Hub : Genes

HDAC5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Mucosa 0.0560 0.0240 0.0029 0.045 NA 0.016 NA 0.024 0.00055 NA 0.027 NA 0.0092
2 GTEx Muscle Skeletal 0.0785 0.0309 0.0028 0.010 NA 0.010 NA 0.013 0.03300 NA 0.029 NA 0.0170

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 3.7 5.9 11.5 -3.4 0.5
Bipolar Disorder or Schizophrenia 0.9 2.2 3.9 -2.0 0.7
Depressed Affect (Nagel 2018) 1.0 2.1 3.6 1.9 0.8
Depression (Nagel 2018) 0.6 0.8 1.5 1.2 0.5
Intelligence (Savage-Jansen 2018) 0.0 0.1 0.2 -0.2 -0.5
Neuroticism (Nagel 2018) 0.0 0.0 0.1 0.3 0.1
Schizophrenia (2018) 0.1 0.1 0.2 0.2 0.5
Schizophrenia vs Biploar Disorder 2.4 3.2 5.8 2.4 -0.8
Worry (Nagel 2018) 0.6 1.4 2.5 -0.5 -1.6
Alzheimer’s Disease (in mother) 1.6 1.8 2.0 -1.3 1.4
Alzheimer’s Disease (in father) 0.1 0.1 0.2 -0.3 0.4
Alzheimer’s Disease (including proxy) 1.7 2.5 2.9 -1.7 1.5
Crohns Disease (2017) 1.1 2.4 2.7 1.6 -1.4
Irritable Bowel Disease (IBD) 0.4 0.9 1.6 0.5 -1.2
Ulcerative Colitis (UC) 0.3 0.5 0.7 -0.6 -0.8
Major Depression (MDD) 2.0 2.4 4.7 0.4 2.2
Reaction Time 1.1 2.0 2.3 1.3 -1.5
Verbal and Numeric Reasoning (VNR) 0.0 0.0 0.0 0.1 -0.0
Breast Cancer 0.0 0.1 0.1 -0.1 -0.3
Ovarian Cancer 1.0 1.3 2.1 1.5 -0.7
Prostate Cancer 1.2 1.7 2.6 -0.9 -1.6
Age at First Birth 0.8 1.1 1.5 -1.2 -0.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.2 0.3 0.6 0.2 0.8
Coronary Artery Disease (CAD) 2.6 3.1 6.2 2.5 -0.1
Crohns Disease (2012) 1.4 2.3 3.1 1.8 -1.2
Mean Putamen Volume 4.0 4.5 6.6 2.6 -1.6
Fasting Glucose 0.2 0.2 0.3 -0.6 -0.3
HbA1C 0.1 0.1 0.2 -0.3 -0.4
HDL Cholesterol 0.3 0.6 1.1 0.2 1.0
LDL Cholesterol 0.6 1.0 1.3 1.1 0.8
Lupus 0.8 1.2 2.0 1.4 -0.6
Neuroticism (2016) 0.3 0.4 0.8 -0.0 0.9
Primary Biliary Cirrhosis 1.3 1.9 3.0 -0.9 1.7
Rheumatoid Arthritis 0.8 1.1 1.6 -0.7 -1.3
Schizophrenia (2014) 0.1 0.3 0.5 -0.7 0.1
Triglycerides 0.8 1.3 2.6 0.2 -1.6
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 0.0 -0.4
Ulcerative Colitis 1.1 1.5 1.7 1.3 -1.2
Blood Eosinophil Count 0.6 4.5 6.5 1.6 -2.5
Blood Platelet Count 3.6 41.3 79.2 -8.9 1.9
Blood Red Count 1.1 11.1 21.9 4.7 0.5
Blood White Count 0.3 2.1 3.7 -1.9 0.7
Heel T-Score 18.9 150.3 299.3 -17.3 -1.2
BMI 1.1 6.6 11.1 -3.3 1.4
Height 0.8 15.1 22.6 -2.8 -4.8
Waist Hip Ratio (WHR) 1.8 8.2 16.3 -4.0 -0.4
Systolic Blood Pressure 0.0 0.1 0.1 -0.4 -0.2
Smoking Status 0.4 1.0 1.3 1.2 -0.8
Allergy or Eczema 0.2 0.7 1.3 1.1 -0.2
Cardiovascular Disease 0.1 0.2 0.4 0.1 0.6
Hypothyroidism (self reported) 1.3 2.9 5.2 2.3 -0.7
Respiratory disease 1.5 3.4 6.5 -0.5 2.5
Type 2 Diabetes (T2D) (2018) 2.1 4.0 7.9 2.8 0.1
Lung FEV1/FVC ratio 0.6 2.9 4.0 -1.4 -2.0
Lung FVC 0.3 1.8 2.7 -0.9 1.6
Neuroticism 0.5 1.3 2.3 0.4 1.5
Chronotype (morning person) 0.3 0.7 1.5 -0.0 -1.2
Hair Pigment 0.1 1.9 3.7 -0.1 -1.9
Tanning 0.0 0.1 0.2 -0.4 0.1
Hand grip strength (left) 0.4 1.1 1.2 -1.0 -1.1
Number of treatments/medications taken 0.1 0.2 0.3 0.6 0.3
Average weekly spirits intake 0.7 0.8 1.4 -1.2 0.6
Sensitivity / hurt feelings 0.0 0.0 0.0 0.0 0.2
Frequency of depressed mood in last 2 weeks 1.1 1.5 2.0 1.0 1.4
Hearing difficulty/problems: Yes 0.9 1.3 2.1 0.7 -1.5
Relative age of first facial hair 0.6 1.2 2.5 -1.6 0.0
Other serious medical condition/disability diagnosed by doctor 2.1 2.7 5.3 2.3 0.1
Ever used hormone-replacement therapy (HRT) 3.3 4.2 8.2 -0.4 -2.9
Ever had hysterectomy (womb removed) 0.6 0.7 1.2 -0.4 -1.1
Systolic blood pressure, automated reading 0.1 0.3 0.4 -0.7 -0.5
Eye problems/disorders: Diabetes related eye disease 3.0 3.2 4.9 2.2 -1.2
Angina 0.4 0.5 0.9 -0.4 -1.0
Medication for hormone replacement therapy 1.4 1.6 1.6 -1.3 -1.3
Vitamin and mineral supplements 0.9 1.2 2.1 1.5 0.6
Supplements: Zinc 1.0 1.1 1.4 -0.8 -1.2
Medication: Co-codamol 0.4 0.5 0.7 -0.8 0.5
Medication: Metformin 1.4 1.9 2.3 1.2 -1.5
Diabetes (father) 0.4 0.5 1.1 -0.1 1.0
Diabetes (mother) 1.3 1.7 3.3 1.8 -0.2
Severe depression (siblings) 0.2 0.2 0.3 -0.6 -0.1
Pack years adult smoking proportion 0.2 0.3 0.6 -0.0 0.8
Impedance of leg (right) 0.4 2.1 3.3 -1.8 1.0
Leg fat-free mass (left) 0.3 1.6 2.8 -1.7 -0.6
Trunk fat percentage 4.4 17.7 29.7 -5.4 2.4
Hand grip strength (right) 0.3 0.8 1.5 -1.2 -0.3
Townsend deprivation index at recruitment 0.8 1.2 1.8 1.3 0.8
Current tobacco smoking 0.8 1.3 1.9 1.4 0.8
Average weekly fortified wine intake 0.9 1.1 1.4 -0.9 -1.2
Maternal smoking around birth 1.9 2.7 5.3 2.3 -0.3
Fed-up feelings 1.6 2.9 3.0 1.6 1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 3.1 1.0 1.8
Relative age voice broke 0.3 0.5 0.8 0.9 -0.4
Taking other prescription medications 0.3 0.4 0.8 0.9 0.3
Age when periods started (menarche) 0.9 2.1 2.1 1.5 -1.4
Bilateral oophorectomy (both ovaries removed) 0.7 0.9 1.0 -1.0 -0.9
Heel bone mineral density (BMD) T-score, automated (left) 15.9 36.0 70.0 -8.4 -1.4
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 3.7 0.3 1.9
Qualifications: CSEs or equivalent 0.0 0.1 0.1 0.1 -0.3
Serious illness, injury or assault to yourself 3.5 4.2 7.6 2.8 -0.9
High blood pressure 0.3 0.7 0.8 0.9 -0.8
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.1 0.3 -0.4
Multivitamins +/- minerals 1.1 1.4 2.6 -0.5 -1.6
Stomach or abdominal pain in last month 0.7 0.9 1.4 -0.5 1.2
Supplements: Glucosamine 4.8 6.3 12.5 -3.5 -0.2
Diverticular disease/diverticulitis (self-reported) 4.2 5.0 9.9 -3.2 0.1
Medication: Atenolol 0.1 0.1 0.2 -0.5 0.0
Medication: Levothyroxine sodium 1.3 2.2 4.0 2.0 -0.7
Sitting height 2.1 15.1 19.1 3.3 -4.4
Chronic bronchitis/emphysema (father) 1.4 1.6 3.1 1.8 0.2
High blood pressure (mother) 0.1 0.1 0.2 0.4 -0.4
Body mass index (BMI) 1.0 4.2 5.8 -2.4 1.6
Impedance of leg (left) 0.3 1.7 2.8 -1.7 0.8
Leg predicted mass (left) 0.3 1.7 3.0 -1.7 -0.6
Trunk fat mass 3.3 14.2 25.7 -5.1 1.6
Waist circumference 2.0 7.2 12.9 -3.6 1.2
Number of incorrect matches in round 3.2 5.3 9.3 1.1 -3.0
Past tobacco smoking 0.2 0.4 0.4 0.7 0.5
Alcohol usually taken with meals 0.7 1.2 2.2 -1.5 -0.3
Nervous feelings 0.9 1.7 3.1 -1.8 -0.6
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 3.0 -0.5 1.7
Hearing difficulty/problems with background noise 1.1 1.8 3.0 1.7 -0.7
Hair/balding pattern: Pattern 2 0.2 0.2 0.4 -0.2 0.6
Had menopause 1.8 2.3 2.8 1.3 -1.7
Had other major operations 0.6 0.8 1.6 0.1 1.3
Forced vital capacity (FVC) 0.4 1.6 1.8 -1.3 1.2
Heel bone mineral density (BMD) T-score, automated (right) 13.1 30.0 56.1 -7.5 -2.0
Ever unenthusiastic/disinterested for a whole week 1.9 2.3 3.8 0.9 1.9
Qualifications: None of the above 1.7 3.7 6.6 2.6 -0.8
Financial difficulties in last 2 years 1.3 1.7 2.1 1.4 1.2
Mouth/teeth dental problems 3.6 5.5 10.4 -0.7 -3.2
Heart attack 0.4 0.5 0.9 0.4 -1.0
Allergy 0.1 0.3 0.6 -0.0 -0.8
Pain all over the body in last month 0.7 0.8 1.5 1.2 -0.2
Diabetes (self-reported) 1.9 2.9 4.7 2.2 -1.1
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.6 0.8 -0.1
Medication: Ramipril 0.1 0.1 0.2 0.0 -0.4
Medication: Simvastatin 0.0 0.1 0.1 0.1 -0.3
Fluid intelligence score 0.0 0.1 0.1 -0.1 0.3
Illnesses of siblings 1.8 2.5 5.0 -2.2 -0.0
Neuroticism score 0.5 1.1 2.1 0.0 1.5
Weight 1.1 5.5 10.9 -3.3 0.2
Impedance of arm (right) 1.9 9.0 13.1 -3.6 2.2
Arm fat percentage (right) 3.8 14.9 20.6 -4.5 3.0
Trunk fat-free mass 0.3 1.4 2.9 -0.2 -1.7
Hip circumference 0.8 3.4 3.5 -1.8 1.9
Time employed in main current job 0.2 0.2 0.4 0.1 -0.7
Alcohol intake versus 10 years previously 1.2 1.8 3.1 1.8 0.6
Father’s age at death 1.3 1.7 2.1 -1.2 -1.4
Worrier / anxious feelings 0.6 1.1 2.0 -0.4 1.4
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 1.9 1.1 1.4
Falls in the last year 0.0 0.1 0.1 -0.2 0.3
Hair/balding pattern: Pattern 3 0.2 0.2 0.5 -0.0 -0.7
Number of live births 0.2 0.4 0.7 0.8 -0.2
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 1.3 -1.1 0.8
Pulse rate 2.5 4.2 8.2 2.9 0.4
Happiness 2.4 2.9 3.0 1.7 1.7
Noisy workplace 0.6 0.7 1.0 0.6 1.0
Qualifications: A levels/AS levels or equivalent 1.7 3.8 7.5 -2.7 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.3 0.2 -1.1
Mouth/teeth dental problems: Dentures 3.1 5.2 7.8 2.8 1.6
Asthma 3.3 6.5 11.6 -1.2 3.4
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.0 0.1 0.3 0.0
Medication: Cholesterol lowering 0.9 1.3 1.8 0.9 -1.3
Depression (self-reported) 0.4 0.5 0.9 -0.3 1.0
Medication: Lansoprazole 0.3 0.3 0.4 -0.7 0.5
Prospective memory result 2.3 2.9 3.6 -1.5 1.9
Lung cancer (father) 0.6 0.7 1.4 -1.2 -0.1
Illnesses of mother 0.2 0.2 0.4 -0.6 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.5 2.9 -1.7 0.0
Pulse wave Arterial Stiffness index 3.0 3.5 4.5 2.1 -1.6
Impedance of arm (left) 1.7 7.7 12.1 -3.5 1.8
Arm fat mass (right) 2.6 10.8 18.1 -4.2 1.9
Trunk predicted mass 0.3 1.6 3.1 -0.1 -1.8
Standing height 0.8 8.0 8.8 -2.7 -3.0
Length of working week for main job 1.8 1.9 3.9 -2.0 -0.2
Exposure to tobacco smoke at home 0.2 0.2 0.4 0.6 0.1
Breastfed as a baby 1.1 1.4 2.5 -0.5 -1.6
Tense / ‘highly strung’ 0.1 0.2 0.5 -0.7 0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 0.9 -0.5 1.0
Hair/balding pattern: Pattern 4 2.2 5.3 10.0 3.2 0.7
Birth weight of first child 0.7 1.2 2.4 -1.5 0.3
Peak expiratory flow (PEF) 0.8 1.7 3.0 1.7 -0.7
Pulse wave reflection index 1.7 2.1 2.9 1.1 -1.7
Ever highly irritable/argumentative for 2 days 1.4 1.7 2.1 -1.1 1.4
Loud music exposure frequency 1.5 1.6 1.9 1.4 1.2
Qualifications: O levels/GCSEs or equivalent 1.9 3.0 5.0 -1.0 2.2
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 0.8 -0.9 0.4
Blood clot in the leg (DVT) 0.0 0.1 0.1 0.3 -0.0
Medication: Paracetamol 1.0 1.6 2.3 -0.9 1.5
Headache pain in last month 3.1 5.3 9.7 1.0 3.1
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 1.9 -1.4 1.2
Glaucoma (self-reported) 0.3 0.3 0.5 -0.7 0.2
Gout (self-reported) 1.2 1.7 3.3 -1.8 0.2
Hypothyroidism/myxoedema (self-reported) 2.1 4.2 7.7 2.8 -0.8
Medication: Amlodipine 0.1 0.2 0.2 0.4 -0.4
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.5 -0.7 -0.3
Birth weight 0.4 0.9 1.7 -0.2 1.3
Chronic bronchitis/emphysema (mother) 2.6 3.0 5.9 2.4 -0.4
High blood pressure (siblings) 1.1 1.5 3.1 1.8 0.0
Forced vital capacity (FVC), Best measure 0.6 2.3 4.1 -2.0 0.7
Body fat percentage 4.2 16.4 24.4 -4.9 2.9
Leg fat percentage (right) 2.4 8.7 10.7 -3.3 2.6
Arm fat-free mass (right) 0.3 1.3 2.3 -0.6 -1.5
Exposure to tobacco smoke outside home 0.3 0.5 0.6 -0.6 0.7
Comparative body size at age 10 0.2 0.4 0.8 -0.3 0.9
Number of full brothers 0.1 0.1 0.2 0.4 -0.2
Worry too long after embarrassment 0.0 0.1 0.1 -0.1 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.2 2.0 0.7 1.4
Wheeze or whistling in the chest in last year 2.5 4.4 8.8 -0.2 3.0
Number of children fathered 0.2 0.2 0.2 -0.4 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 0.8 -0.6 0.9
Age at first live birth 0.9 1.6 2.2 -1.5 -1.0
Pulse wave peak to peak time 3.4 4.1 6.0 -2.4 1.5
Health satisfaction 1.5 1.9 2.5 1.6 -1.1
Shortness of breath walking on level ground 0.8 0.9 1.3 -1.1 0.7
Qualifications: College or University degree 0.6 2.0 2.3 -1.5 -1.3
Eye problems/disorders: None of the above 0.7 0.8 1.0 -1.0 -0.7
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.2 0.4 1.5
Emphysema/chronic bronchitis 0.9 1.0 1.6 -0.7 1.3
Medication for pain relief, constipation, heartburn 0.3 0.6 1.1 0.3 1.0
Neck or shoulder pain in last month 0.0 0.0 0.0 0.0 -0.0
Medication: Blood pressure 0.4 0.8 0.9 0.8 -0.9
Angina (self-reported) 0.3 0.4 0.9 -0.0 -0.9
Migraine (self-reported) 0.4 0.5 0.5 -0.6 0.7
Medication: Ibuprofen 0.3 0.3 0.6 0.8 -0.2
Medication: Allopurinol 0.1 0.1 0.1 -0.3 -0.3
Medication: Omeprazole 0.1 0.1 0.2 0.0 -0.4
Medication: Seretide 50 evohaler 2.5 2.9 3.9 -1.4 2.0
Mean time to correctly identify matches 1.5 2.8 3.7 1.4 -1.9
Heart disease (mother) 1.7 2.0 3.7 1.9 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 0.9 0.9 0.0
Whole body fat mass 3.1 13.0 21.9 -4.7 2.0
Leg fat mass (right) 2.1 8.1 12.9 -3.6 1.8
Arm predicted mass (right) 0.2 1.2 2.2 -0.4 -1.5
Pulse rate, automated reading 1.6 5.2 10.3 3.2 0.0
Alcohol intake frequency. 1.1 2.7 5.1 0.5 2.3
Comparative height size at age 10 0.6 3.5 4.0 -2.0 -1.7
Number of full sisters 0.2 0.3 0.5 -0.7 0.3
Suffer from ‘nerves’ 0.6 1.0 1.5 -0.7 -1.2
Overall health rating 0.9 2.0 2.6 1.6 1.2
Chest pain or discomfort 0.2 0.3 0.5 0.7 0.5
Had major operations 1.2 1.5 1.5 -1.2 1.2
Age at last live birth 1.1 1.6 3.3 -1.8 -0.1
Family relationship satisfaction 1.8 2.2 2.3 1.4 1.5
Leg pain on walking 1.3 1.6 1.9 -1.1 1.4
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.4 4.6 0.4 2.1
Commuting to job workplace: Car/motor vehicle 0.7 0.8 1.1 0.7 -1.0
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.5 -0.7 0.3
Medication: Aspirin 2.9 3.9 6.9 0.9 -2.6
Supplements: Vitamin C 1.1 1.4 2.6 -1.6 0.2
Knee pain experienced in last month 1.9 3.0 3.8 -2.0 1.5
Hypertension (Self-reported) 0.2 0.6 0.9 0.6 -1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.6 1.8 2.5 -1.6 1.1
Illnesses of father: Heart disease 1.4 2.0 4.0 0.2 2.0
Illnesses of siblings: Diabetes 0.5 0.6 1.1 1.1 0.1
Smoking status: Previous 0.6 0.8 1.4 -0.5 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 3.1 -1.8 0.6
Whole body fat-free mass 0.2 1.3 2.0 -0.7 -1.4
Leg fat-free mass (right) 0.3 1.4 2.1 -1.5 -0.8
Arm fat percentage (left) 3.9 15.7 21.3 -4.6 3.2
Average weekly red wine intake 1.1 1.6 1.9 -1.2 -1.4
Handedness (chirality/laterality): Left-handed 1.7 2.1 3.4 -1.8 -0.9
Mood swings 0.8 1.5 2.7 0.5 1.7
Loneliness, isolation 1.5 2.0 2.7 1.2 1.6
Long-standing illness, disability or infirmity 0.5 0.8 1.1 0.7 1.1
Ever had bowel cancer screening 0.6 0.7 1.3 -1.1 -0.2
Diabetes diagnosed by doctor 2.0 3.3 5.7 2.4 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.0 3.6 0.6 1.9
Friendships satisfaction 0.3 0.4 0.8 0.9 0.3
Qualifications: nursing, teaching 2.8 4.4 7.4 -2.7 1.2
Commuting to job workplace: Walk 1.4 1.5 2.9 0.3 1.7
Eye problems/disorders: Cataract 0.3 0.3 0.4 -0.5 -0.6
Mouth/teeth dental problems: Mouth ulcers 2.9 4.7 7.7 -1.3 2.8
Medication for cholesterol 0.0 0.0 0.0 0.2 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.2 0.3 -0.6 0.1
Back pain experienced in last month 1.3 1.9 2.2 1.5 -1.2
Mineral and other dietary supplements 0.3 0.5 0.8 0.9 -0.3
Breast cancer (self-reported) 0.3 0.4 0.6 -0.4 -0.8
Asthma (self-reported) 2.7 5.3 9.4 -1.1 3.1
Osteoporosis (self-reported) 2.7 3.3 4.5 2.1 1.5
Osteoarthritis (self-reported) 3.6 4.6 8.4 -2.9 0.9
Medication: Aspirin 2.4 3.2 5.8 0.7 -2.4
Medication: Gliclazide 0.2 0.2 0.4 0.2 -0.6
Illnesses of father: None of the above (group 1) 1.0 1.3 2.2 0.6 -1.5
Smoking status: Current 0.8 1.2 1.7 1.3 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 0.6 -0.8 0.3
Whole body water mass 0.2 1.3 2.1 -0.7 -1.4
Leg predicted mass (right) 0.3 1.4 2.2 -1.5 -0.8
Arm fat mass (left) 2.5 10.2 16.7 -4.1 1.9
Number of self-reported non-cancer illnesses 0.5 1.0 1.1 0.9 1.0
Average weekly champagne plus white wine intake 1.8 2.5 4.7 -2.2 -0.5
Miserableness 0.7 1.3 2.1 0.7 1.4
Guilty feelings 2.1 3.2 4.5 -1.3 2.1
Wears glasses or contact lenses 0.1 0.1 0.3 -0.1 -0.5
Ever taken oral contraceptive pill 0.5 0.6 0.8 0.6 -0.9
Hearing aid user 2.2 2.5 4.3 -0.8 2.1
Mother’s age at death 0.8 0.9 1.6 -1.3 -0.5
Financial situation satisfaction 0.9 1.1 2.2 0.1 1.5
Tinnitus: Yes, now most or all of the time 0.0 0.0 0.0 -0.0 -0.1
Commuting to job workplace: Public transport 0.5 0.6 1.1 -1.0 -0.3
Eye problems/disorders: Glaucoma 0.5 0.6 0.8 0.6 0.9
Medication: Blood pressure 0.2 0.3 0.5 0.2 -0.7
Pain type(s) experienced in last month: Hip pain 1.2 1.5 2.6 1.6 -0.7
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.0 -1.0 0.2
High cholesterol (Self-reported) 0.0 0.1 0.1 -0.2 0.4
Medication: Bendroflumethiazide 1.7 2.5 4.8 2.2 -0.5
Medication: Paracetamol 1.5 2.3 2.5 -1.4 1.6
Medication: Lisinopril 0.8 1.0 1.9 1.4 -0.3
Medication: Atorvastatin 0.5 0.6 0.7 0.8 0.8
Illnesses of father: High blood pressure 0.7 0.9 1.7 -0.2 1.3
Alcohol drinker status: Never 0.9 1.0 2.0 0.2 1.4
Ever smoked 0.3 0.6 1.0 -1.0 -0.5
Basal metabolic rate 0.3 1.7 2.4 -1.6 -1.0
Leg fat percentage (left) 2.1 7.4 9.6 -3.1 2.3
Arm fat-free mass (left) 0.2 1.1 1.8 -0.6 -1.3
Number of operations (self-reported) 2.8 4.2 6.2 -1.4 2.5
Average weekly beer plus cider intake 0.4 0.6 1.2 -0.0 -1.1
Irritability 0.6 1.0 1.9 -0.3 1.4
Risk taking 0.6 0.9 1.1 0.8 1.0
Ever had prostate specific antigen (PSA) test 3.1 3.5 5.6 -2.4 1.2
Fractured/broken bones in last 5 years 10.0 12.9 24.2 4.9 1.3
Age started oral contraceptive pill 2.2 2.8 4.8 0.9 -2.2
Diastolic blood pressure, automated reading 1.5 4.6 8.0 2.8 -1.1
Ever depressed for a whole week 0.3 0.4 0.5 0.5 0.7
Unable to work because of sickness or disability 0.7 0.9 1.8 -0.0 1.4
Commuting to job workplace: Cycle 0.3 0.4 0.8 0.9 -0.0
Myopia 1.8 2.5 4.9 -2.2 0.4
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.0 -0.8 1.0
Cholesterol lowering medication 0.5 0.8 0.9 -0.9 0.8
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.6 -0.1 -0.8
Pain experienced in last month 0.5 0.8 1.3 -0.6 -1.1
Supplements: Calcium 0.1 0.1 0.2 0.3 -0.4
Basal cell carcinoma (self-reported) 2.4 2.9 3.5 -1.9 -1.5
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.7 0.4 -0.9
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.0 0.1 0.1
Heart disease (siblings) 1.5 1.8 2.2 1.2 -1.5
Alcohol drinker status: Previous 0.5 0.6 1.2 0.2 1.1
Pack years of smoking 0.1 0.1 0.2 -0.1 0.5
Impedance of whole body 1.0 5.2 7.8 -2.8 1.6
Leg fat mass (left) 2.1 8.0 13.4 -3.7 1.6
Arm predicted mass (left) 0.3 1.3 2.4 -0.4 -1.5