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chr4:17,104,059-18,507,692

Best TWAS P=4.72e-19 · Best GWAS P=3.62e-19 conditioned to 0.00196

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Artery Aorta	DCAF16	0.10	0.01	enet	6	0.02	4.7e-02	-8.4	8.9	4.7e-19	-0.79	0.09	0.64	TRUE
6	GTEx	Breast Mammary Tissue (Male)	DCAF16	0.24	0.03	enet	18	-0.01	4.4e-01	-8.3	8.6	6.9e-18	-0.75	0.03	0.67	FALSE
22	The Cancer Genome Atlas	Brain Lower Grade Glioma	NCAPG	0.02	0.03	lasso	1	0.02	9.0e-04	-8.4	-8.4	3.2e-17	0.86	0.01	0.89	FALSE
14	GTEx	Spleen	DCAF16	0.35	0.02	lasso	5	0.11	8.5e-04	5.3	8.4	4.8e-17	-0.65	0.04	0.66	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	DCAF16	0.09	0.02	lasso	3	0.04	5.2e-05	5.3	8.3	8.1e-17	-0.63	0.04	0.89	FALSE
20	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NCAPG	0.14	0.07	lasso	3	0.07	5.2e-08	-8.4	-8.2	2.7e-16	0.83	0.01	0.99	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	DCAF16	0.04	0.02	bslmm	379	0.01	3.9e-02	-8.4	8.1	6.6e-16	-0.83	0.03	0.88	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	DCAF16	0.07	0.04	blup	31	0.07	4.9e-07	5.5	8.1	7.9e-16	-0.64	0.15	0.78	FALSE
16	GTEx	Thyroid	DCAF16	0.11	0.02	lasso	5	0.03	2.3e-03	5.3	8.0	1.6e-15	-0.53	0.19	0.66	FALSE
5	GTEx	Breast Mammary Tissue	DCAF16	0.12	0.08	lasso	4	0.10	6.4e-06	5.3	7.7	1.2e-14	-0.51	0.10	0.76	FALSE
24	The Cancer Genome Atlas	Prostate Adenocarcinoma	DCAF16	0.04	0.04	blup	31	0.04	2.2e-05	5.3	7.5	4.4e-14	-0.56	0.26	0.25	FALSE
19	The Cancer Genome Atlas	Colon Adenocarcinoma	NCAPG	0.08	0.04	blup	34	0.09	1.1e-05	-8.4	-7.5	6.0e-14	0.82	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Prostate Adenocarcinoma	NCAPG	0.02	0.02	blup	34	0.02	3.4e-03	-7.7	-7.2	5.7e-13	0.75	0.02	0.57	FALSE
2	GTEx	Adipose Visceral Omentum	DCAF16	0.19	0.06	enet	10	0.11	3.9e-06	5.3	6.7	2.1e-11	-0.34	0.37	0.31	FALSE
15	GTEx	Stomach	DCAF16	0.21	0.04	lasso	6	0.02	5.6e-02	5.5	6.4	1.5e-10	-0.25	0.19	0.05	FALSE
10	GTEx	Nerve Tibial	DCAF16	0.16	0.14	lasso	3	0.14	2.8e-10	5.3	6.3	2.4e-10	-0.35	0.99	0.00	FALSE
4	GTEx	Artery Tibial	DCAF16	0.16	0.16	lasso	5	0.13	1.5e-10	5.3	6.2	4.9e-10	-0.35	1.00	0.00	FALSE
12	GTEx	Skin Not Sun Exposed Suprapubic	DCAF16	0.16	0.08	lasso	5	0.12	4.4e-07	5.0	6.0	2.4e-09	-0.34	0.64	0.05	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	NCAPG	0.06	0.02	blup	34	0.04	1.0e-05	-8.4	-5.9	2.8e-09	0.67	0.01	0.92	FALSE
8	GTEx	Esophagus Mucosa	DCAF16	0.10	0.02	lasso	4	0.02	8.3e-03	5.3	5.9	3.3e-09	-0.35	0.14	0.36	FALSE
13	GTEx	Skin Sun Exposed Lower leg	DCAF16	0.14	0.12	enet	14	0.12	5.4e-10	5.3	5.8	6.9e-09	-0.27	1.00	0.00	FALSE
1	GTEx	Adipose Subcutaneous	DCAF16	0.21	0.15	lasso	3	0.17	5.1e-14	5.3	5.5	4.8e-08	-0.23	1.00	0.00	FALSE
11	GTEx	Pituitary	DCAF16	0.27	0.20	enet	15	0.19	1.3e-05	5.3	5.4	5.4e-08	-0.37	0.08	0.23	FALSE
7	GTEx	Breast Mammary Tissue (Female)	DCAF16	0.16	0.13	lasso	2	0.06	7.8e-03	5.3	5.4	6.8e-08	-0.26	0.06	0.10	FALSE
18	YFS	Blood	DCAF16	0.02	0.02	lasso	1	0.01	1.1e-04	5.3	5.3	1.1e-07	-0.25	0.84	0.03	FALSE
9	GTEx	Esophagus Muscularis	DCAF16	0.16	0.14	lasso	3	0.14	9.3e-09	5.3	5.2	1.9e-07	-0.25	0.99	0.00	FALSE