Best TWAS P=2.29e-09 · Best GWAS P=2.57e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | DOT1L | 0.09 | 0.06 | lasso | 5 | 0.05 | 7.3e-05 | 5.6 | 5.8 | 9.1e-09 | -0.89 | 0.02 | 0.98 | FALSE |
| 2 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DOT1L | 0.08 | 0.12 | enet | 8 | 0.10 | 2.5e-11 | 5.6 | 6.0 | 2.3e-09 | -0.96 | 0.01 | 0.99 | TRUE |
| 3 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DOT1L | 0.09 | 0.08 | blup | 60 | 0.07 | 4.1e-04 | -5.4 | 5.5 | 3.1e-08 | -0.87 | 0.02 | 0.96 | FALSE |