Best TWAS P=4.95e-17 · Best GWAS P=1.02e-13 conditioned to 0.105
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | PIP4K2B | 0.15 | 0.07 | lasso | 5 | 0.07 | 2.2e-06 | -7.4 | -7.3 | 2.6e-13 | 0.95 | 0.00 | 1.00 | FALSE |
2 | GTEx | Artery Aorta | PSMB3 | 0.23 | 0.17 | enet | 26 | 0.22 | 2.1e-12 | -7.4 | -6.2 | 4.7e-10 | 0.84 | 0.00 | 1.00 | FALSE |
3 | GTEx | Artery Tibial | PSMB3 | 0.10 | 0.02 | enet | 12 | 0.03 | 1.2e-03 | -7.4 | -6.0 | 2.4e-09 | 0.73 | 0.00 | 0.99 | FALSE |
4 | GTEx | Artery Tibial | PIP4K2B | 0.37 | 0.16 | enet | 49 | 0.22 | 2.1e-17 | -7.4 | -8.4 | 4.9e-17 | 0.76 | 0.00 | 1.00 | TRUE |
5 | GTEx | Testis | PSMB3 | 0.30 | 0.24 | lasso | 4 | 0.21 | 8.9e-10 | -7.4 | -7.6 | 3.9e-14 | 1.00 | 0.00 | 1.00 | FALSE |
6 | NTR | Blood | PIP4K2B | 0.02 | 0.01 | lasso | 3 | 0.01 | 6.4e-04 | -7.4 | 7.1 | 1.3e-12 | -0.97 | 0.00 | 0.99 | FALSE |
7 | YFS | Blood | PSMB3 | 0.14 | 0.11 | enet | 31 | 0.16 | 7.2e-49 | -7.3 | -6.3 | 3.6e-10 | 0.81 | 0.00 | 1.00 | FALSE |
8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PSMB3 | 0.04 | 0.00 | blup | 37 | 0.02 | 6.7e-03 | -2.9 | -5.6 | 2.1e-08 | 0.72 | 0.01 | 0.69 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PSMB3 | 0.14 | 0.05 | blup | 42 | 0.05 | 8.9e-07 | -7.3 | -5.5 | 3.2e-08 | 0.70 | 0.00 | 1.00 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PSMB3 | 0.12 | 0.02 | enet | 14 | 0.05 | 1.3e-03 | -6.2 | -5.8 | 6.5e-09 | 0.63 | 0.00 | 0.80 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PIP4K2B | 0.05 | 0.04 | blup | 56 | 0.05 | 5.3e-06 | -6.2 | -7.1 | 1.4e-12 | 0.86 | 0.00 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMB3 | 0.11 | 0.07 | blup | 42 | 0.07 | 9.4e-08 | -7.4 | -6.0 | 1.5e-09 | 0.77 | 0.00 | 1.00 | FALSE |
13 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | PSMB3 | 0.12 | 0.09 | lasso | 3 | 0.06 | 3.0e-03 | -7.3 | -7.2 | 4.5e-13 | 0.97 | 0.00 | 0.94 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | PSMB3 | 0.05 | 0.06 | lasso | 1 | 0.05 | 2.4e-05 | -7.4 | -7.4 | 1.0e-13 | 1.00 | 0.00 | 1.00 | FALSE |