Best TWAS P=1.9e-09 · Best GWAS P=2.11e-08 conditioned to 0.0314
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Female) | CCDC92 | 0.05 | -0.01 | enet | 2 | -0.01 | 6.2e-01 | -5.4 | -5.4 | 7.4e-08 | 1.00 | 0.03 | 0.50 | FALSE |
| 2 | GTEx | Esophagus Mucosa | CCDC92 | 0.11 | 0.02 | lasso | 4 | 0.02 | 1.9e-02 | -5.4 | -5.2 | 1.5e-07 | 0.99 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Heart Left Ventricle | CCDC92 | 0.26 | 0.19 | lasso | 4 | 0.21 | 1.9e-11 | -5.4 | -5.6 | 2.4e-08 | 0.95 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | RP11-380L11.4 | 0.04 | 0.02 | enet | 15 | 0.02 | 1.9e-02 | -4.6 | -5.2 | 2.6e-07 | 0.81 | 0.06 | 0.86 | FALSE |
| 5 | GTEx | Testis | RP11-380L11.3 | 0.14 | 0.05 | enet | 29 | 0.06 | 1.4e-03 | -5.4 | -5.9 | 3.8e-09 | 0.59 | 0.02 | 0.90 | FALSE |
| 6 | GTEx | Thyroid | ZNF664 | 0.13 | 0.06 | lasso | 11 | 0.08 | 6.7e-07 | -5.4 | 5.7 | 1.3e-08 | -0.97 | 0.02 | 0.98 | FALSE |
| 7 | METSIM | Adipose | DNAH10 | 0.03 | 0.00 | bslmm | 475 | 0.01 | 3.2e-03 | -4.4 | -6.0 | 1.9e-09 | 0.66 | 0.04 | 0.78 | TRUE |
| 8 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CCDC92 | 0.05 | 0.03 | blup | 52 | 0.03 | 5.8e-03 | -4.3 | -5.2 | 1.9e-07 | 0.92 | 0.02 | 0.81 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | DNAH10 | 0.04 | 0.03 | lasso | 5 | 0.02 | 4.6e-03 | -5.2 | -5.4 | 7.6e-08 | 0.92 | 0.03 | 0.69 | FALSE |