Best TWAS P=2.05e-10 · Best GWAS P=9.54e-10 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | GOLGA1 | 0.04 | 0.05 | lasso | 1 | 0.05 | 8.6e-05 | 5.4 | 5.4 | 8.2e-08 | 0.92 | 0.05 | 0.93 | FALSE |
2 | GTEx | Adipose Subcutaneous | SCAI | 0.07 | 0.05 | lasso | 4 | 0.02 | 7.4e-03 | 5.6 | -5.7 | 1.2e-08 | -0.89 | 0.03 | 0.97 | FALSE |
3 | GTEx | Artery Tibial | GOLGA1 | 0.09 | 0.09 | lasso | 4 | 0.09 | 7.0e-08 | 5.4 | 5.7 | 9.7e-09 | 0.85 | 0.05 | 0.95 | FALSE |
4 | GTEx | Brain Caudate basal ganglia | OLFML2A | 0.12 | 0.10 | lasso | 4 | 0.03 | 3.7e-02 | 5.7 | 5.6 | 1.9e-08 | 0.88 | 0.03 | 0.87 | FALSE |
5 | GTEx | Brain Cerebellar Hemisphere | ARPC5L | 0.21 | 0.34 | lasso | 2 | 0.32 | 6.1e-09 | 5.5 | -5.5 | 4.0e-08 | -0.91 | 0.05 | 0.95 | FALSE |
6 | GTEx | Brain Cerebellum | ARPC5L | 0.31 | 0.37 | enet | 7 | 0.27 | 1.5e-08 | 5.5 | 5.6 | 1.9e-08 | 0.92 | 0.04 | 0.96 | FALSE |
7 | GTEx | Colon Transverse | GOLGA1 | 0.10 | 0.13 | lasso | 1 | 0.09 | 5.9e-05 | 5.5 | 5.5 | 4.5e-08 | 0.91 | 0.05 | 0.95 | FALSE |
8 | GTEx | Esophagus Muscularis | PPP6C | 0.05 | 0.03 | lasso | 3 | 0.01 | 1.2e-01 | 5.7 | -5.5 | 3.6e-08 | -0.83 | 0.05 | 0.67 | FALSE |
9 | GTEx | Esophagus Muscularis | GOLGA1 | 0.12 | 0.05 | lasso | 9 | 0.06 | 2.4e-04 | 5.5 | 5.5 | 3.6e-08 | 0.88 | 0.04 | 0.95 | FALSE |
10 | GTEx | Lung | GOLGA1 | 0.10 | 0.07 | lasso | 5 | 0.08 | 5.7e-07 | -4.7 | 5.5 | 2.9e-08 | 0.72 | 0.11 | 0.89 | FALSE |
11 | GTEx | Muscle Skeletal | GOLGA1 | 0.07 | 0.02 | lasso | 4 | 0.02 | 2.2e-03 | 5.7 | 6.1 | 1.3e-09 | 0.88 | 0.02 | 0.97 | FALSE |
12 | GTEx | Nerve Tibial | GOLGA1 | 0.07 | 0.04 | lasso | 2 | 0.03 | 5.6e-03 | 6.1 | 6.4 | 2.0e-10 | 0.95 | 0.01 | 0.97 | TRUE |
13 | GTEx | Skin Sun Exposed Lower leg | ARPC5L | 0.11 | 0.02 | lasso | 5 | 0.02 | 8.8e-03 | 5.8 | 5.2 | 2.4e-07 | 0.85 | 0.04 | 0.92 | FALSE |
14 | GTEx | Thyroid | GOLGA1 | 0.07 | 0.01 | lasso | 5 | 0.01 | 1.0e-01 | 5.3 | 5.8 | 8.7e-09 | 0.86 | 0.06 | 0.82 | FALSE |
15 | GTEx | Thyroid | ARPC5L | 0.18 | 0.12 | enet | 17 | 0.16 | 1.5e-12 | 5.6 | 5.2 | 2.6e-07 | 0.85 | 0.05 | 0.95 | FALSE |
16 | METSIM | Adipose | ARPC5L | 0.02 | 0.01 | blup | 270 | 0.02 | 1.5e-03 | 4.3 | 5.2 | 2.2e-07 | 0.83 | 0.08 | 0.84 | FALSE |
17 | ROSMAP | Brain Pre-frontal Cortex | GOLGA1 | 0.08 | 0.07 | bslmm | 281 | 0.07 | 2.3e-09 | 5.5 | 5.6 | 2.4e-08 | 0.84 | 0.06 | 0.94 | FALSE |
18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GOLGA1 | 0.04 | 0.04 | enet | 11 | 0.02 | 7.2e-04 | 5.3 | 5.3 | 1.4e-07 | 0.78 | 0.03 | 0.82 | FALSE |
19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | OLFML2A | 0.06 | 0.03 | blup | 33 | 0.03 | 1.6e-04 | 5.7 | -5.5 | 5.2e-08 | -0.74 | 0.00 | 0.99 | FALSE |
20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SCAI | 0.02 | 0.02 | blup | 94 | 0.01 | 2.1e-02 | 5.5 | -5.5 | 2.9e-08 | -0.88 | 0.02 | 0.90 | FALSE |
21 | The Cancer Genome Atlas | Thyroid Carcinoma | WDR38 | 0.02 | 0.02 | blup | 33 | 0.02 | 5.0e-03 | 4.7 | -5.4 | 8.0e-08 | -0.88 | 0.01 | 0.81 | FALSE |