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chr16:29,412,503-31,026,427

Best TWAS P=1.06e-09 · Best GWAS P=3.03e-09 conditioned to 0.274

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	YPEL3	0.20	0.29	lasso	9	0.30	3.8e-25	5.1	5.6	1.9e-08	0.86	0.26	0.74	FALSE
2	GTEx	Adipose Visceral Omentum	YPEL3	0.13	0.16	lasso	4	0.14	6.8e-08	5.1	5.5	4.1e-08	0.85	0.10	0.90	FALSE
3	GTEx	Adrenal Gland	RP11-347C12.2	0.31	-0.01	lasso	9	0.03	3.7e-02	-3.9	5.2	2.2e-07	0.43	0.04	0.15	FALSE
4	GTEx	Artery Aorta	YPEL3	0.27	0.25	lasso	9	0.26	9.1e-15	5.1	5.1	3.1e-07	0.79	0.28	0.72	FALSE
5	GTEx	Artery Aorta	TBX6	0.14	0.02	lasso	7	0.03	1.2e-02	5.2	5.1	2.8e-07	0.75	0.14	0.66	FALSE
6	GTEx	Artery Tibial	YPEL3	0.19	0.29	lasso	5	0.27	1.5e-21	5.1	5.2	1.7e-07	0.80	0.34	0.66	FALSE
7	GTEx	Brain Cerebellar Hemisphere	YPEL3	0.15	0.13	lasso	6	0.11	8.1e-04	5.3	5.2	1.8e-07	0.87	0.05	0.85	FALSE
8	GTEx	Brain Cerebellum	YPEL3	0.16	0.17	lasso	2	0.16	1.7e-05	5.1	5.1	3.1e-07	0.78	0.11	0.72	FALSE
9	GTEx	Breast Mammary Tissue (Male)	YPEL3	0.30	0.16	lasso	3	0.18	6.2e-05	5.1	5.3	1.2e-07	0.85	0.06	0.88	FALSE
10	GTEx	Cells Transformed fibroblasts	RP11-455F5.3	0.05	0.07	lasso	2	0.06	1.7e-05	5.1	5.1	3.1e-07	0.77	0.23	0.63	FALSE
11	GTEx	Esophagus Mucosa	YPEL3	0.11	0.21	lasso	3	0.20	8.8e-14	5.1	5.2	2.4e-07	0.78	0.36	0.64	FALSE
12	GTEx	Esophagus Muscularis	YPEL3	0.24	0.29	lasso	5	0.27	1.1e-16	5.1	5.2	2.5e-07	0.80	0.28	0.71	FALSE
13	GTEx	Esophagus Muscularis	INO80E	0.10	0.11	enet	20	0.07	4.6e-05	5.0	-5.5	2.9e-08	-0.87	0.06	0.94	FALSE
14	GTEx	Lung	YPEL3	0.10	0.16	lasso	4	0.16	3.2e-12	5.1	5.4	6.6e-08	0.85	0.27	0.72	FALSE
15	GTEx	Muscle Skeletal	TBX6	0.09	0.09	lasso	8	0.09	8.6e-09	5.1	5.3	1.4e-07	0.81	0.23	0.77	FALSE
16	GTEx	Muscle Skeletal	RP11-347C12.1	0.04	0.02	enet	7	0.04	1.8e-04	-4.3	5.5	4.0e-08	0.63	0.22	0.65	FALSE
17	GTEx	Nerve Tibial	YPEL3	0.23	0.33	lasso	5	0.34	1.1e-24	5.1	5.4	8.6e-08	0.81	0.35	0.65	FALSE
18	GTEx	Nerve Tibial	TBX6	0.20	0.24	lasso	7	0.24	1.2e-16	5.9	6.0	2.0e-09	0.95	0.01	0.99	FALSE
19	GTEx	Pituitary	YPEL3	0.12	0.04	lasso	4	0.05	2.5e-02	5.2	6.1	1.1e-09	0.89	0.03	0.78	TRUE
20	GTEx	Skin Sun Exposed Lower leg	YPEL3	0.20	0.26	lasso	4	0.27	2.2e-22	5.1	5.1	2.7e-07	0.78	0.37	0.63	FALSE
21	GTEx	Small Intestine Terminal Ileum	INO80E	0.20	0.14	lasso	17	0.08	6.2e-03	5.8	-6.0	2.6e-09	-0.94	0.04	0.89	FALSE
22	GTEx	Spleen	YPEL3	0.18	0.24	enet	5	0.18	2.3e-05	5.1	5.1	2.7e-07	0.81	0.23	0.54	FALSE
23	GTEx	Spleen	INO80E	0.23	0.20	enet	13	0.26	2.6e-07	-4.4	-5.8	7.2e-09	-0.80	0.13	0.84	FALSE
24	GTEx	Thyroid	YPEL3	0.07	0.11	lasso	4	0.10	2.6e-08	5.1	5.2	2.2e-07	0.80	0.27	0.72	FALSE
25	GTEx	Vagina	YPEL3	0.12	0.08	lasso	2	0.06	2.1e-02	5.1	5.1	3.1e-07	0.78	0.04	0.59	FALSE
26	METSIM	Adipose	YPEL3	0.16	0.21	enet	12	0.22	9.5e-33	5.1	5.3	1.0e-07	0.87	0.37	0.63	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	PPP4C	0.15	0.30	lasso	4	0.31	3.1e-40	5.2	-5.2	1.6e-07	-0.82	0.22	0.78	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	DOC2A	0.03	0.00	blup	199	0.01	1.8e-02	5.0	-5.6	1.9e-08	-0.87	0.03	0.77	FALSE
29	YFS	Blood	INO80E	0.02	0.02	lasso	5	0.02	3.7e-07	5.8	-5.7	1.4e-08	-0.99	0.02	0.98	FALSE
30	YFS	Blood	PPP4C	0.03	0.05	lasso	4	0.05	4.0e-15	5.1	-5.7	1.4e-08	-0.91	0.07	0.93	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	ALDOA	0.02	0.01	enet	9	0.02	9.2e-05	5.9	5.4	6.8e-08	0.91	0.01	0.98	FALSE
32	The Cancer Genome Atlas	Esophageal Carcinoma	PPP4C	0.08	0.04	blup	23	0.05	8.9e-03	5.2	-5.6	1.9e-08	-0.90	0.01	0.80	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FAM57B	0.65	0.02	lasso	4	0.02	2.6e-03	5.8	-5.8	5.0e-09	-0.97	0.02	0.94	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DOC2A	0.03	0.01	blup	47	0.02	3.8e-03	5.8	-5.3	1.0e-07	-0.92	0.01	0.72	FALSE
35	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PPP4C	0.07	0.04	blup	22	0.07	8.8e-05	-3.0	-5.2	1.6e-07	-0.85	0.01	0.92	FALSE
36	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TBX6	0.04	0.04	blup	18	0.04	2.5e-03	5.1	5.5	4.2e-08	0.87	0.01	0.86	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	PPP4C	0.08	0.05	blup	22	0.07	4.9e-08	5.1	-5.5	4.5e-08	-0.83	0.02	0.98	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	TBX6	0.03	0.01	blup	18	0.01	1.1e-02	5.1	5.3	1.2e-07	0.83	0.00	0.84	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	DOC2A	0.03	0.03	lasso	5	0.03	9.6e-04	5.9	-5.9	2.9e-09	-0.99	0.01	0.97	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	FAM57B	0.04	0.05	enet	6	0.04	1.1e-04	5.2	-5.2	1.9e-07	-0.81	0.14	0.81	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	DOC2A	0.03	0.02	blup	48	0.03	6.1e-04	5.0	-5.4	5.2e-08	-0.95	0.02	0.88	FALSE