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chr3:52,020,411-53,860,103

Best TWAS P=1.38e-10 · Best GWAS P=2.29e-09 conditioned to 0.394

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
40	GTEx	Uterus	RFT1	0.52	0.30	enet	21	0.34	9.0e-08	5.4	6.4	1.4e-10	0.90	0.01	0.98	TRUE
1	CommonMind	Brain Pre-frontal Cortex	GNL3	0.15	0.07	bslmm	390	0.08	1.3e-09	4.2	-5.1	2.7e-07	-0.36	0.97	0.02	TRUE
19	GTEx	Cells Transformed fibroblasts	RFT1	0.22	0.21	enet	16	0.22	2.8e-16	5.9	6.3	3.0e-10	0.97	0.01	0.99	FALSE
38	GTEx	Thyroid	RFT1	0.36	0.33	enet	17	0.35	2.4e-27	6.0	6.3	3.2e-10	0.98	0.01	0.99	FALSE
6	GTEx	Adrenal Gland	RFT1	0.15	0.02	enet	11	0.03	4.0e-02	6.0	6.2	6.0e-10	0.94	0.02	0.93	FALSE
35	GTEx	Small Intestine Terminal Ileum	RFT1	0.20	0.20	enet	19	0.11	2.2e-03	5.9	6.1	8.4e-10	0.98	0.01	0.94	FALSE
10	GTEx	Artery Tibial	RFT1	0.40	0.38	enet	22	0.40	8.2e-33	5.9	6.1	8.7e-10	0.99	0.01	0.99	FALSE
20	GTEx	Colon Sigmoid	RFT1	0.55	0.45	enet	15	0.43	1.0e-16	6.0	6.0	1.5e-09	0.99	0.01	0.99	FALSE
18	GTEx	Breast Mammary Tissue (Male)	RFT1	0.23	0.12	enet	8	0.13	5.5e-04	6.0	6.0	1.6e-09	0.99	0.01	0.88	FALSE
37	GTEx	Testis	RFT1	0.20	0.12	enet	8	0.10	2.9e-05	5.9	6.0	1.7e-09	0.98	0.01	0.99	FALSE
13	GTEx	Brain Cerebellum	RFT1	0.72	0.60	enet	20	0.64	2.3e-24	6.0	6.0	1.8e-09	0.97	0.01	0.99	FALSE
50	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RFT1	0.23	0.09	blup	45	0.08	3.8e-04	5.7	6.0	1.9e-09	0.92	0.01	0.96	FALSE
5	GTEx	Adipose Visceral Omentum	RFT1	0.16	0.15	enet	12	0.10	1.0e-05	6.0	6.0	2.4e-09	0.97	0.01	0.99	FALSE
25	GTEx	Heart Atrial Appendage	RFT1	0.14	0.12	enet	16	0.10	4.4e-05	5.3	6.0	2.6e-09	0.91	0.02	0.96	FALSE
34	GTEx	Skin Sun Exposed Lower leg	RFT1	0.18	0.16	enet	7	0.13	1.1e-10	6.0	5.9	2.7e-09	1.00	0.01	0.99	FALSE
36	GTEx	Spleen	RFT1	0.23	0.22	enet	7	0.13	3.6e-04	6.0	5.9	2.7e-09	1.00	0.01	0.97	FALSE
29	GTEx	Nerve Tibial	RFT1	0.35	0.31	enet	17	0.27	1.9e-19	5.9	5.9	3.1e-09	0.99	0.01	0.99	FALSE
30	GTEx	Nerve Tibial	SFMBT1	0.21	0.10	enet	11	0.07	1.4e-05	5.9	-5.9	3.3e-09	-1.00	0.01	0.99	FALSE
47	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RFT1	0.15	0.21	lasso	8	0.22	1.4e-24	6.0	5.9	3.4e-09	0.98	0.01	0.99	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	SERBP1P3	0.47	0.57	lasso	7	0.60	4.3e-98	5.9	-5.9	3.5e-09	-0.98	0.01	0.99	FALSE
45	The Cancer Genome Atlas	Glioblastoma Multiforme	RFT1	0.20	0.14	enet	11	0.09	8.8e-04	5.9	5.9	3.7e-09	0.93	0.01	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RFT1	0.21	0.22	lasso	3	0.22	5.7e-26	6.0	5.9	3.8e-09	0.99	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	RFT1	0.25	0.30	lasso	4	0.29	3.8e-28	5.9	5.9	3.8e-09	0.99	0.01	0.99	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	RFT1	0.33	0.29	enet	27	0.23	1.2e-12	6.0	5.9	4.0e-09	0.96	0.01	0.99	FALSE
41	METSIM	Adipose	RFT1	0.13	0.19	lasso	7	0.18	7.8e-27	5.9	5.9	4.0e-09	1.00	0.01	0.99	FALSE
9	GTEx	Artery Coronary	RFT1	0.38	0.33	lasso	5	0.34	2.6e-12	5.9	5.9	4.4e-09	1.00	0.01	0.99	FALSE
15	GTEx	Brain Frontal Cortex BA9	RFT1	0.23	0.10	enet	17	0.10	1.4e-03	5.9	5.8	5.2e-09	0.94	0.01	0.96	FALSE
31	GTEx	Ovary	SFMBT1	0.24	0.10	enet	12	0.15	2.0e-04	5.4	-5.8	6.5e-09	-0.92	0.02	0.93	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	RFT1	0.26	0.16	lasso	4	0.10	1.1e-03	6.0	5.8	6.6e-09	0.98	0.01	0.95	FALSE
7	GTEx	Artery Aorta	RFT1	0.40	0.32	lasso	13	0.31	8.1e-18	5.9	-5.8	6.7e-09	-1.00	0.01	0.99	FALSE
14	GTEx	Brain Cortex	RFT1	0.31	0.17	enet	14	0.30	5.9e-09	6.0	5.8	7.0e-09	0.90	0.01	0.99	FALSE
28	GTEx	Muscle Skeletal	RFT1	0.17	0.16	enet	17	0.15	3.0e-14	6.0	5.8	8.8e-09	0.96	0.01	0.99	FALSE
11	GTEx	Brain Caudate basal ganglia	RFT1	0.30	0.23	enet	14	0.22	5.4e-07	6.0	5.7	1.0e-08	0.91	0.01	0.99	FALSE
23	GTEx	Esophagus Mucosa	RFT1	0.24	0.24	enet	10	0.22	6.2e-15	6.0	5.7	1.0e-08	0.98	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	RFT1	0.21	0.19	enet	24	0.17	3.7e-14	5.9	5.7	1.1e-08	0.98	0.01	0.99	FALSE
12	GTEx	Brain Cerebellar Hemisphere	RFT1	0.36	0.34	enet	19	0.33	2.4e-09	5.9	5.7	1.3e-08	0.97	0.01	0.99	FALSE
21	GTEx	Colon Transverse	RFT1	0.30	0.27	enet	16	0.24	8.0e-12	5.9	5.7	1.3e-08	0.97	0.01	0.99	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	RFT1	0.43	0.37	enet	18	0.34	7.0e-13	6.0	5.7	1.5e-08	0.97	0.01	0.99	FALSE
24	GTEx	Esophagus Muscularis	RFT1	0.46	0.45	enet	28	0.44	6.5e-29	5.9	5.7	1.6e-08	0.97	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	RFT1	0.22	0.28	enet	13	0.31	2.5e-36	5.9	5.6	1.8e-08	0.94	0.01	0.99	FALSE
26	GTEx	Lung	RFT1	0.24	0.23	enet	12	0.23	2.7e-17	6.0	5.6	2.6e-08	0.98	0.01	0.99	FALSE
32	GTEx	Prostate	RFT1	0.39	0.18	enet	17	0.24	1.1e-06	5.9	5.5	3.1e-08	0.87	0.01	0.98	FALSE
17	GTEx	Breast Mammary Tissue	RFT1	0.24	0.14	lasso	8	0.15	3.1e-08	5.7	5.5	4.1e-08	0.88	0.01	0.99	FALSE
8	GTEx	Artery Aorta	SFMBT1	0.16	0.10	enet	19	0.08	2.3e-05	5.9	-5.4	5.8e-08	-0.92	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RFT1	0.14	0.10	lasso	4	0.12	8.4e-14	6.0	5.4	6.3e-08	0.93	0.01	0.99	FALSE
27	GTEx	Muscle Skeletal	NEK4	0.07	0.03	lasso	5	0.03	9.6e-04	5.5	5.4	7.1e-08	0.75	0.22	0.63	FALSE
49	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RFT1	0.41	0.17	enet	12	0.16	2.4e-07	5.9	5.4	7.4e-08	0.93	0.01	0.99	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	RFT1	0.04	0.00	bslmm	304	0.02	3.2e-03	5.9	5.2	1.5e-07	0.86	0.01	0.96	FALSE
39	GTEx	Thyroid	SFMBT1	0.13	0.09	enet	13	0.10	6.3e-08	-3.6	-5.2	1.9e-07	-0.64	0.86	0.13	FALSE
4	GTEx	Adipose Subcutaneous	SFMBT1	0.10	0.02	lasso	7	0.03	2.9e-03	5.0	-5.2	2.3e-07	-0.84	0.09	0.84	FALSE
42	METSIM	Adipose	SFMBT1	0.04	0.04	lasso	1	0.03	3.5e-05	5.2	-5.2	2.5e-07	-0.85	0.05	0.95	FALSE