TWAS
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Genes
Traits
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Traits
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Hand grip strength (right)
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chr13:20,282,946-21,799,768
Best TWAS P=9.15e-08 · Best GWAS P=3.78e-06 conditioned to 0.23
20.2M
20.4M
20.6M
20.8M
21M
21.2M
21.4M
21.6M
21.8M
0
1
2
3
4
5
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Cells EBV-transformed lymphocytes
CRYL1
0.27
0.00
lasso
11
0.00
0.34400
-4.4
-5.3
9.2e-08
0.71
0.01
0.31
TRUE
3
The Cancer Genome Atlas
Thyroid Carcinoma
IFT88
0.05
0.00
blup
85
0.02
0.00213
2.3
5.3
1.0e-07
-0.61
0.01
0.14
FALSE
2
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
IFT88
0.04
0.03
blup
83
0.03
0.00022
3.5
5.3
1.2e-07
-0.50
0.06
0.31
FALSE