Hub : Genes

HKR1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.3663	0.0795	4.1e-14	0.345	NA	0.411	NA	0.405	3.6e-13	NA	4.8e-16	NA	9.5e-16
2	GTEx	Artery Tibial	0.0508	0.0366	8.5e-03	0.015	NA	0.028	NA	0.011	2.2e-02	NA	2.8e-03	NA	4.5e-02
3	GTEx	Colon Transverse	0.0690	0.0400	8.7e-03	0.083	NA	0.041	NA	0.059	9.3e-05	NA	5.0e-03	NA	8.5e-04
4	GTEx	Skin Sun Exposed Lower leg	0.0990	0.0520	2.6e-03	0.003	NA	0.036	NA	0.036	1.6e-01	NA	5.1e-04	NA	5.5e-04
5	GTEx	Whole Blood	0.0680	0.0310	7.6e-05	0.009	NA	0.019	NA	0.020	4.6e-02	NA	6.3e-03	NA	5.1e-03
6	YFS	Blood	0.0426	0.0160	7.7e-14	0.049	0.050	0.046	0.049	0.049	1.1e-15	6.4e-16	8.3e-15	7.7e-16	1.1e-15
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0360	0.0231	5.8e-03	0.018	0.007	0.007	NA	0.006	3.7e-03	5.3e-02	4.7e-02	NA	5.9e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.6	1.0	2.6	-0.9	0.5	0.2	1.3	0.8	1.0	-1.6
Bipolar Disorder or Schizophrenia	0.4	1.0	1.9	-0.7	0.6	0.8	1.4	0.3	1.2	-1.3
Depressed Affect (Nagel 2018)	1.1	2.3	3.7	-1.2	1.5	-1.0	1.3	1.9	1.9	-1.4
Depression (Nagel 2018)	1.3	1.9	8.1	-1.1	2.9	0.1	1.2	0.4	1.1	-1.0
Intelligence (Savage-Jansen 2018)	1.1	3.3	6.0	2.5	-2.1	-0.5	0.0	-1.3	-2.3	2.4
Neuroticism (Nagel 2018)	0.6	1.3	3.6	-0.8	1.1	-0.5	0.5	1.6	1.9	-0.8
Schizophrenia (2018)	0.2	0.3	0.8	-0.2	0.3	0.9	0.7	-0.4	0.7	-0.4
Schizophrenia vs Biploar Disorder	0.1	0.2	0.6	0.5	0.2	-0.3	0.5	0.1	0.1	0.8
Worry (Nagel 2018)	0.3	0.6	2.0	-0.0	0.5	0.9	0.5	0.9	1.4	-0.0
Alzheimer’s Disease (in mother)	1.8	2.1	2.6	-1.5	1.3	0.7	1.6	1.6	1.5	-1.6
Alzheimer’s Disease (in father)	2.0	2.2	4.1	1.8	-0.6	-0.7	-0.8	-1.5	-2.0	2.0
Alzheimer’s Disease (including proxy)	0.2	0.2	0.8	0.3	0.6	0.2	0.9	0.4	-0.4	0.1
Crohns Disease (2017)	3.3	7.2	17.0	-3.0	-1.6	2.6	-0.6	4.1	2.6	-2.9
Irritable Bowel Disease (IBD)	1.7	4.0	7.1	-1.6	-1.8	2.6	-1.6	2.7	1.7	-1.8
Ulcerative Colitis (UC)	0.4	0.8	3.1	-0.0	-1.0	1.2	-1.8	0.3	0.3	-0.3
Major Depression (MDD)	0.5	0.6	1.5	-0.4	1.0	-1.2	0.9	-0.0	0.7	-0.0
Reaction Time	2.6	5.0	7.7	2.8	-2.3	-1.7	-2.5	-1.9	-2.4	1.9
Verbal and Numeric Reasoning (VNR)	1.8	4.3	7.8	2.4	-1.9	-1.4	-1.0	-1.7	-2.8	2.7
Breast Cancer	1.7	4.1	9.4	2.1	-1.1	0.5	-1.7	-3.1	-2.6	2.0
Ovarian Cancer	2.9	3.8	10.8	-3.3	0.1	0.3	-0.3	1.8	2.3	-2.7
Prostate Cancer	1.7	2.4	6.3	-1.6	2.5	0.1	2.4	0.1	1.3	-0.7
Age at First Birth	1.3	1.8	3.5	-0.9	-0.7	1.9	-1.7	1.7	0.6	-1.3
Bipolar Disorder (2011)	0.5	0.5	1.4	-0.7	0.9	0.4	1.2	-0.3	0.3	-0.7
Body Mass Index (BMI) (2010)	0.4	0.5	2.5	0.0	0.4	-1.6	-0.3	-0.9	-0.1	0.4
Coronary Artery Disease (CAD)	0.3	0.3	1.5	0.3	-0.2	-1.2	-0.4	0.3	-0.6	-0.4
Crohns Disease (2012)	5.4	8.6	21.3	-3.4	-1.6	1.6	-0.8	4.6	3.0	-3.6
Mean Putamen Volume	0.6	0.6	2.3	0.0	-1.5	-0.8	-0.9	0.7	0.1	-0.5
Fasting Glucose	0.7	0.9	2.0	-0.5	-0.4	1.4	-0.3	0.8	1.0	-1.4
HbA1C	2.8	3.1	6.2	-1.8	0.0	1.2	1.4	2.1	2.0	-2.5
HDL Cholesterol	0.4	0.7	1.5	-1.2	-0.0	0.8	0.2	1.0	0.9	-0.7
LDL Cholesterol	0.0	0.1	0.2	0.1	-0.5	-0.2	0.2	0.1	-0.2	0.2
Lupus	0.8	1.3	3.2	1.8	-1.4	-0.3	-1.0	0.4	-0.6	1.4
Neuroticism (2016)	0.8	1.1	5.3	-0.4	2.3	-0.6	1.1	0.2	0.9	-0.1
Primary Biliary Cirrhosis	6.7	9.6	22.0	-4.2	-0.6	0.2	-0.4	3.6	3.7	-4.7
Rheumatoid Arthritis	2.1	2.9	4.3	1.9	0.6	-2.1	-1.0	-2.0	-1.8	2.0
Schizophrenia (2014)	0.3	0.7	2.0	-0.4	0.4	0.8	1.4	0.3	1.2	-0.5
Triglycerides	0.9	1.5	7.3	-1.5	0.5	-2.7	-0.3	-0.0	0.6	-0.5
Type 2 Diabetes (T2D) (2012)	1.3	1.5	3.1	-1.1	0.7	0.3	1.0	1.7	1.7	-1.2
Ulcerative Colitis	0.2	0.2	0.8	0.2	-0.3	0.9	-0.9	0.1	0.2	-0.0
Blood Eosinophil Count	1.7	12.8	27.8	-4.5	-0.5	1.8	0.1	5.3	4.9	-3.7
Blood Platelet Count	0.6	6.7	13.5	3.7	1.3	-1.4	3.0	-2.3	-2.7	2.8
Blood Red Count	0.6	5.7	14.2	1.1	-3.8	-2.2	-3.7	-0.9	-2.3	0.3
Blood White Count	0.3	2.0	3.7	1.7	1.9	-1.1	0.8	-1.4	-1.4	1.2
Heel T-Score	0.2	1.2	5.3	0.0	-0.7	2.3	1.0	1.0	0.8	-0.4
BMI	0.5	2.7	4.5	2.1	0.2	-1.4	1.1	-2.0	-1.9	1.9
Height	2.6	50.3	108.2	-7.3	-1.0	5.3	2.5	10.1	10.4	-7.2
Waist Hip Ratio (WHR)	0.8	3.5	9.5	0.6	1.3	-3.1	0.6	-2.7	-1.8	1.3
Systolic Blood Pressure	1.9	9.5	19.5	-1.8	-4.4	3.4	-1.1	4.4	2.4	-2.5
Smoking Status	0.3	0.7	4.2	0.2	0.1	-0.4	2.1	0.2	-0.1	0.5
Allergy or Eczema	1.2	3.2	6.2	-2.5	1.5	1.4	-0.0	1.5	2.2	-2.2
Cardiovascular Disease	0.7	2.4	9.1	0.5	-3.0	1.0	-1.4	2.1	-0.2	-0.5
Hypothyroidism (self reported)	0.8	1.7	4.4	1.8	-0.6	-0.2	-0.5	-1.0	-1.7	2.1
Respiratory disease	0.3	0.7	1.4	-0.8	-1.2	-0.2	-1.1	1.2	0.3	-0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.7	0.3	-0.0	-0.3	-0.5	-0.4	-0.9	0.3
Lung FEV1/FVC ratio	1.4	7.3	18.8	4.3	-0.7	-1.0	-1.6	-2.4	-3.2	3.5
Lung FVC	0.1	0.5	1.3	-0.1	0.5	0.1	-1.2	-0.7	-1.0	0.3
Neuroticism	0.5	1.2	3.4	-0.2	1.2	-0.3	1.3	1.3	1.8	-0.4
Chronotype (morning person)	0.2	0.4	1.6	-0.0	0.3	0.7	1.3	0.6	0.0	-0.1
Hair Pigment	0.2	5.5	12.5	-3.5	1.2	1.6	-0.6	2.3	2.9	-2.8
Tanning	0.2	2.8	5.8	0.7	2.3	-1.6	2.4	-1.9	-1.0	0.7
Hand grip strength (left)	5.9	15.6	26.6	-4.2	-0.4	5.0	1.8	5.2	4.4	-4.2
Number of treatments/medications taken	0.1	0.2	0.7	0.5	-0.8	-0.3	-0.5	-0.2	-0.6	0.3
Average weekly spirits intake	0.2	0.3	0.8	-0.4	-0.7	0.2	-0.6	0.9	0.2	0.0
Sensitivity / hurt feelings	1.3	2.2	5.1	2.1	0.6	-0.1	1.0	-1.8	-1.1	2.2
Frequency of depressed mood in last 2 weeks	1.2	1.7	5.3	-0.5	2.3	0.6	2.1	0.2	1.0	-0.4
Hearing difficulty/problems: Yes	1.5	2.3	4.8	1.8	0.1	-1.0	-0.1	-2.2	-2.2	1.5
Relative age of first facial hair	0.1	0.3	0.8	-0.9	0.9	0.2	0.4	-0.1	0.4	-0.3
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.9	0.9	0.3	-1.0	0.4	-0.4	-0.9	0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.9	0.1	0.6	1.4	0.0	0.1	0.7	0.5
Ever had hysterectomy (womb removed)	1.3	1.5	4.1	-0.6	2.0	1.5	1.5	0.4	0.8	-0.7
Systolic blood pressure, automated reading	0.7	2.1	4.1	-0.9	-1.9	2.0	-0.7	2.0	0.9	-0.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	-0.5	-0.7	-0.1	-0.7	0.2	0.1	-0.6
Angina	1.6	2.2	4.0	1.8	0.1	-1.5	1.3	-1.1	-2.0	1.6
Medication for hormone replacement therapy	1.8	2.0	9.2	-0.3	3.0	-0.2	1.9	-0.8	0.6	0.3
Vitamin and mineral supplements	5.1	7.0	11.9	-3.4	-0.8	1.9	-0.3	3.5	3.3	-3.1
Supplements: Zinc	0.5	0.5	2.4	-0.1	-0.5	0.6	1.5	0.6	0.3	0.0
Medication: Co-codamol	2.5	2.9	10.2	-1.3	2.6	-0.2	3.2	0.0	1.0	-0.8
Medication: Metformin	0.7	0.9	2.0	1.0	0.0	0.2	0.9	-1.3	-1.0	1.4
Diabetes (father)	0.4	0.4	1.8	0.5	-0.6	-0.2	-1.3	-0.3	-0.3	0.7
Diabetes (mother)	1.7	2.1	4.4	-1.2	0.6	0.8	2.1	1.9	1.8	-1.1
Severe depression (siblings)	0.5	0.5	1.7	0.9	-1.3	0.6	0.1	0.5	-0.4	0.7
Pack years adult smoking proportion	1.9	2.9	5.3	2.3	-0.3	-1.1	0.8	-2.2	-1.7	2.3
Impedance of leg (right)	0.1	0.7	2.1	-1.4	0.0	-0.6	-0.4	0.1	0.8	-1.3
Leg fat-free mass (left)	0.2	1.0	2.1	0.4	-0.5	1.4	1.3	1.5	1.1	0.2
Trunk fat percentage	1.0	3.9	10.5	1.5	0.4	-3.2	-0.2	-2.6	-1.9	2.0
Hand grip strength (right)	5.5	15.0	23.0	-4.2	-0.2	4.8	1.9	4.8	4.4	-4.2
Townsend deprivation index at recruitment	3.9	5.4	14.4	-2.4	1.1	0.7	3.8	1.7	2.6	-2.5
Current tobacco smoking	1.5	2.4	9.0	0.6	2.0	-0.7	3.0	-1.5	-0.3	0.9
Average weekly fortified wine intake	0.9	1.0	4.4	-0.7	2.1	-0.5	1.2	-0.6	-0.0	0.2
Maternal smoking around birth	1.1	1.6	5.9	0.5	1.7	-0.5	2.4	-1.4	-0.2	0.3
Fed-up feelings	0.6	1.1	2.1	-0.3	0.8	-1.3	1.4	1.1	1.3	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.6	-1.1	1.6	0.1	1.4	0.8	1.1	-1.1
Relative age voice broke	0.6	0.9	4.2	0.4	0.6	-0.5	0.1	-2.1	-0.9	0.8
Taking other prescription medications	0.2	0.4	0.9	0.6	-0.9	-0.9	-0.3	0.2	-0.4	0.4
Age when periods started (menarche)	0.2	0.6	1.5	-0.5	1.2	-0.9	-0.5	-0.5	-0.6	-0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.9	0.3	0.5	-0.7	-1.0	-0.5	0.0	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	-1.1	0.5	0.0	1.2	-0.1	0.9	-0.9
Tinnitus: Yes, but not now, but have in the past	2.3	2.4	4.6	1.6	-2.1	-0.8	-2.1	-1.3	-1.1	1.4
Qualifications: CSEs or equivalent	0.7	1.0	2.8	0.8	0.1	-0.8	-0.1	-1.5	-1.7	0.7
Serious illness, injury or assault to yourself	1.3	1.5	4.6	-0.2	1.8	-1.6	2.1	-0.4	0.2	0.1
High blood pressure	0.8	2.2	6.9	0.9	-2.6	0.7	-1.9	1.6	-0.7	0.3
Hayfever, allergic rhinitis or eczema	1.5	3.2	5.9	-2.4	0.6	1.3	0.6	1.8	2.4	-2.3
Multivitamins +/- minerals	5.8	7.3	13.9	3.2	1.6	-2.0	0.7	-3.7	-3.2	3.1
Stomach or abdominal pain in last month	0.4	0.5	1.0	-0.4	0.7	-0.5	0.6	1.0	1.0	-0.4
Supplements: Glucosamine	1.7	2.2	6.0	1.6	0.8	0.4	-0.4	-2.4	-1.6	1.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.2	-0.2	-1.0	1.1	0.1	0.8	0.9	-0.2
Medication: Atenolol	0.2	0.2	0.4	0.6	-0.6	-0.6	-0.0	-0.2	-0.4	0.6
Medication: Levothyroxine sodium	1.4	2.4	5.0	2.2	-0.7	-0.7	-1.2	-1.2	-2.0	2.0
Sitting height	1.2	8.4	22.5	-2.5	-0.9	2.5	1.2	4.7	4.1	-2.3
Chronic bronchitis/emphysema (father)	0.5	0.6	2.4	-0.4	0.4	1.6	-0.8	0.1	-0.2	-0.7
High blood pressure (mother)	0.7	1.0	2.3	1.0	-1.5	0.5	-1.2	1.4	0.0	0.5
Body mass index (BMI)	0.7	3.0	4.3	2.1	1.2	-1.5	1.3	-2.0	-1.8	2.1
Impedance of leg (left)	0.2	1.1	3.0	-1.7	-0.4	-0.9	-0.6	0.2	0.9	-1.6
Leg predicted mass (left)	0.2	1.0	2.2	0.4	-0.6	1.4	1.2	1.5	1.1	0.3
Trunk fat mass	0.4	1.7	4.4	1.3	0.1	-2.1	0.4	-1.4	-1.1	1.6
Waist circumference	1.2	4.3	8.8	1.9	1.0	-3.0	0.9	-2.7	-1.8	2.3
Number of incorrect matches in round	0.5	0.8	2.1	-1.5	-0.4	0.8	-0.9	1.0	0.7	-0.8
Past tobacco smoking	0.1	0.2	0.6	0.4	0.3	0.4	-0.8	-0.4	-0.1	-0.4
Alcohol usually taken with meals	1.3	2.1	3.8	-1.5	-0.8	1.9	-0.4	2.0	1.5	-1.5
Nervous feelings	0.8	1.6	3.9	-0.8	-0.5	1.9	0.4	1.1	2.0	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	1.1	0.3	0.4	-0.1	1.0	0.1	0.4	-0.1
Hearing difficulty/problems with background noise	0.2	0.4	0.5	0.7	0.5	0.5	0.4	-0.7	-0.6	0.7
Hair/balding pattern: Pattern 2	1.0	1.3	3.2	1.4	-1.8	0.7	-1.0	-0.5	-0.9	1.3
Had menopause	0.6	0.7	2.2	0.0	-1.0	0.6	-1.5	1.2	0.4	0.0
Had other major operations	1.4	1.7	7.5	-0.5	1.5	0.2	2.7	0.3	1.2	-0.7
Forced vital capacity (FVC)	1.0	4.0	7.7	-1.7	-1.3	2.8	-0.5	2.8	2.0	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.9	-0.8	0.3	0.6	1.7	-0.2	1.0	-0.8
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	3.2	1.7	0.9	0.1	0.7	-1.0	-0.7	1.8
Qualifications: None of the above	0.5	1.1	5.4	-0.3	2.3	-0.9	0.4	-0.7	0.7	-0.0
Financial difficulties in last 2 years	0.4	0.6	1.5	-0.3	0.4	-1.2	1.2	0.4	0.2	-0.7
Mouth/teeth dental problems	0.3	0.5	1.0	-0.4	-0.7	0.9	-0.5	1.0	0.4	-0.5
Heart attack	1.2	1.5	2.6	1.3	-1.3	-1.6	-1.3	-0.7	-1.1	1.2
Allergy	0.2	0.5	1.4	1.2	-0.5	-0.1	0.2	-0.3	-1.0	1.0
Pain all over the body in last month	0.3	0.3	0.6	0.7	-0.7	-0.7	-0.8	0.1	-0.0	-0.1
Diabetes (self-reported)	0.2	0.3	0.8	0.5	0.0	-0.6	-0.4	-0.4	-0.9	0.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	-0.5	-0.8	0.3	-0.9	1.0	0.8	-0.4
Medication: Ramipril	2.2	2.8	5.9	2.4	-1.1	0.1	-1.3	-0.8	-2.4	2.1
Medication: Simvastatin	0.1	0.1	0.3	-0.1	0.1	0.5	-0.3	0.4	-0.5	-0.5
Fluid intelligence score	2.0	4.2	7.4	2.6	-1.8	-1.2	-1.0	-1.5	-2.7	2.7
Illnesses of siblings	0.2	0.3	1.3	-0.5	1.2	0.2	0.5	-0.3	0.2	-0.4
Neuroticism score	0.8	1.8	4.9	-0.7	0.9	-0.0	1.6	1.7	2.2	-0.8
Weight	0.1	0.6	2.9	0.6	0.6	-0.1	1.7	0.3	0.5	0.7
Impedance of arm (right)	0.4	1.8	5.9	-1.0	-0.7	-2.1	-2.4	-0.4	0.2	-0.6
Arm fat percentage (right)	1.2	4.8	8.2	2.3	0.8	-2.7	0.4	-2.9	-2.4	2.5
Trunk fat-free mass	0.9	4.9	9.8	-0.7	0.1	3.1	2.4	3.1	2.8	-1.0
Hip circumference	0.1	0.4	1.5	0.4	-0.1	-1.2	1.0	0.0	0.2	0.5
Time employed in main current job	0.2	0.2	0.5	-0.7	-0.4	0.1	-0.5	0.2	-0.3	-0.5
Alcohol intake versus 10 years previously	0.8	1.2	3.2	1.1	-1.4	0.4	-1.8	-0.4	-1.1	0.8
Father’s age at death	0.3	0.4	1.5	0.2	-1.0	0.5	-1.2	0.4	0.4	0.3
Worrier / anxious feelings	0.1	0.1	0.6	0.8	-0.3	0.3	-0.1	0.3	0.2	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.3	0.8	1.8	-1.3	1.8	-0.4	0.1	0.4
Falls in the last year	2.3	3.1	5.5	2.3	1.4	-0.7	2.0	-2.4	-1.3	1.8
Hair/balding pattern: Pattern 3	0.9	1.4	2.5	0.9	0.8	-1.6	-0.6	-1.3	-1.6	1.1
Number of live births	0.8	1.1	3.2	0.8	1.8	-0.9	1.0	-1.1	-0.6	0.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	5.6	0.0	-1.7	2.4	-0.9	1.3	0.5	-0.4
Pulse rate	0.3	0.5	1.7	-0.2	-1.3	-1.1	-0.1	0.3	-0.4	-0.2
Happiness	3.7	4.5	9.8	-1.4	0.8	3.1	1.4	2.6	2.7	-1.8
Noisy workplace	0.1	0.2	0.4	0.5	0.3	-0.3	0.1	-0.6	-0.5	0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.0	-1.0	1.0	0.3	0.2	0.6	0.7	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.2	-0.2	-0.3	0.4	-0.6	1.5	0.4	-1.1
Mouth/teeth dental problems: Dentures	0.8	1.4	2.8	0.4	1.7	-1.2	1.6	-1.5	-0.5	0.4
Asthma	0.5	1.0	3.6	0.2	-1.9	0.0	-1.7	0.7	-0.4	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.8	1.4	-0.9	0.5	-0.1	-0.6	-0.3	0.6
Medication: Cholesterol lowering	0.5	0.7	3.2	0.8	-1.8	0.0	-0.7	0.7	-0.6	0.3
Depression (self-reported)	0.9	1.1	5.5	0.1	1.2	-0.2	2.3	-0.8	0.3	0.3
Medication: Lansoprazole	0.8	0.9	3.3	-0.4	1.1	-1.8	0.6	-1.1	-0.2	-0.4
Prospective memory result	0.4	0.5	1.9	0.1	0.4	-1.4	-1.1	-0.2	-0.5	0.1
Lung cancer (father)	1.3	1.5	6.5	1.1	1.5	0.2	2.5	-0.6	-0.2	0.7
Illnesses of mother	0.7	0.9	2.1	0.2	0.9	-1.1	1.1	-1.4	-0.8	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	7.2	-0.3	-1.4	2.7	-0.6	1.5	1.1	-0.8
Pulse wave Arterial Stiffness index	1.9	2.3	3.4	1.8	-1.6	-0.7	-1.5	-1.2	-1.6	1.9
Impedance of arm (left)	0.5	2.5	8.6	-1.2	-0.8	-2.9	-2.5	-0.5	0.0	-0.5
Arm fat mass (right)	0.5	2.0	3.0	1.7	0.8	-1.4	1.1	-1.7	-1.3	1.7
Trunk predicted mass	0.8	4.8	9.5	-0.7	0.1	3.0	2.4	3.1	2.8	-1.0
Standing height	1.3	13.1	28.1	-3.3	-1.3	3.5	1.2	5.3	5.3	-3.2
Length of working week for main job	0.6	0.7	1.4	0.6	0.7	-1.2	-0.3	-1.2	-0.6	0.7
Exposure to tobacco smoke at home	1.0	1.1	2.4	1.5	-0.1	0.2	-0.1	-1.0	-1.6	1.5
Breastfed as a baby	0.3	0.3	0.5	-0.4	0.7	-0.7	-0.7	0.5	0.0	-0.5
Tense / ‘highly strung’	1.1	1.8	4.5	-1.4	0.8	0.1	0.7	1.8	2.1	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.0	1.4	0.4	0.2	1.4	-0.8	-0.4	1.4
Hair/balding pattern: Pattern 4	0.5	1.1	5.4	0.6	-1.4	2.3	0.3	0.3	-0.2	0.0
Birth weight of first child	1.0	1.9	2.6	-1.2	1.4	1.4	1.5	1.3	1.6	-1.1
Peak expiratory flow (PEF)	1.4	3.3	13.2	-0.9	-1.7	3.6	-1.5	1.7	0.8	-0.7
Pulse wave reflection index	6.9	8.5	13.1	3.1	-0.7	-2.2	-3.0	-3.6	-3.4	3.3
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.8	-0.1	1.4	-0.0	0.0	0.7	0.9	-0.4
Loud music exposure frequency	0.6	0.6	1.3	1.0	-0.4	0.8	-1.2	-0.1	-0.8	0.8
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.6	-0.0	-1.3	0.6	-0.8	0.2	-0.1	-0.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.3	-0.1	-1.5	0.2	-1.3	0.4	0.4	-0.3
Blood clot in the leg (DVT)	5.8	7.5	13.0	2.9	-0.2	-2.5	-1.6	-3.6	-3.5	3.1
Medication: Paracetamol	0.6	1.0	2.2	1.1	0.5	1.3	1.5	-0.7	-0.9	0.7
Headache pain in last month	0.3	0.5	1.6	-0.4	0.8	-0.5	1.3	0.1	0.6	-0.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.9	-0.6	1.7	-0.0	1.6	-0.9	0.7	-0.2
Glaucoma (self-reported)	1.1	1.3	2.2	-1.4	0.3	0.0	-0.9	1.5	1.4	-1.4
Gout (self-reported)	1.1	1.5	3.5	1.3	-0.0	-1.4	-0.6	-1.0	-1.9	1.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.3	1.8	-0.4	-0.2	-1.0	-1.0	-1.7	1.8
Medication: Amlodipine	0.1	0.1	0.2	0.3	-0.3	-0.1	0.1	-0.1	-0.5	0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.2	-0.5	-0.2	-0.3	-1.1	0.8	0.3	-0.1
Birth weight	0.8	1.8	6.1	-0.5	0.2	1.3	1.4	2.5	1.4	-0.7
Chronic bronchitis/emphysema (mother)	1.4	1.7	4.5	0.7	2.1	-0.6	1.1	-2.0	-0.7	0.8
High blood pressure (siblings)	1.4	2.0	5.1	-1.0	-1.5	1.0	0.5	2.3	1.6	-1.3
Forced vital capacity (FVC), Best measure	1.0	3.6	6.3	-1.7	-1.3	2.5	-0.7	2.5	2.2	-1.9
Body fat percentage	1.1	4.2	9.8	1.8	0.4	-3.1	-0.1	-2.6	-2.2	2.1
Leg fat percentage (right)	0.8	2.9	4.8	1.9	0.7	-1.9	0.9	-2.2	-1.9	1.9
Arm fat-free mass (right)	0.5	2.7	6.3	-0.6	-0.1	2.0	1.9	2.5	2.0	-0.8
Exposure to tobacco smoke outside home	1.8	2.3	5.6	1.6	1.3	-0.9	-0.1	-2.4	-1.5	1.8
Comparative body size at age 10	3.5	9.7	19.1	4.1	-1.1	-1.7	-0.6	-3.7	-3.7	4.4
Number of full brothers	1.5	1.9	5.4	1.1	2.3	-1.2	0.5	-1.2	-1.4	1.3
Worry too long after embarrassment	0.5	0.8	2.1	-0.5	1.4	-0.1	1.2	0.3	1.2	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.7	1.3	0.8	-0.2	1.0	-1.0	-0.6	1.3
Wheeze or whistling in the chest in last year	0.7	1.2	2.9	1.2	0.2	-0.9	0.9	-1.7	-1.0	1.1
Number of children fathered	0.7	0.8	2.6	-0.4	0.4	-0.9	0.5	1.6	1.0	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.4	0.4	0.5	0.2	0.3	0.5	-0.4
Age at first live birth	0.6	1.1	6.2	-0.2	-0.7	0.6	-2.5	0.1	-0.6	-0.4
Pulse wave peak to peak time	3.0	3.6	5.1	-2.2	1.6	1.1	1.8	1.8	2.2	-2.3
Health satisfaction	0.4	0.5	1.4	0.5	0.9	-1.2	0.8	0.2	-0.1	0.5
Shortness of breath walking on level ground	3.1	3.6	7.8	1.7	2.2	-2.0	0.3	-2.8	-1.8	1.6
Qualifications: College or University degree	0.4	1.2	2.1	-0.2	-1.4	1.4	1.3	1.1	1.0	-0.4
Eye problems/disorders: None of the above	0.8	1.0	2.1	1.0	-0.4	0.8	0.6	-1.5	-1.1	1.2
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.4	0.9	1.5	-0.7	0.6	-0.8	-0.2	0.5
Emphysema/chronic bronchitis	0.5	0.6	2.4	0.1	0.8	-1.6	1.1	-0.3	0.0	0.2
Medication for pain relief, constipation, heartburn	1.0	1.7	4.6	-2.1	-0.0	0.5	-0.7	1.1	1.9	-1.4
Neck or shoulder pain in last month	0.2	0.3	0.6	0.6	-0.4	0.8	-0.5	-0.2	-0.8	0.4
Medication: Blood pressure	1.3	2.3	7.0	0.8	-2.6	0.6	-2.6	0.9	-0.8	0.2
Angina (self-reported)	2.1	2.8	5.5	2.1	0.2	-1.6	1.2	-1.5	-2.3	1.9
Migraine (self-reported)	1.5	1.9	2.8	-1.4	1.2	0.6	1.7	1.5	1.6	-1.3
Medication: Ibuprofen	1.1	1.3	4.3	2.1	-0.8	0.5	0.1	-1.1	-1.0	1.4
Medication: Allopurinol	0.9	1.3	3.2	1.2	-0.1	-1.0	-1.0	-0.9	-1.8	1.1
Medication: Omeprazole	1.0	1.2	4.5	0.8	-0.6	-2.1	-0.2	-0.5	-1.4	0.8
Medication: Seretide 50 evohaler	0.3	0.4	1.6	-0.4	1.3	-0.1	0.2	-0.5	-0.5	0.6
Mean time to correctly identify matches	2.0	3.8	9.9	2.2	-1.5	-1.5	-3.2	-1.2	-1.9	1.4
Heart disease (mother)	0.1	0.1	0.4	-0.5	-0.0	0.6	-0.3	-0.2	0.1	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	5.0	-1.3	2.2	0.6	0.2	-0.3	0.2	-0.6
Whole body fat mass	0.3	1.3	3.3	1.2	0.3	-1.8	0.6	-1.1	-0.9	1.4
Leg fat mass (right)	0.5	2.0	3.2	1.8	0.2	-1.4	0.9	-1.5	-1.5	1.8
Arm predicted mass (right)	0.5	2.4	4.9	-0.2	0.2	2.2	2.2	2.0	1.7	-0.4
Pulse rate, automated reading	0.2	0.6	1.7	-0.9	-0.3	-1.3	1.2	0.1	0.2	-0.6
Alcohol intake frequency.	0.8	1.8	2.5	-1.4	1.5	-1.1	1.5	0.7	1.6	-1.5
Comparative height size at age 10	2.1	11.4	23.8	-3.3	-0.6	3.3	2.1	4.9	4.9	-2.4
Number of full sisters	2.2	2.7	5.2	2.0	-0.1	-1.4	0.4	-1.8	-2.3	2.1
Suffer from ‘nerves’	0.3	0.5	1.7	1.0	0.5	0.3	1.3	-0.2	0.2	0.9
Overall health rating	0.7	1.5	3.0	1.7	-1.1	-1.7	-0.6	-0.2	-1.2	1.2
Chest pain or discomfort	1.8	2.6	4.7	1.9	-0.3	-1.9	0.3	-1.6	-2.2	1.7
Had major operations	1.3	1.5	2.8	1.6	-1.3	-0.8	-1.4	-0.4	-0.9	1.7
Age at last live birth	0.4	0.6	3.2	0.2	-0.5	0.1	-1.8	-0.1	-0.9	-0.2
Family relationship satisfaction	1.7	2.1	3.8	-1.0	1.8	0.3	2.0	1.5	1.9	-0.9
Leg pain on walking	1.8	2.2	4.6	2.1	0.3	-0.9	-0.6	-1.6	-1.9	1.9
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.3	0.0	0.3	-0.3	-0.5	-0.4	-0.3
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.8	-0.2	-0.3	-1.3	-1.0	0.1	-0.5	-0.5
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.8	-0.5	-1.0	1.3	-1.7	0.6	0.7	-0.4
Medication: Aspirin	0.7	1.0	2.3	1.2	-0.4	-1.0	-0.2	-0.7	-1.5	1.1
Supplements: Vitamin C	1.3	1.5	3.7	1.1	0.1	-1.9	-0.3	-1.5	-1.5	1.2
Knee pain experienced in last month	0.6	0.9	2.2	-0.1	1.5	-1.4	0.9	-1.1	-0.3	0.2
Hypertension (Self-reported)	1.0	2.8	9.1	0.7	-3.0	1.2	-2.1	2.0	-0.4	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.8	0.2	0.5	-1.3	0.8	-0.3	-0.3	0.2
Illnesses of father: Heart disease	0.3	0.5	2.1	0.4	-1.5	-0.1	-0.2	0.7	-0.7	0.1
Illnesses of siblings: Diabetes	0.4	0.6	1.1	-1.0	0.1	0.6	1.0	0.4	0.7	-0.9
Smoking status: Previous	0.7	1.0	3.4	-1.3	-1.1	-0.4	-0.2	1.9	0.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.2	-1.2	-0.6	1.0	0.9	1.8	1.5	-1.0
Whole body fat-free mass	0.5	2.8	5.8	-0.3	-0.2	2.4	1.9	2.4	2.1	-0.5
Leg fat-free mass (right)	0.2	1.2	3.1	0.0	-0.7	1.4	1.2	1.8	1.3	-0.1
Arm fat percentage (left)	1.3	5.3	10.5	2.3	0.6	-3.2	0.1	-2.9	-2.5	2.5
Average weekly red wine intake	3.5	5.2	9.7	-2.0	-1.2	2.5	0.5	3.1	3.0	-2.5
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.2	-0.4	-0.2	-1.1	-0.7	0.6	0.3	0.0
Mood swings	1.7	3.1	9.3	-1.4	-0.2	0.7	0.4	3.0	2.4	-2.1
Loneliness, isolation	0.5	0.6	2.0	-0.0	1.0	-1.4	1.1	-0.3	0.3	0.1
Long-standing illness, disability or infirmity	0.9	1.4	3.1	1.8	0.1	-1.2	1.0	-0.6	-1.1	1.7
Ever had bowel cancer screening	0.8	0.9	2.5	0.3	1.2	-1.3	0.1	-1.6	-0.8	0.5
Diabetes diagnosed by doctor	0.4	0.6	1.1	0.6	0.5	-1.1	0.8	-0.6	-0.9	0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.6	1.0	0.8	-1.0	1.6	-1.3	-0.3	0.7
Friendships satisfaction	1.4	1.8	4.8	-1.4	0.8	0.3	0.9	1.5	2.2	-1.4
Qualifications: nursing, teaching	0.9	1.4	3.0	-1.4	1.2	1.1	1.7	0.1	1.1	-1.0
Commuting to job workplace: Walk	0.4	0.5	1.1	0.8	-1.1	1.0	0.2	-0.0	0.1	0.8
Eye problems/disorders: Cataract	0.5	0.6	3.1	-0.5	-0.2	0.1	-0.4	1.8	0.3	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.2	-0.9	0.8	-0.4	-0.5	0.1	1.1	-0.4
Medication for cholesterol	0.6	0.9	1.9	1.1	-1.4	0.3	-1.2	-0.5	-0.7	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.8	0.9	0.4	0.7	0.6	-0.7	-0.3	0.3
Back pain experienced in last month	1.3	2.0	4.4	1.4	1.4	-1.0	1.3	-2.1	-1.0	1.3
Mineral and other dietary supplements	2.1	2.8	6.8	-1.5	-1.6	0.8	0.0	2.6	1.7	-2.1
Breast cancer (self-reported)	0.6	0.8	1.8	-1.3	0.4	0.3	0.6	0.8	1.0	-1.1
Asthma (self-reported)	0.4	0.8	2.8	-0.1	-1.7	-0.2	-1.4	1.0	-0.0	-0.1
Osteoporosis (self-reported)	0.5	0.7	3.1	-0.5	0.4	0.7	1.8	0.3	0.7	-0.4
Osteoarthritis (self-reported)	0.1	0.2	0.5	0.7	-0.3	-0.1	-0.4	-0.1	-0.2	0.7
Medication: Aspirin	0.9	1.2	2.2	1.3	-1.1	-1.0	-0.2	-0.5	-1.5	1.3
Medication: Gliclazide	0.5	0.6	2.2	0.1	0.5	-1.5	-0.8	-0.3	-0.9	0.5
Illnesses of father: None of the above (group 1)	1.3	1.6	4.4	-0.6	1.9	0.3	2.1	-0.7	1.3	-1.0
Smoking status: Current	1.5	2.5	9.3	0.5	2.1	-0.5	3.1	-1.4	-0.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	4.8	-0.8	-0.3	2.2	-1.0	1.3	0.3	-0.7
Whole body water mass	0.5	3.1	6.5	-0.3	-0.2	2.5	1.9	2.6	2.2	-0.6
Leg predicted mass (right)	0.2	1.2	2.8	0.1	-0.7	1.4	1.2	1.7	1.2	0.0
Arm fat mass (left)	0.4	1.8	3.1	1.5	0.7	-1.8	1.0	-1.5	-1.1	1.6
Number of self-reported non-cancer illnesses	0.1	0.2	0.8	0.3	0.1	-0.9	0.3	0.6	-0.1	0.1
Average weekly champagne plus white wine intake	0.2	0.3	1.6	-0.2	-1.3	0.4	-0.0	0.4	0.1	-0.4
Miserableness	0.7	1.2	2.1	-0.9	0.7	-0.7	1.0	1.5	1.4	-1.3
Guilty feelings	0.3	0.4	0.9	-0.4	0.5	-0.6	-0.9	0.9	0.5	-0.5
Wears glasses or contact lenses	1.0	1.2	4.8	-0.3	-0.5	2.2	-0.6	1.2	1.1	-0.5
Ever taken oral contraceptive pill	0.5	0.6	1.3	-1.1	0.0	0.7	0.6	0.6	0.5	-1.1
Hearing aid user	0.3	0.3	1.8	0.5	-0.4	1.3	0.3	0.1	-0.0	0.1
Mother’s age at death	0.6	0.7	1.8	-0.0	-0.3	-1.3	-1.4	-0.7	-0.9	0.3
Financial situation satisfaction	0.4	0.5	1.6	0.5	-0.3	0.9	-0.7	1.2	0.2	-0.0
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.3	0.7	1.5	-0.1	-0.1	-0.5	-1.2	1.1
Commuting to job workplace: Public transport	1.2	1.4	2.9	1.4	-0.4	0.4	0.5	-1.2	-1.7	1.6
Eye problems/disorders: Glaucoma	1.4	1.6	3.0	-1.5	0.0	-0.4	-1.0	1.7	1.5	-1.7
Medication: Blood pressure	0.3	0.6	1.6	0.9	-1.3	0.3	-0.5	0.4	-0.7	0.7
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.8	1.3	-0.4	0.6	0.6	-1.0	-0.8	1.4
Supplements: Fish oil (including cod liver oil)	1.7	2.2	5.7	1.5	1.0	-0.9	-0.4	-2.4	-1.7	1.7
High cholesterol (Self-reported)	0.6	1.0	2.6	-1.2	0.8	-0.1	0.5	1.1	1.0	-1.6
Medication: Bendroflumethiazide	0.3	0.4	2.0	0.4	-1.4	-0.1	-0.5	-0.1	-0.6	0.4
Medication: Paracetamol	0.5	0.7	2.1	0.6	0.3	1.3	1.5	-0.3	-0.7	0.3
Medication: Lisinopril	3.7	4.8	8.1	-1.5	-2.1	2.8	-0.6	2.8	2.2	-2.3
Medication: Atorvastatin	0.7	0.8	5.0	0.2	-0.4	-0.6	2.2	0.5	0.2	0.2
Illnesses of father: High blood pressure	0.4	0.5	2.0	0.2	-0.3	1.0	-0.2	1.4	0.3	0.3
Alcohol drinker status: Never	1.1	1.4	2.3	-1.4	0.3	0.3	1.0	1.4	1.5	-1.5
Ever smoked	0.3	0.6	2.2	-0.0	-0.1	-1.0	1.5	-0.4	0.0	0.8
Basal metabolic rate	0.4	2.0	3.8	-0.0	-0.0	1.9	1.9	1.9	1.7	-0.2
Leg fat percentage (left)	0.7	2.7	4.2	1.9	0.2	-1.8	0.8	-2.1	-1.9	1.8
Arm fat-free mass (left)	0.4	2.0	4.5	0.2	-0.0	2.1	2.0	1.8	1.6	-0.1
Number of operations (self-reported)	0.4	0.6	2.1	0.1	1.1	0.0	1.4	0.1	0.7	0.1
Average weekly beer plus cider intake	0.7	1.0	1.9	0.8	0.4	-1.2	-0.4	-1.3	-1.4	0.9
Irritability	2.5	4.3	9.1	-2.3	-0.3	1.2	0.0	3.0	3.0	-2.3
Risk taking	2.2	3.2	9.8	-0.4	3.1	-1.5	2.7	-1.2	1.1	-0.3
Ever had prostate specific antigen (PSA) test	0.8	0.9	4.2	-0.1	2.1	-0.8	1.0	-0.6	-0.0	-0.2
Fractured/broken bones in last 5 years	2.9	3.8	9.6	3.1	0.5	-0.8	0.1	-1.7	-2.3	2.8
Age started oral contraceptive pill	0.2	0.3	0.7	-0.6	0.4	0.4	-0.7	0.2	0.1	-0.9
Diastolic blood pressure, automated reading	0.1	0.3	1.1	-0.2	-1.0	-0.2	0.4	0.8	-0.2	0.0
Ever depressed for a whole week	1.0	1.2	2.3	1.5	1.1	0.3	0.8	-1.1	-0.8	1.5
Unable to work because of sickness or disability	0.4	0.5	2.8	0.0	0.5	-0.3	1.7	-0.2	-0.1	-0.3
Commuting to job workplace: Cycle	0.2	0.3	0.7	0.4	-0.5	0.4	0.7	-0.4	-0.4	0.8
Myopia	0.7	1.1	2.4	-1.6	-1.1	0.4	-0.5	1.1	0.7	-1.4
Vascular/heart problems diagnosed by doctor	0.8	2.3	8.6	-1.1	2.9	-0.9	1.4	-1.7	0.8	-0.5
Cholesterol lowering medication	0.5	0.8	3.6	0.0	0.8	-0.8	1.9	-0.4	-0.7	0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.5	0.3	-0.1	-1.2	0.2	-0.5	-0.8	0.4
Pain experienced in last month	0.2	0.3	0.8	-0.1	-0.9	0.3	-0.9	0.3	-0.1	0.1
Supplements: Calcium	0.5	0.5	3.0	-0.2	-0.2	1.7	0.1	0.6	0.5	-0.2
Basal cell carcinoma (self-reported)	0.2	0.2	1.0	0.3	1.0	-0.1	0.2	0.1	-0.3	0.3
Heart attack/myocardial infarction (self-reported)	1.1	1.5	2.3	1.1	-1.5	-1.5	-1.3	-0.4	-1.1	1.2
Deep venous thrombosis (DVT) (self-reported)	5.7	7.3	13.3	2.9	0.0	-2.6	-1.4	-3.6	-3.4	3.1
Heart disease (siblings)	0.1	0.1	0.1	0.3	0.4	0.3	-0.1	-0.2	0.4	-0.1
Alcohol drinker status: Previous	0.8	0.9	4.0	-0.4	1.3	-2.0	0.5	0.1	-0.1	-0.4
Pack years of smoking	2.1	3.0	5.5	2.3	-0.3	-1.2	0.5	-2.3	-1.8	2.3
Impedance of whole body	0.4	1.9	5.1	-1.5	-0.8	-2.3	-2.1	-0.3	0.3	-0.9
Leg fat mass (left)	0.5	1.8	3.0	1.7	-0.0	-1.4	0.9	-1.3	-1.4	1.7
Arm predicted mass (left)	0.4	2.1	4.7	0.2	-0.0	2.2	2.0	1.8	1.6	-0.1