TWAS hub - CORT

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Bladder Urothelial Carcinoma	0.040	0.021	4.2e-03	0.052	0.027	0.034	NA	0.042	3.4e-05	0.0022	0.00064	NA	1.7e-04
2	TCGA	Ovarian Serous Cystadenocarcinoma	0.125	0.059	4.2e-05	0.074	0.037	0.034	NA	0.058	1.0e-05	0.0015	0.00240	NA	9.3e-05
3	TCGA	Stomach Adenocarcinoma	0.062	0.032	4.4e-04	0.032	0.035	0.040	NA	0.034	2.0e-03	0.0014	0.00071	NA	1.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Breast Cancer	14.1	33.9	59.1	-4.9	-4.3	-7.7
Hand grip strength (right)	8.1	22.1	34.1	-4.0	-4.1	-5.8
Hand grip strength (left)	7.7	20.3	27.2	-4.1	-4.1	-5.2
Medication: Ventolin 100micrograms inhaler	6.2	8.0	10.2	2.7	2.5	3.2
Pain all over the body in last month	6.1	6.6	7.3	2.7	2.4	2.6
Medication: Atorvastatin	6.0	7.4	7.6	2.7	2.7	2.8
Asthma	5.4	10.7	19.2	2.5	2.6	4.4
Hair/balding pattern: Pattern 4	5.3	13.0	19.4	3.1	3.1	4.4
Relative age of first facial hair	4.9	10.0	11.0	-3.0	-3.2	-3.3
Asthma (self-reported)	4.9	9.8	17.9	2.4	2.4	4.2
Blood White Count	4.8	35.8	43.3	5.6	5.7	6.6
Allergy	4.6	10.6	19.0	-2.5	-2.5	-4.4
Alcohol intake versus 10 years previously	4.6	6.9	9.4	2.6	3.1	2.2
Ever had prostate specific antigen (PSA) test	4.4	5.1	9.8	1.7	1.6	3.1
Average weekly spirits intake	4.2	5.2	6.2	2.5	2.5	1.9
Respiratory disease	4.1	9.1	17.3	2.2	2.3	4.2
Breast cancer (self-reported)	3.6	4.3	8.0	1.6	1.5	2.8
Allergy or Eczema	3.5	9.2	13.8	2.6	2.7	3.7
Severe depression (siblings)	3.5	3.9	5.3	-2.3	-2.2	-1.3
Hair/balding pattern: Pattern 3	3.5	5.2	6.0	2.3	2.4	2.0
Mean Putamen Volume	3.4	3.9	6.2	1.8	1.4	2.5
Pulse rate, automated reading	3.4	11.1	12.3	-3.5	-3.4	-3.1
Sensitivity / hurt feelings	3.3	5.7	7.1	-2.7	-2.4	-2.1
Tinnitus: Yes, now most or all of the time	3.3	3.9	4.8	-1.8	-2.2	-1.9
Current tobacco smoking	3.2	5.3	6.7	-2.6	-2.4	-1.9
Smoking status: Current	3.2	5.0	6.4	-2.5	-2.3	-1.9
Miserableness	3.2	5.5	7.4	-2.7	-2.4	-1.9
Prostate Cancer	3.0	4.2	6.3	1.8	1.8	2.5
Hayfever, allergic rhinitis or eczema	3.0	6.5	10.2	2.2	2.0	3.2
Depressed Affect (Nagel 2018)	2.9	6.2	7.7	-2.8	-2.7	-1.9
Bilateral oophorectomy (both ovaries removed)	2.8	3.2	3.3	-1.8	-1.8	-1.8
Time employed in main current job	2.8	3.2	4.5	1.8	2.1	1.3
Impedance of arm (left)	2.8	12.9	23.4	2.8	2.7	4.8
Impedance of arm (right)	2.7	12.5	23.2	2.8	2.6	4.8
Risk taking	2.7	3.9	5.1	-2.3	-1.9	-1.7
Impedance of whole body	2.7	13.8	24.0	3.0	2.9	4.9
Lung FVC	2.6	13.2	19.5	-3.4	-2.9	-4.4
Chronic bronchitis/emphysema (father)	2.6	3.0	6.6	1.1	1.1	2.6
Pulse rate	2.6	4.4	5.0	-2.2	-2.0	-2.0
Commuting to job workplace: Cycle	2.6	3.1	4.1	1.9	2.0	1.2
Loneliness, isolation	2.5	3.4	3.6	-1.8	-1.9	-1.9
High cholesterol (Self-reported)	2.5	4.4	5.6	2.0	2.0	2.4
Medication for cholesterol, blood pressure or diabetes	2.4	3.9	4.2	-1.9	-1.9	-2.0
Mood swings	2.4	4.3	5.7	-2.4	-2.0	-1.8
Vascular/heart problems diagnosed by doctor	2.4	6.5	8.2	-2.8	-2.9	-1.8
Number of children fathered	2.3	2.6	3.2	1.4	1.8	1.6
Average weekly fortified wine intake	2.2	2.5	2.9	-1.5	-1.6	-1.7
Had major operations	2.2	2.5	5.2	1.3	0.9	2.3
Smoking status: Previous	2.2	3.3	3.6	1.9	1.7	1.8
Cardiovascular Disease	2.1	7.1	8.3	2.8	2.9	2.3
Pack years adult smoking proportion	2.0	3.1	3.2	-1.8	-1.7	-1.8
Long-standing illness, disability or infirmity	2.0	3.1	4.7	1.5	1.5	2.2
Irritability	2.0	3.5	3.9	-1.9	-1.7	-2.0
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	3.2	1.5	1.8	1.4
Medication: Cholesterol lowering	1.9	2.9	4.2	1.5	1.5	2.0
Trunk predicted mass	1.9	10.8	12.7	-3.0	-3.3	-3.6
Hypothyroidism/myxoedema (self-reported)	1.9	3.8	5.9	1.6	1.7	2.4
Neck or shoulder pain in last month	1.9	2.7	2.8	-1.7	-1.6	-1.7
Medication: Blood pressure	1.9	3.4	4.4	1.8	2.1	1.6
Illnesses of father: Heart disease	1.9	2.6	2.8	-1.6	-1.6	-1.7
Trunk fat-free mass	1.8	10.4	12.5	-2.9	-3.2	-3.5
Impedance of leg (left)	1.7	8.1	13.5	2.3	2.3	3.7
Hypertension (Self-reported)	1.7	4.6	6.4	2.4	2.5	1.4
Number of self-reported non-cancer illnesses	1.7	2.9	4.7	1.4	1.4	2.2
Neuroticism (Nagel 2018)	1.6	3.9	5.6	-2.4	-2.2	-1.1
Whole body water mass	1.6	8.9	9.8	-2.8	-3.0	-3.1
Pain type(s) experienced in last month: Hip pain	1.6	2.1	2.6	-1.6	-1.3	-1.4
Arm predicted mass (left)	1.6	8.1	9.7	-2.6	-2.8	-3.1
LDL Cholesterol	1.5	2.3	4.5	1.1	1.1	2.1
Neuroticism	1.5	3.6	4.8	-2.2	-2.2	-1.1
Hair Pigment	1.5	41.5	50.7	-6.0	-6.1	-7.1
Illnesses of siblings	1.5	2.1	2.7	-1.6	-1.6	-1.0
Peak expiratory flow (PEF)	1.5	3.5	4.2	-2.0	-1.9	-1.7
Arm fat-free mass (right)	1.5	7.9	8.6	-2.7	-2.8	-2.9
Worry too long after embarrassment	1.5	2.5	4.1	-1.7	-2.0	-0.7
Arm predicted mass (right)	1.5	7.7	8.4	-2.6	-2.8	-2.9
Whole body fat-free mass	1.5	8.8	9.8	-2.8	-3.0	-3.1
Medication: Aspirin	1.5	1.9	2.8	1.1	1.3	1.7
Hearing aid user	1.5	1.6	3.5	0.8	0.9	1.9
Pack years of smoking	1.5	2.2	2.4	-1.5	-1.4	-1.5
Hearing difficulty/problems: Yes	1.4	2.2	2.9	1.7	1.7	0.9
Impedance of leg (right)	1.4	6.9	12.4	2.1	2.0	3.5
Fed-up feelings	1.4	2.5	3.0	-1.7	-1.7	-1.3
Neuroticism score	1.4	2.8	3.9	-2.0	-1.9	-1.0
Pulse wave reflection index	1.4	1.7	2.1	1.3	1.4	1.2
Headache pain in last month	1.4	2.5	3.0	-1.7	-1.5	-1.4
Birth weight	1.4	3.1	4.6	-2.0	-2.1	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	2.2	-1.2	-1.5	-1.2
Arm fat-free mass (left)	1.4	7.1	8.1	-2.4	-2.7	-2.9
High blood pressure	1.3	3.8	5.2	2.2	2.3	1.1
Hearing difficulty/problems with background noise	1.3	2.0	2.9	1.5	1.7	0.9
Financial difficulties in last 2 years	1.3	1.7	2.2	-1.2	-1.3	-1.5
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.3	-1.5	-1.3	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.4	-1.2	-1.6	-0.4
Leg fat-free mass (left)	1.2	6.5	7.3	-2.5	-2.7	-2.4
Taking other prescription medications	1.2	1.9	4.7	0.6	0.8	2.2
Leg predicted mass (left)	1.2	6.1	6.9	-2.4	-2.6	-2.4
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	2.1	-1.4	-1.3	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	4.3	-2.0	-1.9	-2.1
Leg fat-free mass (right)	1.2	6.3	6.6	-2.4	-2.6	-2.5
Mineral and other dietary supplements	1.2	1.7	2.8	1.3	1.7	0.8
Basal metabolic rate	1.2	6.9	7.5	-2.5	-2.7	-2.6
Smoking Status	1.1	2.5	3.7	-1.9	-1.6	-1.1
Nervous feelings	1.1	2.0	2.3	1.3	1.5	1.5
Medication: Aspirin	1.1	1.5	2.2	1.0	1.2	1.5
Knee pain experienced in last month	1.1	1.7	2.1	-1.4	-1.5	-1.1
Leg predicted mass (right)	1.1	6.0	6.2	-2.3	-2.5	-2.5
Financial situation satisfaction	1.1	1.3	1.6	-1.1	-1.2	-1.2
Relative age voice broke	1.0	1.6	2.2	-1.1	-1.1	-1.5
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	3.7	-1.8	-1.7	-1.9
Overall health rating	1.0	2.2	2.8	1.3	1.7	1.4
Commuting to job workplace: Public transport	1.0	1.2	1.7	1.3	1.2	0.6
Average weekly beer plus cider intake	1.0	1.4	1.7	-1.3	-1.2	-1.1
Waist Hip Ratio (WHR)	0.9	4.2	6.5	1.9	1.6	2.5
Hypothyroidism (self reported)	0.9	2.0	4.8	0.7	0.8	2.2
Lung FEV1/FVC ratio	0.9	4.8	6.4	-2.5	-2.5	-1.3
Ever had hysterectomy (womb removed)	0.9	1.0	1.4	-1.2	-1.2	-0.4
Diabetes (father)	0.9	1.1	1.9	-1.1	-1.4	-0.6
Age when periods started (menarche)	0.9	2.1	2.4	-1.5	-1.4	-1.4
Qualifications: CSEs or equivalent	0.9	1.2	1.3	-1.1	-1.2	-1.1
Medication: Atenolol	0.9	1.2	1.8	0.9	0.9	1.3
Depression (self-reported)	0.9	1.1	1.6	1.1	1.3	0.7
Medication: Amlodipine	0.9	1.3	1.9	1.2	1.4	0.7
Forced vital capacity (FVC), Best measure	0.9	3.5	4.5	-1.8	-1.7	-2.1
Comparative body size at age 10	0.9	2.5	3.6	-1.9	-1.7	-0.9
Leg pain on walking	0.9	1.2	1.3	-1.1	-1.1	-1.0
Average weekly champagne plus white wine intake	0.9	1.2	1.6	-1.3	-1.1	-0.9
Medication: Bendroflumethiazide	0.9	1.3	2.3	1.2	1.5	0.5
Medication: Lisinopril	0.9	1.1	1.6	1.1	1.3	0.7
Alcohol drinker status: Never	0.9	1.1	1.5	-1.1	-1.2	-0.7
Myopia	0.9	1.3	1.6	1.3	1.1	1.0
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.4	-1.0	-1.2	-0.4
Medication: Levothyroxine sodium	0.8	1.4	2.7	0.8	0.9	1.6
Past tobacco smoking	0.8	1.5	1.7	-1.2	-1.3	-1.2
Diabetes (self-reported)	0.8	1.2	2.0	0.9	0.9	1.4
Medication: Lansoprazole	0.8	1.0	1.3	1.1	0.6	1.1
Health satisfaction	0.8	1.0	1.6	-1.0	-0.6	-1.2
Body Mass Index (BMI) (2010)	0.7	1.0	1.6	-1.2	-1.0	-0.5
Lupus	0.7	1.1	1.2	1.1	0.9	1.1
Heel T-Score	0.7	5.4	13.5	1.1	1.2	3.7
Medication: Co-codamol	0.7	0.8	1.2	-1.0	-1.1	-0.3
Trunk fat percentage	0.7	2.6	6.5	0.9	0.8	2.5
Maternal smoking around birth	0.7	1.0	1.6	1.3	1.1	0.4
Number of incorrect matches in round	0.7	1.1	1.2	1.0	1.1	1.0
Heart attack	0.7	0.9	1.6	0.7	0.8	1.3
Mouth/teeth dental problems: Dentures	0.7	1.1	2.6	-0.7	-0.5	-1.6
Exposure to tobacco smoke at home	0.7	0.8	1.8	-0.4	-0.6	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.6	-1.2	-1.3	-0.5
Medication: Seretide 50 evohaler	0.7	0.8	0.8	0.9	0.8	0.9
Illnesses of siblings: Diabetes	0.7	0.9	1.2	0.8	0.9	1.1
Diabetes diagnosed by doctor	0.7	1.1	2.6	0.5	0.7	1.6
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.2	0.7	0.9	1.1
Bipolar Disorder or Schizophrenia	0.6	1.4	1.8	1.4	1.2	0.9
HbA1C	0.6	0.6	0.8	0.9	0.9	0.7
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.2	-0.9	-1.1	-0.6
Medication: Metformin	0.6	0.9	2.2	0.6	0.3	1.5
Stomach or abdominal pain in last month	0.6	0.8	1.0	-1.0	-1.0	-0.7
Forced vital capacity (FVC)	0.6	2.2	2.6	-1.4	-1.4	-1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.0	0.7	0.8	1.7
Qualifications: None of the above	0.6	1.3	1.4	1.1	1.2	1.1
Comparative height size at age 10	0.6	3.5	6.4	1.5	1.4	2.5
Eye problems/disorders: Cataract	0.6	0.8	1.1	-0.7	-0.8	-1.1
Osteoporosis (self-reported)	0.6	0.8	0.9	-0.9	-0.8	-1.0
Bipolar Disorder (2018)	0.5	0.8	1.2	1.1	0.9	0.6
Neuroticism (2016)	0.5	0.7	1.0	-1.0	-0.8	-0.7
Blood Red Count	0.5	5.3	5.9	2.1	2.4	2.4
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.8	0.6	0.6	1.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.2	-0.8	-1.1	-0.4
Body fat percentage	0.5	1.9	4.8	0.6	0.6	2.2
Wheeze or whistling in the chest in last year	0.5	0.9	2.5	0.3	0.3	1.6
Ever had bowel cancer screening	0.5	0.5	0.8	-0.9	-0.9	-0.0
Friendships satisfaction	0.5	0.7	0.9	1.0	1.0	0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.3	-0.8	-1.1	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.9	0.3	0.3	1.4
Alcohol drinker status: Previous	0.5	0.6	0.8	-0.9	-0.9	-0.5
Bipolar Disorder (2011)	0.4	0.4	0.6	0.8	0.8	0.2
Rheumatoid Arthritis	0.4	0.5	0.8	-0.6	-0.6	-0.9
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.8	-0.6	-0.5	-0.9
Blood Eosinophil Count	0.4	3.2	4.3	1.3	1.9	2.1
BMI	0.4	2.2	2.8	-1.7	-1.7	-1.0
Medication for hormone replacement therapy	0.4	0.4	0.6	-0.7	-0.8	-0.4
Supplements: Zinc	0.4	0.5	0.9	0.5	0.4	1.0
Diabetes (mother)	0.4	0.5	0.8	0.9	0.8	-0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.1	-0.3	-0.5	1.0
Weight	0.4	1.8	2.6	-1.4	-1.6	-0.9
Falls in the last year	0.4	0.6	0.7	-0.7	-0.8	-0.8
Number of live births	0.4	0.6	0.9	-1.0	-0.9	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.8	0.9	0.7	0.2
Length of working week for main job	0.4	0.4	0.6	0.7	0.6	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.6	0.6	0.8	0.7
Medication: Ibuprofen	0.4	0.4	0.5	-0.7	-0.6	-0.7
Chest pain or discomfort	0.4	0.5	0.7	-0.8	-0.9	-0.4
Family relationship satisfaction	0.4	0.5	0.6	0.7	0.8	0.6
Supplements: Vitamin C	0.4	0.5	0.9	-0.6	-1.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.2	-0.7	-0.9	-1.1
Commuting to job workplace: Walk	0.4	0.4	1.0	-0.3	-0.1	-1.0
Wears glasses or contact lenses	0.4	0.4	0.6	-0.5	-0.7	-0.8
Ever smoked	0.4	0.7	0.8	0.6	0.9	0.9
Number of operations (self-reported)	0.4	0.6	1.0	-0.7	-1.0	0.6
Unable to work because of sickness or disability	0.4	0.5	0.6	0.8	0.6	0.7
Pain experienced in last month	0.4	0.7	0.8	0.9	0.7	0.9
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.2	1.0	1.1	0.7
Schizophrenia (2018)	0.3	0.7	0.7	0.9	0.9	0.7
Crohns Disease (2017)	0.3	0.6	0.8	0.8	0.6	0.9
Irritable Bowel Disease (IBD)	0.3	0.6	0.9	0.7	0.6	1.0
Reaction Time	0.3	0.5	1.2	-0.6	-1.1	0.1
Number of treatments/medications taken	0.3	0.6	1.2	0.5	0.5	1.1
Systolic blood pressure, automated reading	0.3	0.8	2.3	0.0	0.1	-1.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.6	0.8	0.5	0.5
Body mass index (BMI)	0.3	1.1	1.3	-1.1	-1.1	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.7	-0.6	-0.4	-0.8
Lung cancer (father)	0.3	0.3	0.7	-0.0	0.4	0.9
Breastfed as a baby	0.3	0.3	1.0	-0.1	-0.1	-1.0
Glaucoma (self-reported)	0.3	0.3	0.6	0.8	0.5	0.4
High blood pressure (siblings)	0.3	0.4	0.7	0.8	0.8	0.2
Angina (self-reported)	0.3	0.3	0.4	-0.6	-0.6	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.5	0.6	0.2	0.7
Number of full sisters	0.3	0.3	0.5	0.6	0.4	0.7
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.8	0.3	0.2	0.9
Illnesses of father: None of the above (group 1)	0.3	0.4	0.7	0.7	0.8	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	0.7	-0.8	-0.7	-0.8
Guilty feelings	0.3	0.5	1.2	-0.2	-0.4	1.1
Fractured/broken bones in last 5 years	0.3	0.3	0.5	-0.7	-0.7	0.1
Major Depression (MDD)	0.2	0.3	0.8	-0.2	-0.0	-0.9
Coronary Artery Disease (CAD)	0.2	0.2	0.4	0.6	0.5	-0.3
Crohns Disease (2012)	0.2	0.3	0.4	-0.6	-0.7	0.0
Primary Biliary Cirrhosis	0.2	0.2	0.6	0.2	0.2	0.8
Schizophrenia (2014)	0.2	0.5	0.7	0.7	0.8	0.6
Ulcerative Colitis	0.2	0.3	0.5	-0.7	-0.5	-0.4
Systolic Blood Pressure	0.2	0.8	2.3	-0.0	-0.1	-1.5
Vitamin and mineral supplements	0.2	0.3	0.8	-0.4	0.0	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	1.5	-0.2	-0.3	1.2
Multivitamins +/- minerals	0.2	0.3	0.8	0.3	0.0	0.9
Sitting height	0.2	1.6	1.8	-1.1	-1.3	-1.4
High blood pressure (mother)	0.2	0.2	0.4	0.5	0.6	0.2
Alcohol usually taken with meals	0.2	0.3	0.5	-0.5	-0.5	-0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.3	-0.4	-0.5	-0.6
Arm fat percentage (right)	0.2	0.7	2.0	0.3	0.3	1.4
Hip circumference	0.2	0.7	1.2	-0.9	-1.1	-0.0
Worrier / anxious feelings	0.2	0.4	0.6	0.5	0.5	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.5	-0.6	-0.7	0.3
Happiness	0.2	0.2	0.3	-0.3	-0.5	-0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.6	0.6	0.7	0.6
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	0.4	0.6	0.4
Blood clot in the leg (DVT)	0.2	0.3	0.7	-0.2	-0.1	0.9
Leg fat percentage (right)	0.2	0.6	1.6	0.2	0.0	1.3
Exposure to tobacco smoke outside home	0.2	0.3	1.0	-0.1	-0.1	-1.0
Pulse wave peak to peak time	0.2	0.3	0.4	-0.4	-0.6	-0.4
Qualifications: College or University degree	0.2	0.6	1.4	0.5	0.4	1.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	0.5	0.6	-0.3
Emphysema/chronic bronchitis	0.2	0.3	0.8	0.2	0.1	0.9
Arm fat percentage (left)	0.2	0.7	2.1	0.2	0.2	1.5
Back pain experienced in last month	0.2	0.3	0.6	0.5	0.8	0.3
Osteoarthritis (self-reported)	0.2	0.2	0.5	-0.4	-0.7	-0.2
Ever taken oral contraceptive pill	0.2	0.2	0.3	-0.3	-0.5	-0.5
Eye problems/disorders: Glaucoma	0.2	0.2	0.5	0.7	0.5	0.1
Leg fat percentage (left)	0.2	0.6	1.7	0.3	0.2	1.3
Diastolic blood pressure, automated reading	0.2	0.7	1.9	-0.2	-0.3	-1.4
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	0.3	0.3	0.7
Depression (Nagel 2018)	0.1	0.2	0.4	-0.5	-0.6	-0.1
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.2	0.2	0.5
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.2	-0.3	-0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.2	-0.0	0.4
Ulcerative Colitis (UC)	0.1	0.1	0.3	0.3	0.2	0.6
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.4	0.6	0.6	-0.4
Ovarian Cancer	0.1	0.1	0.3	-0.3	-0.3	-0.5
Age at First Birth	0.1	0.1	0.4	0.3	0.1	-0.6
Fasting Glucose	0.1	0.2	0.4	-0.6	-0.2	-0.1
HDL Cholesterol	0.1	0.2	0.4	-0.4	-0.7	0.0
Height	0.1	1.2	1.6	1.1	0.9	1.3
Chronotype (morning person)	0.1	0.1	0.2	0.4	0.3	0.3
Tanning	0.1	0.7	1.0	-1.0	-0.7	-0.8
Townsend deprivation index at recruitment	0.1	0.1	0.2	-0.5	-0.2	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.2	-0.3	0.5
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.3	0.4	0.3
Supplements: Glucosamine	0.1	0.1	0.2	0.2	-0.0	-0.5
Trunk fat mass	0.1	0.5	1.5	-0.0	-0.1	1.2
Waist circumference	0.1	0.2	0.3	-0.4	-0.5	0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	-0.3	-0.3	-0.3
Had menopause	0.1	0.2	0.2	0.4	0.3	0.5
Had other major operations	0.1	0.2	0.2	-0.5	-0.4	0.3
Medication: Simvastatin	0.1	0.2	0.6	0.1	0.1	0.8
Fluid intelligence score	0.1	0.3	0.5	0.6	0.7	-0.3
Prospective memory result	0.1	0.1	0.2	0.1	-0.1	0.5
Illnesses of mother	0.1	0.1	0.1	-0.3	-0.3	0.3
Arm fat mass (right)	0.1	0.3	0.5	-0.6	-0.7	0.2
Standing height	0.1	1.2	2.1	-1.1	-1.5	-0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	-0.3	-0.3	-0.7
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	-0.3	-0.6	0.1
Medication: Paracetamol	0.1	0.2	0.3	-0.6	-0.4	-0.4
Gout (self-reported)	0.1	0.1	0.2	0.4	0.3	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.4	-0.5	-0.0
Shortness of breath walking on level ground	0.1	0.2	0.5	0.0	0.0	0.7
Medication for pain relief, constipation, heartburn	0.1	0.2	0.3	-0.3	-0.5	-0.5
Medication: Allopurinol	0.1	0.1	0.1	-0.3	-0.3	0.2
Mean time to correctly identify matches	0.1	0.2	0.3	-0.2	-0.4	0.6
Heart disease (mother)	0.1	0.1	0.1	0.3	-0.2	0.3
Whole body fat mass	0.1	0.3	0.8	-0.2	-0.3	0.9
Leg fat mass (right)	0.1	0.5	0.9	-0.8	-1.0	0.1
Suffer from ‘nerves’	0.1	0.1	0.2	-0.5	-0.3	0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.4	-0.5	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.4	-0.4	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	0.1	0.2	0.4
Medication for cholesterol	0.1	0.1	0.2	0.4	0.4	-0.0
Medication: Gliclazide	0.1	0.1	0.1	-0.0	-0.4	0.3
Arm fat mass (left)	0.1	0.4	0.6	-0.7	-0.8	0.2
Mother’s age at death	0.1	0.2	0.3	0.5	0.4	0.3
Illnesses of father: High blood pressure	0.1	0.1	0.1	-0.1	-0.3	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.1	0.3	0.3	0.4
Supplements: Calcium	0.1	0.2	0.4	-0.3	-0.6	0.0
Heart disease (siblings)	0.1	0.1	0.2	0.2	0.4	-0.5
Leg fat mass (left)	0.1	0.6	0.9	-0.8	-1.0	-0.0
Worry (Nagel 2018)	0.0	0.1	0.2	-0.1	0.0	0.5
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	0.2	0.0	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.1	0.2
Blood Platelet Count	0.0	0.2	0.3	0.5	0.4	-0.4
Angina	0.0	0.1	0.1	-0.3	-0.2	-0.2
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	-0.2	-0.0	-0.1
Mouth/teeth dental problems	0.0	0.1	0.1	-0.1	-0.3	0.2
Medication: Ramipril	0.0	0.0	0.1	0.1	0.2	0.3
Father’s age at death	0.0	0.0	0.1	0.3	0.2	0.1
Noisy workplace	0.0	0.1	0.1	-0.3	-0.2	0.2
Tense / ‘highly strung’	0.0	0.1	0.1	0.2	0.1	0.4
Birth weight of first child	0.0	0.0	0.1	-0.2	-0.1	0.2
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.2	-0.2	-0.2
Loud music exposure frequency	0.0	0.0	0.1	0.2	0.2	0.2
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.1	0.0	-0.3	0.0
Number of full brothers	0.0	0.0	0.1	-0.1	-0.3	-0.1
Age at first live birth	0.0	0.1	0.2	-0.1	0.1	-0.4
Eye problems/disorders: None of the above	0.0	0.0	0.0	0.1	-0.0	0.2
Migraine (self-reported)	0.0	0.0	0.0	-0.1	-0.1	0.2
Medication: Omeprazole	0.0	0.0	0.0	-0.0	0.1	0.0
Alcohol intake frequency.	0.0	0.1	0.2	-0.2	-0.3	-0.4
Age at last live birth	0.0	0.0	0.0	-0.1	-0.0	-0.2
Average weekly red wine intake	0.0	0.1	0.2	0.4	-0.1	0.2
Qualifications: nursing, teaching	0.0	0.0	0.0	-0.2	-0.1	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.1	-0.3	-0.2	-0.1
Medication: Blood pressure	0.0	0.0	0.0	-0.0	0.1	-0.1
Medication: Paracetamol	0.0	0.0	0.0	-0.2	-0.2	-0.1
Age started oral contraceptive pill	0.0	0.0	0.0	-0.0	-0.2	0.1
Ever depressed for a whole week	0.0	0.1	0.1	-0.2	-0.3	-0.2
Cholesterol lowering medication	0.0	0.1	0.1	-0.4	-0.3	0.1

Hub : Genes

CORT

Models

Trait associations