TWAS
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Models
Genes
Traits
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Traits
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Hand grip strength (left)
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chr18:45,873,080-47,686,517
Best TWAS P=2.24e-10 · Best GWAS P=2.54e-12 conditioned to 0.0198
46M
46.5M
47M
47.5M
0
2
4
6
8
10
12
physical position
-log10 P
Conditional
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
YFS
Blood
DYM
0.05
0.05
lasso
4
0.04
1.5e-13
-5.3
6.3
2.2e-10
0.74
0.84
0.16
TRUE
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
C18orf32
0.04
0.03
blup
48
0.04
6.5e-05
3.9
5.2
2.1e-07
0.57
0.10
0.75
TRUE
1
GTEx
Adrenal Gland
DYM
0.30
0.01
enet
15
0.01
1.2e-01
6.6
5.9
4.3e-09
0.80
0.03
0.81
FALSE
2
GTEx
Esophagus Mucosa
DYM
0.12
0.01
enet
12
0.04
1.0e-03
6.6
5.7
1.4e-08
0.67
0.03
0.93
FALSE