[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (right) : ← →

chr19:32,482,073-34,392,158

Best TWAS P=4.7e-47 · Best GWAS P=4.82e-46 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RHPN2	0.19	0.16	enet	18	0.18	5.7e-21	8.6	-12.1	8.6e-34	-0.68	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	WDR88	0.09	0.07	lasso	4	0.06	1.8e-07	6.9	7.4	1.1e-13	0.34	1.00	0.00	TRUE
3	GTEx	Artery Aorta	RHPN2	0.13	0.09	lasso	3	0.07	7.0e-05	12.1	-10.8	2.5e-27	-0.43	0.87	0.01	FALSE
4	GTEx	Artery Tibial	RHPN2	0.09	0.09	enet	17	0.11	5.1e-09	12.2	-11.0	2.6e-28	-0.50	0.99	0.00	FALSE
5	GTEx	Brain Caudate basal ganglia	RHPN2	0.20	-0.01	enet	18	0.03	4.8e-02	6.0	-8.9	4.4e-19	-0.52	0.06	0.38	TRUE
6	GTEx	Brain Frontal Cortex BA9	CTD-2538C1.2	0.45	0.02	enet	40	0.18	1.3e-05	-2.1	-5.3	1.2e-07	-0.10	0.21	0.05	FALSE
7	GTEx	Brain Hippocampus	RHPN2	0.22	-0.01	enet	9	0.00	3.3e-01	-4.5	-11.3	1.2e-29	-0.58	0.05	0.30	TRUE
8	GTEx	Breast Mammary Tissue (Male)	CEP89	0.10	0.06	lasso	2	0.06	1.4e-02	-2.9	5.8	4.8e-09	0.30	0.05	0.09	TRUE
9	GTEx	Cells Transformed fibroblasts	GPATCH1	0.08	0.12	lasso	3	0.12	5.3e-09	4.5	5.2	2.0e-07	0.00	1.00	0.00	FALSE
10	GTEx	Cells Transformed fibroblasts	RHPN2	0.08	0.00	enet	12	0.01	1.2e-01	4.4	-6.3	3.3e-10	-0.15	0.18	0.03	TRUE
11	GTEx	Esophagus Muscularis	CEP89	0.15	0.05	lasso	5	0.08	1.1e-05	-4.4	6.7	1.9e-11	0.23	0.89	0.02	FALSE
12	GTEx	Esophagus Muscularis	RHPN2	0.20	0.08	enet	24	0.10	1.7e-06	8.7	-5.4	7.8e-08	-0.36	0.74	0.12	FALSE
13	GTEx	Muscle Skeletal	GPATCH1	0.07	0.03	enet	13	0.02	1.7e-03	4.4	6.3	3.0e-10	-0.02	0.28	0.02	FALSE
14	GTEx	Muscle Skeletal	RHPN2	0.06	0.05	lasso	3	0.05	1.6e-05	8.7	-10.8	4.3e-27	-0.51	0.66	0.22	FALSE
15	GTEx	Nerve Tibial	RHPN2	0.17	0.09	enet	19	0.12	1.5e-08	8.7	-7.8	5.1e-15	-0.48	0.98	0.00	FALSE
16	GTEx	Testis	GPATCH1	0.21	0.04	enet	27	0.08	2.8e-04	8.6	7.7	1.8e-14	0.32	0.54	0.08	FALSE
17	GTEx	Testis	CTD-2538C1.2	0.44	0.39	enet	24	0.36	5.7e-17	4.5	-5.4	5.5e-08	-0.11	1.00	0.00	TRUE
18	GTEx	Thyroid	RHPN2	0.18	0.02	enet	25	0.05	1.2e-04	7.4	-7.4	1.2e-13	-0.44	0.38	0.41	TRUE
19	METSIM	Adipose	GPATCH1	0.12	0.12	lasso	11	0.11	9.7e-17	8.8	10.3	4.7e-25	0.49	1.00	0.00	FALSE
20	METSIM	Adipose	RHPN2	0.11	0.05	blup	478	0.11	1.5e-15	8.7	-8.0	1.8e-15	-0.32	1.00	0.00	FALSE
21	METSIM	Adipose	WDR88	0.07	0.06	lasso	7	0.08	2.1e-11	5.0	8.5	2.6e-17	0.46	0.99	0.01	FALSE
22	YFS	Blood	GPATCH1	0.05	0.01	blup	453	0.03	2.8e-09	8.7	6.7	2.3e-11	0.46	0.03	0.97	FALSE
23	YFS	Blood	LRP3	0.18	0.12	bslmm	431	0.16	7.1e-49	7.5	8.3	8.5e-17	0.38	1.00	0.00	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	GPATCH1	0.03	0.01	blup	63	0.01	2.3e-02	12.8	10.6	3.8e-26	0.47	0.19	0.04	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	RHPN2	0.02	0.01	blup	66	0.02	4.2e-05	14.2	-12.9	3.8e-38	-0.78	0.00	0.99	FALSE
26	The Cancer Genome Atlas	Colon Adenocarcinoma	GPATCH1	0.06	0.07	blup	63	0.05	7.5e-04	8.6	9.7	3.3e-22	0.51	0.25	0.08	FALSE
27	The Cancer Genome Atlas	Colon Adenocarcinoma	RHPN2	0.12	0.01	blup	66	0.05	7.5e-04	8.7	-8.6	7.6e-18	-0.54	0.05	0.11	FALSE
28	The Cancer Genome Atlas	Glioblastoma Multiforme	GPATCH1	0.10	0.11	blup	63	0.10	6.5e-04	12.5	12.5	4.6e-36	0.59	0.05	0.53	TRUE
29	The Cancer Genome Atlas	Glioblastoma Multiforme	RHPN2	0.11	0.01	blup	65	0.00	2.5e-01	13.3	-14.4	4.7e-47	-0.79	0.01	0.81	TRUE
30	The Cancer Genome Atlas	Glioblastoma Multiforme	SLC7A9	0.36	0.13	blup	59	0.18	3.0e-06	-4.1	5.2	1.6e-07	0.18	0.03	0.73	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GPATCH1	0.03	0.05	lasso	2	0.04	2.2e-05	8.7	9.1	1.2e-19	0.44	0.86	0.04	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GPATCH1	0.07	0.11	lasso	6	0.10	2.3e-11	8.7	7.9	3.2e-15	0.30	1.00	0.00	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RHPN2	0.05	0.01	blup	65	0.03	4.6e-04	13.1	-12.6	1.3e-36	-0.77	0.01	0.82	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	WDR88	0.03	0.01	lasso	3	0.02	1.7e-03	8.1	7.5	9.3e-14	0.34	0.12	0.05	FALSE
35	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RHPN2	0.21	0.02	blup	66	0.08	3.2e-05	8.6	-12.2	5.2e-34	-0.70	0.02	0.78	FALSE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	GPATCH1	0.05	0.05	enet	8	0.07	4.2e-08	4.5	6.8	1.3e-11	0.17	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	RHPN2	0.05	0.03	enet	11	0.05	3.5e-06	12.5	-13.4	3.4e-41	-0.74	0.14	0.85	TRUE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	TDRD12	0.03	0.01	blup	58	0.01	1.1e-02	-4.9	-5.4	6.3e-08	-0.17	0.01	0.95	FALSE
39	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	WDR88	0.08	0.05	enet	6	0.09	6.3e-05	5.7	8.2	3.8e-16	0.43	0.22	0.05	TRUE
40	The Cancer Genome Atlas	Lung Adenocarcinoma	GPATCH1	0.04	0.04	blup	63	0.05	2.9e-06	8.8	10.1	8.0e-24	0.40	0.98	0.00	FALSE
41	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RHPN2	0.04	0.02	blup	65	0.02	5.1e-03	14.2	-9.2	2.9e-20	-0.66	0.00	0.96	TRUE
42	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GPATCH1	0.07	0.05	blup	63	0.08	3.0e-04	3.3	9.4	5.0e-21	0.33	0.25	0.03	FALSE
43	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GPATCH1	0.16	0.12	blup	63	0.13	8.4e-06	12.5	9.9	3.1e-23	0.36	0.78	0.04	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	GPATCH1	0.27	0.20	lasso	4	0.24	2.0e-25	8.7	8.6	5.8e-18	0.30	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	WDR88	0.05	0.03	blup	66	0.03	6.5e-04	6.9	5.4	6.0e-08	0.23	0.18	0.02	FALSE
46	The Cancer Genome Atlas	Stomach Adenocarcinoma	GPATCH1	0.05	0.04	blup	64	0.04	4.7e-04	8.4	9.2	3.1e-20	0.42	0.16	0.06	FALSE
47	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC7A10	0.08	0.00	blup	56	0.02	2.1e-02	6.9	-6.0	1.5e-09	-0.26	0.01	0.69	FALSE