Hub : Genes

FAM57B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Breast Invasive Carcinoma 0.0426 0.0221 7.2e-08 0.014 0.032 0.029 NA 0.025 5.2e-04 2.6e-07 1.1e-06 NA 4.9e-06
2 TCGA Head and Neck Squamous Cell Carcinoma 0.6451 0.1274 3.7e-05 0.024 0.004 0.007 NA 0.019 8.1e-04 9.2e-02 5.1e-02 NA 2.6e-03
3 TCGA Prostate Adenocarcinoma 0.0397 0.0246 2.0e-04 0.049 0.018 0.036 NA -0.001 6.4e-06 4.9e-03 1.1e-04 NA 4.4e-01
4 TCGA Thyroid Carcinoma 0.0630 0.0350 2.1e-06 0.051 0.059 0.046 NA 0.048 1.0e-05 1.9e-06 2.6e-05 NA 1.8e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 2.7 4.2 13.6 -3.7 1.4 1.0 0.4
Bipolar Disorder or Schizophrenia 6.3 15.4 30.8 -5.6 3.7 3.4 2.3
Depressed Affect (Nagel 2018) 1.1 2.3 7.9 2.8 -1.0 0.0 0.7
Depression (Nagel 2018) 1.0 1.4 2.8 -0.3 1.2 1.1 1.7
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.1 0.5 -0.7 -1.0 -1.0
Neuroticism (Nagel 2018) 1.6 3.8 6.8 0.2 1.8 2.3 2.6
Schizophrenia (2018) 6.0 12.4 17.4 -4.2 3.7 3.5 2.5
Schizophrenia vs Biploar Disorder 0.7 0.9 1.5 -0.2 1.0 1.2 1.0
Worry (Nagel 2018) 9.3 19.5 25.2 -2.7 4.8 5.0 4.7
Alzheimer’s Disease (in mother) 7.1 8.3 11.0 -2.0 3.3 3.0 3.0
Alzheimer’s Disease (in father) 0.5 0.5 0.5 -0.7 0.7 0.6 0.7
Alzheimer’s Disease (including proxy) 8.7 12.6 16.8 -2.7 4.1 3.7 3.6
Crohns Disease (2017) 0.3 0.6 1.1 -0.3 0.5 0.9 1.0
Irritable Bowel Disease (IBD) 0.6 1.4 3.4 0.8 0.1 1.2 1.8
Ulcerative Colitis (UC) 0.7 1.3 2.3 1.5 -0.6 0.6 1.5
Major Depression (MDD) 1.8 2.1 2.5 -1.6 1.4 1.6 1.2
Reaction Time 0.8 1.6 3.0 -1.7 1.4 1.1 0.4
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.3 0.6 -0.2 -0.2 0.1
Breast Cancer 0.1 0.1 0.2 0.5 -0.1 0.4 0.4
Ovarian Cancer 0.0 0.1 0.1 -0.2 0.2 0.2 0.3
Prostate Cancer 0.8 1.2 1.9 -0.9 1.4 1.2 0.7
Age at First Birth 0.4 0.5 1.4 -1.2 0.1 -0.5 -0.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 5.1 7.0 9.2 2.2 -2.9 -3.0 -2.4
Coronary Artery Disease (CAD) 0.3 0.3 1.1 -1.1 0.3 0.0 0.0
Crohns Disease (2012) 0.5 0.7 1.2 -0.7 0.5 1.1 1.0
Mean Putamen Volume 0.4 0.4 0.9 1.0 0.3 0.4 0.7
Fasting Glucose 1.3 1.5 2.2 -0.7 1.3 1.4 1.5
HbA1C 0.4 0.4 0.8 -0.8 0.3 -0.3 -0.9
HDL Cholesterol 0.4 0.7 1.1 -0.5 0.8 1.1 1.0
LDL Cholesterol 2.6 4.2 5.1 -1.8 2.3 2.3 1.8
Lupus 0.4 0.7 1.4 -0.2 0.7 0.9 1.2
Neuroticism (2016) 0.4 0.6 1.3 0.6 0.4 0.9 1.1
Primary Biliary Cirrhosis 0.8 1.1 2.1 1.4 -1.3 -0.9 -0.3
Rheumatoid Arthritis 0.5 0.8 2.4 1.6 0.2 0.2 0.7
Schizophrenia (2014) 6.2 13.7 17.3 -4.2 3.7 3.9 2.9
Triglycerides 1.1 1.8 5.9 2.4 -1.1 -0.4 -0.2
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 1.2 1.7 4.3 2.1 -1.2 0.4 1.0
Blood Eosinophil Count 13.3 102.2 139.2 -6.3 11.8 11.4 10.0
Blood Platelet Count 1.2 14.0 21.3 -2.3 4.5 4.6 3.0
Blood Red Count 15.8 152.5 213.2 -6.7 13.8 14.6 12.7
Blood White Count 1.4 10.3 14.5 -2.0 3.8 3.5 3.2
Heel T-Score 2.0 15.6 26.6 -5.2 4.2 3.5 2.5
BMI 15.6 90.2 123.2 11.1 -10.8 -8.7 -6.8
Height 7.4 141.9 190.4 10.4 -13.8 -13.0 -10.0
Waist Hip Ratio (WHR) 0.9 4.1 15.4 3.9 -0.9 -0.1 0.3
Systolic Blood Pressure 2.0 9.9 15.1 3.9 -3.5 -2.6 -2.3
Smoking Status 0.6 1.5 3.8 2.0 -1.2 -0.6 -0.5
Allergy or Eczema 1.8 4.7 14.7 -3.8 1.8 0.4 -0.8
Cardiovascular Disease 2.3 7.7 22.0 4.7 -2.6 -1.3 -0.7
Hypothyroidism (self reported) 0.2 0.4 0.9 -0.4 -0.5 -0.6 -0.9
Respiratory disease 2.1 4.8 7.2 -0.5 -2.3 -2.7 -2.5
Type 2 Diabetes (T2D) (2018) 5.9 11.1 17.0 4.1 -3.9 -2.9 -2.0
Lung FEV1/FVC ratio 2.2 11.3 17.1 -0.9 3.4 4.1 4.0
Lung FVC 0.7 3.3 8.2 -2.9 2.1 0.6 0.5
Neuroticism 1.1 2.7 4.6 0.9 1.2 2.0 2.1
Chronotype (morning person) 3.8 8.7 12.0 3.2 -3.5 -2.8 -2.1
Hair Pigment 0.0 0.3 0.5 -0.6 0.7 0.3 0.6
Tanning 0.3 4.0 5.0 -2.1 2.2 1.9 1.8
Hand grip strength (left) 9.3 24.5 34.2 4.4 -5.8 -5.2 -4.1
Number of treatments/medications taken 1.7 3.1 8.9 3.0 -1.7 -0.7 -0.0
Average weekly spirits intake 0.0 0.0 0.1 0.2 -0.0 -0.1 -0.0
Sensitivity / hurt feelings 0.9 1.6 2.9 -0.2 1.3 1.7 1.3
Frequency of depressed mood in last 2 weeks 1.3 1.8 2.6 0.1 1.5 1.6 1.6
Hearing difficulty/problems: Yes 0.1 0.1 0.2 0.3 -0.4 -0.2 -0.3
Relative age of first facial hair 2.1 4.4 4.9 -1.7 2.2 2.2 2.2
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.3 -0.5 0.1 0.2 0.0
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.6 0.8 -0.2 -0.0 0.1
Ever had hysterectomy (womb removed) 2.7 3.1 5.5 0.1 1.7 2.4 1.9
Systolic blood pressure, automated reading 1.9 5.6 17.6 4.2 -2.0 -0.7 -0.3
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.3 0.5 -0.5 -0.6 -0.2
Angina 2.7 3.6 5.2 2.1 -2.3 -1.8 -1.2
Medication for hormone replacement therapy 0.4 0.4 0.7 -0.4 0.7 0.7 0.8
Vitamin and mineral supplements 3.0 4.0 6.0 0.0 2.1 2.5 2.4
Supplements: Zinc 0.8 0.9 1.2 -0.9 -0.7 -1.1 -1.1
Medication: Co-codamol 0.3 0.3 0.4 0.5 -0.6 -0.6 -0.6
Medication: Metformin 4.1 5.8 7.5 2.5 -2.7 -2.4 -1.9
Diabetes (father) 9.6 11.9 14.9 2.6 -3.7 -3.9 -3.5
Diabetes (mother) 5.6 7.2 12.7 3.6 -3.1 -2.1 -1.5
Severe depression (siblings) 0.2 0.2 0.3 -0.1 -0.5 -0.4 -0.6
Pack years adult smoking proportion 0.5 0.8 1.4 0.7 0.6 1.0 1.2
Impedance of leg (right) 15.9 77.0 99.2 -9.6 10.0 8.7 6.3
Leg fat-free mass (left) 26.1 138.2 182.2 12.2 -13.5 -11.8 -9.1
Trunk fat percentage 5.9 23.6 40.3 6.3 -5.2 -3.8 -3.6
Hand grip strength (right) 7.6 20.6 29.6 4.1 -5.4 -4.7 -3.8
Townsend deprivation index at recruitment 0.7 1.0 1.8 1.4 -1.0 -0.7 -0.6
Current tobacco smoking 1.1 1.8 5.5 2.3 -1.3 -0.4 -0.1
Average weekly fortified wine intake 4.3 5.1 6.6 -2.5 2.6 2.0 1.8
Maternal smoking around birth 0.9 1.3 4.0 2.0 -1.0 -0.0 0.2
Fed-up feelings 2.6 4.7 10.0 3.2 -2.2 -1.7 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 2.3 1.5 0.0 0.2 0.7
Relative age voice broke 3.0 4.6 6.6 -0.7 2.3 2.6 2.4
Taking other prescription medications 0.3 0.5 1.7 1.3 -0.4 -0.0 0.4
Age when periods started (menarche) 5.9 14.1 20.2 -4.5 3.9 3.4 3.1
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.7 1.3 -0.0 0.8 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.0 3.5 -1.9 0.7 0.3 -0.3
Tinnitus: Yes, but not now, but have in the past 1.7 1.8 3.3 -0.7 -1.2 -1.4 -1.8
Qualifications: CSEs or equivalent 2.6 3.4 4.2 1.3 -2.0 -2.0 -2.0
Serious illness, injury or assault to yourself 2.8 3.4 3.9 1.7 -2.0 -1.9 -1.8
High blood pressure 4.5 12.5 36.5 6.0 -3.3 -1.6 -0.7
Hayfever, allergic rhinitis or eczema 1.5 3.2 8.8 -3.0 0.5 -0.8 -1.8
Multivitamins +/- minerals 6.5 8.3 11.8 1.0 -3.1 -3.3 -3.4
Stomach or abdominal pain in last month 0.6 0.8 1.2 0.0 1.0 1.1 0.9
Supplements: Glucosamine 2.8 3.6 5.2 1.5 -2.3 -1.9 -1.8
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 2.5 -0.2 1.2 1.6 1.1
Medication: Atenolol 0.4 0.5 1.8 1.3 -0.1 0.1 0.2
Medication: Levothyroxine sodium 0.2 0.4 0.6 0.8 -0.6 -0.5 -0.7
Sitting height 2.3 16.6 24.2 3.7 -4.9 -4.2 -3.2
Chronic bronchitis/emphysema (father) 1.6 1.9 3.0 1.4 0.7 1.4 1.7
High blood pressure (mother) 5.9 8.3 9.7 2.6 -3.1 -3.0 -2.8
Body mass index (BMI) 17.0 72.3 112.3 10.6 -9.4 -7.4 -5.8
Impedance of leg (left) 14.2 69.0 88.0 -9.1 9.4 8.3 6.0
Leg predicted mass (left) 26.3 139.1 182.2 12.2 -13.5 -11.9 -9.2
Trunk fat mass 14.2 61.0 88.4 9.4 -8.7 -6.9 -5.8
Waist circumference 23.8 87.2 144.0 12.0 -10.2 -7.9 -6.2
Number of incorrect matches in round 16.7 27.7 33.6 -4.7 5.8 5.7 4.7
Past tobacco smoking 0.5 0.8 3.0 -1.7 0.5 0.2 -0.0
Alcohol usually taken with meals 0.8 1.3 2.6 -0.8 -0.6 -1.6 -1.3
Nervous feelings 12.5 23.3 28.6 -3.4 5.1 5.3 5.2
Frequency of tenseness / restlessness in last 2 weeks 2.7 4.1 5.6 -1.1 2.3 2.4 2.1
Hearing difficulty/problems with background noise 0.2 0.3 1.0 -1.0 0.3 0.4 0.2
Hair/balding pattern: Pattern 2 0.2 0.3 1.1 -1.0 0.3 -0.2 -0.1
Had menopause 0.2 0.2 0.5 0.3 0.4 0.7 0.4
Had other major operations 0.2 0.2 0.3 0.3 -0.5 -0.6 -0.4
Forced vital capacity (FVC) 3.6 13.8 22.9 1.6 -4.1 -4.8 -3.7
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 3.7 -1.9 -0.2 -0.7 -1.2
Ever unenthusiastic/disinterested for a whole week 6.5 8.0 11.2 -1.4 3.0 3.1 3.4
Qualifications: None of the above 1.2 2.7 4.8 2.2 0.4 1.4 1.9
Financial difficulties in last 2 years 1.5 2.0 3.6 -0.1 -1.4 -1.9 -1.6
Mouth/teeth dental problems 2.6 4.0 8.2 -2.9 2.2 1.1 1.2
Heart attack 0.1 0.1 0.1 0.2 -0.2 -0.3 -0.3
Allergy 1.0 2.3 4.8 2.2 0.2 1.2 1.8
Pain all over the body in last month 3.9 4.2 7.2 2.7 -2.3 -1.7 -1.2
Diabetes (self-reported) 3.2 5.0 8.6 2.9 -2.6 -1.9 -1.1
Hayfever/allergic rhinitis (self-reported) 1.4 1.8 2.6 -0.3 1.4 1.6 1.6
Medication: Ramipril 2.9 3.7 5.2 2.3 -2.0 -1.7 -1.8
Medication: Simvastatin 1.6 2.4 3.8 1.4 0.8 1.9 1.7
Fluid intelligence score 0.2 0.5 0.9 0.2 -0.8 -0.9 -0.6
Illnesses of siblings 0.7 1.0 3.3 -1.8 0.9 0.0 0.0
Neuroticism score 0.9 2.0 3.1 1.4 0.6 1.5 1.8
Weight 27.0 132.9 171.6 13.0 -13.1 -10.9 -8.5
Impedance of arm (right) 10.3 47.9 76.7 -8.8 7.9 6.2 3.8
Arm fat percentage (right) 10.6 41.8 61.0 7.8 -7.0 -5.7 -5.1
Trunk fat-free mass 24.7 141.7 190.4 12.4 -13.8 -12.1 -8.7
Hip circumference 21.8 94.0 121.0 10.3 -11.0 -9.4 -7.8
Time employed in main current job 1.2 1.4 1.9 -1.2 1.4 1.2 0.9
Alcohol intake versus 10 years previously 8.2 12.2 18.7 4.3 -3.9 -3.1 -2.4
Father’s age at death 0.2 0.3 0.7 -0.4 0.5 0.0 0.8
Worrier / anxious feelings 7.0 13.2 18.3 -2.0 4.1 4.3 3.7
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 2.0 1.4 0.2 0.4 0.4
Falls in the last year 1.3 1.8 3.3 0.0 -1.3 -1.5 -1.8
Hair/balding pattern: Pattern 3 1.1 1.6 2.9 -1.7 1.5 1.1 0.4
Number of live births 2.7 3.9 6.1 -1.4 2.0 2.5 1.9
Forced expiratory volume in 1-second (FEV1) 2.0 6.7 11.6 0.8 -2.8 -3.4 -2.6
Pulse rate 0.8 1.4 1.7 -1.2 1.3 1.3 0.9
Happiness 0.6 0.7 2.2 -1.5 0.7 0.1 0.3
Noisy workplace 0.1 0.2 0.4 0.6 -0.3 -0.1 0.4
Qualifications: A levels/AS levels or equivalent 0.8 1.9 2.8 -1.7 1.6 1.1 1.0
Serious illness, injury or assault of a close relative in last 2 years 2.8 3.3 6.4 -1.3 -1.0 -2.0 -2.5
Mouth/teeth dental problems: Dentures 3.2 5.4 13.9 3.7 -2.2 -1.2 -1.1
Asthma 3.7 7.4 10.9 0.3 -3.0 -3.3 -3.1
Medication: Ibuprofen (e.g. Nurofen) 3.7 4.7 5.6 2.4 -2.2 -2.2 -1.9
Medication: Cholesterol lowering 0.5 0.8 1.3 1.1 0.4 1.1 0.9
Depression (self-reported) 3.2 3.9 5.8 -0.0 2.0 2.4 2.4
Medication: Lansoprazole 0.0 0.0 0.0 0.1 -0.1 0.1 0.2
Prospective memory result 0.6 0.8 1.1 -0.5 1.1 0.9 1.0
Lung cancer (father) 0.4 0.4 0.7 0.3 0.8 0.6 0.7
Illnesses of mother 1.9 2.4 3.0 -1.5 1.7 1.5 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 3.8 -0.7 -1.1 -1.9 -1.3
Pulse wave Arterial Stiffness index 0.8 0.9 3.1 1.8 -0.7 -0.0 0.4
Impedance of arm (left) 12.1 56.1 87.0 -9.3 8.5 6.8 4.3
Arm fat mass (right) 20.2 83.1 116.6 10.8 -10.1 -8.3 -6.7
Trunk predicted mass 24.7 141.2 190.4 12.3 -13.8 -12.1 -8.8
Standing height 6.7 66.8 91.6 7.0 -9.6 -8.9 -6.9
Length of working week for main job 0.2 0.2 0.3 0.2 -0.6 -0.5 -0.0
Exposure to tobacco smoke at home 0.6 0.6 0.8 0.7 -0.9 -0.9 -0.7
Breastfed as a baby 1.1 1.4 2.1 -1.4 -0.5 -1.4 -1.1
Tense / ‘highly strung’ 7.4 12.3 16.4 -2.1 3.9 4.0 3.6
Seen doctor (GP) for nerves, anxiety, tension or depression 2.7 4.2 5.4 -1.5 2.2 2.3 2.0
Hair/balding pattern: Pattern 4 0.3 0.8 1.5 0.8 -1.2 -0.9 -0.3
Birth weight of first child 1.1 1.9 3.1 1.8 -1.6 -1.4 -0.6
Peak expiratory flow (PEF) 1.5 3.5 5.9 -0.1 -2.0 -2.4 -2.0
Pulse wave reflection index 1.0 1.2 2.1 1.1 -1.4 -1.1 -0.6
Ever highly irritable/argumentative for 2 days 2.6 3.1 3.9 1.6 -2.0 -1.8 -1.7
Loud music exposure frequency 1.0 1.1 2.1 -1.3 1.4 0.7 0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 1.1 -1.0 0.0 -0.4 -0.0
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.5 -0.6 -0.6 -0.7 -1.2
Blood clot in the leg (DVT) 0.8 1.0 1.8 -0.9 1.4 0.9 0.7
Medication: Paracetamol 0.5 0.9 3.2 1.8 -0.3 0.2 0.2
Headache pain in last month 0.2 0.4 0.8 -0.4 0.8 0.9 0.3
Medication for cholesterol, blood pressure or diabetes 2.1 3.5 12.1 -3.5 1.3 0.2 -0.4
Glaucoma (self-reported) 3.3 3.9 5.6 0.7 -2.1 -2.4 -2.2
Gout (self-reported) 0.4 0.5 1.1 1.0 0.1 0.3 0.9
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.2 -0.0 0.3 0.4 0.1
Medication: Amlodipine 1.4 1.9 5.9 2.4 -1.4 -0.3 0.0
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.4 -0.7 0.1 -0.4 -0.1
Birth weight 0.5 1.1 1.5 1.2 -1.1 -1.2 -0.6
Chronic bronchitis/emphysema (mother) 1.3 1.6 2.7 0.8 0.9 1.5 1.6
High blood pressure (siblings) 0.5 0.7 2.2 1.5 -0.8 0.1 -0.1
Forced vital capacity (FVC), Best measure 2.3 8.5 16.4 0.2 -2.9 -4.0 -3.1
Body fat percentage 6.6 26.2 46.2 6.8 -5.5 -3.9 -3.7
Leg fat percentage (right) 4.4 16.1 33.5 5.8 -4.2 -2.7 -2.5
Arm fat-free mass (right) 24.7 126.7 169.0 12.4 -13.0 -11.0 -8.0
Exposure to tobacco smoke outside home 0.0 0.0 0.1 -0.3 0.1 0.2 0.1
Comparative body size at age 10 4.1 11.4 25.9 5.1 -3.5 -2.3 -1.4
Number of full brothers 0.8 1.1 1.7 0.7 -1.2 -1.3 -0.8
Worry too long after embarrassment 0.6 1.0 1.8 -0.0 0.9 1.4 1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 6.7 8.7 11.0 -2.2 3.2 3.3 2.9
Wheeze or whistling in the chest in last year 5.7 10.2 14.2 2.6 -3.8 -3.4 -2.9
Number of children fathered 6.4 7.2 10.5 2.3 -3.2 -2.9 -2.2
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 0.8 -0.7 0.9 0.7 0.7
Age at first live birth 0.6 1.0 2.1 -0.5 -0.8 -1.1 -1.5
Pulse wave peak to peak time 0.6 0.7 1.6 -1.3 0.0 -0.6 -0.9
Health satisfaction 0.4 0.5 0.7 0.6 -0.7 -0.7 -0.8
Shortness of breath walking on level ground 0.2 0.3 0.6 0.5 -0.0 0.4 0.8
Qualifications: College or University degree 2.6 8.1 20.5 -4.5 2.9 1.5 1.0
Eye problems/disorders: None of the above 0.8 1.0 2.1 0.9 0.3 0.9 1.5
Mouth/teeth dental problems: Loose teeth 1.1 1.3 2.2 0.0 -1.3 -1.5 -1.1
Emphysema/chronic bronchitis 0.6 0.7 1.0 1.0 0.5 0.8 1.0
Medication for pain relief, constipation, heartburn 1.2 2.0 6.8 -2.6 0.1 -0.7 -0.9
Neck or shoulder pain in last month 8.0 11.4 14.9 2.3 -3.9 -3.6 -3.5
Medication: Blood pressure 4.6 8.1 20.1 4.5 -2.9 -1.7 -1.2
Angina (self-reported) 2.6 3.5 5.2 1.9 -2.3 -1.9 -1.3
Migraine (self-reported) 2.5 3.1 4.7 -0.9 2.1 2.2 1.6
Medication: Ibuprofen 1.9 2.3 2.8 1.4 -1.6 -1.7 -1.4
Medication: Allopurinol 0.2 0.2 0.7 0.8 -0.4 0.0 0.3
Medication: Omeprazole 2.0 2.4 4.5 0.7 1.2 1.8 2.1
Medication: Seretide 50 evohaler 0.3 0.4 0.7 0.5 -0.9 -0.6 -0.4
Mean time to correctly identify matches 2.0 3.9 5.4 -2.2 2.3 1.9 1.3
Heart disease (mother) 0.9 1.1 2.2 0.9 -1.5 -1.0 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.3 0.5 0.3 0.6 0.3
Whole body fat mass 16.2 67.8 100.0 10.0 -9.1 -7.2 -6.0
Leg fat mass (right) 15.1 58.7 88.4 9.4 -8.5 -6.7 -5.4
Arm predicted mass (right) 25.0 128.0 171.6 12.3 -13.1 -11.1 -8.1
Pulse rate, automated reading 0.0 0.2 0.6 -0.7 0.0 -0.0 -0.2
Alcohol intake frequency. 13.4 31.2 44.0 6.0 -6.6 -5.3 -4.0
Comparative height size at age 10 8.6 47.2 65.8 6.8 -8.1 -7.1 -5.1
Number of full sisters 0.3 0.3 0.9 1.0 -0.6 -0.2 -0.2
Suffer from ‘nerves’ 7.4 11.7 17.8 -1.1 3.6 4.2 3.8
Overall health rating 0.5 1.0 3.4 1.8 -0.3 0.3 0.7
Chest pain or discomfort 1.0 1.4 2.0 0.9 -1.4 -1.4 -1.0
Had major operations 0.1 0.2 0.3 0.0 -0.4 -0.5 -0.6
Age at last live birth 0.1 0.1 0.2 -0.2 0.3 0.4 0.4
Family relationship satisfaction 0.5 0.6 1.1 -1.0 -0.2 -1.0 -0.4
Leg pain on walking 1.0 1.2 1.8 1.2 -1.3 -1.1 -0.7
Qualifications: NVQ or HND or HNC or equivalent 8.1 9.8 16.7 4.1 -3.6 -2.4 -1.9
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 -0.5 0.3 0.1 -0.1
Illness, injury, bereavement, stress in last 2 years 3.4 4.1 7.4 0.0 1.7 2.5 2.7
Medication: Aspirin 1.0 1.3 1.9 1.1 0.7 1.3 1.4
Supplements: Vitamin C 1.4 1.7 4.4 -2.1 -0.4 -1.0 -1.0
Knee pain experienced in last month 0.5 0.8 1.5 0.5 0.4 1.2 1.1
Hypertension (Self-reported) 4.3 12.0 34.1 5.8 -3.2 -1.7 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 0.9 0.9 0.0 0.5 0.9
Illnesses of father: Heart disease 0.5 0.6 2.1 1.4 -0.7 0.1 0.2
Illnesses of siblings: Diabetes 1.3 1.5 3.2 1.8 -1.2 -0.8 -1.0
Smoking status: Previous 0.1 0.2 0.5 0.7 0.2 0.3 0.4
Forced expiratory volume in 1-second (FEV1), predicted 3.1 6.5 9.7 1.4 -2.7 -3.1 -2.6
Whole body fat-free mass 26.5 151.4 201.6 12.9 -14.2 -12.4 -9.2
Leg fat-free mass (right) 27.0 144.2 190.4 12.4 -13.8 -12.1 -9.3
Arm fat percentage (left) 9.8 39.1 57.6 7.6 -6.7 -5.4 -4.9
Average weekly red wine intake 0.5 0.8 1.7 -1.3 1.1 0.6 0.1
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.2 0.4 -0.7 -0.8 -1.1
Mood swings 0.3 0.5 1.2 1.1 -0.3 0.4 0.7
Loneliness, isolation 0.7 1.0 2.9 1.7 -0.7 -0.7 -0.2
Long-standing illness, disability or infirmity 0.4 0.6 0.9 0.8 -1.0 -0.8 -0.4
Ever had bowel cancer screening 0.8 1.0 1.7 1.3 0.2 0.7 1.3
Diabetes diagnosed by doctor 3.8 6.2 9.2 3.0 -2.9 -2.2 -1.5
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.1 1.8 0.2 -1.3 -1.3 -1.0
Friendships satisfaction 0.2 0.3 0.9 -1.0 0.1 -0.2 -0.3
Qualifications: nursing, teaching 0.1 0.2 0.5 -0.7 -0.0 -0.4 -0.5
Commuting to job workplace: Walk 0.2 0.2 0.5 -0.7 0.4 0.4 0.2
Eye problems/disorders: Cataract 5.0 5.8 9.0 -2.0 3.0 2.7 1.7
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.1 0.4 -0.4 0.2 0.2
Medication for cholesterol 1.3 2.0 6.8 -2.6 0.5 -0.4 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.4 4.0 7.2 -0.1 1.8 2.4 2.7
Back pain experienced in last month 0.3 0.4 0.8 0.8 0.3 0.5 0.9
Mineral and other dietary supplements 2.7 3.6 4.9 -0.5 2.1 2.1 2.2
Breast cancer (self-reported) 0.1 0.1 0.2 -0.2 0.1 -0.3 -0.5
Asthma (self-reported) 3.9 7.7 11.5 0.4 -3.1 -3.4 -3.1
Osteoporosis (self-reported) 0.8 0.9 1.8 -0.1 -0.9 -1.3 -1.1
Osteoarthritis (self-reported) 0.3 0.4 0.7 -0.5 0.9 0.8 0.3
Medication: Aspirin 0.4 0.5 0.9 0.9 0.1 0.6 0.7
Medication: Gliclazide 3.5 3.9 5.3 1.3 -2.3 -2.3 -1.9
Illnesses of father: None of the above (group 1) 1.7 2.1 3.2 -1.8 1.6 1.2 1.0
Smoking status: Current 1.1 1.7 4.4 2.1 -1.4 -0.7 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.9 8.3 10.7 -2.9 3.3 2.8 2.5
Whole body water mass 27.0 153.8 204.5 13.0 -14.3 -12.5 -9.2
Leg predicted mass (right) 26.8 143.2 190.4 12.3 -13.8 -12.1 -9.2
Arm fat mass (left) 20.0 82.2 112.4 10.6 -10.1 -8.3 -6.8
Number of self-reported non-cancer illnesses 0.4 0.7 0.8 0.8 0.6 0.9 0.9
Average weekly champagne plus white wine intake 0.7 0.9 3.0 -1.7 0.0 -0.5 -0.7
Miserableness 1.9 3.2 7.2 2.7 -1.9 -1.2 -0.7
Guilty feelings 1.1 1.7 5.6 2.4 -1.0 -0.4 -0.1
Wears glasses or contact lenses 1.2 1.4 1.8 0.9 -1.3 -1.3 -1.2
Ever taken oral contraceptive pill 2.6 2.9 4.5 1.0 -2.0 -2.1 -1.5
Hearing aid user 0.6 0.7 1.6 1.3 0.5 0.7 0.7
Mother’s age at death 0.1 0.1 0.2 -0.4 0.0 -0.3 -0.2
Financial situation satisfaction 0.1 0.1 0.2 0.2 -0.4 -0.5 -0.4
Tinnitus: Yes, now most or all of the time 0.3 0.4 0.7 -0.4 0.5 0.6 0.9
Commuting to job workplace: Public transport 0.4 0.5 0.9 0.3 -0.8 -0.7 -0.9
Eye problems/disorders: Glaucoma 2.4 2.8 4.4 0.5 -1.7 -1.9 -2.1
Medication: Blood pressure 2.7 5.1 15.8 4.0 -1.9 -0.9 0.0
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.2 0.2 -0.4 -0.1 -0.3
Supplements: Fish oil (including cod liver oil) 2.6 3.3 4.8 0.5 -2.0 -2.2 -2.0
High cholesterol (Self-reported) 2.2 4.0 7.1 0.7 1.9 2.7 2.2
Medication: Bendroflumethiazide 9.5 14.4 31.0 5.6 -4.1 -2.7 -1.4
Medication: Paracetamol 0.2 0.2 0.8 0.9 -0.1 0.2 0.3
Medication: Lisinopril 2.6 3.3 5.8 2.4 -2.2 -1.4 -0.8
Medication: Atorvastatin 0.1 0.2 0.3 0.3 0.6 0.5 0.2
Illnesses of father: High blood pressure 3.5 4.3 5.6 1.5 -2.4 -2.0 -2.3
Alcohol drinker status: Never 0.8 1.0 1.5 0.8 -1.2 -1.0 -0.9
Ever smoked 0.5 1.0 1.0 0.9 -1.0 -1.0 -1.0
Basal metabolic rate 28.4 157.5 207.4 13.3 -14.4 -12.5 -9.4
Leg fat percentage (left) 5.7 20.7 42.8 6.5 -4.8 -3.1 -2.7
Arm fat-free mass (left) 27.2 137.8 182.2 12.9 -13.5 -11.4 -8.5
Number of operations (self-reported) 0.5 0.7 2.2 1.5 -0.7 -0.2 -0.4
Average weekly beer plus cider intake 1.4 2.1 3.2 1.1 1.1 1.8 1.7
Irritability 0.5 0.8 2.4 1.5 -0.8 -0.3 0.3
Risk taking 3.1 4.6 8.3 -0.5 -2.2 -2.9 -2.2
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.3 -0.4 -0.6 -1.0 -1.1
Fractured/broken bones in last 5 years 0.3 0.4 0.8 0.4 -0.9 -0.7 -0.6
Age started oral contraceptive pill 0.7 0.9 1.3 -0.8 1.1 1.1 0.8
Diastolic blood pressure, automated reading 1.1 3.4 8.9 3.0 -1.8 -1.1 -0.7
Ever depressed for a whole week 2.7 3.4 5.1 -1.0 2.0 1.9 2.3
Unable to work because of sickness or disability 0.0 0.0 0.0 -0.1 0.1 -0.0 -0.0
Commuting to job workplace: Cycle 1.1 1.3 2.3 -0.8 -0.8 -1.3 -1.5
Myopia 0.2 0.3 0.8 -0.9 0.2 -0.4 -0.6
Vascular/heart problems diagnosed by doctor 4.2 11.5 31.7 -5.6 3.3 1.7 0.8
Cholesterol lowering medication 1.5 2.2 3.3 1.4 0.8 1.8 1.7
Medication: Omeprazole (e.g. Zanprol) 3.1 3.8 6.4 0.5 1.7 2.4 2.5
Pain experienced in last month 0.2 0.3 0.3 -0.6 0.6 0.3 0.5
Supplements: Calcium 1.0 1.1 3.7 -1.9 0.7 0.4 -0.3
Basal cell carcinoma (self-reported) 1.6 2.0 4.2 -2.0 1.7 0.8 0.2
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.2 0.2 -0.3 -0.4 -0.5
Deep venous thrombosis (DVT) (self-reported) 1.2 1.5 2.6 -1.2 1.6 1.1 0.9
Heart disease (siblings) 0.9 1.1 3.4 1.8 -0.8 -0.1 0.5
Alcohol drinker status: Previous 1.0 1.2 4.1 2.0 -0.7 -0.2 0.0
Pack years of smoking 0.8 1.1 1.8 0.4 0.8 1.3 1.4
Impedance of whole body 15.5 79.0 104.0 -10.2 10.1 8.7 5.9
Leg fat mass (left) 16.0 62.7 96.8 9.8 -8.8 -6.8 -5.5
Arm predicted mass (left) 27.4 139.5 185.0 12.9 -13.6 -11.5 -8.6