Best TWAS P=3.1e-13 · Best GWAS P=1.59e-12 conditioned to 0.0223
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NOB1 | 0.04 | 0.05 | enet | 12 | 0.04 | 7.2e-06 | -4.6 | 5.2 | 1.9e-07 | 0.61 | 0.81 | 0.17 | FALSE |
| 2 | GTEx | Thyroid | NOB1 | 0.03 | 0.01 | enet | 6 | 0.02 | 7.7e-03 | -6.7 | 7.3 | 3.1e-13 | 0.77 | 0.06 | 0.82 | TRUE |
| 3 | GTEx | Thyroid | CTD-2033A16.3 | 0.03 | 0.02 | enet | 7 | 0.02 | 6.7e-03 | -5.0 | 6.8 | 9.0e-12 | 0.69 | 0.11 | 0.63 | FALSE |
| 4 | METSIM | Adipose | NOB1 | 0.03 | 0.03 | lasso | 2 | 0.03 | 2.8e-05 | -4.4 | 5.6 | 2.2e-08 | 0.76 | 0.10 | 0.88 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NFAT5 | 0.02 | 0.01 | enet | 5 | 0.01 | 6.6e-04 | -2.5 | -5.4 | 7.8e-08 | -0.64 | 0.02 | 0.55 | FALSE |
| 6 | The Cancer Genome Atlas | Rectum Adenocarcinoma | CLEC18A | 0.15 | 0.03 | blup | 23 | 0.09 | 4.3e-03 | 3.7 | 5.2 | 2.5e-07 | 0.63 | 0.01 | 0.22 | FALSE |
| 7 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | CLEC18A | 0.17 | 0.09 | enet | 8 | 0.11 | 8.5e-04 | 3.7 | 5.3 | 1.3e-07 | 0.63 | 0.05 | 0.24 | FALSE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CLEC18A | 0.20 | 0.09 | lasso | 5 | 0.08 | 8.8e-04 | 5.8 | 5.9 | 4.0e-09 | 0.70 | 0.05 | 0.31 | FALSE |