Best TWAS P=1.64e-13 · Best GWAS P=2.31e-10 conditioned to 0.822
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | ZCCHC24 | 0.12 | 0.01 | lasso | 6 | 0.03 | 3.4e-03 | 3.4 | 6.7 | 2.5e-11 | 0.52 | 0.04 | 0.85 | TRUE |
2 | GTEx | Adipose Visceral Omentum | BEND3P3 | 0.27 | 0.13 | lasso | 10 | 0.13 | 3.0e-07 | 6.0 | -6.3 | 3.6e-10 | -0.90 | 0.01 | 0.99 | FALSE |
3 | GTEx | Artery Aorta | BEND3P3 | 0.19 | 0.05 | enet | 22 | 0.09 | 7.5e-06 | 4.5 | -5.5 | 4.3e-08 | -0.79 | 0.05 | 0.94 | FALSE |
4 | GTEx | Artery Aorta | RP11-119F19.2 | 0.22 | 0.16 | lasso | 9 | 0.18 | 2.7e-10 | 5.9 | -5.8 | 8.9e-09 | -0.87 | 0.03 | 0.97 | FALSE |
5 | GTEx | Artery Coronary | RP11-119F19.2 | 0.24 | 0.14 | lasso | 6 | 0.12 | 7.0e-05 | 6.3 | -6.4 | 1.9e-10 | -0.97 | 0.01 | 0.98 | FALSE |
6 | GTEx | Artery Tibial | BEND3P3 | 0.22 | 0.07 | enet | 14 | 0.10 | 5.8e-08 | 5.9 | -5.3 | 1.2e-07 | -0.77 | 0.02 | 0.98 | FALSE |
7 | GTEx | Artery Tibial | RP11-506M13.3 | 0.12 | 0.06 | lasso | 5 | 0.04 | 3.2e-04 | 5.9 | -5.8 | 6.1e-09 | -0.85 | 0.02 | 0.96 | FALSE |
8 | GTEx | Esophagus Mucosa | RP11-119F19.2 | 0.20 | 0.10 | lasso | 5 | 0.18 | 2.1e-12 | 5.9 | -5.1 | 2.7e-07 | -0.82 | 0.04 | 0.96 | FALSE |
9 | GTEx | Esophagus Muscularis | BEND3P3 | 0.17 | 0.13 | lasso | 6 | 0.13 | 4.4e-08 | 4.5 | -5.5 | 4.9e-08 | -0.79 | 0.11 | 0.89 | FALSE |
10 | GTEx | Heart Atrial Appendage | RP11-119F19.2 | 0.18 | 0.03 | lasso | 7 | 0.05 | 2.5e-03 | 5.9 | -5.7 | 1.5e-08 | -0.79 | 0.02 | 0.89 | FALSE |
11 | GTEx | Liver | RP11-119F19.2 | 0.24 | 0.05 | lasso | 6 | 0.02 | 7.5e-02 | 5.8 | 5.3 | 1.2e-07 | 0.47 | 0.04 | 0.45 | FALSE |
12 | GTEx | Lung | BEND3P3 | 0.16 | 0.06 | enet | 12 | 0.09 | 2.7e-07 | 4.3 | -6.3 | 3.0e-10 | -0.75 | 0.03 | 0.97 | FALSE |
13 | GTEx | Lung | RP11-119F19.2 | 0.24 | 0.09 | lasso | 12 | 0.18 | 1.5e-13 | 5.8 | -5.2 | 2.1e-07 | -0.63 | 0.04 | 0.96 | FALSE |
14 | GTEx | Nerve Tibial | RP11-506M13.3 | 0.08 | 0.04 | lasso | 3 | 0.05 | 3.3e-04 | 2.2 | -5.7 | 1.5e-08 | -0.70 | 0.05 | 0.88 | FALSE |
15 | GTEx | Thyroid | BEND3P3 | 0.20 | 0.12 | lasso | 4 | 0.17 | 4.1e-13 | 6.0 | -5.9 | 3.4e-09 | -0.82 | 0.02 | 0.98 | FALSE |
16 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ZCCHC24 | 0.06 | 0.00 | blup | 89 | 0.01 | 6.2e-02 | 4.9 | 6.2 | 6.1e-10 | 0.63 | 0.01 | 0.22 | FALSE |
17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SFTPA2 | 0.06 | 0.03 | enet | 12 | 0.04 | 2.1e-09 | 4.5 | -6.8 | 9.3e-12 | -0.83 | 0.19 | 0.81 | FALSE |
18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZCCHC24 | 0.03 | 0.01 | blup | 89 | 0.02 | 2.0e-04 | 4.9 | 5.9 | 4.5e-09 | 0.67 | 0.15 | 0.64 | FALSE |
19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SFTPA2 | 0.14 | 0.08 | enet | 8 | 0.10 | 7.6e-12 | 5.8 | -7.4 | 1.6e-13 | -0.77 | 0.02 | 0.98 | TRUE |