Best TWAS P=7.59e-10 · Best GWAS P=5.04e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CD79B | 0.15 | 0.16 | enet | 9 | 0.17 | 3.5e-14 | -5.6 | 6.2 | 7.6e-10 | -0.98 | 0.00 | 1.00 | TRUE |
| 2 | GTEx | Adipose Visceral Omentum | CD79B | 0.15 | 0.00 | lasso | 6 | 0.02 | 4.1e-02 | -5.6 | 5.2 | 2.3e-07 | -0.89 | 0.03 | 0.82 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | CD79B | 0.04 | 0.07 | lasso | 2 | 0.03 | 4.2e-02 | -5.6 | 5.7 | 1.2e-08 | -0.70 | 0.03 | 0.36 | FALSE |
| 4 | GTEx | Esophagus Mucosa | STRADA | 0.05 | 0.07 | lasso | 2 | 0.05 | 1.9e-04 | -5.5 | -5.5 | 4.5e-08 | 0.74 | 0.08 | 0.73 | FALSE |
| 5 | GTEx | Esophagus Muscularis | PSMC5 | 0.12 | 0.08 | lasso | 3 | 0.07 | 3.8e-05 | -5.5 | -5.2 | 1.7e-07 | 0.74 | 0.07 | 0.87 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CD79B | 0.02 | 0.02 | lasso | 2 | 0.01 | 3.0e-03 | -6.2 | 6.0 | 1.6e-09 | -0.99 | 0.00 | 0.93 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | STRADA | 0.05 | 0.03 | lasso | 1 | 0.02 | 1.7e-03 | -5.5 | -5.5 | 3.8e-08 | 0.75 | 0.00 | 0.91 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMC5 | 0.04 | 0.03 | lasso | 1 | 0.03 | 5.6e-04 | -5.5 | -5.5 | 3.8e-08 | 0.76 | 0.01 | 0.96 | FALSE |