Best TWAS P=5.13e-08 · Best GWAS P=5.8e-08 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NFATC2IP | 0.05 | 0.03 | blup | 183 | 0.04 | 1.3e-05 | -4.4 | -5.4 | 5.7e-08 | 0.05 | 0.07 | 0.90 | TRUE |
2 | GTEx | Adipose Subcutaneous | EIF3CL | 0.11 | 0.08 | enet | 9 | 0.14 | 7.8e-12 | -4.7 | -5.4 | 7.0e-08 | 0.04 | 0.04 | 0.94 | FALSE |
3 | GTEx | Artery Tibial | EIF3C | 0.07 | 0.07 | lasso | 5 | 0.07 | 2.6e-06 | -4.8 | -5.2 | 1.5e-07 | 0.06 | 0.05 | 0.93 | FALSE |
4 | GTEx | Nerve Tibial | TBX6 | 0.20 | 0.24 | lasso | 7 | 0.24 | 1.2e-16 | 5.4 | 5.4 | 8.2e-08 | 0.95 | 0.01 | 0.99 | FALSE |
5 | GTEx | Nerve Tibial | EIF3C | 0.15 | 0.05 | lasso | 6 | 0.08 | 1.8e-06 | -4.2 | -5.2 | 1.6e-07 | 0.05 | 0.08 | 0.79 | FALSE |
6 | GTEx | Pituitary | YPEL3 | 0.12 | 0.04 | lasso | 4 | 0.05 | 2.5e-02 | 4.7 | 5.4 | 5.2e-08 | 0.89 | 0.03 | 0.77 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | EIF3C | 0.07 | 0.06 | lasso | 4 | 0.07 | 4.1e-06 | -4.8 | -5.3 | 1.3e-07 | 0.07 | 0.02 | 0.96 | FALSE |
8 | GTEx | Small Intestine Terminal Ileum | INO80E | 0.20 | 0.14 | lasso | 17 | 0.08 | 6.2e-03 | 5.3 | -5.2 | 2.0e-07 | -0.94 | 0.04 | 0.88 | FALSE |
9 | YFS | Blood | INO80E | 0.02 | 0.02 | lasso | 5 | 0.02 | 3.7e-07 | 5.3 | -5.2 | 2.3e-07 | -0.99 | 0.02 | 0.98 | FALSE |
10 | YFS | Blood | PPP4C | 0.03 | 0.05 | lasso | 4 | 0.05 | 4.0e-15 | 4.8 | -5.3 | 1.2e-07 | -0.91 | 0.06 | 0.94 | FALSE |
11 | The Cancer Genome Atlas | Esophageal Carcinoma | PPP4C | 0.08 | 0.04 | blup | 23 | 0.05 | 8.9e-03 | 4.8 | -5.1 | 2.9e-07 | -0.90 | 0.01 | 0.76 | FALSE |
12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FAM57B | 0.65 | 0.02 | lasso | 4 | 0.02 | 2.6e-03 | 5.3 | -5.4 | 5.2e-08 | -0.97 | 0.02 | 0.94 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DOC2A | 0.03 | 0.03 | lasso | 5 | 0.03 | 9.6e-04 | 5.4 | -5.4 | 5.1e-08 | -0.99 | 0.01 | 0.97 | TRUE |