[Hub]/) : Traits : Hand grip strength (left) :

chr16:29,412,503-31,026,427

Best TWAS P=1.06e-09 · Best GWAS P=3.03e-09 conditioned to 0.274

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous YPEL3 0.20 0.29 lasso 9 0.30 3.8e-25 5.1 5.6 1.9e-08 0.86 0.26 0.74 FALSE
2 GTEx Adipose Visceral Omentum YPEL3 0.13 0.16 lasso 4 0.14 6.8e-08 5.1 5.5 4.1e-08 0.85 0.10 0.90 FALSE
3 GTEx Adrenal Gland RP11-347C12.2 0.31 -0.01 lasso 9 0.03 3.7e-02 -3.9 5.2 2.2e-07 0.43 0.04 0.15 FALSE
4 GTEx Artery Aorta YPEL3 0.27 0.25 lasso 9 0.26 9.1e-15 5.1 5.1 3.1e-07 0.79 0.28 0.72 FALSE
5 GTEx Artery Aorta TBX6 0.14 0.02 lasso 7 0.03 1.2e-02 5.2 5.1 2.8e-07 0.75 0.14 0.66 FALSE
6 GTEx Artery Tibial YPEL3 0.19 0.29 lasso 5 0.27 1.5e-21 5.1 5.2 1.7e-07 0.80 0.34 0.66 FALSE
7 GTEx Brain Cerebellar Hemisphere YPEL3 0.15 0.13 lasso 6 0.11 8.1e-04 5.3 5.2 1.8e-07 0.87 0.05 0.85 FALSE
8 GTEx Brain Cerebellum YPEL3 0.16 0.17 lasso 2 0.16 1.7e-05 5.1 5.1 3.1e-07 0.78 0.11 0.72 FALSE
9 GTEx Breast Mammary Tissue (Male) YPEL3 0.30 0.16 lasso 3 0.18 6.2e-05 5.1 5.3 1.2e-07 0.85 0.06 0.88 FALSE
10 GTEx Cells Transformed fibroblasts RP11-455F5.3 0.05 0.07 lasso 2 0.06 1.7e-05 5.1 5.1 3.1e-07 0.77 0.23 0.63 FALSE
11 GTEx Esophagus Mucosa YPEL3 0.11 0.21 lasso 3 0.20 8.8e-14 5.1 5.2 2.4e-07 0.78 0.36 0.64 FALSE
12 GTEx Esophagus Muscularis YPEL3 0.24 0.29 lasso 5 0.27 1.1e-16 5.1 5.2 2.5e-07 0.80 0.28 0.71 FALSE
13 GTEx Esophagus Muscularis INO80E 0.10 0.11 enet 20 0.07 4.6e-05 5.0 -5.5 2.9e-08 -0.87 0.06 0.94 FALSE
14 GTEx Lung YPEL3 0.10 0.16 lasso 4 0.16 3.2e-12 5.1 5.4 6.6e-08 0.85 0.27 0.72 FALSE
15 GTEx Muscle Skeletal TBX6 0.09 0.09 lasso 8 0.09 8.6e-09 5.1 5.3 1.4e-07 0.81 0.23 0.77 FALSE
16 GTEx Muscle Skeletal RP11-347C12.1 0.04 0.02 enet 7 0.04 1.8e-04 -4.3 5.5 4.0e-08 0.63 0.22 0.65 FALSE
17 GTEx Nerve Tibial YPEL3 0.23 0.33 lasso 5 0.34 1.1e-24 5.1 5.4 8.6e-08 0.81 0.35 0.65 FALSE
18 GTEx Nerve Tibial TBX6 0.20 0.24 lasso 7 0.24 1.2e-16 5.9 6.0 2.0e-09 0.95 0.01 0.99 FALSE
19 GTEx Pituitary YPEL3 0.12 0.04 lasso 4 0.05 2.5e-02 5.2 6.1 1.1e-09 0.89 0.03 0.78 TRUE
20 GTEx Skin Sun Exposed Lower leg YPEL3 0.20 0.26 lasso 4 0.27 2.2e-22 5.1 5.1 2.7e-07 0.78 0.37 0.63 FALSE
21 GTEx Small Intestine Terminal Ileum INO80E 0.20 0.14 lasso 17 0.08 6.2e-03 5.8 -6.0 2.6e-09 -0.94 0.04 0.89 FALSE
22 GTEx Spleen YPEL3 0.18 0.24 enet 5 0.18 2.3e-05 5.1 5.1 2.7e-07 0.81 0.23 0.54 FALSE
23 GTEx Spleen INO80E 0.23 0.20 enet 13 0.26 2.6e-07 -4.4 -5.8 7.2e-09 -0.80 0.13 0.84 FALSE
24 GTEx Thyroid YPEL3 0.07 0.11 lasso 4 0.10 2.6e-08 5.1 5.2 2.2e-07 0.80 0.27 0.72 FALSE
25 GTEx Vagina YPEL3 0.12 0.08 lasso 2 0.06 2.1e-02 5.1 5.1 3.1e-07 0.78 0.04 0.59 FALSE
26 METSIM Adipose YPEL3 0.16 0.21 enet 12 0.22 9.5e-33 5.1 5.3 1.0e-07 0.87 0.37 0.63 FALSE
27 ROSMAP Brain Pre-frontal Cortex PPP4C 0.15 0.30 lasso 4 0.31 3.1e-40 5.2 -5.2 1.6e-07 -0.82 0.22 0.78 FALSE
28 ROSMAP Brain Pre-frontal Cortex DOC2A 0.03 0.00 blup 199 0.01 1.8e-02 5.0 -5.6 1.9e-08 -0.87 0.03 0.77 FALSE
29 YFS Blood INO80E 0.02 0.02 lasso 5 0.02 3.7e-07 5.8 -5.7 1.4e-08 -0.99 0.02 0.98 FALSE
30 YFS Blood PPP4C 0.03 0.05 lasso 4 0.05 4.0e-15 5.1 -5.7 1.4e-08 -0.91 0.07 0.93 FALSE
31 The Cancer Genome Atlas Breast Invasive Carcinoma ALDOA 0.02 0.01 enet 9 0.02 9.2e-05 5.9 5.4 6.8e-08 0.91 0.01 0.98 FALSE
32 The Cancer Genome Atlas Esophageal Carcinoma PPP4C 0.08 0.04 blup 23 0.05 8.9e-03 5.2 -5.6 1.9e-08 -0.90 0.01 0.80 FALSE
33 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FAM57B 0.65 0.02 lasso 4 0.02 2.6e-03 5.8 -5.8 5.0e-09 -0.97 0.02 0.94 FALSE
34 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DOC2A 0.03 0.01 blup 47 0.02 3.8e-03 5.8 -5.3 1.0e-07 -0.92 0.01 0.72 FALSE
35 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PPP4C 0.07 0.04 blup 22 0.07 8.8e-05 -3.0 -5.2 1.6e-07 -0.85 0.01 0.92 FALSE
36 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma TBX6 0.04 0.04 blup 18 0.04 2.5e-03 5.1 5.5 4.2e-08 0.87 0.01 0.86 FALSE
37 The Cancer Genome Atlas Brain Lower Grade Glioma PPP4C 0.08 0.05 blup 22 0.07 4.9e-08 5.1 -5.5 4.5e-08 -0.83 0.02 0.98 FALSE
38 The Cancer Genome Atlas Lung Adenocarcinoma TBX6 0.03 0.01 blup 18 0.01 1.1e-02 5.1 5.3 1.2e-07 0.83 0.00 0.84 FALSE
39 The Cancer Genome Atlas Prostate Adenocarcinoma DOC2A 0.03 0.03 lasso 5 0.03 9.6e-04 5.9 -5.9 2.9e-09 -0.99 0.01 0.97 FALSE
40 The Cancer Genome Atlas Prostate Adenocarcinoma FAM57B 0.04 0.05 enet 6 0.04 1.1e-04 5.2 -5.2 1.9e-07 -0.81 0.14 0.81 FALSE
41 The Cancer Genome Atlas Thyroid Carcinoma DOC2A 0.03 0.02 blup 48 0.03 6.1e-04 5.0 -5.4 5.2e-08 -0.95 0.02 0.88 FALSE