Best TWAS P=1.08e-11 · Best GWAS P=8.05e-10 conditioned to 0.00628
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Caudate basal ganglia | KIF1B | 0.25 | 0.00 | lasso | 5 | 0.02 | 1.1e-01 | 5.5 | 6.8 | 1.1e-11 | -0.57 | 0.04 | 0.44 | TRUE |
| 2 | GTEx | Esophagus Mucosa | KIF1B | 0.10 | 0.00 | enet | 17 | 0.01 | 1.2e-01 | 4.4 | 6.4 | 1.7e-10 | -0.66 | 0.10 | 0.58 | FALSE |
| 3 | NTR | Blood | KIF1B | 0.11 | 0.08 | enet | 11 | 0.09 | 3.7e-28 | -5.6 | -6.3 | 2.9e-10 | 0.95 | 0.01 | 0.99 | FALSE |
| 4 | YFS | Blood | KIF1B | 0.30 | 0.26 | enet | 49 | 0.29 | 7.8e-97 | -5.6 | -6.0 | 1.7e-09 | 0.91 | 0.03 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CORT | 0.06 | 0.03 | enet | 5 | 0.04 | 7.1e-04 | 4.0 | -5.8 | 5.2e-09 | 0.24 | 0.04 | 0.82 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PEX14 | 0.07 | 0.00 | enet | 19 | 0.01 | 5.2e-02 | -4.5 | 5.5 | 4.1e-08 | -0.41 | 0.06 | 0.35 | FALSE |
| 5 | The Cancer Genome Atlas | Glioblastoma Multiforme | PEX14 | 0.12 | 0.00 | blup | 123 | 0.05 | 9.9e-03 | 5.8 | -5.3 | 1.4e-07 | 0.26 | 0.01 | 0.74 | FALSE |