarche)	0.9	2.1	2.1	1.5	-1.4
Nervous feelings	0.9	1.7	3.1	-1.8	-0.6
Medication: Cholesterol lowering	0.9	1.3	1.8	0.9	-1.3
Age at first live birth	0.9	1.6	2.2	-1.5	-1.0
Emphysema/chronic bronchitis	0.9	1.0	1.6	-0.7	1.3
Overall health rating	0.9	2.0	2.6	1.6	1.2
Financial situation satisfaction	0.9	1.1	2.2	0.1	1.5
Alcohol drinker status: Never	0.9	1.0	2.0	0.2	1.4
Age at First Birth	0.8	1.1	1.5	-1.2	-0.9
Lupus	0.8	1.2	2.0	1.4	-0.6
Rheumatoid Arthritis	0.8	1.1	1.6	-0.7	-1.3
Triglycerides	0.8	1.3	2.6	0.2	-1.6
Height	0.8	15.1	22.6	-2.8	-4.8
Townsend deprivation index at recruitment	0.8	1.2	1.8	1.3	0.8
Current tobacco smoking	0.8	1.3	1.9	1.4	0.8
Hip circumference	0.8	3.4	3.5	-1.8	1.9
Standing height	0.8	8.0	8.8	-2.7	-3.0
Peak expiratory flow (PEF)	0.8	1.7	3.0	1.7	-0.7
Shortness of breath walking on level ground	0.8	0.9	1.3	-1.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.1	-1.8	0.6
Mood swings	0.8	1.5	2.7	0.5	1.7
Smoking status: Current	0.8	1.2	1.7	1.3	0.8
Mother’s age at death	0.8	0.9	1.6	-1.3	-0.5
Medication: Lisinopril	0.8	1.0	1.9	1.4	-0.3
Average weekly spirits intake	0.7	0.8	1.4	-1.2	0.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	1.0	-1.0	-0.9
Stomach or abdominal pain in last month	0.7	0.9	1.4	-0.5	1.2
Alcohol usually taken with meals	0.7	1.2	2.2	-1.5	-0.3
Pain all over the body in last month	0.7	0.8	1.5	1.2	-0.2
Birth weight of first child	0.7	1.2	2.4	-1.5	0.3
Eye problems/disorders: None of the above	0.7	0.8	1.0	-1.0	-0.7
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.1	0.7	-1.0
Miserableness	0.7	1.3	2.1	0.7	1.4
Illnesses of father: High blood pressure	0.7	0.9	1.7	-0.2	1.3
Unable to work because of sickness or disability	0.7	0.9	1.8	-0.0	1.4
Depression (Nagel 2018)	0.6	0.8	1.5	1.2	0.5
Worry (Nagel 2018)	0.6	1.4	2.5	-0.5	-1.6
LDL Cholesterol	0.6	1.0	1.3	1.1	0.8
Blood Eosinophil Count	0.6	4.5	6.5	1.6	-2.5
Lung FEV1/FVC ratio	0.6	2.9	4.0	-1.4	-2.0
Relative age of first facial hair	0.6	1.2	2.5	-1.6	0.0
Ever had hysterectomy (womb removed)	0.6	0.7	1.2	-0.4	-1.1
Had other major operations	0.6	0.8	1.6	0.1	1.3
Worrier / anxious feelings	0.6	1.1	2.0	-0.4	1.4
Noisy workplace	0.6	0.7	1.0	0.6	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.3	0.2	-1.1
Lung cancer (father)	0.6	0.7	1.4	-1.2	-0.1
Forced vital capacity (FVC), Best measure	0.6	2.3	4.1	-2.0	0.7
Qualifications: College or University degree	0.6	2.0	2.3	-1.5	-1.3
Comparative height size at age 10	0.6	3.5	4.0	-2.0	-1.7
Suffer from ‘nerves’	0.6	1.0	1.5	-0.7	-1.2
Smoking status: Previous	0.6	0.8	1.4	-0.5	-1.2
Ever had bowel cancer screening	0.6	0.7	1.3	-1.1	-0.2
Irritability	0.6	1.0	1.9	-0.3	1.4
Risk taking	0.6	0.9	1.1	0.8	1.0
Neuroticism	0.5	1.3	2.3	0.4	1.5
Neuroticism score	0.5	1.1	2.1	0.0	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	2.9	-1.7	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	0.8	-0.6	0.9
Illnesses of siblings: Diabetes	0.5	0.6	1.1	1.1	0.1
Long-standing illness, disability or infirmity	0.5	0.8	1.1	0.7	1.1
Number of self-reported non-cancer illnesses	0.5	1.0	1.1	0.9	1.0
Ever taken oral contraceptive pill	0.5	0.6	0.8	0.6	-0.9
Commuting to job workplace: Public transport	0.5	0.6	1.1	-1.0	-0.3
Eye problems/disorders: Glaucoma	0.5	0.6	0.8	0.6	0.9
Medication: Atorvastatin	0.5	0.6	0.7	0.8	0.8
Cholesterol lowering medication	0.5	0.8	0.9	-0.9	0.8
Pain experienced in last month	0.5	0.8	1.3	-0.6	-1.1
Alcohol drinker status: Previous	0.5	0.6	1.2	0.2	1.1
Irritable Bowel Disease (IBD)	0.4	0.9	1.6	0.5	-1.2
Smoking Status	0.4	1.0	1.3	1.2	-0.8
Hand grip strength (left)	0.4	1.1	1.2	-1.0	-1.1
Angina	0.4	0.5	0.9	-0.4	-1.0
Medication: Co-codamol	0.4	0.5	0.7	-0.8	0.5
Diabetes (father)	0.4	0.5	1.1	-0.1	1.0
Impedance of leg (right)	0.4	2.1	3.3	-1.8	1.0
Forced vital capacity (FVC)	0.4	1.6	1.8	-1.3	1.2
Heart attack	0.4	0.5	0.9	0.4	-1.0
Depression (self-reported)	0.4	0.5	0.9	-0.3	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.9	-0.5	1.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.8	-0.9	0.4
Birth weight	0.4	0.9	1.7	-0.2	1.3
Medication: Blood pressure	0.4	0.8	0.9	0.8	-0.9
Migraine (self-reported)	0.4	0.5	0.5	-0.6	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.9	0.9	0.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	-1.0	0.2
Average weekly beer plus cider intake	0.4	0.6	1.2	-0.0	-1.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.7	0.4	-0.9
Ulcerative Colitis (UC)	0.3	0.5	0.7	-0.6	-0.8
HDL Cholesterol	0.3	0.6	1.1	0.2	1.0
Neuroticism (2016)	0.3	0.4	0.8	-0.0	0.9
Blood White Count	0.3	2.1	3.7	-1.9	0.7
Lung FVC	0.3	1.8	2.7	-0.9	1.6
Chronotype (morning person)	0.3	0.7	1.5	-0.0	-1.2
Leg fat-free mass (left)	0.3	1.6	2.8	-1.7	-0.6
Hand grip strength (right)	0.3	0.8	1.5	-1.2	-0.3
Relative age voice broke	0.3	0.5	0.8	0.9	-0.4
Taking other prescription medications	0.3	0.4	0.8	0.9	0.3
High blood pressure	0.3	0.7	0.8	0.9	-0.8
Impedance of leg (left)	0.3	1.7	2.8	-1.7	0.8
Leg predicted mass (left)	0.3	1.7	3.0	-1.7	-0.6
Trunk fat-free mass	0.3	1.4	2.9	-0.2	-1.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.3	-1.1	0.8
Medication: Lansoprazole	0.3	0.3	0.4	-0.7	0.5
Trunk predicted mass	0.3	1.6	3.1	-0.1	-1.8
Glaucoma (self-reported)	0.3	0.3	0.5	-0.7	0.2
Arm fat-free mass (right)	0.3	1.3	2.3	-0.6	-1.5
Exposure to tobacco smoke outside home	0.3	0.5	0.6	-0.6	0.7
Medication for pain relief, constipation, heartburn	0.3	0.6	1.1	0.3	1.0
Angina (self-reported)	0.3	0.4	0.9	-0.0	-0.9
Medication: Ibuprofen	0.3	0.3	0.6	0.8	-0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.5	-0.7	0.3
Leg fat-free mass (right)	0.3	1.4	2.1	-1.5	-0.8
Friendships satisfaction	0.3	0.4	0.8	0.9	0.3
Eye problems/disorders: Cataract	0.3	0.3	0.4	-0.5	-0.6
Mineral and other dietary supplements	0.3	0.5	0.8	0.9	-0.3
Breast cancer (self-reported)	0.3	0.4	0.6	-0.4	-0.8
Leg predicted mass (right)	0.3	1.4	2.2	-1.5	-0.8
Ever smoked	0.3	0.6	1.0	-1.0	-0.5
Basal metabolic rate	0.3	1.7	2.4	-1.6	-1.0
Ever depressed for a whole week	0.3	0.4	0.5	0.5	0.7
Commuting to job workplace: Cycle	0.3	0.4	0.8	0.9	-0.0
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.0	-0.8	1.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.6	-0.1	-0.8
Arm predicted mass (left)	0.3	1.3	2.4	-0.4	-1.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.6	0.2	0.8
Fasting Glucose	0.2	0.2	0.3	-0.6	-0.3
Allergy or Eczema	0.2	0.7	1.3	1.1	-0.2
Severe depression (siblings)	0.2	0.2	0.3	-0.6	-0.1
Pack years adult smoking proportion	0.2	0.3	0.6	-0.0	0.8
Past tobacco smoking	0.2	0.4	0.4	0.7	0.5
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	-0.2	0.6
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	0.8	-0.1
Time employed in main current job	0.2	0.2	0.4	0.1	-0.7
Hair/balding pattern: Pattern 3	0.2	0.2	0.5	-0.0	-0.7
Number of live births	0.2	0.4	0.7	0.8	-0.2
Illnesses of mother	0.2	0.2	0.4	-0.6	0.1
Exposure to tobacco smoke at home	0.2	0.2	0.4	0.6	0.1
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.5	-0.7	-0.3
Comparative body size at age 10	0.2	0.4	0.8	-0.3	0.9
Number of children fathered	0.2	0.2	0.2	-0.4	0.4
Arm predicted mass (right)	0.2	1.2	2.2	-0.4	-1.5
Number of full sisters	0.2	0.3	0.5	-0.7	0.3
Chest pain or discomfort	0.2	0.3	0.5	0.7	0.5
Hypertension (Self-reported)	0.2	0.6	0.9	0.6	-1.0
Whole body fat-free mass	0.2	1.3	2.0	-0.7	-1.4
Medication: Gliclazide	0.2	0.2	0.4	0.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.6	-0.8	0.3
Whole body water mass	0.2	1.3	2.1	-0.7	-1.4
Medication: Blood pressure	0.2	0.3	0.5	0.2	-0.7
Arm fat-free mass (left)	0.2	1.1	1.8	-0.6	-1.3
Schizophrenia (2018)	0.1	0.1	0.2	0.2	0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.3	0.4
HbA1C	0.1	0.1	0.2	-0.3	-0.4
Schizophrenia (2014)	0.1	0.3	0.5	-0.7	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	0.0	-0.4
Cardiovascular Disease	0.1	0.2	0.4	0.1	0.6
Hair Pigment	0.1	1.9	3.7	-0.1	-1.9
Number of treatments/medications taken	0.1	0.2	0.3	0.6	0.3
Systolic blood pressure, automated reading	0.1	0.3	0.4	-0.7	-0.5
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.1	0.3	-0.4
Medication: Atenolol	0.1	0.1	0.2	-0.5	0.0
High blood pressure (mother)	0.1	0.1	0.2	0.4	-0.4
Allergy	0.1	0.3	0.6	-0.0	-0.8
Medication: Ramipril	0.1	0.1	0.2	0.0	-0.4
Tense / ‘highly strung’	0.1	0.2	0.5	-0.7	0.0
Medication: Amlodipine	0.1	0.2	0.2	0.4	-0.4
Number of full brothers	0.1	0.1	0.2	0.4	-0.2
Medication: Allopurinol	0.1	0.1	0.1	-0.3	-0.3
Medication: Omeprazole	0.1	0.1	0.2	0.0	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.3	-0.6	0.1
Wears glasses or contact lenses	0.1	0.1	0.3	-0.1	-0.5
Supplements: Calcium	0.1	0.1	0.2	0.3	-0.4
Pack years of smoking	0.1	0.1	0.2	-0.1	0.5
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	-0.2	-0.5
Neuroticism (Nagel 2018)	0.0	0.0	0.1	0.3	0.1
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.0	0.1	-0.0
Breast Cancer	0.0	0.1	0.1	-0.1	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Systolic Blood Pressure	0.0	0.1	0.1	-0.4	-0.2
Tanning	0.0	0.1	0.2	-0.4	0.1
Sensitivity / hurt feelings	0.0	0.0	0.0	0.0	0.2
Qualifications: CSEs or equivalent	0.0	0.1	0.1	0.1	-0.3
Medication: Simvastatin	0.0	0.1	0.1	0.1	-0.3
Fluid intelligence score	0.0	0.1	0.1	-0.1	0.3
Falls in the last year	0.0	0.1	0.1	-0.2	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.3	0.0
Blood clot in the leg (DVT)	0.0	0.1	0.1	0.3	-0.0
Worry too long after embarrassment	0.0	0.1	0.1	-0.1	-0.3
Neck or shoulder pain in last month	0.0	0.0	0.0	0.0	-0.0
Medication for cholesterol	0.0	0.0	0.0	0.2	-0.1
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.0	-0.0	-0.1
High cholesterol (Self-reported)	0.0	0.1	0.1	-0.2	0.4
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.0	0.1	0.1

Hub : Genes

HDAC5

Models

Trait associations