Best TWAS P=6.66e-15 · Best GWAS P=9.56e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PSMB3 | 0.11 | 0.01 | enet | 8 | 0.03 | 2.7e-03 | -5.7 | -5.9 | 4.8e-09 | 0.68 | 0.01 | 0.94 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | PIP4K2B | 0.15 | 0.07 | lasso | 5 | 0.07 | 2.2e-06 | -7.7 | -7.3 | 2.3e-13 | 0.92 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Aorta | PSMB3 | 0.23 | 0.17 | enet | 26 | 0.22 | 2.1e-12 | -7.7 | -6.4 | 1.2e-10 | 0.83 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Artery Tibial | PSMB3 | 0.10 | 0.02 | enet | 12 | 0.03 | 1.2e-03 | -7.7 | -6.3 | 3.3e-10 | 0.73 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Artery Tibial | PIP4K2B | 0.37 | 0.16 | enet | 49 | 0.22 | 2.1e-17 | -7.7 | -7.5 | 7.1e-14 | 0.73 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Testis | PSMB3 | 0.30 | 0.24 | lasso | 4 | 0.21 | 8.9e-10 | -7.7 | -7.8 | 6.7e-15 | 0.97 | 0.00 | 1.00 | TRUE |
| 7 | METSIM | Adipose | PIP4K2B | 0.06 | 0.01 | blup | 360 | 0.02 | 7.0e-04 | -4.3 | -5.6 | 1.8e-08 | 0.49 | 0.01 | 0.98 | FALSE |
| 8 | NTR | Blood | PIP4K2B | 0.02 | 0.01 | lasso | 3 | 0.01 | 6.4e-04 | -7.7 | 7.2 | 5.6e-13 | -0.94 | 0.00 | 0.99 | FALSE |
| 9 | YFS | Blood | PSMB3 | 0.14 | 0.11 | enet | 31 | 0.16 | 7.2e-49 | -7.7 | -6.2 | 4.4e-10 | 0.82 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PSMB3 | 0.04 | 0.00 | blup | 37 | 0.02 | 6.7e-03 | -4.3 | -6.3 | 2.2e-10 | 0.73 | 0.01 | 0.73 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PIP4K2B | 0.04 | 0.01 | blup | 56 | 0.03 | 6.3e-04 | -7.7 | -5.8 | 6.3e-09 | 0.84 | 0.00 | 0.95 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PSMB3 | 0.14 | 0.05 | blup | 42 | 0.05 | 8.9e-07 | -7.7 | -6.0 | 2.1e-09 | 0.69 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PSMB3 | 0.12 | 0.02 | enet | 14 | 0.05 | 1.3e-03 | -6.6 | -6.1 | 1.1e-09 | 0.64 | 0.00 | 0.83 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PIP4K2B | 0.05 | 0.04 | blup | 56 | 0.05 | 5.3e-06 | -6.6 | -7.4 | 1.2e-13 | 0.85 | 0.00 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMB3 | 0.11 | 0.07 | blup | 42 | 0.07 | 9.4e-08 | -7.7 | -6.8 | 1.3e-11 | 0.76 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PSMB3 | 0.12 | 0.09 | lasso | 3 | 0.06 | 3.0e-03 | -7.7 | -7.7 | 1.8e-14 | 0.99 | 0.00 | 0.94 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | PSMB3 | 0.05 | 0.06 | lasso | 1 | 0.05 | 2.4e-05 | -7.7 | -7.7 | 1.7e-14 | 0.97 | 0.00 | 1.00 | FALSE |