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chr5:129,797,129-132,839,137

Best TWAS P=5.4e-17 · Best GWAS P=2.44e-16 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PDLIM4	0.11	0.18	lasso	5	0.18	8.0e-21	-7.06	-7.2	6.6e-13	-0.69	0.96	0.04	FALSE
2	GTEx	Adipose Subcutaneous	SLC22A5	0.05	0.04	lasso	4	0.04	4.2e-04	7.71	-8.0	1.8e-15	-0.83	0.05	0.93	TRUE
3	GTEx	Adipose Subcutaneous	AC034220.3	0.11	0.11	lasso	10	0.09	4.8e-08	-6.23	6.2	4.9e-10	0.71	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	AC034220.3	0.10	0.09	lasso	7	0.08	7.3e-05	-6.29	6.3	3.2e-10	0.71	0.41	0.32	FALSE
5	GTEx	Adrenal Gland	AC034220.3	0.12	0.11	lasso	16	0.08	7.7e-04	-6.24	6.4	1.4e-10	0.71	0.67	0.12	FALSE
6	GTEx	Artery Aorta	P4HA2	0.12	0.14	lasso	2	0.11	1.2e-06	8.07	8.1	6.6e-16	0.96	0.01	0.99	FALSE
7	GTEx	Artery Aorta	HINT1	0.07	0.07	enet	8	0.06	4.7e-04	-4.22	-5.3	9.4e-08	-0.34	0.07	0.62	FALSE
8	GTEx	Artery Aorta	AC034220.3	0.08	0.06	lasso	3	0.05	1.1e-03	-6.25	6.6	4.0e-11	0.75	0.42	0.36	FALSE
9	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	8.09	8.1	4.6e-16	0.99	0.02	0.96	FALSE
10	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	8.11	8.1	7.3e-16	0.98	0.01	0.99	FALSE
11	GTEx	Artery Tibial	SLC22A5	0.18	0.12	enet	8	0.12	2.5e-09	7.71	-7.1	9.7e-13	-0.82	0.13	0.87	FALSE
12	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	8.10	8.4	5.4e-17	0.95	0.01	0.99	TRUE
13	GTEx	Brain Caudate basal ganglia	AC034220.3	0.41	0.45	enet	19	0.46	8.8e-15	-6.29	6.5	9.6e-11	0.73	0.99	0.01	FALSE
14	GTEx	Brain Cortex	AC034220.3	0.43	0.39	lasso	15	0.17	2.4e-05	-6.29	6.2	6.0e-10	0.70	0.92	0.07	FALSE
15	GTEx	Brain Frontal Cortex BA9	AC034220.3	0.31	0.20	lasso	14	0.21	3.3e-06	-6.29	5.7	8.9e-09	0.65	0.62	0.25	FALSE
16	GTEx	Brain Hippocampus	AC034220.3	0.21	0.15	lasso	14	0.18	5.8e-05	-6.29	6.7	2.1e-11	0.85	0.07	0.88	FALSE
17	GTEx	Brain Nucleus accumbens basal ganglia	AC034220.3	0.24	0.24	enet	34	0.24	3.7e-07	-6.21	6.4	1.5e-10	0.71	0.88	0.06	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	SLC22A5	0.37	0.05	lasso	13	0.10	2.8e-04	7.76	-6.6	4.2e-11	-0.77	0.06	0.87	FALSE
19	GTEx	Cells Transformed fibroblasts	PDLIM4	0.08	0.09	lasso	1	0.07	6.4e-06	-7.10	-7.1	1.3e-12	-0.68	0.75	0.12	FALSE
20	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	-6.84	-7.6	2.6e-14	-0.84	0.55	0.45	FALSE
21	GTEx	Colon Sigmoid	AC034220.3	0.18	0.11	lasso	12	0.06	3.7e-03	-6.31	6.6	5.7e-11	0.70	0.25	0.13	FALSE
22	GTEx	Colon Transverse	SLC22A5	0.12	0.07	enet	8	0.07	2.5e-04	7.76	-7.6	3.2e-14	-0.81	0.15	0.73	FALSE
23	GTEx	Colon Transverse	AC034220.3	0.30	0.15	lasso	3	0.11	8.4e-06	-6.25	6.4	1.3e-10	0.73	0.92	0.04	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	SEPT8	0.22	0.08	lasso	12	0.10	2.2e-04	-5.97	6.6	5.4e-11	0.61	0.40	0.40	FALSE
25	GTEx	Esophagus Mucosa	P4HA2	0.23	0.10	lasso	6	0.14	6.1e-10	8.07	7.7	1.0e-14	0.93	0.01	0.99	FALSE
26	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	7.76	-7.8	9.0e-15	-0.94	0.02	0.98	FALSE
27	GTEx	Esophagus Mucosa	AC034220.3	0.08	0.03	lasso	3	0.05	4.7e-04	-6.29	6.4	2.1e-10	0.71	0.95	0.03	FALSE
28	GTEx	Esophagus Mucosa	P4HA2-AS1	0.09	0.06	lasso	6	0.08	5.4e-06	8.07	7.9	2.3e-15	0.96	0.02	0.98	FALSE
29	GTEx	Esophagus Muscularis	AC034220.3	0.12	0.08	enet	20	0.07	3.8e-05	-6.25	6.0	2.1e-09	0.64	0.86	0.05	FALSE
30	GTEx	Heart Atrial Appendage	AC034220.3	0.16	0.09	enet	17	0.18	1.7e-08	-6.27	6.7	2.6e-11	0.78	0.57	0.43	FALSE
31	GTEx	Heart Left Ventricle	AC034220.3	0.25	0.22	lasso	6	0.25	8.6e-14	-6.25	6.5	8.6e-11	0.71	1.00	0.00	FALSE
32	GTEx	Liver	AC034220.3	0.30	0.16	lasso	6	0.16	3.9e-05	-6.27	5.3	1.0e-07	0.57	0.59	0.05	FALSE
33	GTEx	Lung	SLC22A5	0.10	0.15	enet	11	0.13	3.4e-10	7.76	-7.7	1.6e-14	-0.93	0.06	0.94	FALSE
34	GTEx	Muscle Skeletal	AC034220.3	0.27	0.23	lasso	9	0.24	9.1e-24	-6.29	7.1	9.1e-13	0.77	1.00	0.00	FALSE
35	GTEx	Muscle Skeletal	MIR3936	0.04	0.01	lasso	4	0.00	9.9e-02	-7.10	8.0	1.1e-15	0.83	0.09	0.62	FALSE
36	GTEx	Nerve Tibial	P4HA2	0.19	0.12	enet	26	0.14	6.2e-10	-6.27	6.2	6.2e-10	0.86	0.02	0.98	FALSE
37	GTEx	Nerve Tibial	AC034220.3	0.15	0.11	lasso	5	0.10	1.9e-07	-6.24	6.2	6.3e-10	0.71	1.00	0.00	FALSE
38	GTEx	Nerve Tibial	P4HA2-AS1	0.14	0.05	lasso	8	0.08	3.8e-06	7.33	6.5	7.5e-11	0.89	0.03	0.97	FALSE
39	GTEx	Ovary	PDLIM4	0.25	0.22	enet	10	0.05	2.1e-02	-4.05	5.9	4.3e-09	0.60	0.30	0.32	FALSE
40	GTEx	Ovary	AC004041.2	0.21	-0.01	lasso	2	-0.01	7.7e-01	-6.57	6.0	2.0e-09	0.65	0.06	0.30	FALSE
41	GTEx	Pituitary	AC034220.3	0.25	0.22	lasso	12	0.18	3.1e-05	-6.10	6.5	8.8e-11	0.66	0.66	0.10	FALSE
42	GTEx	Prostate	AC034220.3	0.38	0.37	lasso	5	0.37	3.0e-10	-6.25	6.0	2.3e-09	0.69	0.94	0.04	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	7.76	-7.6	3.1e-14	-0.84	0.07	0.88	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A5	0.13	0.05	lasso	8	0.05	8.3e-04	-6.21	-7.3	2.4e-13	-0.82	0.15	0.84	FALSE
45	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	8.07	-8.3	1.1e-16	-0.91	0.02	0.98	FALSE
46	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	7.71	-7.7	1.1e-14	-0.89	0.13	0.87	FALSE
47	GTEx	Spleen	SLC22A5	0.26	0.28	lasso	4	0.28	6.6e-08	7.76	7.7	1.5e-14	0.88	0.08	0.80	TRUE
48	GTEx	Stomach	SLC22A5	0.09	0.04	lasso	4	0.01	9.0e-02	-6.65	-6.9	4.9e-12	-0.71	0.07	0.57	FALSE
49	GTEx	Stomach	AC034220.3	0.17	0.15	enet	21	0.16	4.2e-08	-6.09	6.8	9.9e-12	0.68	1.00	0.00	FALSE
50	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	8.07	8.3	8.2e-17	0.95	0.02	0.98	FALSE
51	GTEx	Testis	PDLIM4	0.15	0.07	enet	8	0.05	2.5e-03	-6.29	5.8	6.6e-09	0.71	0.24	0.14	FALSE
52	GTEx	Testis	RAPGEF6	0.50	0.35	lasso	4	0.32	6.5e-15	-6.58	-6.6	3.9e-11	-0.32	0.00	1.00	TRUE
53	GTEx	Testis	AC034220.3	0.15	0.12	lasso	9	0.12	4.4e-06	-6.29	6.3	3.4e-10	0.71	0.87	0.04	FALSE
54	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	8.11	7.6	2.7e-14	0.98	0.01	0.99	FALSE
55	GTEx	Thyroid	PDLIM4	0.05	0.02	enet	5	0.01	3.1e-02	7.33	-8.0	8.3e-16	-0.90	0.06	0.87	FALSE
56	GTEx	Thyroid	SLC22A5	0.17	0.07	lasso	5	0.13	4.8e-10	-0.94	-5.2	1.6e-07	-0.66	0.14	0.86	FALSE
57	GTEx	Thyroid	AC034220.3	0.29	0.29	lasso	5	0.31	4.8e-24	-6.10	5.3	1.2e-07	0.47	1.00	0.00	FALSE
58	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	8.11	7.4	1.5e-13	0.91	0.01	0.99	FALSE
59	GTEx	Whole Blood	SLC22A4	0.07	0.05	enet	16	0.05	4.6e-05	-6.84	-7.3	2.4e-13	-0.71	0.14	0.77	FALSE
60	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	7.76	-7.8	8.2e-15	-0.89	0.10	0.90	FALSE
61	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	7.77	-8.1	7.3e-16	-0.79	0.09	0.91	FALSE
62	GTEx	Whole Blood	AC116366.6	0.05	0.04	lasso	17	0.03	5.7e-04	-4.49	5.9	4.2e-09	0.50	0.36	0.37	FALSE
63	METSIM	Adipose	P4HA2	0.09	0.08	lasso	12	0.09	2.4e-13	8.10	5.7	1.0e-08	0.87	0.01	0.99	FALSE
64	METSIM	Adipose	PDLIM4	0.05	0.04	lasso	4	0.02	2.8e-04	7.35	-7.4	1.6e-13	-0.87	0.63	0.32	TRUE
65	METSIM	Adipose	SLC22A4	0.05	0.02	lasso	3	0.03	8.4e-06	4.35	-5.3	1.4e-07	-0.49	0.94	0.02	FALSE
66	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	7.76	-7.8	8.2e-15	-0.89	0.10	0.90	FALSE
67	NTR	Blood	IRF1	0.03	0.02	blup	424	0.01	5.7e-05	-4.49	5.2	1.6e-07	0.50	1.00	0.00	FALSE
68	NTR	Blood	SLC22A4	0.02	0.00	blup	423	0.01	5.2e-04	4.35	-5.9	2.7e-09	-0.67	0.26	0.69	FALSE
69	ROSMAP	Brain Pre-frontal Cortex	PDLIM4	0.25	0.27	lasso	4	0.26	2.7e-33	-7.02	-7.3	2.3e-13	-0.75	0.95	0.05	FALSE
70	ROSMAP	Brain Pre-frontal Cortex	SLC22A4	0.03	0.05	lasso	2	0.04	1.2e-05	-7.08	-6.8	1.1e-11	-0.73	0.61	0.29	TRUE
71	YFS	Blood	CDC42SE2	0.14	0.05	lasso	9	0.07	3.1e-22	-6.40	6.1	8.4e-10	0.20	0.00	1.00	TRUE
72	YFS	Blood	SLC22A4	0.10	0.12	enet	47	0.14	5.1e-42	-6.26	-6.8	1.3e-11	-0.70	1.00	0.00	FALSE
73	YFS	Blood	SLC22A5	0.38	0.36	bslmm	430	0.37	3.0e-128	7.76	-7.9	3.6e-15	-0.87	0.11	0.89	FALSE
74	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PDLIM4	0.05	0.01	enet	4	0.02	1.2e-02	-6.57	-5.5	4.5e-08	-0.56	0.08	0.07	FALSE
75	The Cancer Genome Atlas	Breast Invasive Carcinoma	P4HA2	0.03	0.02	blup	47	0.03	3.1e-06	8.10	5.6	1.9e-08	0.86	0.01	0.99	FALSE
76	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDLIM4	0.05	0.05	lasso	4	0.05	9.0e-11	-7.02	-7.4	1.3e-13	-0.71	0.90	0.10	FALSE
77	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A4	0.05	0.01	enet	7	0.02	1.6e-05	7.76	-6.5	8.7e-11	-0.82	0.02	0.96	FALSE
78	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A5	0.05	0.07	enet	11	0.09	5.3e-17	-6.09	-6.5	1.1e-10	-0.68	1.00	0.00	FALSE
79	The Cancer Genome Atlas	Colon Adenocarcinoma	PDLIM4	0.14	0.04	enet	9	0.09	6.8e-06	-6.21	-5.6	1.6e-08	-0.65	0.40	0.33	FALSE
80	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A5	0.08	0.04	blup	92	0.07	1.2e-04	-6.84	-6.9	6.8e-12	-0.75	0.03	0.91	FALSE
81	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A4	0.02	0.02	lasso	1	0.02	3.0e-03	-5.97	-6.0	2.3e-09	-0.58	0.12	0.56	FALSE
82	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A5	0.06	0.05	blup	93	0.08	1.2e-09	-6.24	-7.0	2.2e-12	-0.76	0.08	0.92	FALSE
83	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDLIM4	0.09	0.02	lasso	6	0.05	4.5e-06	-6.57	-7.5	9.1e-14	-0.69	0.20	0.64	FALSE
84	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC22A4	0.03	0.03	lasso	1	0.02	3.5e-03	-6.21	-6.2	5.2e-10	-0.71	0.37	0.22	FALSE
85	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CDC42SE2	0.10	0.07	lasso	1	0.06	2.6e-04	-5.94	5.9	2.8e-09	0.15	0.02	0.88	FALSE
86	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC22A4	0.04	0.03	blup	108	0.01	7.1e-02	-6.08	-6.4	1.2e-10	-0.63	0.12	0.14	FALSE
87	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PDLIM4	0.08	0.03	blup	67	0.05	2.4e-03	-6.08	-6.2	4.5e-10	-0.62	0.04	0.38	FALSE
88	The Cancer Genome Atlas	Lung Adenocarcinoma	LYRM7	0.03	0.01	enet	10	0.02	7.5e-04	-4.55	6.0	2.2e-09	0.37	0.05	0.39	FALSE
89	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC22A5	0.06	0.03	lasso	4	0.02	9.3e-04	-6.84	-6.6	3.2e-11	-0.68	0.05	0.76	FALSE
90	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A4	0.04	0.01	blup	111	0.03	3.0e-04	-2.98	-6.4	1.7e-10	-0.64	0.06	0.73	FALSE
91	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A5	0.05	0.03	blup	93	0.05	1.9e-06	-6.08	-7.0	2.7e-12	-0.74	0.04	0.96	FALSE
92	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDLIM4	0.32	0.36	enet	13	0.37	3.8e-40	-6.57	-7.5	8.3e-14	-0.77	0.98	0.02	FALSE
93	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A4	0.09	0.07	blup	108	0.09	3.0e-09	-6.27	-6.7	1.6e-11	-0.78	0.19	0.81	FALSE
94	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC22A5	0.05	0.01	blup	92	0.02	1.1e-02	-3.43	-5.2	1.7e-07	-0.50	0.09	0.14	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf56	0.06	0.04	blup	98	0.03	1.3e-03	-4.60	6.6	3.6e-11	0.55	0.79	0.12	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	IRF1	0.05	0.02	blup	83	0.03	1.5e-03	7.29	7.1	1.8e-12	0.79	0.00	0.94	FALSE
97	The Cancer Genome Atlas	Thyroid Carcinoma	P4HA2	0.21	0.35	enet	10	0.35	4.7e-35	8.10	7.8	9.0e-15	0.98	0.01	0.99	FALSE
98	The Cancer Genome Atlas	Thyroid Carcinoma	SLC22A5	0.03	0.02	lasso	1	0.01	2.6e-02	-6.84	-6.8	8.1e-12	-0.72	0.02	0.70	FALSE