Best TWAS P=9.09e-08 · Best GWAS P=3.47e-08 conditioned to 0.00071
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | ZNF607 | 0.09 | 0.08 | lasso | 5 | 0.07 | 9.8e-09 | 4.8 | 5.1 | 2.7e-07 | 0.59 | 0.09 | 0.90 | FALSE |
2 | GTEx | Artery Aorta | ZNF571 | 0.08 | 0.01 | enet | 14 | 0.02 | 2.1e-02 | -3.6 | 5.3 | 1.4e-07 | 0.44 | 0.15 | 0.34 | FALSE |
3 | GTEx | Breast Mammary Tissue (Male) | ZNF571 | 0.11 | 0.00 | enet | 8 | 0.01 | 1.9e-01 | 5.1 | 5.3 | 1.2e-07 | 0.55 | 0.03 | 0.32 | FALSE |
4 | GTEx | Esophagus Mucosa | ZNF573 | 0.06 | 0.02 | enet | 13 | 0.02 | 2.2e-02 | 3.8 | 5.3 | 9.1e-08 | 0.48 | 0.06 | 0.73 | TRUE |
5 | GTEx | Pituitary | ZNF781 | 0.37 | 0.01 | enet | 25 | 0.10 | 2.1e-03 | -4.0 | 5.2 | 2.3e-07 | 0.41 | 0.07 | 0.60 | FALSE |
6 | GTEx | Thyroid | ZNF571 | 0.10 | 0.01 | enet | 11 | 0.04 | 2.9e-04 | 5.0 | 5.1 | 2.7e-07 | 0.66 | 0.02 | 0.91 | FALSE |
7 | GTEx | Whole Blood | HKR1 | 0.07 | 0.01 | lasso | 8 | 0.02 | 5.1e-03 | -4.6 | 5.2 | 2.5e-07 | 0.40 | 0.24 | 0.54 | FALSE |
8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZNF573 | 0.06 | 0.05 | lasso | 2 | 0.04 | 8.4e-06 | 4.9 | 5.2 | 1.6e-07 | 0.56 | 0.01 | 0.98 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZNF607 | 0.04 | 0.03 | enet | 3 | 0.03 | 4.4e-04 | 4.9 | 5.3 | 1.3e-07 | 0.57 | 0.01 | 0.88 | FALSE |