TWAS hub - NEK4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0690	0.0240	1.4e-13	0.108	0.111	0.114	0.108	0.085	5.0e-13	2.2e-13	1.0e-13	5.1e-13	1.8e-10
2	GTEx	Adipose Subcutaneous	0.0360	0.0180	1.6e-03	0.009	NA	0.002	NA	0.005	5.8e-02	NA	2.2e-01	NA	1.2e-01
3	GTEx	Adipose Visceral Omentum	0.1040	0.0460	2.0e-05	0.092	NA	0.050	NA	0.082	1.8e-05	NA	1.4e-03	NA	5.0e-05
4	GTEx	Artery Tibial	0.1132	0.0409	7.0e-08	0.096	NA	0.117	NA	0.111	5.5e-08	NA	2.1e-09	NA	5.0e-09
5	GTEx	Breast Mammary Tissue	0.0640	0.0340	4.4e-03	0.034	NA	0.056	NA	0.035	7.4e-03	NA	7.8e-04	NA	6.3e-03
6	GTEx	Breast Mammary Tissue (Female)	0.0194	0.0248	2.3e-01	-0.009	NA	0.009	NA	0.012	7.6e-01	NA	1.7e-01	NA	1.4e-01
7	GTEx	Cells Transformed fibroblasts	0.0680	0.0280	2.8e-06	0.111	NA	0.075	NA	0.084	1.1e-08	NA	2.7e-06	NA	7.2e-07
8	GTEx	Esophagus Mucosa	0.0540	0.0250	2.5e-04	0.029	NA	0.009	NA	0.017	5.0e-03	NA	7.3e-02	NA	2.4e-02
9	GTEx	Esophagus Muscularis	0.0610	0.0320	1.4e-03	0.000	NA	0.000	NA	0.018	3.0e-01	NA	3.4e-01	NA	2.8e-02
10	GTEx	Lung	0.0473	0.0210	2.2e-04	0.008	NA	0.000	NA	0.002	7.5e-02	NA	3.3e-01	NA	2.1e-01
11	GTEx	Muscle Skeletal	0.0677	0.0309	4.4e-04	0.033	NA	0.018	NA	0.027	3.4e-04	NA	6.8e-03	NA	9.6e-04
12	GTEx	Nerve Tibial	0.0609	0.0272	4.0e-05	0.060	NA	0.065	NA	0.055	4.3e-05	NA	2.2e-05	NA	8.8e-05
13	GTEx	Prostate	0.1480	0.0770	2.1e-03	0.053	NA	0.068	NA	0.048	1.9e-02	NA	8.9e-03	NA	2.4e-02
14	GTEx	Skin Sun Exposed Lower leg	0.0650	0.0260	1.7e-06	0.116	NA	0.081	NA	0.096	7.4e-10	NA	3.3e-07	NA	2.2e-08
15	GTEx	Thyroid	0.0870	0.0360	6.5e-07	0.089	NA	0.090	NA	0.101	2.4e-07	NA	2.2e-07	NA	4.1e-08
16	ROSMAP	Brain Pre-frontal Cortex	0.0380	0.0175	5.7e-06	0.045	0.047	0.036	0.045	0.038	1.6e-06	1.1e-06	1.9e-05	1.7e-06	9.6e-06
17	TCGA	Breast Invasive Carcinoma	0.0146	0.0118	7.6e-03	0.002	0.005	0.006	NA	0.003	1.0e-01	2.2e-02	2.0e-02	NA	7.8e-02
18	TCGA	Cervical Squamous Cell Carcinoma	0.0670	0.0620	7.8e-03	0.011	0.038	0.026	NA	0.029	8.8e-02	5.8e-03	1.8e-02	NA	1.4e-02
19	TCGA	Kidney Renal Clear Cell Carcinoma	0.0551	0.0262	2.6e-09	0.087	0.073	0.076	NA	0.084	5.6e-10	1.3e-08	6.6e-09	NA	1.1e-09
20	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0720	0.0500	6.0e-04	0.038	0.029	0.018	NA	0.027	3.1e-03	8.6e-03	3.3e-02	NA	1.1e-02
21	TCGA	Brain Lower Grade Glioma	0.0796	0.0398	2.3e-05	0.014	0.046	0.053	NA	0.045	9.7e-03	5.2e-06	1.2e-06	NA	6.5e-06
22	TCGA	Prostate Adenocarcinoma	0.1282	0.0606	4.2e-08	0.074	0.049	0.052	NA	0.062	3.3e-08	6.8e-06	3.4e-06	NA	4.0e-07
23	TCGA	Soft Tissue Sarcoma	0.0620	0.0470	3.4e-03	0.038	0.028	0.028	NA	0.015	2.5e-03	8.2e-03	8.8e-03	NA	4.2e-02
24	TCGA	Stomach Adenocarcinoma	0.3990	0.1340	2.6e-04	0.016	0.015	0.007	NA	0.071	2.4e-02	2.7e-02	9.7e-02	NA	7.9e-06
25	TCGA	Thyroid Carcinoma	0.0670	0.0300	3.4e-11	0.122	0.122	0.120	NA	0.118	6.5e-12	6.3e-12	1.0e-11	NA	1.5e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25
Worry (Nagel 2018)	16.1	33.9	61.1	6.3	5.9	5.7	5.9	7.2	6.4	6.9	7.8	7.5	6.1	2.6	6.1	5.3	5.9	6.2	6.5	4.5	6.0	5.6	5.5	3.0	4.9	5.4	1.5	6.0
Bipolar Disorder (2011)	13.6	13.1	24.7	4.9	4.9	4.9	4.7	4.4	3.2	4.3	4.5	4.8	5.0	3.0	4.9	4.2	4.9	5.0	4.2	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	13.4	32.8	52.1	6.1	6.0	5.9	6.4	6.8	6.4	6.6	6.9	7.1	6.2	4.5	5.9	5.6	5.9	6.4	7.2	3.9	5.7	5.7	5.4	2.1	4.2	5.1	-0.0	5.5
Waist Hip Ratio (WHR)	11.3	50.6	121.0	7.8	6.9	7.5	9.5	7.4	9.9	9.9	10.1	7.5	6.8	4.5	6.6	1.8	6.9	8.6	11.0	0.7	7.0	7.1	5.7	-0.9	4.7	5.4	-3.8	6.9
Nervous feelings	11.0	20.6	30.1	4.9	4.9	4.6	4.7	4.8	4.2	5.1	5.4	5.5	4.9	1.7	4.9	4.1	4.9	5.0	5.2	3.7	5.0	4.6	4.7	2.7	4.2	4.6	1.8	4.9
Bipolar Disorder (2018)	10.5	16.6	29.5	4.3	4.2	4.3	5.0	5.0	4.2	4.4	4.8	5.4	4.5	4.4	4.0	3.3	4.2	4.5	4.8	2.6	4.0	4.2	3.7	1.4	2.9	3.7	-0.4	3.9
Impedance of whole body	10.5	53.2	94.7	7.7	8.1	7.2	9.7	8.6	5.0	8.4	6.8	8.3	8.8	7.5	8.3	6.2	7.8	8.5	8.5	4.2	8.0	7.7	7.2	1.7	5.0	6.8	-1.8	7.6
Impedance of arm (left)	10.2	47.2	79.4	7.2	7.9	6.9	8.9	7.5	4.3	7.5	5.9	7.4	8.6	6.8	8.0	5.9	7.6	8.0	7.2	4.6	7.8	7.5	7.2	2.5	5.2	6.9	-0.9	7.4
Intelligence (Savage-Jansen 2018)	10.1	31.0	45.6	-6.7	-6.3	-6.0	-5.3	-5.5	-4.3	-6.8	-5.9	-4.9	-6.2	-0.1	-6.5	-3.0	-6.4	-6.3	-6.0	-3.7	-6.4	-6.3	-6.0	-3.5	-6.1	-6.1	-1.6	-6.7
Impedance of arm (right)	9.8	45.7	78.7	6.9	7.6	6.7	8.9	7.7	4.5	7.3	5.8	7.5	8.4	7.4	7.8	6.3	7.4	7.7	7.0	4.7	7.5	7.1	7.0	2.4	4.8	6.6	-0.9	7.0
Worrier / anxious feelings	9.7	18.3	45.8	4.6	3.9	3.6	4.8	6.8	4.5	5.1	5.8	5.1	4.4	4.3	4.3	5.8	3.8	4.0	5.2	3.2	3.9	3.5	3.5	1.4	2.4	3.4	0.1	4.0
Schizophrenia (2014)	9.6	21.3	38.9	4.9	4.8	4.7	4.8	5.5	5.5	5.7	5.5	6.0	5.0	3.0	4.8	4.7	4.7	5.2	6.2	2.9	4.5	4.5	4.3	1.5	3.2	3.9	-0.7	4.3
Verbal and Numeric Reasoning (VNR)	9.2	22.0	35.4	-5.8	-5.2	-4.8	-4.6	-5.4	-4.0	-5.9	-5.5	-5.0	-4.9	-0.5	-5.4	-2.3	-5.2	-5.4	-5.9	-2.4	-5.2	-5.2	-4.7	-1.9	-4.6	-4.8	-0.5	-5.5
Headache pain in last month	8.9	15.2	21.6	4.7	4.3	4.5	4.3	3.7	3.6	4.5	4.0	3.5	4.4	3.1	4.1	2.6	4.3	4.3	3.9	3.7	4.1	4.4	3.9	2.8	3.7	4.0	-0.3	4.2
Neuroticism	8.3	20.0	26.5	5.1	4.9	5.1	3.8	4.6	4.2	4.9	5.0	4.9	4.7	0.5	5.0	3.0	5.0	5.0	4.1	3.4	5.0	4.9	4.9	3.3	4.8	5.0	1.7	5.1
Schizophrenia (2018)	7.9	16.4	29.2	4.3	4.3	4.1	4.2	4.0	4.9	4.9	5.0	4.4	4.3	2.3	4.4	4.6	4.3	4.6	5.4	2.9	4.1	4.0	4.0	1.6	3.1	3.6	0.3	3.9
Smoking Status	7.7	18.4	27.2	-4.1	-4.5	-4.1	-4.3	-4.7	-3.7	-3.2	-4.1	-3.3	-4.8	-4.1	-5.0	-5.2	-4.6	-4.6	-3.3	-4.9	-4.8	-4.5	-4.8	-4.0	-3.9	-4.5	-2.1	-4.7
Suffer from ‘nerves’	7.6	12.0	16.6	3.9	3.9	3.9	2.6	3.4	3.4	3.3	4.1	4.0	3.4	-0.1	3.9	2.7	4.0	3.8	3.2	2.6	3.8	4.0	3.7	2.7	4.0	3.8	1.0	4.0
Prospective memory result	7.4	9.1	12.2	3.3	3.3	3.2	2.8	3.3	2.8	3.2	3.0	3.5	3.4	1.9	3.5	1.9	3.4	3.4	2.6	2.4	3.5	3.3	3.3	2.0	3.1	3.3	1.2	3.5
Neuroticism (Nagel 2018)	7.3	17.1	25.3	4.7	4.3	4.4	3.6	4.7	4.0	4.6	5.0	4.8	4.3	0.6	4.5	2.8	4.4	4.3	3.9	3.5	4.5	4.5	4.3	3.2	4.4	4.4	2.1	4.6
Impedance of leg (left)	6.9	33.5	66.4	6.1	6.0	5.3	8.2	7.4	4.2	7.2	5.8	7.1	6.6	6.7	6.3	5.0	5.8	6.7	7.5	2.6	6.0	5.6	5.2	0.1	3.2	4.8	-2.3	5.7
BMI	6.7	39.1	78.3	-6.2	-6.2	-5.0	-7.6	-8.8	-4.1	-7.0	-6.2	-8.0	-7.2	-8.4	-6.5	-7.7	-6.1	-6.7	-7.3	-5.0	-6.3	-5.9	-5.8	-1.7	-3.6	-5.3	-0.4	-5.8
Ever smoked	6.6	11.6	17.1	-3.4	-3.6	-3.6	-3.4	-4.1	-3.9	-3.5	-4.1	-3.2	-3.6	-2.1	-3.7	-3.1	-3.7	-3.8	-3.3	-3.0	-3.7	-3.6	-3.5	-2.4	-3.3	-3.4	-0.6	-3.7
Family relationship satisfaction	6.5	8.0	13.7	2.9	3.3	3.1	3.7	2.9	1.1	2.3	2.1	2.9	3.5	3.2	3.2	3.0	3.2	3.3	2.6	1.8	3.3	3.2	3.0	1.3	2.3	2.9	0.7	3.3
Age when periods started (menarche)	6.4	15.3	38.4	-4.4	-4.0	-4.6	-4.6	-4.9	-4.5	-5.2	-5.2	-4.7	-3.8	-1.2	-3.4	-1.8	-3.9	-4.7	-6.2	0.2	-3.9	-4.0	-3.0	0.9	-2.8	-3.1	1.9	-4.0
Height	6.3	120.6	259.2	10.9	11.8	11.4	9.4	8.5	7.0	8.1	8.9	5.4	13.0	11.7	12.1	9.6	12.0	10.4	3.1	16.1	12.1	11.9	12.9	14.6	11.8	12.9	8.3	11.7
Impedance of leg (right)	6.1	29.5	60.4	5.6	5.5	4.8	7.8	7.1	3.9	6.8	5.4	6.8	6.3	6.7	5.9	4.9	5.3	6.2	7.0	2.5	5.6	5.1	4.8	0.0	2.7	4.4	-2.1	5.2
Major Depression (MDD)	6.0	7.3	12.9	3.0	2.8	2.9	2.3	3.6	1.4	3.0	2.7	3.6	2.7	0.2	2.9	2.2	3.1	3.2	2.6	2.2	2.9	3.0	2.9	2.0	2.8	2.9	1.4	3.0
Frequency of tenseness / restlessness in last 2 weeks	6.0	9.3	16.4	3.5	3.2	3.1	2.6	3.8	3.3	3.3	4.0	3.9	2.9	-0.1	3.1	1.1	3.1	3.1	2.9	2.4	3.3	3.2	3.0	2.3	3.2	3.3	2.3	3.4
Standing height	6.0	59.6	121.0	7.5	8.3	8.3	6.9	5.7	5.0	5.1	6.4	3.5	9.2	9.3	8.4	7.1	8.5	7.4	2.4	11.0	8.5	8.5	8.9	9.7	8.1	9.1	6.0	8.1
Pulse rate	5.9	10.0	22.8	3.5	3.1	3.4	3.9	3.5	3.7	3.7	4.0	3.9	3.1	2.1	3.2	2.3	3.2	3.8	4.8	0.9	3.3	3.3	2.7	0.2	2.3	2.7	-0.7	3.3
Comparative height size at age 10	5.9	32.4	49.4	5.6	6.4	6.7	5.0	4.4	4.9	4.2	5.1	4.3	6.7	5.6	6.0	4.6	6.5	5.9	2.3	7.0	6.4	6.6	6.5	6.2	6.2	6.7	3.6	6.1
Tense / ‘highly strung’	5.6	9.2	20.4	3.2	3.1	3.0	3.4	3.5	3.5	3.1	4.5	3.4	3.3	1.2	3.2	2.3	3.0	3.0	3.0	3.1	3.1	2.8	3.0	2.4	2.6	3.0	1.5	3.1
Forced expiratory volume in 1-second (FEV1), predicted	5.6	11.7	19.8	3.6	3.9	3.8	3.3	2.0	1.7	2.5	2.8	2.1	4.1	2.5	3.7	2.5	4.0	3.6	1.6	4.5	4.0	4.0	4.0	4.1	3.9	4.2	2.5	3.9
Past tobacco smoking	5.4	10.0	16.6	3.0	3.1	3.0	3.0	4.1	3.4	2.7	3.7	3.1	3.2	3.1	3.5	3.9	3.3	3.4	2.9	3.0	3.3	3.2	3.2	2.2	2.8	3.1	1.1	3.4
Blood Red Count	5.3	51.5	90.2	8.3	7.6	7.7	8.6	6.8	7.7	9.5	8.9	6.2	7.5	3.7	7.9	5.1	7.7	8.8	9.5	3.1	7.9	7.7	7.0	1.6	5.9	6.6	-0.5	8.0
Guilty feelings	5.2	7.8	12.5	3.1	2.9	2.9	2.4	3.5	2.2	3.0	2.8	3.5	2.8	0.9	3.0	1.3	3.1	3.1	2.6	1.8	3.3	3.0	3.2	1.7	2.9	3.1	2.6	3.1
LDL Cholesterol	5.1	8.0	12.6	-3.1	-3.2	-3.1	-2.3	-2.3	-1.6	-2.0	-2.4	-2.1	-3.3	-1.2	-3.3	-1.7	-3.3	-2.8	-1.7	-3.4	-3.2	-3.1	-3.4	-3.6	-3.4	-3.4	-2.1	-3.3
Friendships satisfaction	5.1	6.3	10.4	2.7	3.0	2.8	2.9	2.2	0.6	2.0	1.9	2.1	3.2	1.6	2.8	2.6	2.9	2.7	1.6	2.4	2.9	2.9	2.8	2.4	2.6	3.0	1.2	3.0
Depression (Nagel 2018)	5.0	7.5	10.5	2.6	3.1	3.2	2.7	2.6	2.3	2.5	2.9	3.2	3.2	1.7	3.0	1.7	3.2	3.2	2.5	2.6	3.0	3.1	2.8	2.1	2.6	3.0	1.6	2.9
Happiness	5.0	6.0	8.7	2.6	2.8	2.6	2.2	2.6	1.9	2.0	2.4	1.9	2.9	0.8	3.0	2.4	2.7	2.4	1.4	2.9	2.8	2.6	2.9	2.6	2.5	2.9	1.4	2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	5.0	7.6	11.5	3.3	3.0	3.4	3.1	3.0	2.1	3.1	3.3	2.6	2.9	0.4	2.8	2.3	3.1	3.2	3.3	1.6	3.0	3.1	2.7	1.2	2.6	2.9	0.4	3.1
Body mass index (BMI)	4.9	21.0	41.0	-4.5	-4.7	-3.9	-5.8	-5.7	-2.7	-4.5	-4.1	-5.1	-5.5	-6.4	-5.1	-5.4	-4.7	-4.9	-4.7	-4.2	-4.9	-4.5	-4.7	-2.0	-2.9	-4.3	-1.2	-4.5
Wears glasses or contact lenses	4.9	5.6	11.7	-2.6	-2.6	-2.7	-2.6	-2.3	-2.8	-3.1	-3.2	-2.7	-2.4	-0.9	-2.3	0.1	-2.5	-2.9	-3.4	-0.4	-2.3	-2.5	-2.0	-0.3	-2.2	-2.0	1.4	-2.5
Fluid intelligence score	4.7	9.9	17.8	-3.9	-3.3	-3.0	-2.8	-4.0	-2.9	-4.2	-3.9	-3.5	-3.2	0.5	-3.6	-1.5	-3.3	-3.4	-4.1	-1.6	-3.4	-3.2	-3.0	-1.4	-3.0	-3.1	-0.8	-3.7
Seen a psychiatrist for nerves, anxiety, tension or depression	4.7	6.0	12.6	3.0	2.5	2.8	2.5	2.9	2.6	3.0	3.6	2.5	2.4	0.8	2.4	1.8	2.6	2.7	3.1	1.6	2.5	2.6	2.3	1.1	2.1	2.4	0.6	2.5
Basal cell carcinoma (self-reported)	4.7	5.6	9.9	2.5	2.2	2.4	2.9	3.1	3.1	2.7	3.1	2.8	2.4	2.9	2.3	1.6	2.2	2.5	2.9	1.8	2.3	2.2	2.2	0.8	1.3	1.9	0.3	2.1
Sitting height	4.6	32.8	79.8	5.8	6.1	6.5	3.7	3.4	3.0	3.5	4.6	2.0	6.3	4.0	5.9	4.8	6.4	5.3	1.1	8.9	6.2	6.6	6.6	8.5	6.9	7.1	5.9	6.2
Neuroticism score	4.6	9.6	14.1	3.5	3.4	3.5	2.3	2.6	3.1	3.1	3.8	3.2	3.0	-0.8	3.4	1.2	3.4	3.3	2.6	2.3	3.6	3.3	3.5	2.7	3.7	3.6	2.5	3.7
Ever highly irritable/argumentative for 2 days	4.6	5.5	8.5	-2.7	-2.6	-2.3	-2.2	-2.4	-1.7	-2.9	-2.4	-2.3	-2.9	-1.6	-2.8	-2.5	-2.6	-2.5	-2.6	-2.3	-2.5	-2.4	-2.5	-1.6	-2.0	-2.3	0.2	-2.5
Diabetes diagnosed by doctor	4.6	7.6	10.4	-2.9	-3.0	-3.1	-2.9	-2.6	-1.8	-2.3	-2.4	-2.8	-3.2	-2.8	-3.0	-3.2	-3.1	-3.0	-2.2	-3.1	-3.0	-3.0	-3.0	-2.3	-2.5	-3.0	-0.7	-2.9
Mouth/teeth dental problems: Bleeding gums	4.5	5.8	11.4	2.6	2.6	2.1	3.3	3.2	1.0	3.4	2.2	2.6	2.7	2.1	2.8	2.1	2.5	2.9	3.1	0.7	2.7	2.4	2.5	0.1	1.8	2.1	-0.8	2.6
Age at First Birth	4.4	6.3	14.4	-3.2	-2.8	-2.7	-3.8	-2.7	-2.1	-3.4	-2.9	-2.9	-3.0	-1.1	-2.5	-0.1	-2.5	-2.7	-3.7	-1.6	-2.5	-2.3	-2.0	-0.6	-1.8	-2.1	1.4	-2.7
Neuroticism (2016)	4.3	6.2	12.7	2.6	2.5	2.8	2.0	3.0	3.1	2.5	3.6	3.1	2.6	1.1	2.7	2.3	2.7	2.6	2.1	2.4	2.5	2.2	2.4	1.9	2.5	2.4	0.6	2.5
Number of incorrect matches in round	4.3	7.2	14.5	3.0	2.7	2.8	2.4	3.8	1.7	3.1	2.5	3.3	3.0	2.3	2.9	2.7	2.8	2.6	2.6	3.0	2.6	2.8	2.6	2.2	2.2	2.6	0.1	2.5
Frequency of depressed mood in last 2 weeks	4.1	5.7	10.6	2.4	2.8	2.8	1.6	1.8	2.7	2.1	3.2	2.5	2.6	-0.3	2.4	0.8	2.7	2.5	2.1	2.4	2.5	2.7	2.5	2.2	2.8	2.7	1.6	2.6
Average weekly champagne plus white wine intake	4.1	5.6	9.5	-2.7	-2.5	-2.7	-2.5	-2.2	-3.1	-2.8	-2.8	-2.0	-2.4	-0.6	-2.4	-1.2	-2.5	-2.7	-2.7	-1.5	-2.7	-2.6	-2.5	-1.4	-2.4	-2.4	-1.0	-2.6
Hearing aid user	4.0	4.5	11.9	-2.1	-2.1	-2.0	-2.9	-2.5	-1.7	-1.8	-2.4	-2.6	-2.5	-3.5	-2.3	-1.7	-2.2	-2.2	-2.3	-1.2	-1.9	-2.1	-1.9	-0.6	-1.3	-1.8	1.7	-2.0
Stomach or abdominal pain in last month	3.8	4.7	9.2	2.6	2.1	2.2	2.1	2.9	2.8	2.8	2.9	2.1	2.0	1.7	2.1	2.9	2.0	2.4	3.0	0.3	1.7	2.0	1.5	-0.1	1.3	1.4	-2.3	2.0
Systolic blood pressure, automated reading	3.7	10.8	26.2	-3.4	-3.7	-3.6	-5.1	-2.5	-3.3	-3.0	-3.3	-2.9	-4.1	-4.7	-3.5	-1.3	-3.5	-3.6	-3.5	-2.2	-3.6	-3.5	-3.4	-1.1	-2.1	-3.3	0.2	-3.2
Relative age voice broke	3.7	5.6	9.3	-2.8	-2.6	-2.9	-2.1	-1.4	-2.8	-2.4	-2.6	-2.4	-2.2	0.1	-2.6	-1.5	-2.8	-2.9	-2.4	-1.5	-2.7	-3.0	-2.5	-1.3	-2.7	-2.6	0.1	-2.9
Diabetes (self-reported)	3.7	5.7	9.8	-2.4	-2.4	-2.6	-2.7	-2.7	-1.8	-2.0	-2.3	-2.4	-2.7	-3.1	-2.5	-3.1	-2.5	-2.4	-1.9	-2.6	-2.5	-2.4	-2.5	-1.6	-1.7	-2.4	-0.8	-2.3
Migraine (self-reported)	3.7	4.5	7.3	2.2	2.4	1.8	2.3	1.8	0.9	2.1	1.3	0.9	2.5	2.2	2.4	2.5	2.2	2.2	1.4	2.7	2.5	2.2	2.7	2.2	2.0	2.4	1.9	2.2
Ulcerative Colitis	3.6	5.2	9.3	2.5	2.4	2.3	1.3	2.1	2.0	3.1	2.6	2.5	2.1	-1.3	2.4	1.2	2.4	2.3	2.0	2.2	2.3	2.3	2.4	2.4	3.0	2.5	1.5	2.5
Pulse wave reflection index	3.5	4.3	10.8	-2.2	-2.2	-1.8	-3.0	-2.6	-1.1	-2.5	-1.5	-1.7	-2.6	-3.3	-2.2	-2.3	-2.1	-2.3	-2.6	-1.2	-2.2	-1.9	-1.9	-0.1	-1.0	-1.7	0.7	-2.0
Chest pain or discomfort	3.5	5.1	13.0	2.4	2.3	2.0	2.4	2.9	2.4	2.7	2.6	3.6	2.5	1.0	2.4	1.7	2.3	2.4	2.4	2.1	2.2	2.1	2.1	1.5	1.8	2.0	-0.1	2.2
Hand grip strength (left)	3.2	8.5	33.4	3.2	3.0	2.9	3.9	2.4	0.6	1.7	2.1	0.3	3.8	5.8	2.9	4.4	2.9	2.5	2.0	3.7	2.7	2.8	2.6	2.5	1.8	2.9	0.3	2.8
Depression (self-reported)	3.1	3.7	9.3	2.1	1.7	1.5	2.0	3.0	2.5	2.0	3.0	2.2	2.1	0.5	1.9	1.8	1.6	1.4	2.2	2.0	1.9	1.4	1.9	1.5	1.2	1.8	1.3	1.9
Mood swings	3.1	5.7	14.0	2.5	2.7	2.7	1.1	0.6	2.3	1.6	2.3	1.4	2.2	-2.5	2.7	0.0	2.7	2.3	1.0	1.9	2.7	2.7	2.8	3.1	3.7	3.1	1.8	3.1
Wheeze or whistling in the chest in last year	3.0	5.3	9.2	2.6	2.7	2.9	1.6	1.7	2.9	2.5	2.6	2.7	2.2	-0.9	2.4	-0.3	2.7	2.7	2.1	0.8	2.5	2.9	2.3	1.3	3.0	2.5	-0.4	2.8
Blood Eosinophil Count	2.9	22.0	65.6	-4.8	-4.4	-4.1	-6.3	-8.1	-2.6	-4.2	-4.8	-6.2	-5.5	-7.1	-4.7	-4.5	-4.2	-4.3	-4.7	-5.0	-4.1	-4.0	-4.1	-2.6	-2.3	-3.9	0.3	-4.0
Systolic Blood Pressure	2.9	14.6	28.5	-4.2	-4.3	-4.3	-5.3	-3.2	-3.5	-3.5	-3.7	-3.1	-4.6	-5.0	-4.2	-1.4	-4.2	-4.2	-3.6	-3.1	-4.3	-4.2	-4.2	-2.2	-3.0	-4.1	-0.7	-4.0
Medication: Blood pressure	2.9	5.1	17.0	-2.4	-2.2	-2.4	-3.1	-2.5	-1.9	-2.7	-2.4	-2.9	-2.4	-4.1	-1.9	-1.4	-2.2	-2.6	-2.8	-0.7	-2.3	-2.3	-1.8	0.5	-1.0	-1.8	0.6	-2.0
Pulse rate, automated reading	2.9	9.3	32.1	2.5	2.0	2.2	4.4	3.4	3.9	3.3	3.7	4.5	2.1	3.9	2.0	3.4	2.0	3.2	5.7	-1.9	2.1	2.0	1.1	-3.1	0.2	0.9	-4.3	2.1
Smoking status: Previous	2.9	4.3	11.2	-1.8	-1.9	-1.7	-1.9	-2.9	-2.0	-1.6	-2.2	-1.9	-2.1	-2.4	-2.2	-3.3	-2.0	-2.1	-1.9	-2.3	-2.2	-1.9	-2.1	-1.4	-1.6	-1.9	-1.2	-2.1
Type 2 Diabetes (T2D) (2018)	2.8	5.3	17.6	-2.2	-2.2	-2.3	-1.9	-2.9	-1.1	-1.6	-2.1	-2.4	-2.3	-2.7	-2.3	-4.2	-2.4	-2.3	-1.7	-2.9	-2.2	-2.4	-2.3	-2.0	-1.9	-2.3	-0.9	-2.1
Lung FEV1/FVC ratio	2.8	14.3	24.7	-4.3	-4.5	-4.5	-4.4	-3.3	-3.4	-4.0	-3.2	-3.9	-4.7	-2.3	-4.0	-3.0	-4.5	-4.6	-5.0	-1.2	-4.2	-4.4	-3.7	-0.5	-3.0	-3.7	1.8	-4.2
Alcohol intake versus 10 years previously	2.8	4.2	8.4	-2.5	-2.1	-2.3	-2.6	-2.2	-2.3	-2.5	-2.9	-1.2	-2.3	-1.8	-1.9	-1.4	-2.0	-2.1	-2.9	-1.6	-2.1	-2.0	-1.9	-1.0	-1.5	-2.0	-0.6	-2.0
Medication for cholesterol, blood pressure or diabetes	2.8	4.7	9.5	2.4	2.2	2.4	2.7	2.4	1.7	2.6	2.2	2.9	2.3	3.1	2.1	1.0	2.3	2.6	2.5	0.9	2.3	2.3	2.0	0.0	1.4	1.9	-0.4	2.1
Medication: Bendroflumethiazide	2.8	4.2	7.4	-2.3	-2.5	-2.3	-2.7	-1.1	-1.2	-2.0	-1.5	-2.0	-2.6	-2.4	-2.6	-0.7	-2.4	-2.4	-1.9	-1.1	-2.5	-2.3	-2.5	-1.0	-1.8	-2.3	0.3	-2.5
Myopia	2.8	4.1	8.9	-2.5	-2.1	-2.0	-1.4	-2.0	-2.2	-3.0	-2.3	-1.6	-1.9	0.8	-2.3	-1.4	-2.2	-2.2	-1.9	-1.8	-2.1	-2.0	-2.1	-2.0	-2.4	-2.0	0.0	-2.3
Blood Platelet Count	2.7	31.3	41.6	-5.8	-6.4	-6.3	-4.8	-4.2	-6.5	-5.1	-6.1	-4.6	-6.1	-2.4	-6.0	-3.1	-6.4	-6.1	-4.1	-6.0	-6.2	-6.3	-6.3	-5.8	-6.4	-6.4	-3.3	-6.1
Medication: Cholesterol lowering	2.7	4.2	6.6	-2.4	-2.3	-2.5	-2.3	-1.8	-1.7	-2.2	-2.2	-2.4	-2.2	-1.5	-2.1	-0.9	-2.4	-2.6	-2.3	-1.4	-2.3	-2.4	-2.2	-0.9	-1.9	-2.2	-0.3	-2.3
Medication: Amlodipine	2.7	3.8	9.9	-1.9	-2.3	-2.4	-3.1	-0.5	-0.8	-1.3	-1.1	-1.7	-2.4	-2.4	-2.3	0.6	-2.3	-2.2	-1.0	-1.7	-2.4	-2.2	-2.4	-1.6	-1.8	-2.3	-0.1	-2.2
Hypertension (Self-reported)	2.7	7.5	14.7	-3.0	-3.1	-3.4	-3.8	-1.6	-2.1	-2.3	-2.6	-2.2	-3.2	-3.3	-3.0	-1.2	-3.2	-3.3	-2.9	-1.7	-3.2	-3.4	-2.9	-1.0	-2.3	-3.0	-0.3	-3.1
Medication: Paracetamol	2.6	4.3	11.5	2.4	1.9	2.1	1.8	2.7	3.4	2.8	3.0	2.4	2.1	2.1	1.6	1.9	1.9	2.1	3.3	1.1	1.7	1.8	1.5	0.2	1.2	1.5	-0.5	1.6
Eye problems/disorders: None of the above	2.6	3.0	7.1	-1.9	-1.8	-1.6	-1.1	-1.3	-2.2	-2.1	-2.0	-0.1	-1.7	0.6	-1.9	-0.2	-1.6	-1.5	-1.2	-2.0	-1.9	-1.5	-1.9	-2.3	-2.0	-1.9	-2.7	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.6	3.0	6.6	2.0	1.8	1.8	0.7	0.6	1.4	1.8	1.0	1.2	1.6	-0.8	1.9	-1.0	1.8	1.4	0.8	1.8	1.9	1.9	2.2	2.5	2.6	2.3	2.1	2.0
Supplements: Fish oil (including cod liver oil)	2.6	3.4	7.5	-2.0	-2.0	-1.7	-2.4	-2.0	0.0	-1.9	-1.6	-1.6	-2.1	-1.2	-2.1	-2.7	-2.0	-2.2	-2.6	-0.8	-1.8	-2.0	-1.6	-0.4	-1.5	-1.6	1.7	-2.0
Primary Biliary Cirrhosis	2.5	3.5	5.6	-2.4	-2.1	-2.3	-1.6	-1.7	-1.5	-2.2	-2.0	-1.4	-2.0	0.3	-2.1	-0.9	-2.2	-2.1	-2.0	-1.6	-2.0	-2.2	-2.0	-1.5	-2.1	-2.1	-0.6	-2.2
Average weekly spirits intake	2.5	3.1	7.2	-2.0	-1.5	-1.3	-2.3	-2.7	-1.9	-2.4	-2.5	-1.9	-1.9	-2.4	-1.7	-1.4	-1.6	-1.8	-2.4	-1.2	-1.6	-1.5	-1.3	-0.2	-0.8	-1.3	0.0	-1.5
Allergy	2.5	5.8	9.9	-2.5	-2.9	-3.1	-2.7	-1.4	-2.1	-2.5	-2.2	-2.9	-2.6	-0.4	-2.6	0.8	-2.9	-3.2	-2.4	-1.0	-2.8	-3.0	-2.5	-1.2	-2.8	-2.6	0.6	-2.8
Reason for reducing amount of alcohol drunk: Health precaution	2.5	3.0	5.9	1.5	2.2	1.9	1.9	0.7	1.1	1.3	1.4	1.4	2.4	1.1	2.1	-0.0	2.1	1.9	0.9	1.9	2.0	1.9	2.2	1.9	2.0	2.0	0.2	2.0
Medication for cholesterol	2.5	3.8	8.5	2.0	2.5	2.1	1.2	-0.4	0.2	0.5	0.5	0.2	2.4	-0.2	2.6	1.5	2.5	1.8	0.3	2.6	2.4	2.4	2.7	2.9	2.6	2.7	0.9	2.5
Mineral and other dietary supplements	2.5	3.3	7.1	1.9	2.1	1.5	2.3	2.1	0.1	2.0	1.7	1.5	2.4	0.5	2.3	2.7	2.0	2.0	2.3	1.2	1.9	1.8	1.8	0.8	1.5	1.7	-0.7	2.0
Tinnitus: Yes, now most or all of the time	2.5	2.9	5.7	1.8	1.9	1.6	1.0	1.4	2.0	2.1	1.8	2.4	1.6	-0.8	2.0	0.4	1.8	2.0	2.1	0.9	1.9	1.8	1.9	1.1	2.0	1.7	0.6	1.9
Cardiovascular Disease	2.4	8.0	13.7	-3.2	-3.0	-3.0	-3.7	-2.7	-1.2	-2.4	-2.5	-2.6	-3.3	-3.7	-3.1	-2.6	-3.1	-3.2	-3.1	-2.3	-3.2	-3.2	-3.0	-1.2	-2.0	-3.0	-1.4	-3.0
Number of treatments/medications taken	2.4	4.4	8.1	-2.0	-2.5	-2.1	-2.6	-1.4	0.2	-1.5	-1.1	-1.2	-2.6	-2.8	-2.6	-1.2	-2.5	-2.5	-1.1	-2.4	-2.5	-2.4	-2.6	-1.9	-2.1	-2.4	-0.5	-2.3
Multivitamins +/- minerals	2.4	3.0	8.3	-1.9	-1.7	-1.5	-1.6	-1.9	-1.4	-2.3	-2.3	-2.9	-1.7	0.5	-1.8	-1.4	-1.7	-1.9	-2.5	-0.8	-1.8	-1.5	-1.7	-0.6	-1.6	-1.6	-0.9	-1.8
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.9	8.9	2.3	1.7	2.2	1.7	2.4	2.9	2.5	3.0	2.6	1.7	1.1	1.7	1.4	1.9	2.0	2.2	1.4	1.9	2.0	1.8	1.0	1.8	1.9	0.2	1.9
Eye problems/disorders: Cataract	2.4	2.8	5.9	1.9	1.8	1.5	1.9	0.8	1.6	1.8	1.2	-0.3	2.0	0.6	2.0	1.0	1.6	1.4	1.2	2.0	2.0	1.5	2.1	2.0	1.7	1.9	2.4	1.8
Hand grip strength (right)	2.3	6.3	29.0	2.3	2.6	2.2	3.6	1.6	-0.9	0.8	0.8	0.1	3.5	5.4	2.6	3.2	2.4	1.8	0.6	3.7	2.4	2.1	2.5	2.8	1.5	2.5	1.4	2.4
High blood pressure	2.2	6.1	11.7	-2.7	-2.8	-3.0	-3.4	-1.1	-2.3	-2.2	-2.5	-2.1	-2.8	-2.5	-2.7	-1.0	-2.9	-3.0	-2.7	-1.6	-2.9	-3.0	-2.6	-0.8	-2.0	-2.7	-0.3	-2.8
Glaucoma (self-reported)	2.2	2.6	7.7	1.7	1.4	1.0	1.7	2.8	2.5	2.4	2.7	2.4	1.5	0.4	1.5	0.3	1.2	1.5	2.6	-0.4	1.3	1.0	0.9	-0.7	0.4	0.7	-0.8	1.4
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	8.7	-1.9	-1.4	-1.7	-2.7	-1.6	-3.0	-2.2	-2.4	-1.4	-1.2	-1.3	-1.2	-0.6	-1.2	-1.8	-2.8	0.6	-1.4	-1.3	-0.9	0.8	-0.7	-0.9	1.6	-1.5
Back pain experienced in last month	2.1	3.1	6.2	-2.3	-1.9	-1.9	-2.4	-1.9	-0.7	-1.9	-1.6	-1.0	-2.1	-2.2	-1.9	-0.6	-1.9	-2.0	-2.5	-0.5	-2.0	-2.0	-1.8	-0.1	-1.3	-1.8	0.2	-1.9
Smoking status: Current	2.1	3.3	6.2	-1.8	-1.8	-1.9	-1.6	-2.1	-1.6	-1.4	-1.9	-1.1	-2.0	-1.6	-2.1	-2.5	-1.9	-1.9	-1.2	-2.1	-1.9	-1.8	-2.0	-1.9	-1.6	-1.8	-1.0	-1.9
Medication: Blood pressure	2.1	4.0	7.3	-2.2	-2.6	-2.5	-2.1	-0.2	-1.3	-1.2	-1.2	-1.1	-2.5	-0.9	-2.7	-0.8	-2.6	-2.4	-1.4	-1.5	-2.5	-2.7	-2.4	-1.6	-2.3	-2.5	0.3	-2.6
Commuting to job workplace: Cycle	2.1	2.5	5.1	-1.9	-1.6	-2.2	-1.5	-1.6	-2.0	-1.9	-2.3	-1.8	-1.5	-0.6	-1.2	0.1	-1.6	-1.7	-2.3	-0.5	-1.3	-1.9	-1.2	-0.5	-1.5	-1.5	1.5	-1.4
Rheumatoid Arthritis	2.0	2.8	5.6	-2.1	-1.8	-2.4	-1.5	-1.3	-1.5	-2.4	-1.7	-1.1	-1.6	-0.2	-1.6	-0.8	-1.9	-2.0	-2.2	-0.9	-1.9	-2.0	-1.8	-0.8	-1.8	-1.9	-0.5	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.7	11.2	-2.0	-2.4	-2.3	-2.2	-1.8	-0.4	-1.0	-1.6	-1.9	-2.6	-2.4	-1.9	-2.0	-2.4	-2.1	-1.0	-3.3	-2.3	-2.4	-2.4	-2.6	-2.2	-2.6	-2.4	-2.0
Comparative body size at age 10	2.0	5.6	11.4	-2.6	-2.2	-2.1	-2.0	-3.4	-2.2	-2.8	-2.5	-2.7	-2.2	-1.6	-2.9	-2.4	-2.5	-2.8	-2.3	-2.0	-2.5	-2.5	-2.4	-1.4	-2.0	-2.1	-0.9	-2.6
Pulse wave peak to peak time	2.0	2.4	4.8	1.5	1.9	1.6	2.0	1.0	1.3	1.3	1.2	0.9	2.2	2.0	1.9	0.9	1.8	1.5	0.7	2.0	1.6	1.5	1.8	1.6	1.2	1.7	-0.3	1.6
Depressed Affect (Nagel 2018)	1.9	3.9	8.4	2.2	2.2	2.4	0.3	1.0	1.4	1.5	1.5	1.5	1.7	-2.1	2.2	0.2	2.3	1.9	0.6	1.8	2.2	2.3	2.3	2.7	2.9	2.6	2.2	2.4
Type 2 Diabetes (T2D) (2012)	1.9	2.1	8.5	1.0	1.3	1.2	0.7	1.2	2.9	1.9	1.8	1.4	1.0	-1.7	1.2	-1.5	1.3	1.6	1.7	-1.8	1.3	1.5	1.1	-1.0	1.7	1.0	-0.4	1.3
Lung FVC	1.9	9.6	18.2	-3.5	-3.8	-4.3	-3.9	-1.4	-1.9	-2.2	-2.4	-1.3	-3.8	-1.4	-3.7	-1.8	-3.7	-3.4	-2.1	-2.4	-3.8	-3.8	-3.6	-2.8	-3.6	-3.8	-0.5	-4.0
Average weekly fortified wine intake	1.9	2.2	8.2	1.3	1.3	1.2	1.4	0.9	-0.1	0.4	0.4	0.1	1.6	1.2	1.6	2.3	1.3	1.0	-0.4	2.9	1.6	1.3	1.7	2.5	1.3	1.7	1.7	1.6
Heel bone mineral density (BMD) T-score, automated (left)	1.9	4.4	9.2	-2.0	-2.4	-2.1	-2.0	-1.8	-0.3	-1.3	-1.2	-1.8	-2.7	-2.7	-1.9	-2.5	-2.3	-2.0	-1.2	-3.0	-2.2	-2.3	-2.3	-2.3	-1.9	-2.5	-2.0	-1.9
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	9.1	1.3	1.1	1.2	2.0	2.3	2.0	1.2	2.3	1.6	1.2	3.0	1.0	2.6	1.0	1.2	1.9	0.7	0.8	1.0	0.6	-0.1	0.2	0.7	-0.9	0.9
Gout (self-reported)	1.9	2.7	6.9	1.8	1.5	1.3	0.1	1.4	2.5	2.4	2.6	1.1	0.9	-2.5	1.6	0.7	1.6	1.7	2.3	-0.1	1.5	1.5	1.3	0.6	2.1	1.4	0.1	1.8
Loneliness, isolation	1.9	2.6	6.9	1.3	1.6	1.9	0.4	-0.2	0.7	0.7	0.8	0.7	1.2	-2.2	1.7	-0.5	1.8	1.4	-0.2	1.4	1.9	1.8	2.1	2.4	2.6	2.2	2.6	1.9
Vascular/heart problems diagnosed by doctor	1.9	5.1	9.1	2.4	2.5	2.8	3.0	1.1	1.9	1.9	2.4	2.0	2.4	2.7	2.4	0.9	2.6	2.8	2.3	1.7	2.6	2.8	2.3	1.0	1.9	2.4	0.5	2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.5	5.4	1.2	1.6	1.7	1.2	1.4	1.4	0.8	2.1	2.3	1.6	0.7	1.5	0.8	1.7	1.6	1.1	2.0	1.6	1.6	1.6	1.6	1.7	1.7	1.7	1.6
Qualifications: CSEs or equivalent	1.8	2.3	4.6	1.8	2.0	2.0	1.4	0.3	0.2	1.3	1.0	1.6	1.6	-1.0	1.7	0.3	2.0	1.8	1.0	0.7	1.8	2.1	1.6	1.0	2.1	1.9	-0.6	2.1
Alcohol usually taken with meals	1.8	2.9	13.0	1.7	1.4	1.5	2.8	2.1	1.4	1.5	1.8	0.7	2.1	3.6	1.6	2.2	1.4	1.5	1.8	1.6	1.5	1.3	1.4	0.7	0.5	1.3	0.5	1.3
Medication: Atorvastatin	1.8	2.2	5.2	-2.0	-1.8	-2.3	-1.6	-1.0	-0.7	-1.1	-0.9	-1.3	-1.7	-0.4	-1.5	-0.1	-2.0	-1.8	-1.2	-1.3	-1.7	-2.2	-1.5	-1.1	-1.6	-1.9	-0.2	-1.8
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	4.4	1.6	1.7	1.6	1.2	0.6	1.4	1.7	1.1	0.4	1.7	-0.7	1.9	-0.5	1.8	1.7	1.0	1.5	2.0	1.5	2.1	1.7	2.0	1.9	1.2	1.9
Townsend deprivation index at recruitment	1.7	2.4	11.7	-1.2	-0.8	-1.0	-1.8	-2.3	0.1	-1.3	-1.0	-1.1	-1.0	-3.0	-1.3	-3.4	-0.9	-1.2	-1.0	-2.6	-1.2	-0.9	-1.2	-1.4	-0.5	-1.0	-1.5	-1.1
Medication: Atenolol	1.7	2.1	3.5	-1.5	-1.6	-1.9	-1.0	-0.6	-0.5	-1.0	-1.1	-1.0	-1.6	-1.4	-1.5	-0.8	-1.8	-1.6	-0.5	-1.9	-1.6	-1.8	-1.7	-1.9	-1.9	-1.8	-0.8	-1.6
Forced vital capacity (FVC)	1.7	6.6	16.5	2.6	2.5	2.3	1.8	2.3	2.2	1.9	3.0	1.8	2.8	2.7	2.5	2.1	2.6	2.2	1.3	4.1	2.6	2.5	2.7	3.3	2.5	2.8	3.0	2.5
Forced vital capacity (FVC), Best measure	1.7	6.1	16.4	2.4	2.2	2.2	1.7	2.4	2.4	1.7	3.1	1.7	2.5	3.1	2.4	2.1	2.4	2.1	1.3	4.1	2.4	2.4	2.6	3.2	2.4	2.6	2.6	2.3
Leg fat percentage (right)	1.7	6.1	11.2	-2.2	-2.5	-1.9	-2.2	-2.4	-1.2	-1.6	-2.0	-2.4	-3.0	-3.0	-2.7	-3.3	-2.6	-2.3	-1.7	-3.4	-2.7	-2.5	-2.8	-2.3	-2.1	-2.7	-2.4	-2.4
Illnesses of father: Heart disease	1.7	2.3	6.7	-1.0	-1.6	-1.9	-0.3	1.0	-0.8	-0.3	-0.4	-0.5	-1.5	0.5	-1.5	0.1	-1.9	-1.6	0.1	-1.9	-1.8	-1.9	-2.0	-2.6	-2.3	-2.0	-2.2	-1.7
High cholesterol (Self-reported)	1.7	3.0	7.7	-2.1	-1.9	-2.1	-2.8	-1.1	-0.5	-1.5	-1.2	-0.9	-2.1	-1.9	-1.9	-1.1	-2.0	-2.1	-2.1	-0.9	-2.0	-2.1	-1.8	-0.3	-1.1	-1.8	1.4	-1.9
Medication: Lisinopril	1.7	2.2	6.6	-1.2	-1.4	-1.5	-1.4	-1.6	-1.1	-0.3	-1.3	-2.3	-1.5	-2.6	-1.6	-0.5	-1.6	-1.6	-0.5	-1.6	-1.5	-1.7	-1.6	-1.4	-1.4	-1.5	-0.3	-1.5
Pack years adult smoking proportion	1.6	2.4	8.0	1.6	1.1	1.1	0.7	0.9	2.6	2.6	1.9	2.0	0.6	-2.8	1.0	-0.7	1.2	1.6	2.3	-1.1	1.0	1.2	0.6	-0.9	1.2	0.7	-2.0	1.3
Hayfever, allergic rhinitis or eczema	1.6	3.4	7.6	2.0	2.0	2.2	2.8	1.4	1.7	1.9	1.9	2.2	1.8	1.8	1.8	0.1	2.0	2.4	2.3	0.5	1.9	2.2	1.6	0.3	1.7	1.7	-1.3	2.1
Heart attack	1.6	2.1	3.4	-1.7	-1.5	-1.7	-0.9	-1.7	-1.6	-1.4	-1.8	-1.1	-1.3	-1.7	-1.3	-0.8	-1.6	-1.6	-1.2	-1.5	-1.4	-1.7	-1.6	-1.4	-1.5	-1.5	-0.3	-1.4
Birth weight	1.6	3.6	14.5	1.4	1.6	1.9	0.6	1.5	0.7	0.4	1.3	0.5	1.8	3.1	1.6	2.2	1.9	1.4	-0.4	3.8	1.6	2.0	2.0	3.3	2.2	2.1	1.3	1.6
Worry too long after embarrassment	1.6	2.8	8.1	1.6	1.4	1.9	1.8	2.0	2.1	1.9	2.8	2.6	1.0	1.2	1.1	1.2	1.4	1.9	2.5	0.8	1.5	1.6	1.1	0.1	1.3	1.4	1.1	1.5
Qualifications: College or University degree	1.6	5.1	14.7	1.9	2.1	2.1	3.0	1.9	2.9	1.4	2.9	1.5	2.6	3.8	2.2	2.6	2.0	2.1	2.0	2.8	2.2	1.9	2.3	2.1	1.5	2.1	0.9	1.9
Leg fat percentage (left)	1.6	5.8	13.0	-2.1	-2.4	-1.8	-2.2	-2.5	-1.2	-1.5	-2.0	-2.4	-3.0	-3.3	-2.6	-3.6	-2.5	-2.2	-1.6	-3.3	-2.5	-2.3	-2.7	-2.2	-1.8	-2.6	-2.3	-2.2
Medication: Metformin	1.5	2.1	6.0	-1.4	-1.4	-1.4	-1.7	-1.8	-0.6	-1.3	-1.1	-2.0	-1.6	-2.2	-1.3	-2.5	-1.4	-1.6	-1.4	-1.2	-1.4	-1.4	-1.2	-0.5	-0.7	-1.2	0.3	-1.3
Hearing difficulty/problems with background noise	1.5	2.4	4.8	1.5	1.6	1.8	1.2	1.7	1.9	1.7	2.0	2.2	1.3	0.4	1.6	-0.3	1.8	2.0	1.5	0.8	1.6	1.8	1.5	0.9	1.9	1.5	0.5	1.7
Pain all over the body in last month	1.5	1.6	4.6	1.2	1.3	1.4	1.1	0.9	1.4	1.3	1.1	1.4	0.9	-1.7	1.2	-0.8	1.3	1.5	1.6	-0.6	1.1	1.5	0.9	-0.4	1.1	1.0	-2.2	1.3
Tanning	1.4	17.4	29.7	-4.7	-4.4	-4.4	-4.4	-4.4	-4.1	-4.8	-4.9	-3.6	-4.4	-2.9	-4.4	-4.3	-4.4	-4.8	-5.4	-3.1	-4.5	-4.4	-4.2	-2.2	-3.7	-4.1	-0.9	-4.4
Severe depression (siblings)	1.4	1.6	4.4	1.2	1.0	1.1	1.9	2.1	1.2	1.4	1.7	1.3	1.3	1.4	1.0	1.9	1.0	1.1	1.7	0.8	0.9	1.0	0.8	0.1	0.4	0.8	-1.1	0.9
Current tobacco smoking	1.4	2.3	5.8	-1.4	-1.5	-1.5	-1.3	-1.7	-1.1	-1.0	-1.4	-0.5	-1.7	-1.2	-1.8	-2.4	-1.6	-1.5	-0.8	-1.9	-1.6	-1.5	-1.7	-1.8	-1.3	-1.6	-1.1	-1.6
Serious illness, injury or assault to yourself	1.4	1.7	6.1	1.2	0.7	1.0	1.7	2.0	2.5	1.7	1.9	1.3	0.8	2.5	0.6	1.2	0.6	1.1	2.0	-0.3	0.6	0.6	0.3	-0.9	-0.2	0.2	-1.7	0.6
Hip circumference	1.4	6.1	15.7	-2.5	-2.4	-1.8	-3.4	-3.4	-2.3	-3.2	-2.9	-3.7	-2.7	-2.0	-2.6	-1.7	-2.3	-2.8	-4.0	-0.4	-2.6	-2.1	-2.2	0.7	-1.0	-1.8	0.2	-2.4
Illnesses of mother	1.4	1.8	4.9	-1.6	-1.2	-1.3	-1.3	-2.2	-1.8	-1.8	-2.2	-1.1	-1.1	-0.4	-1.2	-1.5	-1.2	-1.3	-1.8	-0.6	-1.1	-1.2	-1.0	-0.5	-1.0	-1.0	-0.3	-1.3
Blood clot in the leg (DVT)	1.4	1.8	3.6	1.4	1.5	1.3	1.1	0.5	1.3	1.5	1.0	0.2	1.4	-0.8	1.7	-0.7	1.4	1.4	0.8	1.3	1.8	1.3	1.9	1.5	1.7	1.6	1.1	1.7
Number of full brothers	1.4	1.7	3.0	-1.5	-1.2	-1.0	-1.3	-1.7	-1.0	-1.6	-1.5	-0.9	-1.2	-1.3	-1.4	-1.2	-1.3	-1.5	-1.1	-1.2	-1.5	-1.1	-1.5	-1.2	-1.2	-1.3	-1.2	-1.5
Had major operations	1.4	1.7	4.0	-1.3	-1.3	-2.0	-0.8	-0.1	-1.2	-0.7	-1.4	-0.5	-1.1	0.3	-1.2	0.4	-1.5	-1.3	-0.7	-1.2	-1.5	-1.7	-1.4	-1.3	-1.9	-1.8	-1.6	-1.7
HDL Cholesterol	1.3	2.1	11.9	-0.3	0.6	0.1	-0.3	-0.6	-2.0	-1.9	-1.3	-1.1	1.1	1.4	0.6	2.3	0.5	-0.5	-2.1	3.5	0.3	0.1	0.9	3.1	0.6	0.9	1.9	0.2
Heart attack/myocardial infarction (self-reported)	1.3	1.7	2.7	-1.5	-1.3	-1.6	-0.7	-1.6	-1.3	-1.0	-1.5	-0.9	-1.2	-1.7	-1.1	-0.9	-1.5	-1.4	-0.8	-1.5	-1.3	-1.6	-1.4	-1.5	-1.4	-1.4	-0.4	-1.2
Irritable Bowel Disease (IBD)	1.2	2.8	6.5	1.5	1.3	1.5	1.2	2.5	1.6	2.0	2.1	2.0	1.4	2.1	1.4	1.8	1.4	1.5	1.1	2.5	1.4	1.4	1.5	1.9	1.5	1.5	1.6	1.3
Ulcerative Colitis (UC)	1.2	2.2	4.8	1.5	1.4	1.6	0.2	1.4	1.5	2.2	1.7	1.4	1.0	-1.0	1.2	0.6	1.5	1.5	1.2	1.6	1.4	1.5	1.5	1.9	2.1	1.6	2.0	1.3
Sensitivity / hurt feelings	1.2	2.1	4.0	1.7	1.6	1.6	2.0	1.3	0.7	2.0	1.8	1.0	1.7	0.5	1.7	0.9	1.6	1.8	1.9	0.4	1.7	1.4	1.4	0.1	1.1	1.4	-0.2	1.8
Ever used hormone-replacement therapy (HRT)	1.2	1.5	7.0	-0.1	-0.8	-0.1	0.1	1.2	1.6	1.2	1.1	0.3	-0.8	0.5	-1.2	-0.7	-0.8	-0.3	1.4	-2.1	-1.1	-0.8	-1.5	-2.6	-1.5	-1.3	-2.2	-1.1
Qualifications: None of the above	1.2	2.6	27.5	-0.8	-0.4	-0.7	-3.2	-1.6	-0.0	-0.6	-1.3	-0.2	-1.1	-5.2	-0.6	-3.3	-0.4	-0.9	-1.6	-1.6	-0.8	-0.4	-0.5	0.2	0.7	-0.3	0.9	-0.5
Breastfed as a baby	1.2	1.5	5.3	-1.4	-1.1	-1.5	-1.3	-1.0	-2.3	-1.4	-2.2	-0.8	-1.0	-0.0	-1.2	-1.0	-1.1	-1.2	-2.0	-0.0	-1.2	-1.1	-0.9	0.2	-0.7	-0.9	0.7	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	3.5	-1.3	-1.1	-1.1	-1.2	-1.1	-1.3	-1.2	-1.0	-0.4	-1.3	-1.3	-1.3	-0.6	-1.1	-1.1	-0.6	-1.9	-1.4	-1.2	-1.7	-1.7	-1.2	-1.4	-1.1	-1.1
Leg fat mass (right)	1.2	4.5	10.1	-1.9	-2.0	-1.2	-2.7	-3.1	-0.7	-2.0	-1.8	-3.2	-2.6	-2.9	-2.3	-3.0	-2.0	-2.1	-2.7	-1.7	-2.2	-1.8	-2.1	-0.4	-0.9	-1.8	-0.7	-1.9
Mother’s age at death	1.2	1.4	3.4	0.8	1.2	0.7	0.6	0.9	-1.3	0.6	-0.5	0.5	1.5	1.8	1.5	1.5	1.3	1.1	-0.3	1.9	1.3	1.2	1.7	1.5	1.0	1.4	0.9	1.1
Heel T-Score	1.1	8.5	22.2	-3.1	-2.8	-3.4	-1.9	-3.7	-0.5	-2.5	-2.0	-1.5	-3.0	-4.3	-1.9	-4.7	-2.9	-2.5	-1.9	-4.5	-2.6	-3.2	-2.8	-2.9	-2.3	-3.2	-2.9	-1.9
Chronotype (morning person)	1.1	2.6	7.2	-1.4	-1.8	-0.9	-2.0	-1.0	0.9	-0.7	-0.4	-1.4	-2.1	-2.5	-2.1	-2.7	-1.7	-1.5	-1.2	-1.6	-1.8	-1.5	-2.2	-1.3	-1.1	-1.7	0.4	-1.5
Vitamin and mineral supplements	1.1	1.5	5.1	1.3	1.2	1.0	1.1	1.3	0.7	1.9	1.4	2.3	1.1	-1.1	1.2	-0.1	1.2	1.4	2.0	-0.1	1.2	1.1	0.9	0.0	1.4	1.0	-0.7	1.4
Medication: Levothyroxine sodium	1.1	1.8	5.9	-1.2	-1.2	-1.8	-1.4	-1.7	-2.4	-1.2	-2.3	-1.7	-1.1	-0.5	-0.8	1.1	-1.3	-1.4	-1.9	0.2	-1.1	-1.4	-0.8	0.3	-1.1	-1.1	0.1	-1.1
Had menopause	1.1	1.4	3.0	-1.1	-1.6	-1.7	-1.2	-0.5	-0.7	-0.5	-0.7	-0.6	-1.5	-0.9	-1.4	-0.6	-1.6	-1.4	-0.8	-0.7	-1.5	-1.6	-1.4	-0.9	-1.4	-1.5	-0.3	-1.6
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	4.1	1.2	1.1	0.9	1.9	1.3	1.2	1.5	1.2	2.0	1.1	0.4	1.2	0.9	1.0	1.3	1.4	1.0	1.3	1.1	1.1	0.4	1.0	1.0	0.5	1.3
Birth weight of first child	1.1	2.0	9.9	1.1	1.5	1.4	2.2	1.0	0.0	0.9	0.5	0.5	1.8	3.1	1.4	1.0	1.4	1.4	0.4	1.7	1.7	1.4	1.7	1.1	0.9	1.5	1.0	1.4
Qualifications: O levels/GCSEs or equivalent	1.1	1.8	4.7	1.2	1.2	1.5	2.1	0.7	0.2	0.4	0.7	0.4	1.3	1.5	1.4	1.2	1.3	1.4	0.7	1.6	1.7	1.4	1.7	1.3	1.1	1.7	2.2	1.4
Leg pain on walking	1.1	1.3	4.8	-1.0	-1.2	-1.3	-1.5	-0.2	-0.6	-0.3	-1.0	-0.0	-1.5	-2.2	-1.1	-1.2	-1.2	-1.0	-0.7	-1.3	-1.2	-1.1	-1.2	-0.9	-0.6	-1.3	-1.5	-1.1
Eye problems/disorders: Glaucoma	1.1	1.3	5.2	1.1	1.1	0.5	0.7	2.3	1.6	1.6	1.8	1.8	1.2	0.1	1.2	0.6	0.9	1.0	1.7	0.1	0.9	0.7	0.7	-0.2	0.5	0.5	-0.1	1.1
Pack years of smoking	1.1	1.6	8.8	1.3	0.9	0.9	0.3	0.7	2.2	2.3	1.6	1.5	0.4	-3.0	0.9	-0.5	1.0	1.3	1.7	-0.6	0.8	1.0	0.5	-0.5	1.1	0.7	-1.2	1.1
Leg fat mass (left)	1.1	4.4	10.2	-1.8	-2.0	-1.1	-2.6	-3.1	-0.6	-1.9	-1.7	-3.2	-2.5	-3.2	-2.2	-3.2	-1.9	-2.0	-2.6	-1.7	-2.1	-1.7	-2.0	-0.3	-0.7	-1.7	-0.6	-1.8
Alzheimer’s Disease (including proxy)	1.0	1.4	4.5	0.8	1.3	1.5	1.0	0.5	0.7	0.5	0.7	0.9	1.4	0.1	1.2	-0.4	1.5	1.4	-0.0	1.3	1.4	1.3	1.6	1.4	1.3	1.5	2.1	1.3
Body Mass Index (BMI) (2010)	1.0	1.3	3.4	-1.3	-1.1	-0.7	-1.1	-1.6	-0.2	-1.7	-1.0	-1.5	-1.4	-1.0	-1.1	-1.8	-1.1	-1.2	-1.6	-1.3	-0.9	-1.0	-0.9	-0.6	-0.6	-0.7	0.5	-0.9
Crohns Disease (2012)	1.0	1.6	15.5	0.9	0.5	0.4	1.4	2.4	0.4	0.8	1.1	1.3	1.0	3.9	0.8	1.5	0.5	0.5	0.6	2.0	0.6	0.6	0.8	1.0	0.1	0.6	0.1	0.5
Mean Putamen Volume	1.0	1.2	5.1	0.9	1.2	0.9	1.2	1.2	0.5	0.7	1.2	2.2	1.4	1.2	1.2	0.3	1.1	1.1	0.8	0.7	1.2	1.0	1.1	0.7	0.9	1.1	0.6	1.1
High blood pressure (mother)	1.0	1.4	6.0	1.5	0.8	1.1	1.3	2.0	1.9	1.8	2.4	0.5	0.9	0.3	0.7	1.5	0.8	1.0	2.3	-0.0	0.8	0.8	0.5	-0.2	0.5	0.6	-0.2	1.0
Hair/balding pattern: Pattern 4	1.0	2.4	4.2	-1.6	-1.8	-1.6	-1.7	-1.1	-1.1	-1.7	-1.6	-1.3	-2.0	-0.9	-1.7	-1.3	-1.8	-1.8	-2.1	-1.5	-1.7	-1.7	-1.7	-1.2	-1.5	-1.6	-0.1	-1.6
Medication: Ibuprofen	1.0	1.2	3.0	-1.1	-1.0	-0.7	-1.7	-1.7	-0.4	-1.5	-0.9	-1.3	-1.1	-1.2	-1.2	-0.7	-1.1	-1.4	-1.3	-0.7	-1.0	-1.0	-1.0	-0.2	-0.5	-0.7	0.8	-1.0
Medication: Allopurinol	1.0	1.4	3.6	1.2	1.0	0.9	0.1	1.2	1.6	1.8	1.8	1.6	0.6	-1.9	1.2	-0.4	1.1	1.2	1.5	-0.3	1.0	1.0	0.8	0.4	1.5	0.9	0.2	1.3
Illnesses of siblings: Diabetes	1.0	1.2	3.7	-1.4	-1.1	-1.4	-1.1	-1.9	-1.5	-1.4	-1.3	-1.4	-1.0	-0.4	-1.0	0.0	-1.1	-1.2	-1.4	0.0	-1.1	-1.1	-0.8	0.2	-0.6	-0.9	-0.1	-1.1
Illnesses of father: High blood pressure	1.0	1.2	3.9	-1.0	-1.1	-2.0	-1.9	-0.3	-1.3	-0.9	-0.9	-0.8	-1.1	-1.4	-0.8	0.8	-1.2	-1.4	-1.0	-0.0	-1.0	-1.4	-0.6	0.4	-0.6	-0.9	1.6	-1.0
Crohns Disease (2017)	0.9	1.9	17.6	0.6	0.4	0.4	1.3	2.4	0.5	0.5	1.0	1.5	0.9	4.2	0.8	2.3	0.5	0.6	0.0	2.4	0.6	0.5	0.8	1.3	0.2	0.6	0.8	0.5
Prostate Cancer	0.9	1.2	2.1	1.3	1.1	0.9	0.8	0.6	1.2	1.5	0.8	0.5	1.2	-0.1	1.4	0.4	1.1	1.0	0.8	1.4	1.3	1.0	1.4	1.3	1.3	1.2	1.0	1.2
Respiratory disease	0.9	1.9	4.2	1.1	1.7	1.8	0.1	0.5	1.0	0.9	1.0	2.0	1.4	-1.5	1.3	-1.1	1.7	1.5	0.5	0.7	1.5	1.8	1.6	1.3	2.0	1.7	0.5	1.5
Ever had hysterectomy (womb removed)	0.9	1.0	6.0	-0.6	-0.9	-0.2	-0.5	0.2	0.3	0.4	-0.1	-0.4	-1.1	0.1	-1.1	-0.8	-0.8	-0.4	0.0	-1.8	-1.0	-0.6	-1.2	-1.8	-1.0	-1.2	-2.5	-1.0
Medication for hormone replacement therapy	0.9	1.1	5.4	0.0	-0.5	-0.1	0.5	0.8	0.7	0.8	0.7	0.3	-0.6	0.8	-0.7	-0.6	-0.5	0.1	1.5	-1.9	-0.7	-0.4	-1.1	-2.3	-1.2	-1.0	-2.3	-0.6
Medication: Ramipril	0.9	1.2	5.3	-1.0	-0.8	-1.2	-0.9	-1.2	-1.4	-1.0	-1.5	-1.2	-0.8	-2.3	-0.7	-1.7	-0.9	-1.0	-1.4	-0.2	-0.7	-1.0	-0.6	0.5	-0.0	-0.5	1.2	-0.6
Arm fat percentage (right)	0.9	3.6	13.0	-1.6	-1.5	-0.9	-2.1	-2.9	-0.8	-1.6	-1.8	-2.4	-2.1	-3.6	-1.9	-3.0	-1.6	-1.7	-1.8	-2.2	-1.8	-1.5	-1.7	-0.8	-0.7	-1.5	-1.5	-1.5
Pulse wave Arterial Stiffness index	0.9	1.1	2.4	-1.0	-1.3	-1.0	-1.5	-0.7	-1.0	-0.9	-0.8	-0.7	-1.6	-1.3	-1.3	-0.4	-1.1	-0.9	-0.6	-1.3	-1.0	-0.9	-1.2	-1.0	-0.7	-1.0	0.6	-1.0
Arm fat mass (right)	0.9	3.6	10.1	-1.6	-1.6	-0.9	-2.6	-3.0	-0.7	-2.0	-1.7	-3.1	-2.1	-3.2	-1.9	-2.7	-1.5	-1.9	-2.8	-1.1	-1.8	-1.4	-1.6	0.3	-0.4	-1.3	-0.2	-1.5
Length of working week for main job	0.9	1.0	7.3	-0.6	-0.1	-0.0	-1.4	-2.1	0.1	-1.1	-0.8	-0.5	-0.4	-2.7	-0.1	-1.7	-0.1	-0.5	-1.4	-0.5	-0.4	-0.1	-0.1	0.7	0.6	-0.0	-1.0	-0.0
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.6	0.9	1.0	0.9	1.0	0.9	1.6	1.0	1.2	1.4	1.2	-0.2	1.1	0.4	1.0	0.9	0.8	1.2	1.0	0.8	1.1	1.0	1.0	1.0	0.3	1.0
Medication for pain relief, constipation, heartburn	0.9	1.6	8.7	-1.5	-1.0	-1.3	-0.3	-1.5	-2.9	-1.7	-2.4	-1.5	-1.0	0.3	-0.8	-0.4	-1.0	-0.9	-1.7	-0.2	-1.0	-1.0	-0.9	-0.5	-1.2	-1.1	-0.7	-1.0
Arm fat mass (left)	0.9	3.9	11.8	-1.6	-1.6	-0.8	-2.6	-3.2	-0.7	-2.0	-1.6	-3.2	-2.2	-3.4	-1.9	-3.0	-1.6	-1.9	-2.8	-1.3	-1.8	-1.4	-1.6	0.3	-0.3	-1.3	-0.2	-1.5
Pain type(s) experienced in last month: Hip pain	0.9	1.1	6.1	-0.3	-0.8	-0.0	-0.0	0.3	1.1	0.3	0.7	0.2	-1.0	-0.8	-0.8	-1.3	-0.6	-0.1	0.8	-2.5	-0.7	-0.5	-1.1	-2.3	-0.9	-1.0	-2.3	-0.6
Alzheimer’s Disease (in mother)	0.8	0.9	4.4	0.9	1.0	1.2	1.1	0.5	0.6	0.7	0.6	1.0	0.8	0.4	0.6	-0.8	1.0	1.1	0.4	0.5	1.1	1.1	1.0	0.5	1.1	1.1	2.1	1.0
Triglycerides	0.8	1.3	4.4	0.9	0.2	1.1	1.1	0.9	1.7	1.9	1.3	1.5	-0.1	0.0	-0.1	-0.7	0.3	1.0	1.9	-2.0	0.3	0.7	-0.3	-2.1	-0.0	-0.1	-2.0	0.3
Trunk fat-free mass	0.8	4.3	20.1	-0.9	-0.7	-0.1	-2.5	-2.5	-0.2	-2.6	-0.8	-3.4	-0.6	0.2	-0.7	-0.5	-0.4	-1.5	-4.3	3.5	-0.6	-0.3	0.2	4.5	1.3	0.6	4.3	-0.4
Trunk predicted mass	0.8	4.5	20.5	-0.9	-0.7	-0.1	-2.5	-2.6	-0.3	-2.7	-0.8	-3.4	-0.6	0.2	-0.8	-0.5	-0.5	-1.6	-4.4	3.5	-0.6	-0.3	0.2	4.5	1.3	0.5	4.4	-0.5
Knee pain experienced in last month	0.8	1.3	4.1	-1.0	-1.3	-1.2	-0.5	-0.3	-0.2	0.1	-0.9	-0.3	-1.6	-0.9	-1.2	-1.4	-1.4	-0.9	-0.7	-2.0	-1.1	-1.3	-1.4	-1.5	-1.0	-1.5	-1.0	-1.1
Arm fat percentage (left)	0.8	3.2	14.2	-1.4	-1.3	-0.7	-2.0	-2.8	-0.7	-1.3	-1.6	-2.3	-1.9	-3.8	-1.6	-3.0	-1.3	-1.4	-1.6	-2.2	-1.5	-1.2	-1.5	-0.8	-0.5	-1.3	-1.6	-1.2
Long-standing illness, disability or infirmity	0.8	1.3	4.2	-0.8	-1.2	-0.7	-1.0	-1.5	0.8	-0.4	-0.1	-0.1	-1.5	-2.0	-1.4	-1.5	-1.2	-0.8	-0.2	-1.9	-1.0	-1.0	-1.4	-1.5	-0.8	-1.1	0.3	-1.0
Medication: Paracetamol	0.8	1.2	5.5	1.3	0.9	1.2	0.3	1.6	2.3	1.6	1.8	1.2	1.0	0.5	0.7	1.2	0.9	0.9	1.7	0.9	0.7	0.9	0.7	0.4	0.7	0.7	-0.3	0.7
Fractured/broken bones in last 5 years	0.8	1.0	3.0	-1.0	-0.9	-0.9	-1.4	-1.1	-1.5	-1.1	-1.1	-0.8	-1.0	-1.7	-1.1	-1.0	-0.8	-0.9	-1.1	-0.8	-0.8	-0.7	-0.8	-0.4	-0.3	-0.6	1.0	-0.9
Age started oral contraceptive pill	0.8	1.0	9.2	-0.0	-0.2	-0.3	-0.4	-0.4	0.5	-0.5	0.0	-0.2	0.0	0.2	0.3	1.3	-0.1	-0.4	-1.0	2.3	0.3	-0.3	0.8	2.1	0.1	0.5	3.0	-0.1
Arm predicted mass (left)	0.8	3.9	16.1	-1.3	-1.3	-0.5	-3.0	-2.8	-0.2	-2.7	-0.9	-3.4	-1.5	-1.3	-1.4	-1.6	-1.0	-1.9	-4.0	1.9	-1.2	-0.9	-0.7	3.1	0.7	-0.2	3.2	-1.0
Leg fat-free mass (left)	0.7	3.8	16.6	-1.1	-0.7	-0.0	-2.8	-3.2	-0.4	-2.7	-1.3	-3.7	-1.0	-1.5	-1.1	-1.6	-0.6	-1.6	-4.1	1.9	-0.8	-0.3	-0.2	3.4	1.2	0.3	2.8	-0.6
Maternal smoking around birth	0.7	1.0	5.2	0.5	0.5	0.5	0.5	1.0	1.2	1.2	1.0	1.9	0.3	-1.4	0.5	-0.8	0.6	0.9	1.5	-1.4	0.4	0.6	0.2	-1.2	0.4	0.1	-2.3	0.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	5.8	0.4	-0.4	0.6	0.0	1.5	1.2	1.2	1.0	0.6	-0.6	-0.4	-0.4	-0.5	-0.2	0.2	1.4	-1.4	-0.5	0.1	-0.7	-1.5	-0.5	-0.6	-2.4	-0.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	3.2	0.7	0.7	0.8	0.2	1.4	0.9	1.0	1.0	1.8	0.6	0.4	0.7	-0.8	0.9	0.9	0.4	0.1	0.7	1.0	0.6	0.2	1.0	0.7	0.7	0.9
Leg predicted mass (left)	0.7	3.8	16.8	-1.1	-0.7	0.0	-2.8	-3.2	-0.4	-2.7	-1.3	-3.7	-1.0	-1.4	-1.0	-1.6	-0.5	-1.6	-4.1	1.9	-0.8	-0.3	-0.2	3.5	1.2	0.3	2.9	-0.6
Mouth/teeth dental problems	0.7	1.0	2.2	-1.0	-1.2	-1.2	-0.6	-0.3	-0.3	-1.2	-0.2	-0.9	-1.0	0.8	-1.2	-0.5	-1.4	-1.4	-0.8	-0.0	-1.3	-1.5	-1.2	-0.3	-1.5	-1.2	0.1	-1.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	11.0	1.1	1.0	1.0	0.5	1.1	0.9	0.6	1.8	0.4	1.3	2.1	1.1	1.5	1.2	0.8	-0.0	3.3	1.2	1.1	1.4	2.6	1.4	1.5	3.1	1.0
Noisy workplace	0.7	0.9	3.6	-1.0	-0.8	-0.9	-1.3	-1.3	-1.9	-1.0	-1.5	-0.9	-1.0	-1.7	-0.7	0.0	-0.7	-0.6	-1.0	-0.9	-0.6	-0.6	-0.5	-0.4	-0.3	-0.6	0.4	-0.6
Chronic bronchitis/emphysema (mother)	0.7	0.9	1.6	0.9	1.2	0.6	0.9	0.8	0.8	0.9	0.7	1.1	1.2	-0.7	1.2	-0.2	1.1	0.9	0.5	0.7	1.1	0.9	1.2	0.8	1.1	1.0	0.0	1.0
Arm fat-free mass (right)	0.7	3.6	15.1	-1.0	-1.0	-0.3	-2.8	-2.9	-0.4	-2.6	-0.9	-3.5	-1.2	-1.1	-1.2	-1.6	-0.8	-1.6	-3.9	1.9	-0.9	-0.6	-0.4	3.3	1.0	0.1	3.2	-0.7
Arm predicted mass (right)	0.7	3.7	15.8	-1.1	-1.1	-0.5	-2.8	-2.9	-0.5	-2.7	-1.0	-3.6	-1.2	-0.9	-1.2	-1.2	-0.9	-1.8	-4.0	2.0	-1.0	-0.7	-0.4	3.2	0.8	-0.0	3.1	-0.8
Alcohol intake frequency.	0.7	1.5	4.9	1.3	1.1	1.4	0.8	1.2	2.2	1.6	1.8	1.9	0.9	-0.4	1.0	0.5	1.3	1.5	1.6	-0.2	1.1	1.3	0.8	-0.1	1.1	0.9	-0.6	1.2
Whole body fat-free mass	0.7	4.0	17.6	-0.9	-0.6	-0.0	-2.6	-2.8	-0.2	-2.6	-0.8	-3.5	-0.7	-0.5	-0.8	-0.9	-0.4	-1.5	-4.2	2.8	-0.6	-0.3	0.1	4.1	1.4	0.5	3.8	-0.4
Osteoarthritis (self-reported)	0.7	0.8	2.0	-0.3	-1.1	-0.7	-0.5	0.5	1.4	0.5	-0.2	0.1	-1.2	-0.7	-1.0	-1.4	-1.1	-0.7	-0.3	-1.2	-0.9	-1.0	-1.0	-1.0	-1.1	-1.2	-1.1	-1.0
Illnesses of father: None of the above (group 1)	0.7	0.9	2.4	0.8	0.9	1.6	0.8	0.1	1.4	0.5	0.7	1.0	0.9	0.9	0.8	-0.4	1.1	1.3	0.5	0.6	1.1	1.4	0.9	0.4	0.9	1.0	0.6	1.0
Whole body water mass	0.7	4.2	18.2	-1.0	-0.8	-0.1	-2.7	-2.9	-0.2	-2.8	-0.9	-3.6	-0.9	-0.7	-1.0	-1.1	-0.5	-1.6	-4.3	2.7	-0.7	-0.4	-0.1	4.0	1.3	0.4	3.8	-0.5
Ever taken oral contraceptive pill	0.7	0.7	5.8	-0.6	-0.4	-0.2	-1.2	-1.6	0.4	-0.6	-0.3	-1.0	-0.8	-2.4	-0.7	-1.6	-0.5	-0.6	-0.6	-0.9	-0.6	-0.4	-0.6	-0.2	0.1	-0.4	0.1	-0.5
Arm fat-free mass (left)	0.7	3.6	14.8	-1.0	-1.1	-0.3	-2.7	-2.7	-0.0	-2.5	-0.7	-3.4	-1.3	-1.1	-1.2	-1.4	-0.8	-1.7	-3.9	2.1	-1.0	-0.6	-0.4	3.4	0.9	0.0	3.4	-0.7
Risk taking	0.7	1.0	5.2	0.9	0.7	1.0	0.8	1.0	2.3	1.4	1.7	0.4	0.7	0.2	0.8	-1.5	0.7	0.9	1.4	-0.1	0.6	0.8	0.5	-0.0	0.8	0.4	-1.2	0.8
Breast Cancer	0.6	1.6	5.4	-1.6	-1.4	-0.9	-1.1	-1.4	-1.4	-2.3	-1.5	-1.5	-1.2	-0.3	-1.4	-0.5	-1.3	-1.4	-1.4	-0.9	-1.2	-1.2	-1.2	-0.3	-1.0	-1.0	-0.1	-1.3
Ovarian Cancer	0.6	0.8	3.0	0.9	0.8	0.9	1.7	1.3	0.4	1.1	1.0	1.1	0.8	0.7	0.8	0.4	0.7	1.0	1.4	-0.1	0.9	0.7	0.6	-0.4	0.3	0.6	-0.4	0.9
Fasting Glucose	0.6	0.7	4.2	0.1	-0.6	0.0	-0.3	-0.2	0.3	0.5	0.4	-0.3	-1.0	-0.9	-0.6	-0.1	-0.6	-0.1	1.2	-2.0	-0.6	-0.4	-1.0	-1.8	-0.7	-0.8	-1.6	-0.4
Allergy or Eczema	0.6	1.6	5.6	1.1	1.5	1.5	2.4	0.1	0.6	1.1	0.7	1.1	1.4	1.0	1.2	-0.7	1.4	1.8	1.2	0.4	1.5	1.6	1.2	0.4	1.4	1.3	-0.8	1.6
Hypothyroidism (self reported)	0.6	1.3	4.8	-0.8	-1.1	-1.5	-0.6	-1.4	-2.1	-0.7	-2.2	-1.8	-0.8	-0.4	-0.7	0.5	-1.1	-1.2	-1.2	0.1	-1.0	-1.4	-0.8	-0.2	-1.4	-1.1	-0.7	-1.0
Medication: Co-codamol	0.6	0.7	4.6	-0.2	-0.4	-0.5	0.6	0.9	0.8	0.3	0.4	1.3	-0.2	0.4	-0.3	-0.2	-0.5	-0.2	1.0	-1.0	-0.4	-0.6	-0.6	-1.5	-1.0	-0.8	-2.1	-0.4
Diabetes (father)	0.6	0.7	5.6	-0.4	-0.4	-0.1	-0.6	-1.0	0.3	-0.0	-0.3	-0.8	-0.8	-2.4	-0.5	-1.9	-0.4	-0.3	0.3	-1.0	-0.5	-0.4	-0.4	-0.8	-0.4	-0.6	-1.5	-0.5
Fed-up feelings	0.6	1.1	5.0	1.2	1.0	1.1	-0.2	1.0	1.4	0.8	1.3	0.6	0.7	-2.2	1.0	-0.3	1.0	0.7	0.5	0.2	0.9	1.0	0.9	0.9	1.4	1.1	0.6	1.2
Supplements: Glucosamine	0.6	0.8	1.7	-0.8	-1.2	-0.9	-1.3	-0.7	0.1	-0.6	-0.9	-0.6	-1.2	-0.2	-1.2	-0.5	-1.1	-1.0	-1.0	-0.2	-1.0	-1.1	-1.0	-0.4	-1.1	-1.1	0.4	-1.1
Weight	0.6	2.7	11.6	-1.0	-0.8	-0.0	-2.4	-2.9	-0.4	-2.0	-1.1	-3.3	-1.2	-2.0	-1.1	-2.1	-0.7	-1.4	-3.4	0.9	-0.9	-0.5	-0.5	2.4	0.9	-0.1	1.4	-0.6
Time employed in main current job	0.6	0.7	2.9	-0.8	-0.5	-0.3	-0.3	-0.9	-0.3	-0.6	-0.4	-0.1	-0.7	-1.5	-0.9	-0.6	-0.7	-0.4	0.6	-1.7	-0.8	-0.7	-1.1	-1.5	-0.8	-1.0	-1.2	-0.7
Father’s age at death	0.6	0.8	2.4	1.0	1.0	0.9	1.0	0.2	0.2	0.3	0.7	0.2	1.0	1.5	0.8	0.8	1.0	0.9	0.8	0.8	1.1	1.1	1.0	0.4	0.6	1.1	1.5	0.9
Hair/balding pattern: Pattern 3	0.6	0.9	1.7	-1.2	-1.2	-1.0	-0.7	-1.0	-0.9	-0.9	-1.0	-0.8	-1.0	0.7	-1.3	-0.2	-1.1	-1.0	-0.8	-0.4	-1.1	-1.1	-1.1	-0.7	-1.1	-1.1	-0.5	-1.2
Mouth/teeth dental problems: Dentures	0.6	0.9	7.7	-0.5	-0.3	-0.4	-1.4	-1.4	-0.8	-0.4	-1.1	-0.4	-0.5	-2.8	-0.3	-1.4	-0.2	-0.5	-1.1	-0.1	-0.1	-0.2	-0.0	0.6	0.6	0.1	2.2	-0.1
Medication: Lansoprazole	0.6	0.7	3.1	0.5	0.1	0.4	1.2	1.8	1.7	0.7	1.4	0.5	0.3	1.4	0.2	1.4	0.0	0.3	1.5	-0.2	0.3	0.1	0.0	-0.7	-0.5	-0.1	-0.0	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	9.4	0.9	0.7	0.7	0.4	1.3	1.2	0.6	1.9	0.6	0.9	2.4	0.9	0.8	0.8	0.6	0.0	3.1	0.8	0.8	1.1	2.3	1.0	1.1	2.4	0.8
Peak expiratory flow (PEF)	0.6	1.5	12.8	0.7	0.8	0.8	-0.1	-0.2	-0.0	-0.1	0.7	-0.0	0.7	-0.1	0.8	0.1	0.9	0.5	-0.7	2.3	0.9	0.9	1.2	2.5	1.5	1.4	3.6	0.9
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	4.1	-0.9	-0.9	-1.4	-0.9	-1.2	-1.8	-0.8	-2.0	-1.3	-0.8	-0.6	-0.5	0.6	-1.0	-1.2	-1.5	0.4	-0.9	-1.3	-0.7	0.4	-1.0	-0.9	-0.0	-0.9
Number of children fathered	0.6	0.6	2.5	-0.4	-0.8	-0.1	-0.6	-1.3	-0.7	-0.7	-1.2	-1.6	-1.0	-0.2	-0.9	-1.4	-0.7	-0.6	-0.7	-0.1	-0.8	-0.5	-0.8	0.1	-0.4	-0.6	0.6	-0.7
Age at first live birth	0.6	1.0	5.7	-0.5	-0.1	-0.5	-0.1	-0.6	-1.4	-1.1	-0.9	-2.0	0.2	1.7	-0.0	2.0	-0.1	-0.3	-0.7	1.1	0.1	-0.2	0.3	0.9	-0.2	0.2	2.4	-0.1
Shortness of breath walking on level ground	0.6	0.7	6.0	0.3	0.1	0.3	-1.3	-0.1	0.7	0.3	0.0	0.4	-0.4	-2.4	-0.1	-2.1	0.2	-0.0	-0.4	-0.2	0.2	0.5	0.2	0.7	1.0	0.5	1.6	0.3
Emphysema/chronic bronchitis	0.6	0.7	2.9	0.2	0.7	0.2	0.2	1.3	-0.2	0.6	0.3	1.7	0.9	0.1	0.9	1.6	0.8	0.8	-0.2	1.3	0.7	0.6	0.8	1.0	0.7	0.7	1.0	0.7
Heart disease (mother)	0.6	0.7	1.5	-0.7	-1.0	-0.7	-0.7	0.6	0.5	-0.1	-0.0	0.4	-1.1	0.9	-0.9	1.1	-1.0	-0.8	-0.3	-0.4	-1.1	-1.0	-1.1	-0.7	-1.2	-1.2	-1.1	-1.0
Leg fat-free mass (right)	0.6	3.3	13.8	-0.7	-0.4	0.3	-2.5	-2.9	-0.2	-2.4	-0.9	-3.4	-0.7	-1.2	-0.8	-1.4	-0.3	-1.2	-3.7	2.0	-0.5	-0.0	0.1	3.6	1.5	0.6	2.9	-0.3
Commuting to job workplace: Walk	0.6	0.6	3.2	-0.3	-0.5	-0.5	0.1	-0.6	-0.8	0.6	-0.8	-0.6	-0.4	0.2	-0.6	-0.2	-0.4	-0.1	0.9	-1.6	-0.4	-0.4	-0.7	-1.8	-0.9	-0.8	-1.5	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	3.5	-1.2	-1.6	-1.9	-0.3	0.8	-0.2	-0.7	0.1	0.6	-1.1	1.3	-0.9	-0.1	-1.5	-1.3	-0.5	0.1	-1.3	-1.7	-1.3	-0.8	-1.8	-1.6	-0.0	-1.3
Leg predicted mass (right)	0.6	3.3	14.2	-0.8	-0.5	0.2	-2.5	-2.9	-0.2	-2.4	-0.9	-3.5	-0.8	-1.2	-0.8	-1.4	-0.3	-1.3	-3.8	2.0	-0.6	-0.1	0.0	3.5	1.4	0.5	2.9	-0.4
Basal metabolic rate	0.6	3.4	15.6	-0.9	-0.6	0.1	-2.5	-2.8	-0.1	-2.4	-0.8	-3.5	-0.8	-0.8	-0.9	-1.2	-0.5	-1.4	-4.0	2.3	-0.7	-0.3	-0.1	3.6	1.2	0.4	3.1	-0.5
Irritability	0.6	1.0	4.7	-0.5	-0.6	-0.1	-1.1	-1.4	-0.8	-1.0	-0.8	-1.9	-0.9	-2.2	-0.7	-1.9	-0.5	-1.0	-1.5	-0.3	-0.7	-0.5	-0.5	0.7	0.2	-0.2	0.5	-0.5
Diastolic blood pressure, automated reading	0.6	1.8	5.3	1.5	0.8	1.3	0.3	1.7	1.5	1.9	2.0	2.0	0.2	-2.3	0.8	0.4	1.0	1.5	2.2	-0.9	0.9	1.2	0.6	-0.3	1.5	0.7	-1.2	1.3
Schizophrenia vs Biploar Disorder	0.5	0.6	3.2	-0.8	-0.8	-1.2	-1.4	-0.2	0.4	-0.4	-0.2	-0.6	-0.7	-1.8	-0.4	0.0	-0.9	-1.0	-0.5	-0.7	-0.7	-1.2	-0.4	-0.1	-0.6	-0.8	0.0	-0.7
HbA1C	0.5	0.5	3.3	-0.3	-0.3	-0.6	-0.8	-0.9	0.1	0.0	-0.2	-0.2	-0.5	-1.8	-0.2	-1.5	-0.3	-0.4	-0.8	-0.7	-0.0	-0.6	-0.1	-0.1	0.2	-0.3	1.6	-0.1
Blood White Count	0.5	3.4	17.8	-0.6	-1.1	-0.7	0.7	-1.0	0.2	0.4	-0.3	0.2	-1.3	-1.3	-1.6	-2.6	-1.2	-0.4	1.8	-4.2	-1.2	-0.9	-2.2	-4.2	-1.7	-1.9	-3.7	-1.0
Diabetes (mother)	0.5	0.7	2.7	0.6	0.9	0.8	1.6	-0.1	0.3	0.9	0.7	0.6	1.1	0.4	0.8	0.6	0.8	1.0	1.4	-0.5	0.9	0.6	0.7	-0.3	0.5	0.6	-0.8	0.9
Hair/balding pattern: Pattern 2	0.5	0.6	4.1	-0.5	-0.4	-0.5	-0.4	-1.2	-0.3	-0.9	-1.0	-2.0	-0.3	-0.7	-0.3	-1.2	-0.6	-1.1	-1.4	0.1	-0.4	-0.8	-0.1	0.8	-0.4	-0.2	0.4	-0.5
Falls in the last year	0.5	0.7	4.2	-0.3	-0.5	-0.1	0.0	1.1	0.4	0.4	0.6	1.5	-0.7	-0.2	-0.8	-1.4	-0.4	0.2	0.7	-2.1	-0.4	-0.1	-0.8	-1.9	-0.4	-0.7	-1.1	-0.3
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.2	-1.0	-1.0	-0.7	-0.2	-0.6	-0.6	-1.8	-0.7	-1.1	-0.6	1.8	-0.8	1.5	-0.9	-1.1	-1.3	1.3	-0.8	-1.0	-0.6	0.4	-1.2	-0.6	1.3	-1.1
Exposure to tobacco smoke at home	0.5	0.6	1.5	0.7	1.1	0.9	0.6	0.8	-0.7	0.3	0.3	0.1	1.2	0.3	0.9	-0.0	1.0	0.7	0.2	0.7	0.7	0.9	0.9	1.0	1.0	0.9	-0.8	0.8
Overall health rating	0.5	1.1	5.5	0.9	0.6	0.7	1.0	1.4	2.3	1.4	1.8	1.7	0.4	-0.8	0.7	-0.1	0.6	1.0	1.4	-0.7	0.7	0.8	0.3	-0.7	0.4	0.3	-1.1	0.8
Qualifications: nursing, teaching	0.5	0.8	5.1	-0.5	-0.7	-0.3	0.7	0.1	-0.1	-1.0	0.0	-1.2	-0.2	2.3	-0.6	1.3	-0.7	-0.6	-0.2	0.5	-0.8	-0.7	-0.8	-0.5	-1.4	-0.8	-1.7	-0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.7	0.7	0.6	0.7	1.2	0.8	0.8	0.6	1.0	0.8	0.4	0.6	0.7	0.5	0.6	0.9	1.3	-0.4	0.7	0.7	0.5	-0.5	0.3	0.5	-0.3	0.8
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.0	-0.7	-0.6	-0.8	-0.7	-0.6	-0.1	-0.6	0.1	-0.7	-0.7	-0.8	-0.7	-1.0	-0.7	-0.7	-0.1	-1.0	-0.8	-0.8	-0.8	-0.7	-0.5	-0.8	-0.7	-0.6
Angina	0.4	0.5	1.5	-0.9	-0.8	-0.9	-1.2	-0.8	-0.3	-0.9	-0.8	-0.3	-0.6	-0.4	-0.7	-0.2	-0.7	-1.1	-0.8	0.4	-0.8	-0.8	-0.6	0.2	-0.6	-0.5	0.7	-0.9
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	2.8	0.0	0.1	-0.1	0.8	0.4	0.9	0.3	0.6	0.3	0.2	1.7	0.0	0.9	0.1	0.4	0.9	-0.7	0.1	0.1	-0.3	-1.4	-0.6	-0.3	-1.2	-0.0
Number of live births	0.4	0.6	2.4	-0.8	-0.7	-1.0	0.2	0.0	0.2	-0.1	0.2	0.8	-0.4	-0.3	-0.6	-0.3	-0.8	-0.7	-0.1	-0.2	-0.9	-1.1	-1.0	-0.8	-1.2	-1.1	-1.6	-0.8
Loud music exposure frequency	0.4	0.4	2.5	0.2	0.5	-0.0	0.2	1.6	-0.5	0.8	0.4	1.3	0.9	0.7	0.5	1.3	0.4	0.4	0.8	0.2	0.4	0.1	0.5	-0.1	0.2	0.3	0.0	0.3
Medication: Ventolin 100micrograms inhaler	0.4	0.5	3.0	0.4	0.0	0.4	1.0	1.0	0.8	0.7	0.7	1.3	0.2	0.7	-0.3	-0.1	0.0	0.2	1.1	-0.9	-0.1	-0.0	-0.4	-1.4	-0.7	-0.2	-1.7	-0.1
Exposure to tobacco smoke outside home	0.4	0.5	1.8	0.9	0.6	0.8	0.1	1.3	0.4	1.0	0.6	1.1	0.5	-0.9	0.7	-0.7	0.7	0.6	0.4	0.2	0.6	0.7	0.7	0.4	0.7	0.7	0.1	0.7
Angina (self-reported)	0.4	0.5	1.3	-0.8	-0.8	-0.9	-1.2	-0.7	-0.4	-0.8	-0.7	-0.2	-0.7	-0.5	-0.8	-0.2	-0.8	-1.1	-0.7	0.3	-0.9	-0.9	-0.7	0.0	-0.7	-0.6	0.5	-1.0
Medication: Omeprazole	0.4	0.5	3.9	-0.3	-0.6	-0.4	-0.6	-0.6	2.0	0.1	0.9	0.1	-0.8	-1.0	-0.6	-0.9	-0.7	-0.4	0.4	-0.8	-0.6	-0.7	-0.7	-0.8	-0.5	-0.7	0.0	-0.6
Medication: Seretide 50 evohaler	0.4	0.4	5.3	-0.4	-0.3	-0.0	-0.8	-0.9	0.1	-0.4	-0.1	-0.2	-0.8	-2.3	-0.6	-0.8	-0.2	-0.2	-0.3	-0.5	-0.5	-0.0	-0.5	-0.4	-0.0	-0.3	-0.3	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	3.3	0.4	0.1	-0.1	1.2	0.5	0.2	1.2	0.2	0.1	0.3	0.8	0.2	1.0	0.0	0.3	1.3	-0.5	0.1	-0.2	-0.1	-1.2	-0.6	-0.3	-1.8	0.0
Miserableness	0.4	0.7	8.2	-0.1	-0.3	0.1	-2.0	-0.9	-0.1	-0.8	0.0	-0.1	-0.9	-2.9	-0.4	-1.0	-0.2	-0.6	-0.5	-0.4	-0.5	-0.1	-0.2	0.5	0.6	0.1	1.0	-0.2
Alcohol drinker status: Never	0.4	0.5	1.9	0.8	0.6	0.5	0.2	0.9	1.0	1.4	0.9	0.3	0.8	-1.0	0.8	1.1	0.5	0.5	1.1	-0.2	0.7	0.4	0.6	-0.2	0.3	0.6	0.5	0.8
Average weekly beer plus cider intake	0.4	0.6	2.8	0.5	0.8	0.5	0.2	-0.4	-0.8	0.6	-0.1	1.3	0.5	-1.4	0.9	-0.5	0.9	1.0	0.3	0.1	0.6	0.8	0.6	0.4	1.1	0.6	-1.7	0.8
Ever had prostate specific antigen (PSA) test	0.4	0.4	3.4	-0.2	-0.3	-0.1	-0.7	-0.5	0.0	-0.4	-0.1	-0.5	-0.3	-1.2	-0.1	0.1	-0.3	-0.5	-0.8	1.1	-0.1	-0.3	0.2	1.2	0.1	0.1	1.9	-0.2
Alzheimer’s Disease (in father)	0.3	0.4	1.9	0.1	0.5	0.4	-0.1	-0.3	0.4	-0.3	0.3	0.1	0.4	-1.4	0.8	-0.6	0.6	0.5	-0.5	0.4	0.6	0.4	0.9	1.1	0.9	0.7	0.4	0.7
Supplements: Zinc	0.3	0.4	1.6	-0.3	-0.5	-0.6	-0.6	-0.4	0.8	-0.2	0.1	-0.5	-0.7	0.1	-0.7	-0.6	-0.6	-0.6	0.1	-1.3	-0.6	-0.6	-0.6	-0.9	-0.6	-0.6	0.3	-0.6
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	3.3	-0.2	-0.3	0.2	0.3	0.5	1.8	0.2	0.9	0.3	-0.4	-0.2	-0.4	-0.1	-0.2	0.1	0.7	-0.8	-0.2	-0.1	-0.4	-0.9	-0.3	-0.3	-0.9	-0.2
Medication: Simvastatin	0.3	0.5	0.9	-0.8	-0.8	-0.7	-0.8	-0.0	-0.2	-0.6	-0.4	-0.3	-0.7	-0.6	-0.8	-0.5	-0.8	-0.9	-0.8	-0.3	-0.8	-0.8	-0.8	-0.1	-0.5	-0.7	1.0	-0.8
Health satisfaction	0.3	0.4	1.7	-0.4	-0.5	-0.5	-0.3	0.6	1.3	-0.2	0.8	0.5	-0.6	-0.9	-0.5	-1.1	-0.5	-0.4	-0.0	-1.3	-0.4	-0.5	-0.6	-0.8	-0.3	-0.6	-0.6	-0.2
Number of full sisters	0.3	0.3	3.5	-0.2	-0.0	0.1	-1.0	-0.7	-0.6	-0.4	-0.6	0.1	-0.2	-1.9	-0.5	-0.3	0.1	-0.2	-0.4	0.4	-0.5	0.1	-0.4	0.6	0.5	-0.0	-0.6	-0.4
Age at last live birth	0.3	0.4	2.7	-0.3	0.1	-0.4	-0.2	-0.5	-0.4	-0.5	-0.4	-1.6	0.5	1.0	0.1	0.9	0.0	-0.2	-0.4	0.9	0.1	-0.3	0.3	0.8	-0.1	0.2	1.5	-0.0
Medication: Aspirin	0.3	0.4	1.8	-0.4	-0.7	-0.5	-0.5	0.6	0.6	0.4	0.3	0.5	-0.6	-0.7	-0.7	-0.5	-0.6	-0.6	0.2	-1.3	-0.7	-0.7	-0.7	-1.1	-0.5	-0.7	-0.4	-0.7
Supplements: Vitamin C	0.3	0.4	1.4	-0.3	-0.9	-0.6	-0.5	0.6	0.2	-0.3	0.0	0.2	-0.8	1.0	-0.6	0.8	-0.7	-0.5	-0.3	-0.5	-0.6	-0.6	-0.7	-1.0	-1.2	-0.7	0.1	-0.7
Ever had bowel cancer screening	0.3	0.4	1.9	-0.3	-0.1	-0.1	0.6	0.6	0.7	-0.0	0.7	1.0	0.1	1.3	0.1	-0.5	-0.1	-0.1	-0.3	1.4	0.1	-0.1	0.0	0.8	-0.2	0.0	1.3	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.9	-0.3	0.1	0.5	-1.0	-1.4	-0.2	-0.4	-0.6	-0.8	-0.6	-1.2	-0.3	-0.7	0.3	0.3	-0.6	-1.0	-0.2	0.5	-0.1	-0.2	0.8	0.0	-0.8	-0.1
Breast cancer (self-reported)	0.3	0.4	1.5	0.2	-0.2	-0.0	0.8	1.1	0.5	0.5	0.5	0.5	-0.1	1.1	-0.2	1.1	-0.2	0.1	0.7	-0.7	-0.1	-0.1	-0.4	-1.2	-0.7	-0.3	-0.7	-0.2
Asthma (self-reported)	0.3	0.6	2.3	0.5	0.9	1.0	0.1	0.3	1.1	0.6	0.6	1.5	0.6	-1.2	0.5	-1.5	0.8	0.8	0.5	-0.2	0.6	0.9	0.7	0.3	0.9	0.7	-0.3	0.6
Medication: Aspirin	0.3	0.3	1.7	-0.2	-0.6	-0.5	-0.4	0.7	0.4	0.5	0.1	0.4	-0.5	-0.7	-0.5	-0.3	-0.6	-0.5	0.3	-1.3	-0.5	-0.6	-0.6	-1.1	-0.5	-0.6	-0.3	-0.6
Medication: Gliclazide	0.3	0.3	3.0	-0.4	-0.2	-0.1	0.5	-0.2	0.5	0.3	0.2	0.3	-0.1	-0.5	-0.2	-0.7	-0.2	0.1	0.2	-1.0	-0.3	-0.2	-0.5	-1.0	-0.2	-0.5	-1.7	-0.1
Financial situation satisfaction	0.3	0.4	4.5	0.0	0.3	-0.0	0.1	-0.0	0.1	0.3	0.0	0.5	0.2	-1.9	0.1	-2.1	0.2	0.1	-0.3	-0.7	0.2	0.2	0.1	0.1	0.6	0.2	-0.3	0.4
Commuting to job workplace: Public transport	0.3	0.4	1.3	0.5	0.6	0.8	1.0	0.6	0.1	0.5	0.4	-0.2	0.9	1.2	0.7	0.5	0.6	0.6	0.5	0.0	0.7	0.6	0.5	0.0	0.4	0.5	-0.7	0.8
Number of operations (self-reported)	0.3	0.5	5.1	0.2	0.0	0.1	0.4	0.7	0.7	0.6	0.4	0.6	0.1	0.7	-0.2	1.1	-0.1	0.1	0.8	-0.5	-0.3	-0.1	-0.4	-0.9	-0.8	-0.5	-2.3	-0.4
Unable to work because of sickness or disability	0.3	0.4	2.1	0.0	-0.1	-0.0	-0.6	0.4	0.7	0.2	0.7	1.0	-0.3	-1.0	-0.1	0.4	0.0	0.3	1.0	-0.9	-0.2	0.2	-0.3	-1.0	-0.0	-0.3	-1.5	-0.1
Cholesterol lowering medication	0.3	0.5	1.3	-0.7	-0.8	-0.6	-0.7	0.3	0.7	-0.0	0.4	1.1	-0.9	-0.2	-0.7	-1.2	-0.7	-0.5	-0.4	-0.8	-0.7	-0.7	-0.7	-0.6	-0.5	-0.8	0.4	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	3.6	-0.2	-0.6	-0.4	-0.4	-0.2	1.9	0.2	1.1	0.1	-0.7	-0.4	-0.5	-0.1	-0.6	-0.3	0.5	-0.6	-0.4	-0.7	-0.5	-0.7	-0.6	-0.6	-0.0	-0.5
Alcohol drinker status: Previous	0.3	0.4	1.7	-0.3	-0.3	-0.1	-0.4	0.1	1.0	0.4	0.8	0.5	-0.6	-1.3	-0.4	-1.2	-0.3	-0.1	0.1	-0.8	-0.5	-0.2	-0.6	-0.6	-0.0	-0.5	-0.8	-0.3
Coronary Artery Disease (CAD)	0.2	0.3	0.6	-0.3	-0.6	-0.7	-0.7	0.1	-0.2	-0.0	-0.4	-0.4	-0.4	-0.6	-0.6	-0.2	-0.7	-0.7	0.1	-0.6	-0.5	-0.7	-0.6	-0.8	-0.7	-0.5	0.6	-0.4
Lupus	0.2	0.3	2.3	-0.2	-0.4	-0.3	-0.2	-0.6	-0.3	-0.3	-0.7	-1.5	-0.3	1.3	-0.1	0.3	-0.3	-0.3	-0.4	0.0	-0.1	-0.3	0.1	0.0	-0.4	-0.1	1.1	-0.3
Trunk fat percentage	0.2	1.0	2.6	1.1	1.3	1.6	0.9	-0.0	0.9	1.2	0.6	-0.1	0.9	-0.8	1.0	-0.5	1.2	1.2	0.5	-0.0	1.0	1.3	0.9	0.5	1.3	1.1	-1.2	1.1
Taking other prescription medications	0.2	0.3	1.9	-0.2	-0.4	-0.6	-0.0	0.1	1.4	0.3	0.5	0.1	-0.4	-1.3	-0.1	-0.6	-0.6	-0.5	0.2	-0.8	-0.3	-0.7	-0.4	-0.7	-0.7	-0.6	-0.4	-0.3
Chronic bronchitis/emphysema (father)	0.2	0.3	1.3	0.1	0.8	0.2	0.4	0.3	-0.8	0.5	-0.1	1.1	0.8	-0.1	0.7	0.8	0.6	0.5	0.0	0.4	0.4	0.5	0.4	0.5	0.5	0.4	-0.1	0.4
Trunk fat mass	0.2	0.8	3.0	0.7	0.9	1.5	0.0	-0.9	0.7	0.2	0.2	-1.2	0.6	-0.8	0.6	-0.9	0.9	0.6	-0.9	0.8	0.7	1.1	0.8	1.7	1.6	1.1	0.1	0.9
Waist circumference	0.2	0.9	4.4	0.3	0.0	0.9	-0.0	-0.9	2.1	0.9	1.3	-0.6	-0.5	-1.8	-0.3	-1.8	0.1	0.5	0.8	-1.2	-0.1	0.4	-0.3	-0.5	0.6	-0.1	-1.9	0.1
Had other major operations	0.2	0.3	2.6	-0.0	-0.3	0.1	0.3	0.2	0.6	0.3	0.1	-0.4	-0.4	0.7	-0.5	0.1	-0.4	-0.2	0.3	-0.4	-0.5	-0.3	-0.6	-0.7	-0.7	-0.5	-1.6	-0.5
Financial difficulties in last 2 years	0.2	0.3	2.0	0.2	0.0	0.1	0.5	-0.2	1.4	0.5	0.2	0.5	-0.2	-0.6	-0.1	-0.8	-0.1	0.1	0.7	-0.7	-0.1	-0.0	-0.2	-0.6	-0.2	-0.2	-1.3	-0.0
Illnesses of siblings	0.2	0.3	3.2	0.4	0.0	0.5	0.8	-0.1	-0.0	-0.1	-0.0	-0.2	-0.1	1.8	0.1	-0.4	0.2	0.4	0.4	-0.3	0.2	0.4	0.0	-0.5	-0.1	0.1	-0.9	0.2
Asthma	0.2	0.4	2.9	0.2	0.5	0.7	-0.2	0.1	0.9	0.4	0.3	1.1	0.4	-1.4	0.2	-1.7	0.5	0.4	0.2	-0.4	0.2	0.5	0.3	0.0	0.5	0.3	-0.7	0.2
Lung cancer (father)	0.2	0.3	1.1	0.7	0.5	0.6	0.6	0.6	0.3	0.5	0.4	1.0	0.4	-0.7	0.5	0.2	0.5	0.6	0.8	0.4	0.3	0.6	0.2	-0.1	0.2	0.3	-0.8	0.5
High blood pressure (siblings)	0.2	0.3	1.7	-0.5	-0.5	-0.7	-1.1	-0.2	0.1	-0.2	0.0	0.1	-0.5	-1.3	-0.6	0.5	-0.6	-0.7	-0.4	-0.2	-0.6	-0.6	-0.4	0.0	-0.2	-0.4	0.6	-0.6
Body fat percentage	0.2	0.6	3.7	-0.1	-0.1	0.4	-0.4	-1.2	0.1	0.1	-0.5	-1.1	-0.6	-1.9	-0.4	-1.8	-0.2	-0.1	-0.4	-1.4	-0.4	-0.0	-0.4	-0.5	0.2	-0.3	-1.7	-0.2
Neck or shoulder pain in last month	0.2	0.3	2.2	0.3	0.0	0.0	0.0	0.6	1.5	1.1	0.6	0.5	-0.3	-0.4	0.1	-0.2	0.0	0.4	0.5	-0.8	0.2	0.0	0.1	-0.5	0.2	-0.1	0.7	0.2
Mean time to correctly identify matches	0.2	0.3	2.3	-0.4	-0.4	-0.6	-1.2	0.4	-0.6	-0.0	-1.0	-0.4	-0.5	-1.5	-0.1	-0.9	-0.3	-0.4	-0.7	0.0	-0.3	-0.3	0.1	0.5	0.2	-0.1	0.2	-0.5
Whole body fat mass	0.2	1.0	5.2	-0.5	-0.4	0.2	-1.3	-2.0	0.1	-0.8	-0.7	-2.3	-0.8	-1.8	-0.7	-1.7	-0.4	-0.6	-1.8	-0.3	-0.6	-0.2	-0.4	0.8	0.5	-0.2	-0.3	-0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	1.5	0.1	0.1	0.2	-0.1	0.5	0.1	-0.1	0.0	0.9	0.2	1.2	0.1	-0.2	0.1	0.0	-0.4	1.1	0.1	0.1	0.3	0.9	0.2	0.3	1.0	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	3.1	0.1	0.4	0.5	0.4	-0.8	0.6	-0.5	0.5	0.1	0.5	-0.0	0.2	1.8	0.4	0.3	0.2	0.5	0.3	0.4	0.3	0.4	0.3	0.4	-0.1	0.3
Average weekly red wine intake	0.2	0.2	1.2	0.3	0.1	0.6	0.7	-0.0	-0.4	-0.4	-0.4	-0.4	0.1	0.9	-0.2	-1.1	-0.0	-0.2	-0.1	0.2	0.1	0.1	0.2	0.8	0.2	0.3	1.1	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.2	-0.2	-0.2	-0.2	-0.2	-0.5	0.1	0.5	-0.3	-0.7	-0.3	-0.9	-0.6	-0.6	-0.3	-0.2	-0.1	-1.1	-0.3	-0.3	-0.6	-0.9	-0.2	-0.4	-0.3	-0.3
Osteoporosis (self-reported)	0.2	0.2	0.8	-0.1	-0.4	-0.6	0.3	0.0	-0.9	-0.2	-0.5	-0.2	-0.3	0.8	-0.3	0.5	-0.5	-0.4	0.3	-0.6	-0.2	-0.4	-0.4	-0.9	-0.7	-0.4	0.4	-0.3
Number of self-reported non-cancer illnesses	0.2	0.3	1.1	-0.3	-0.6	-0.5	-0.6	0.8	1.0	-0.1	0.4	0.8	-0.4	-0.5	-0.5	0.5	-0.6	-0.6	0.2	-0.1	-0.5	-0.7	-0.5	-0.3	-0.7	-0.6	0.5	-0.6
Ever depressed for a whole week	0.2	0.2	0.9	0.2	-0.1	0.4	0.9	1.0	0.8	0.5	0.6	0.7	-0.2	-0.3	-0.3	-0.5	-0.0	0.3	0.6	-0.1	0.1	0.2	-0.1	-0.4	-0.1	0.0	-0.2	0.0
Pain experienced in last month	0.2	0.3	3.8	0.3	0.2	-0.2	0.6	0.4	-1.9	-0.0	-0.5	-0.1	0.6	1.0	0.3	0.5	0.2	0.0	0.6	0.2	0.2	0.0	0.2	-0.4	-0.4	0.2	0.3	0.1
Supplements: Calcium	0.2	0.2	1.7	0.1	-0.1	-0.2	-0.1	0.6	0.9	0.0	0.1	0.0	0.2	1.3	-0.2	0.1	-0.1	-0.3	-0.5	0.6	-0.0	-0.2	0.1	0.3	-0.2	0.1	0.8	-0.3
Heart disease (siblings)	0.2	0.2	2.6	0.2	0.4	0.2	0.1	1.2	0.5	0.5	0.6	1.6	0.4	0.0	0.3	-0.5	0.1	0.1	0.1	-0.2	0.0	0.2	-0.1	-0.2	0.1	0.0	-0.4	0.2
Reaction Time	0.1	0.3	2.0	0.2	0.3	0.1	-0.5	0.7	0.2	0.4	-0.3	0.1	0.2	-1.1	0.4	-1.4	0.4	0.2	-0.1	-0.3	0.3	0.4	0.6	0.5	0.8	0.5	-0.5	0.3
Hearing difficulty/problems: Yes	0.1	0.1	0.7	-0.6	-0.4	-0.4	-0.7	0.0	0.8	-0.3	0.2	0.3	-0.4	-0.3	-0.2	-0.0	-0.2	-0.0	-0.4	-0.4	-0.1	-0.3	-0.2	-0.1	0.1	-0.3	0.7	0.0
Relative age of first facial hair	0.1	0.2	1.6	-0.3	-0.3	-0.6	0.2	-0.1	-1.2	-0.4	-0.2	-0.4	-0.1	1.3	-0.2	0.1	-0.3	-0.3	-0.2	-0.1	-0.2	-0.5	-0.2	-0.3	-0.6	-0.4	0.6	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	1.0	-0.1	0.1	0.4	-0.8	-1.0	0.3	-0.7	0.1	-0.6	0.0	-0.5	-0.2	-0.4	-0.0	-0.4	-0.4	-0.0	-0.1	0.1	-0.1	0.4	0.5	0.3	0.7	-0.0
Handedness (chirality/laterality): Left-handed	0.1	0.2	1.3	0.2	0.0	0.1	0.4	0.3	1.1	-0.2	0.6	-0.2	0.2	0.1	0.0	0.5	0.0	-0.1	-0.2	0.7	0.2	0.1	0.1	0.4	0.1	0.3	1.1	0.2
Hair Pigment	0.0	0.6	5.5	-0.2	0.0	0.2	-1.0	-1.8	0.2	-0.1	-0.3	-0.2	-0.5	-2.3	-0.4	-2.2	-0.0	-0.1	-0.2	-0.8	-0.1	0.1	-0.1	0.3	0.8	0.1	0.0	-0.1

Hub : Genes

NEK4

Models

Trait associations