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chr4:305,291-2,058,475

Best TWAS P=8e-10 · Best GWAS P=4.95e-08 conditioned to 0.00336

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	GTEx	Nerve Tibial	CRIPAK	0.50	0.11	enet	76	0.38	1.1e-28	-3.5	-6.1	8.0e-10	0.46	0.72	0.11	TRUE
4	GTEx	Artery Aorta	UVSSA	0.33	0.06	enet	30	0.28	7.2e-16	-4.1	-6.1	1.2e-09	0.56	0.01	0.99	FALSE
19	GTEx	Muscle Skeletal	CRIPAK	0.25	0.11	enet	32	0.18	7.6e-18	-4.2	-6.0	2.0e-09	0.52	0.36	0.56	FALSE
24	GTEx	Skin Sun Exposed Lower leg	CRIPAK	0.36	0.09	enet	40	0.35	8.7e-30	-3.5	-5.9	2.9e-09	0.46	0.58	0.28	FALSE
16	GTEx	Esophagus Mucosa	CRIPAK	0.49	0.14	enet	28	0.40	6.8e-29	-4.2	-5.9	3.1e-09	0.53	0.29	0.64	FALSE
9	GTEx	Brain Cortex	CRIPAK	0.34	0.10	lasso	6	0.18	9.5e-06	-4.2	-5.8	5.1e-09	0.47	0.04	0.78	FALSE
21	GTEx	Ovary	CRIPAK	0.43	0.27	enet	19	0.32	9.0e-09	-4.2	-5.8	6.9e-09	0.44	0.17	0.56	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CRIPAK	0.31	0.15	enet	34	0.26	1.2e-31	-3.5	-5.8	8.2e-09	0.52	0.73	0.10	FALSE
17	GTEx	Lung	CRIPAK	0.61	0.22	enet	46	0.41	1.1e-33	-4.2	-5.7	1.3e-08	0.45	0.40	0.51	FALSE
3	GTEx	Adipose Visceral Omentum	UVSSA	0.46	0.05	lasso	11	0.24	1.1e-12	-4.1	-5.6	2.4e-08	0.48	0.16	0.78	FALSE
8	GTEx	Brain Cerebellum	CRIPAK	0.37	0.09	enet	24	0.31	8.8e-10	-3.6	-5.5	2.9e-08	0.47	0.12	0.66	FALSE
7	GTEx	Artery Tibial	CRIPAK	0.42	0.09	enet	50	0.34	1.3e-27	2.5	-5.5	4.7e-08	0.37	0.78	0.03	FALSE
13	GTEx	Breast Mammary Tissue (Female)	UVSSA	0.21	0.02	enet	24	0.05	1.3e-02	-3.3	-5.4	5.5e-08	0.49	0.04	0.42	FALSE
5	GTEx	Artery Aorta	CRIPAK	0.31	0.20	enet	34	0.30	2.8e-17	-4.2	-5.4	5.7e-08	0.45	0.35	0.57	FALSE
15	GTEx	Colon Transverse	CRIPAK	0.33	0.10	enet	22	0.24	5.8e-12	-3.5	-5.4	6.3e-08	0.36	0.53	0.33	FALSE
10	GTEx	Brain Hippocampus	CRIPAK	0.48	0.22	lasso	4	0.23	4.0e-06	-3.5	-5.4	6.6e-08	0.46	0.06	0.64	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	CRIPAK	0.39	0.14	lasso	13	0.34	1.5e-19	-4.2	-5.4	6.7e-08	0.43	0.13	0.84	FALSE
26	NTR	Blood	KIAA1530	0.19	0.04	blup	345	0.10	9.1e-32	-4.1	-5.4	8.7e-08	0.48	0.41	0.50	FALSE
2	GTEx	Adipose Subcutaneous	CRIPAK	0.42	0.11	enet	42	0.34	9.0e-29	-3.5	-5.3	1.0e-07	0.42	0.71	0.12	FALSE
6	GTEx	Artery Tibial	UVSSA	0.27	0.01	enet	40	0.14	1.9e-11	1.6	-5.3	1.3e-07	0.39	0.48	0.34	FALSE
25	GTEx	Whole Blood	CRIPAK	0.38	0.17	lasso	9	0.28	3.4e-26	-3.5	-5.3	1.4e-07	0.32	0.70	0.13	FALSE
11	GTEx	Brain Putamen basal ganglia	CRIPAK	0.30	0.00	enet	25	0.10	1.9e-03	-3.9	-5.2	1.6e-07	0.49	0.02	0.63	FALSE
12	GTEx	Breast Mammary Tissue	CRIPAK	0.42	0.12	enet	35	0.39	5.2e-21	-4.2	-5.2	1.9e-07	0.30	0.40	0.50	FALSE
18	GTEx	Muscle Skeletal	FGFRL1	0.14	0.08	lasso	4	0.06	3.7e-06	-5.5	5.2	1.9e-07	-0.98	0.00	1.00	FALSE
22	GTEx	Pancreas	CRIPAK	0.34	0.13	lasso	6	0.27	1.0e-11	-3.5	-5.2	2.3e-07	0.31	0.50	0.28	FALSE
14	GTEx	Cells Transformed fibroblasts	CRIPAK	0.35	0.06	enet	33	0.22	3.0e-16	-3.5	-5.2	2.5e-07	0.39	0.71	0.12	FALSE
27	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CRIPAK	0.34	0.13	blup	29	0.19	3.9e-13	-4.2	-5.1	3.0e-07	0.27	0.00	0.86	FALSE