Best TWAS P=5.32e-11 · Best GWAS P=9.61e-11 conditioned to 0.0256
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Thyroid | NOB1 | 0.03 | 0.01 | enet | 6 | 0.02 | 7.7e-03 | -5.6 | 6.6 | 5.3e-11 | 0.77 | 0.04 | 0.86 | TRUE |
2 | GTEx | Thyroid | CTD-2033A16.3 | 0.03 | 0.02 | enet | 7 | 0.02 | 6.7e-03 | -4.2 | 6.0 | 1.9e-09 | 0.69 | 0.10 | 0.65 | FALSE |
3 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | CLEC18A | 0.10 | 0.06 | lasso | 2 | 0.04 | 6.3e-03 | 5.6 | 5.6 | 1.8e-08 | 0.53 | 0.03 | 0.42 | FALSE |
4 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PDXDC2 | 0.20 | 0.02 | blup | 26 | 0.07 | 1.8e-04 | 5.0 | 5.4 | 8.0e-08 | 0.46 | 0.06 | 0.37 | FALSE |
5 | The Cancer Genome Atlas | Colon Adenocarcinoma | CLEC18A | 0.14 | 0.18 | lasso | 5 | 0.15 | 4.5e-09 | 5.6 | 5.9 | 3.6e-09 | 0.56 | 0.05 | 0.95 | FALSE |
6 | The Cancer Genome Atlas | Glioblastoma Multiforme | PDXDC2 | 0.10 | 0.12 | lasso | 3 | 0.10 | 4.7e-04 | 5.6 | 5.6 | 1.8e-08 | 0.53 | 0.01 | 0.85 | FALSE |
7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PDXDC2 | 0.14 | 0.05 | enet | 6 | 0.05 | 3.2e-06 | 4.9 | 5.5 | 3.3e-08 | 0.42 | 0.12 | 0.85 | FALSE |
8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CLEC18A | 0.06 | 0.10 | lasso | 1 | 0.09 | 6.9e-11 | 5.6 | 5.6 | 2.1e-08 | 0.53 | 0.08 | 0.92 | FALSE |
9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PDXDC2 | 0.09 | 0.01 | blup | 26 | 0.06 | 4.7e-05 | 4.8 | 5.5 | 3.0e-08 | 0.47 | 0.02 | 0.87 | FALSE |
10 | The Cancer Genome Atlas | Rectum Adenocarcinoma | CLEC18A | 0.15 | 0.03 | blup | 23 | 0.09 | 4.3e-03 | 5.0 | 5.8 | 5.0e-09 | 0.63 | 0.01 | 0.47 | FALSE |
11 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CLEC18A | 0.12 | 0.11 | lasso | 2 | 0.11 | 3.4e-07 | 5.8 | 5.9 | 4.6e-09 | 0.56 | 0.04 | 0.96 | FALSE |
12 | The Cancer Genome Atlas | Soft Tissue Sarcoma | PDXDC2 | 0.05 | 0.01 | blup | 26 | 0.03 | 9.5e-03 | 4.9 | 6.1 | 1.1e-09 | 0.55 | 0.02 | 0.54 | FALSE |
13 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | CLEC18A | 0.17 | 0.09 | enet | 8 | 0.11 | 8.5e-04 | 5.0 | 6.2 | 7.3e-10 | 0.63 | 0.01 | 0.82 | FALSE |
14 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CLEC18A | 0.20 | 0.09 | lasso | 5 | 0.08 | 8.8e-04 | 6.0 | 6.1 | 1.1e-09 | 0.70 | 0.01 | 0.90 | FALSE |