Best TWAS P=4.85e-08 · Best GWAS P=5.18e-08 conditioned to 0.244
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | DLG5 | 0.22 | 0.14 | lasso | 6 | 0.11 | 8.5e-05 | -4.9 | -5.5 | 4.8e-08 | 0.91 | 0.03 | 0.95 | TRUE |
2 | GTEx | Artery Aorta | DLG5 | 0.26 | 0.19 | enet | 10 | 0.22 | 2.6e-12 | -4.8 | -5.2 | 1.7e-07 | 0.96 | 0.01 | 0.99 | FALSE |
3 | GTEx | Breast Mammary Tissue | DLG5 | 0.15 | 0.09 | lasso | 7 | 0.08 | 6.7e-05 | -5.4 | -5.2 | 2.0e-07 | 0.94 | 0.01 | 0.98 | FALSE |
4 | GTEx | Heart Atrial Appendage | DLG5 | 0.32 | 0.23 | lasso | 4 | 0.24 | 3.9e-11 | -5.4 | -5.2 | 1.6e-07 | 0.97 | 0.01 | 0.99 | FALSE |
5 | GTEx | Heart Left Ventricle | DLG5 | 0.13 | 0.10 | lasso | 4 | 0.09 | 1.2e-05 | -5.4 | -5.3 | 1.1e-07 | 0.98 | 0.01 | 0.99 | FALSE |
6 | GTEx | Ovary | DLG5 | 0.62 | 0.38 | lasso | 6 | 0.40 | 5.3e-11 | -5.2 | -5.3 | 1.3e-07 | 0.95 | 0.01 | 0.99 | FALSE |
7 | GTEx | Ovary | RP13-39P12.3 | 0.42 | 0.29 | lasso | 5 | 0.33 | 7.5e-09 | -5.2 | -5.3 | 1.4e-07 | 0.93 | 0.01 | 0.99 | FALSE |
8 | GTEx | Pancreas | DLG5 | 0.39 | 0.43 | enet | 11 | 0.44 | 3.5e-20 | -4.8 | -5.2 | 2.3e-07 | 0.95 | 0.03 | 0.97 | FALSE |
9 | GTEx | Pituitary | DLG5 | 0.45 | 0.36 | lasso | 11 | 0.31 | 1.9e-08 | -5.2 | -5.2 | 2.5e-07 | 0.96 | 0.01 | 0.99 | FALSE |